KEGG   ENZYME: 3.6.1.14Help
Entry
EC 3.6.1.14                 Enzyme                                 

Name
adenosine-tetraphosphatase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
adenosine-tetraphosphate phosphohydrolase
Reaction(IUBMB)
adenosine 5'-tetraphosphate + H2O = ATP + phosphate [RN:R00128]
Reaction(KEGG)
R00128;
(other) R00723
Show
Substrate
adenosine 5'-tetraphosphate [CPD:C03483];
H2O [CPD:C00001]
Product
ATP [CPD:C00002];
phosphate [CPD:C00009]
Comment
Also acts on inosine tetraphosphate and tripolyphosphate but shows little or no activity with other nucleotides or polyphosphates.
History
EC 3.6.1.14 created 1972
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:4287215]
  Authors
Small GD, Cooper C.
  Title
Purification and properties of nucleoside tetraphosphate hydrolase from rabbit muscle.
  Journal
Biochemistry 5:14-26 (1966)
DOI:10.1021/bi00865a003
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.14
IUBMB Enzyme Nomenclature: 3.6.1.14
ExPASy - ENZYME nomenclature database: 3.6.1.14
BRENDA, the Enzyme Database: 3.6.1.14
CAS: 37289-26-2

KEGG   REACTION: R00723Help
Entry
R00723                      Reaction                               

Name
Inosine 5'-tetraphosphate phosphohydrolase
Definition
Inosine 5'-tetraphosphate + H2O <=> ITP + Orthophosphate
Equation
Reaction class
RC00002  C00081_C03614
Enzyme
Pathway
rn00230  Purine metabolism
rn01100  Metabolic pathways

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