KEGG   ENZYME: 3.1.1.10Help
Entry
EC 3.1.1.10                 Enzyme                                 

Name
tropinesterase;
tropine esterase;
atropinase;
atropine esterase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
atropine acylhydrolase
Reaction(IUBMB)
atropine + H2O = tropine + tropate [RN:R03563]
Reaction(KEGG)
Substrate
atropine [CPD:C01479];
H2O [CPD:C00001]
Product
tropine [CPD:C00729];
tropate [CPD:C01456]
Comment
Also acts on cocaine and other tropine esters.
History
EC 3.1.1.10 created 1961, deleted 1972, reinstated 1976
Pathway
ec00960  Tropane, piperidine and pyridine alkaloid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Reference
1
  Authors
Glick, D., Glaubach, S. and Moore, D.H.
  Title
Azolesterase activities of electrophoretically separated proteins of serum.
  Journal
J Biol Chem 144:525-528 (1942)
Reference
2  [PMID:4435736]
  Authors
Moog P, Krisch K.
  Title
[The purification and characterization of atropine esterase from rabbit liver microsomes (author's transl)]
  Journal
Hoppe Seylers Z Physiol Chem 355:529-42 (1974)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.10
IUBMB Enzyme Nomenclature: 3.1.1.10
ExPASy - ENZYME nomenclature database: 3.1.1.10
UM-BBD (Biocatalysis/Biodegradation Database): 3.1.1.10
BRENDA, the Enzyme Database: 3.1.1.10
CAS: 59536-71-9

KEGG   REACTION: R03563Help
Entry
R03563                      Reaction                               

Name
Atropine acylhydrolase
Definition
Atropine + H2O <=> Tropine + Tropate
Equation
Reaction class
RC00055  C00729_C01479
RC00523  C01456_C01479
Enzyme
Pathway
rn00960  Tropane, piperidine and pyridine alkaloid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Other DBs
RHEA: 23307

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