KEGG   ENZYME: 4.1.2.5
Entry
EC 4.1.2.5                  Enzyme                                 

Name
L-threonine aldolase;
L-threonine acetaldehyde-lyase
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
Sysname
L-threonine acetaldehyde-lyase (glycine-forming)
Reaction(IUBMB)
L-threonine = glycine + acetaldehyde [RN:R00751]
Reaction(KEGG)
R00751
Substrate
L-threonine [CPD:C00188]
Product
glycine [CPD:C00037];
acetaldehyde [CPD:C00084]
Comment
A pyridoxal-phosphate protein. This enzyme is specific for L-threonine and can not utilize L-allo-threonine. Different from EC 4.1.2.49, L-allo-threonine aldolase, and EC 4.1.2.48, low-specificity L-threonine aldolase.
History
EC 4.1.2.5 created 1961, deleted 1972, reinstated 1976, modified 2011
Pathway
ec00260  Glycine, serine and threonine metabolism
Reference
1  [PMID:5419751]
  Authors
Dainty RH
  Title
Purification and properties of threonine aldolase from Clostridium pasteurianum.
  Journal
Biochem J 117:585-92 (1970)
DOI:10.1042/bj1170585
Reference
2  [PMID:13449064]
  Authors
KARASEK MA, GREENBERG DM.
  Title
Studies on the properties of threonine aldolases.
  Journal
J Biol Chem 227:191-205 (1957)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.5
IUBMB Enzyme Nomenclature: 4.1.2.5
ExPASy - ENZYME nomenclature database: 4.1.2.5
BRENDA, the Enzyme Database: 4.1.2.5
CAS: 62213-23-4

KEGG   REACTION: R00751
Entry
R00751                      Reaction                               

Name
L-threonine acetaldehyde-lyase (glycine-forming)
Definition
L-Threonine <=> Glycine + Acetaldehyde
Equation
Reaction class
RC00312  C00037_C00188
RC00372  C00084_C00188
Enzyme
4.1.2.5         4.1.2.48
Pathway
rn00260  Glycine, serine and threonine metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01230  Biosynthesis of amino acids
Orthology
K01620  threonine aldolase [EC:4.1.2.48]
Other DBs
RHEA: 19628

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