KEGG   ENZYME: 4.1.1.78
Entry
EC 4.1.1.78                 Enzyme                                 

Name
acetylenedicarboxylate decarboxylase;
acetylenedicarboxylate hydratase;
acetylenedicarboxylate hydrase;
acetylenedicarboxylate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
acetylenedicarboxylate carboxy-lyase (pyruvate-forming)
Reaction(IUBMB)
acetylenedicarboxylate + H2O = pyruvate + CO2 [RN:R00218]
Reaction(KEGG)
R00218;
(other) R04177
Substrate
acetylenedicarboxylate [CPD:C03248];
H2O [CPD:C00001]
Product
pyruvate [CPD:C00022];
CO2 [CPD:C00011]
Comment
The mechanism appears to involve hydration of the acetylene and decarboxylation of the oxaloacetic acid formed, although free oxaloacetate is not an intermediate. It is thus analogous to EC 4.2.1.27 (acetylenecarboxylate hydratase) in its mechanism.
History
EC 4.1.1.78 created 1978 as EC 4.2.1.72, transferred 2000 to EC 4.1.1.78
Pathway
ec00620  Pyruvate metabolism
Reference
1  [PMID:13575441]
  Authors
YAMADA EW, JAKOBY WB.
  Title
Enzymatic utilization of acetylenic compounds. I. An enzyme converting acetylenedicarboxylic acid to pyruvate.
  Journal
J Biol Chem 233:706-11 (1958)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.78
IUBMB Enzyme Nomenclature: 4.1.1.78
ExPASy - ENZYME nomenclature database: 4.1.1.78
BRENDA, the Enzyme Database: 4.1.1.78
CAS: 72561-10-5

KEGG   REACTION: R04177
Entry
R04177                      Reaction                               

Name
2-Hydroxyethylenedicarboxylate hydro-lyase
Definition
2-Hydroxyethylenedicarboxylate <=> Acetylenedicarboxylate + H2O
Equation
Reaction class
RC01096  C03248_C03981
Enzyme
Pathway
rn00620  Pyruvate metabolism

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