| Entry |
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| Name |
2-keto-3-deoxy-L-rhamnonate aldolase;
KDR aldolase;
2-dehydro-3-deoxyrhamnonate aldolase;
2-keto-3-deoxy acid sugar aldolase;
YfaU;
2-dehydro-3-deoxy-L-rhamnonate (S)-lactaldehyde lyase (pyruvate-forming);
2-dehydro-3-deoxy-L-rhamnonate (R)-lactaldehyde lyase (pyruvate-forming)
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| Class |
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
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| Sysname |
2-dehydro-3-deoxy-L-rhamnonate (S)-lactaldehyde-lyase (pyruvate-forming)
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| Reaction(IUBMB) |
2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (S)-lactaldehyde [RN: R02261]
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| Reaction(KEGG) |
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| Substrate |
2-dehydro-3-deoxy-L-rhamnonate [CPD: C03979]
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| Product |
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| Comment |
Requires Mg2+ for activity. The enzyme can also use 2-oxo-3-deoxy-L-mannonate, 2-oxo-3-deoxy-L-lyxonate and 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) as substrates [2].
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| History |
EC 4.1.2.53 created 2013
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| Pathway |
| ec00051 | Fructose and mannose metabolism |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K12660 | 2-dehydro-3-deoxy-L-rhamnonate aldolase |
| K18339 | 2-keto-3-deoxy-L-rhamnonate aldolase |
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| Genes |
» show all
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| Reference |
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| Authors |
Rakus JF, Fedorov AA, Fedorov EV, Glasner ME, Hubbard BK, Delli JD, Babbitt PC, Almo SC, Gerlt JA |
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| Title |
Evolution of enzymatic activities in the enolase superfamily: L-rhamnonate dehydratase. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Rea D, Hovington R, Rakus JF, Gerlt JA, Fulop V, Bugg TD, Roper DI |
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| Title |
Crystal structure and functional assignment of YfaU, a metal ion dependent class II aldolase from Escherichia coli K12. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.1.2.53 |
| ExPASy - ENZYME nomenclature database: | 4.1.2.53 |
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