KEGG   ENZYME: 4.1.2.32
Entry
EC 4.1.2.32                 Enzyme                                 
Name
trimethylamine-oxide aldolase;
trimethylamine N-oxide formaldehyde-lyase;
trimethylamine N-oxide aldolase;
trimethylamine N-oxide demethylase;
trimethylamine-N-oxide formaldehyde-lyase
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
Sysname
trimethylamine-N-oxide formaldehyde-lyase (dimethylamine-forming)
Reaction(IUBMB)
trimethylamine N-oxide = dimethylamine + formaldehyde [RN:R02512]
Reaction(KEGG)
R02512
Substrate
trimethylamine N-oxide [CPD:C01104]
Product
dimethylamine [CPD:C00543];
formaldehyde [CPD:C00067]
History
EC 4.1.2.32 created 1978
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Reference
1  [PMID:11946146]
  Authors
Large PJ.
  Title
Non-oxidative demethylation of trimethylamine N-oxide by Pseudomonas aminovorans.
  Journal
FEBS Lett 18:297-300 (1971)
DOI:10.1016/0014-5793(71)80470-2
Reference
2  [PMID:5116524]
  Authors
Myers PA, Zatman LJ.
  Title
The metabolism of trimethylamine N-oxide by Bacillus PM6.
  Journal
Biochem J 121:10P (1971)
DOI:10.1042/bj1210010pa
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.32
IUBMB Enzyme Nomenclature: 4.1.2.32
ExPASy - ENZYME nomenclature database: 4.1.2.32
UM-BBD (Biocatalysis/Biodegradation Database): 4.1.2.32
BRENDA, the Enzyme Database: 4.1.2.32
CAS: 72561-08-1

  All links  
Protein sequence (112)   
   UniProt (8)   
   SWISS-PROT (1)   
   RefSeq(pep) (103)   
DNA sequence (183)   
   RefSeq(nuc) (139)   
   GenBank (22)   
   EMBL (22)   
Protein domain (6)   
   InterPro (6)   
Enzyme (1)   
   UMBBD-EC (1)   
All databases (302)   

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KEGG   REACTION: R02512
Entry
R02512                      Reaction                               
Name
trimethylamine-N-oxide formaldehyde-lyase
Definition
Trimethylamine N-oxide <=> Dimethylamine + Formaldehyde
Equation
C01104 <=> C00543 + C00067
Reaction class
RC00733  C00067_C01104
RC00734  C00543_C01104
Enzyme
4.1.2.32
Pathway
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.32
     R02512  Trimethylamine N-oxide <=> Dimethylamine + Formaldehyde
Other DBs
RHEA: 20220

  All links  
Chemical reaction (1)   
   UMBBD-RN (1)   
All databases (1)   

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