KEGG ENZYME: 2.7.1.3

ENZYME: 2.7.1.3

Entry

EC 2.7.1.3 Enzyme

Name

ketohexokinase;
ketohexokinase (phosphorylating)

Class

Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor

Sysname

ATP:D-fructose 1-phosphotransferase

Reaction(IUBMB)

ATP + D-fructose = ADP + D-fructose 1-phosphate [RN:R00866]

Reaction(KEGG)

R00866;
(other) R03819

Substrate

ATP [CPD:C00002];
D-fructose [CPD:C00095]

Product

ADP [CPD:C00008];
D-fructose 1-phosphate [CPD:C01094]

Comment

D-Sorbose, D-tagatose and 5-dehydro-D-fructose and a number of other ketoses and their analogues can also act as substrates [4].

History

EC 2.7.1.3 created 1961

Pathway

ec00051

Fructose and mannose metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K00846

ketohexokinase

Genes

HSA:

3795(KHK)

PTR:	740614(KHK)

PPS:	100986057(KHK)

GGO:	101134632(KHK)

PON:	100447147(KHK)

NLE:	100601410(KHK)

MCC:	698328(KHK)

MCF:	102130504(KHK)

CSAB:

103220615(KHK)

RRO:	104668507(KHK)

RBB:	108532700(KHK)

CJC:	100415528(KHK)

SBQ:	101036824(KHK)

MMU:	16548(Khk)

MCAL:

110294244(Khk)

MPAH:

110324630(Khk)

RNO:	25659(Khk)

MUN:	110547704(Khk)

CGE:	100763359(Khk)

NGI:	103735676(Khk)

HGL:	101705832(Khk)

CCAN:

109679815(Khk)

OCU:	100351729(KHK)

TUP:	102484270(KHK)

CFA:	100170647(KHK)

VVP:	112908466(KHK)

AML:	100467138(KHK)

UMR:	103671661(KHK)

UAH:	113270973(KHK)

ORO:	101384115(KHK)

ELK:

111158431

FCA:	101080375(KHK)

PTG:	102962169(KHK)

PPAD:

109267095(KHK)

AJU:	106967844(KHK)

BTA:	614868(KHK)

BOM:	102268699(KHK)

BIU:	109566299(KHK)

BBUB:

102390464(KHK)

CHX:	102184448(KHK)

OAS:	101113479(KHK)

SSC:	100523241(KHK)

CFR:	102511333(KHK)

CDK:	105098529(KHK)

BACU:

103010435(KHK)

LVE:	103091631(KHK)

OOR:	105747917(KHK)

DLE:	111174970(KHK)

PCAD:

102990262(KHK)

ECB:	100055449(KHK)

EPZ:	103546444(KHK)

EAI:	106837028(KHK)

MYB:	102258355(KHK)

MYD:	102771838(KHK)

MNA:	107534324(KHK)

HAI:	109381471(KHK)

DRO:	112297774(KHK)

PALE:

102893977(KHK)

RAY:	107502157(KHK)

MJV:	108391207(KHK)

LAV:	100654223(KHK)

TMU:

101357800

MDO:	100025922(KHK)

SHR:	116421501(KHK)

PCW:	110206493(KHK)

OAA:	100078974(KHK)

GGA:	107053156(KHK)

MGP:	104915942(KHK)

CJO:	107312319(KHK)

NMEL:

110396880(KHK)

TGU:	115493320(KHK)

LSR:	110478492(KHK)

FAB:	101819131(KHK)

PHI:	102102222(KHK)

PMAJ:

107198696(KHK)

ETL:	114070004(KHK)

FPG:	101916509(KHK)

FCH:	102052292(KHK)

CLV:	102091341(KHK)

ASN:	102372834(KHK)

AMJ:	102559964(KHK)

CMY:	102943037(KHK)

CPIC:

101931226(KHK)

ACS:	100561006(khk)

PVT:	110086983(KHK)

PBI:	103057572(KHK)

PMUR:

107286452(KHK)

TSR:	106545882(KHK)

PMUA:

114593444 114595007

GJA:	107113758(KHK)

XLA:	447317(khk.S)

XTR:	100492918(khk)

NPR:	108803683(KHK)

DRE:	436909(khk)

SRX:	107725530 107729261

SANH:

107681984 107693158

SGH:	107586608(khk) 107589689

CCAR:

109062640 109106840(khk)

IPU:	108269966(khk)

PHYP:

113525410(khk)

AMEX:

103034968(khk)

EEE:	113571086(khk)

TRU:	101064289(khk)

TNG:	GSTEN00010148G001

LCO:	104938896(khk)

MZE:	101480218 112434039

ONL:	100700794(khk)

OLA:	101158269(khk)

XMA:	102233542(khk)

XCO:	114136256(khk)

PRET:

103460363(khk)

CVG:	107102976(khk)

NFU:	107384879(khk)

KMR:	108251243(khk)

ALIM:

106531860 106536394

AOCE:

111566822(khk)

CSEM:

103386816(khk)

POV:	109643312(khk)

LCF:	108890712(khk)

SDU:	111219447(khk)

SLAL:

111649710 111657341(khk)

HCQ:	109522373(khk)

BPEC:

110170273(khk)

MALB:

109966909(khk)

SASA:

100306748(khk)

OTW:	112262142(khk)

SALP:

112071068(khk)

ELS:	105015956(khk)

SFM:	108933631(khk)

PKI:	111857675(khk)

LCM:	102364548(KHK)

CMK:	103184052(khk)

RTP:

109935513

BFO:	118409339 118409679

CIN:

SPU:

APLC:

SKO:

DME:	Dmel_CG12289(CG12289) Dmel_CG7328(CG7328) Dmel_CG7335(CG7335) Dmel_CG7551(CG7551)

DER:	6544584 6544585 6545892 6545893

DSE:	6616242 6616243

DSI:	Dsimw501_GD12218(Dsim_GD12218) Dsimw501_GD12219(Dsim_GD12219) Dsimw501_GD12805(Dsim_GD12805) Dsimw501_GD14306(Dsim_GD14306)

DYA:	Dyak_GE20217 Dyak_GE21811 Dyak_GE22430 Dyak_GE22431 Dyak_GE23230 Dyak_GE28062

DSR:	110178551 110178560 110180400 110180402 110181236 110181237

DPO:	Dpse_GA20264 Dpse_GA20271 Dpse_GA20433 Dpse_GA23880

DPE:	6595995 6595996 6598983 6598987 6598990

DMN:	108151013 108151015 108153686

DWI:	6639377 6639549

DGR:	Dgri_GH14844 Dgri_GH15118 Dgri_GH15119 Dgri_GH16650

DMO:	Dmoj_GI11611 Dmoj_GI13697 Dmoj_GI13699 Dmoj_GI13769 Dmoj_GI13771

DAZ:	108613124 108613130 108614724 108614745

DNV:	108650288 108650597 108651097 108651102 115562088

DHE:	111593110 111593120 111593132 111601003 111601005

MDE:

101899690

LCQ:

111686313

AGA:	AgaP_AGAP002483

CQU:	CpipJ_CPIJ012838

AME:

BIM:

BTER:

CCAL:

OBB:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

LHU:

PGC:

OBO:

PCF:

NVI:

CSOL:

MDL:

FCD:

DPX:	DAPPUDRAFT_213561

PVM:	113811632 113813578

TUT:

107371958

CSCU:

111624977

PTEP:

107455070

LOA:	LOAG_12304

LGI:	LOTGIDRAFT_122584 LOTGIDRAFT_204853

PCAN:

112557004 112566312

CRG:

105331023

MYI:	110448125 110448126

OBI:

106876478

LAK:	106157266 106157428 106167802

NVE:	116602276 116602281 116617953 5518877 5518890

EPA:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

TAD:	TRIADDRAFT_58015

AQU:

100637048

SLY:

101251969

NCR:

NCU03742

NTE:	NEUTE1DRAFT144445(NEUTE1DRAFT_144445)

SMP:	SMAC_02593

PAN:	PODANSg8149

TTT:	THITE_2107054

MTM:	MYCTH_2116851

CTHR:

CTHT_0065770

MGR:

MGG_15061

SSCK:

SPSK_10998

FPU:	FPSE_04113

FVR:	FVEG_16233

NHE:	NECHADRAFT_48854

TRE:	TRIREDRAFT_53989

TRR:	M419DRAFT_68938

MAW:

MAC_00511

MAJ:

MAA_11256

CMT:

CCM_05591

VAL:	VDBG_04219

VDA:	VDAG_01448

CFJ:	CFIO01_06771

SAPO:

SAPIO_CDS10423

PFY:	PFICI_12080

ANI:

AN0344.2

ACT:	ACLA_032210

NFI:	NFIA_022430

AOR:	AO090005000876

ANG:	ANI_1_774014(An01g06030)

AFV:	AFLA_081250

PCS:	Pc22g22030

TMF:	PMAA_084000

TRG:	TRUGW13939_08233

CIM:	CIMG_03621

CPW:	CPC735_006510

PBL:	PAAG_01961

PBN:	PADG_00630

URE:	UREG_06285

AJE:	HCAG_00040

BGH:	BDBG_06300

PNO:	SNOG_00283

PTE:

PTT_11946

BZE:	COCCADRAFT_36990

BSC:	COCSADRAFT_87238

BOR:	COCMIDRAFT_24285

AALT:

CC77DRAFT_977803

PFJ:	MYCFIDRAFT_210004

WSE:	WALSEDRAFT_59637

AAF:	AURANDRAFT_4866

PIF:	PITG_02500

PSOJ:

PHYSODRAFT_467118 PHYSODRAFT_470432

SPAR:

SPRG_00529

EHX:	EMIHUDRAFT_117776 EMIHUDRAFT_203243

TCX:

Tcr_1488

HTR:	EPV75_07980

HMAR:

HVMH_1610

TCY:	Thicy_1233

TAO:	THIAE_02530

THIO:

MEJ:

MEC:

THIG:

TSE:	THMIRHAS_08630

TZO:	THMIRHAT_17430

TIG:

THIS:

NOC:

NHL:

NWA:

NWR:	E3U44_01960

TMB:	Thimo_2207

MPUR:

MARPU_01580

TEE:

Tel_15560

NTT:

TAO_0241

TSY:	THSYN_22105

NTG:	NSCAC_1404(khk)

HHA:

Hhal_0921

EBS:	ECTOBSL9_1159

TGR:

Tgr7_0113

TKM:

TK90_0283

TNI:	TVNIR_3462(ydjH_[C])

TTI:	THITH_14855

TVR:

TVD_01845

APRS:

BI364_00505

HNA:	Hneap_0029

HAZ:	A9404_09215

GHL:	GM160_00165

TTC:	FOKN1_2948

TBN:

TBH_C0398

REV:	HUE57_18300

ENM:	EBS_2134(khk)

AMIC:

Ami3637_01690

MOX:	DAMO_2523(KHK)

» show all

Reference

1 [PMID:14858418]

Authors

CORI GT, OCHOA S, SLEIN MW, CORI CF.

Title

The metabolism of fructose in liver; isolation of fructose-I-phosphate and inorganic pyrophosphate.

Journal

Biochim Biophys Acta 7:304-17 (1951)
DOI:10.1016/0006-3002(51)90032-7

Reference

2 [PMID:13208667]

Authors

HERS HG.

Title

[Liver fructokinase.]

Journal

Biochim Biophys Acta 8:416-23 (1952)
DOI:10.1016/0006-3002(52)90067-x

Reference

3 [PMID:13449068]

Authors

PARKS RE Jr, BEN-GERSHOM E, LARDY HA.

Title

Liver fructokinase.

Journal

J Biol Chem 227:231-42 (1957)

Reference

4 [PMID:193556]

Authors

Raushel FM, Cleland WW.

Title

Bovine liver fructokinase: purification and kinetic properties.

Journal

Biochemistry 16:2169-75 (1977)
DOI:10.1021/bi00629a020

Other DBs

ExplorEnz - The Enzyme Database:

2.7.1.3

IUBMB Enzyme Nomenclature:

2.7.1.3

ExPASy - ENZYME nomenclature database:

2.7.1.3

BRENDA, the Enzyme Database:

2.7.1.3

CAS:

9030-50-6

DBGET integrated database retrieval system