KEGG   ENZYME: 2.7.4.15
Entry
EC 2.7.4.15                 Enzyme                                 

Name
thiamine-diphosphate kinase;
ATP:thiamin-diphosphate phosphotransferase;
TDP kinase;
thiamin diphosphate kinase;
thiamin diphosphate phosphotransferase;
thiamin pyrophosphate kinase;
thiamine diphosphate kinase;
protein bound thiamin diphosphate:ATP phosphoryltransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor
Sysname
ATP:thiamine-diphosphate phosphotransferase
Reaction(IUBMB)
ATP + thiamine diphosphate = ADP + thiamine triphosphate [RN:R00616]
Reaction(KEGG)
R00616
Substrate
ATP [CPD:C00002];
thiamine diphosphate [CPD:C00068]
Product
ADP [CPD:C00008];
thiamine triphosphate [CPD:C03028]
History
EC 2.7.4.15 created 1972
Pathway
ec00730  Thiamine metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:5661031]
  Authors
Itokawa Y, Cooper JR.
  Title
The enzymatic synthesis of triphosphothiamin.
  Journal
Biochim Biophys Acta 158:180-2 (1968)
DOI:10.1016/0304-4165(68)90093-7
Reference
2
  Authors
Kikuchi, M. and Ikawa, T.
  Title
Presence of an enzyme mediating transfer of phosphate from thiamine triphosphate to ADP in germinating maize.
  Journal
Bot Mag (Tokyo) 97:193-205 (1984)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.4.15
IUBMB Enzyme Nomenclature: 2.7.4.15
ExPASy - ENZYME nomenclature database: 2.7.4.15
BRENDA, the Enzyme Database: 2.7.4.15
CAS: 9075-79-0

KEGG   REACTION: R00616
Entry
R00616                      Reaction                               

Name
ATP:thiamine-diphosphate phosphotransferase
Definition
ATP + Thiamin diphosphate <=> ADP + Thiamin triphosphate
Equation
Reaction class
RC00002  C00002_C00008  C00068_C03028
Enzyme
Pathway
rn00730  Thiamine metabolism
rn01100  Metabolic pathways
Other DBs
RHEA: 11243

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