KEGG ENZYME: 4.1.2.53

ENZYME: 4.1.2.53

Entry

EC 4.1.2.53                 Enzyme

Name

2-keto-3-deoxy-L-rhamnonate aldolase;
KDR aldolase;
2-dehydro-3-deoxyrhamnonate aldolase;
2-keto-3-deoxy acid sugar aldolase;
YfaU;
2-dehydro-3-deoxy-L-rhamnonate (S)-lactaldehyde lyase (pyruvate-forming);
2-dehydro-3-deoxy-L-rhamnonate (R)-lactaldehyde lyase (pyruvate-forming)

Class

Lyases;
Carbon-carbon lyases;
Aldehyde-lyases

Sysname

2-dehydro-3-deoxy-L-rhamnonate (S)-lactaldehyde-lyase (pyruvate-forming)

Reaction(IUBMB)

2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (S)-lactaldehyde [RN:R02261]

Reaction(KEGG)

R02261

Substrate

2-dehydro-3-deoxy-L-rhamnonate [CPD:C03979]

Product

pyruvate [CPD:C00022];
(S)-lactaldehyde [CPD:C00424]

Comment

Requires Mg2+ for activity. The enzyme can also use 2-oxo-3-deoxy-L-mannonate, 2-oxo-3-deoxy-L-lyxonate and 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) as substrates [2].

History

EC 4.1.2.53 created 2013

Pathway

ec00051

Fructose and mannose metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K12660

2-dehydro-3-deoxy-L-rhamnonate aldolase

K18339

2-keto-3-deoxy-L-rhamnonate aldolase

Genes

DHA:	DEHA2C17688g DEHA2E00660g DEHA2E01056g DEHA2G19448g

PIC:	PICST_57832 PICST_64442

PGU:	PGUG_00213 PGUG_03287 PGUG_03590

CTEN:

18249052(PSN45_000412) 18249123(PSN45_000860) 18249645(PSN45_002893) 18249796(PSN45_004018) 18250726(PSN45_004012)

CLU:	CLUG_02928

CLUS:

A9F13_18g00407

PPA:	PAS_chr1-1_0356 PAS_chr4_0341 PAS_chr4_0577

BNN:	FOA43_001684 FOA43_001969 FOA43_001972

OPA:	HPODL_01988 HPODL_05174

YLI:	2906980(YALI2_C00616g)

SLB:	AWJ20_3014

NCR:

NCU05037

NTE:	NEUTE1DRAFT69855(NEUTE1DRAFT_69855)

SMP:	10805509(SMAC4_07611)

PAN:	PODANSg2280

PBEL:

QC761_507350

PPSD:

QC762_507350

PPSP:

QC763_507350

PPSA:

QC764_507350

TTT:	THITE_2144816

MTM:	MYCTH_103080

CTHR:

CTHT_0050150

MGR:

MGG_00956

PPEI:

PpBr36_08183

PGRI:

PgNI_08288

FGR:	FGSG_10210

FPU:	FPSE_03663

FPOA:

FPOAC1_001913 FPOAC1_003306

FVN:	FVRRES_02153 FVRRES_03650

FVR:	FVEG_03007

FOX:	FOXG_05126 FOXG_17406

NHE:	NECHADRAFT_100628

FFC:	NCS54_00716900 NCS54_01504200

FKR:	NCS57_00757000

FMU:	J7337_005910 J7337_010252

TRE:	TRIREDRAFT_65882

TRR:	M419DRAFT_37122

TATV:

25775784(TrAtP1_012354)

TASP:

36617238(TrAFT101_010355)

MAW:	90962608(J3458_005824)

MAJ:

MAA_03126

MBRN:

26241378(G6M90_00g077570)

PCHM:

VFPPC_09465

AMUS:

LMH87_007897

PLJ:	28886674(PLICBS_002006)

PTKZ:

JDV02_006925

VAL:	VDBG_07785

VDA:	VDAG_00197 VDAG_09650

CFJ:	CFIO01_01164

CHIG:

CH63R_06613

CDET:

87948000(CDEST_11500)

SAPO:

SAPIO_CDS10762

PFY:	PFICI_08543 PFICI_12530

SSL:	SS1G_00980 SS1G_10069

BFU:	BCIN_03g00250 BCIN_14g02460

MBE:

MBM_04586

PSCO:

LY89DRAFT_47291 LY89DRAFT_706903

GLZ:	GLAREA_03429

ANI:	ANIA_07929

APUU:

APUU_41632S

PNO:	SNOG_09634

PTE:

PTT_14653

PTRR:

6349819(PtrM4_002100)

BZE:	COCCADRAFT_2548

BSC:	COCSADRAFT_37501

BOR:	COCMIDRAFT_88207

AALT:

CC77DRAFT_1048685

ADAC:

96083697(ACET3X_003375)

ARAB:

EKO05_0000414

ZTR:	MYCGRDRAFT_65551

PFJ:	MYCFIDRAFT_38913

FFU:	CLAFUR5_12025

CBET:

CB0940_11601

NPA:	UCRNP2_7897

TML:	GSTUM_00003022001

CCAC:

CcaHIS019_0607320(CcaverHIS019_0607320)

ECO:	b2245(yfaU)

ECJ:	JW2239(yfaU)

ECD:	ECDH10B_2405(yfaU)

EBW:	BWG_2018(yfaU)

ECOK:

ECMDS42_1815(yfaU)

ECOC:

C3026_12545

ECE:

Z3503

ECS:	ECs_3130(rhmA)

ETW:	ECSP_3120(yfaU)

ELX:	CDCO157_2894

ECOO:

ECRM13514_3001(yfaU)

ECOH:

ECRM13516_2945(yfaU)

ESL:

O3K_08250

ESO:

O3O_17385

ESM:

O3M_08200

ECG:	E2348C_2389(yfaU)

EOK:	G2583_2785(yfaU)

ELR:	ECO55CA74_13785

ELH:

ETEC_2379

ECW:	EcE24377A_2543

EUN:	UMNK88_2797

ECP:

ECP_2288

ENA:	ECNA114_2338(yfaU)

ECOS:

EC958_2583(yfaU)

ECV:	APECO1_4316(yfaU)

ECOA:

APECO78_15060

ECX:	EcHS_A2387

ECM:	EcSMS35_2399

ECY:

ECSE_2507

ECQ:	ECED1_2711(yfaU)

EUM:	ECUMN_2586(yfaU)

ECT:	ECIAI39_2389(yfaU)

EOC:	CE10_2625(rhmA)

EBR:	ECB_02171(yfaU)

ECOB:

C3029_15410

EBL:	ECD_02171(rhmA)

EBE:	B21_02130(yfaU)

EBD:

ECBD_1414

ECI:	UTI89_C2527(yfaU)

EIH:	ECOK1_2481

ECZ:	ECS88_2393(yfaU)

ECC:	c2787(yfaU)

ELO:	EC042_2489

ELN:	NRG857_11385

ESE:

ECSF_2125

ECL:	EcolC_1404

EKF:	KO11_11445(rhmA)

EAB:	ECABU_c25790(yfaU)

EDH:	EcDH1_1413

EDJ:	ECDH1ME8569_2181(yfaU)

ELU:	UM146_05575

ELL:	WFL_11935(rhmA)

ELC:	i14_2586(yfaU)

ELD:	i02_2586(yfaU)

ELP:	P12B_c2339

ELF:	LF82_3041(yfaU)

ECOL:

LY180_11675

ECOI:

ECOPMV1_02406(rhmA)

ECOJ:

P423_12575

EAL:	EAKF1_ch3735

EMA:	C1192_00665

ESZ:	FEM44_01415

ESF:	ACK8NJ_07785(yfaU)

STY:

STY2519

STT:

t0574

SEX:	STBHUCCB_6150

SENT:

TY21A_02920

STM:

STM2289

SEO:	STM14_2826

SEV:	STMMW_23131

SEY:	SL1344_2258

SEM:	STMDT12_C23100

SEJ:	STMUK_2319

SEB:	STM474_2385

SEF:	UMN798_2470

SETU:

STU288_07820

SETC:

CFSAN001921_05350

SENR:

STMDT2_22581

SEND:

DT104_23471

SENI:

CY43_12270

SEEN:

SE451236_17640

SPT:

SPA0574

SEK:

SSPA0538

SPQ:	SPAB_00694

SEI:

SPC_1422

SEC:	SCH_2292(yfaU)

SEH:	SeHA_C2529

SHB:

SU5_02884

SENH:

CFSAN002069_20400

SEEH:

SEEH1578_20720

SEE:	SNSL254_A2474

SENN:

SN31241_33940

SEW:	SeSA_A2517

SEA:	SeAg_B2425

SENS:

Q786_11285

SED:

SeD_A2633

SEG:

SG2317

SEL:

SPUL_0602

SEGA:

SPUCDC_0602

SET:

SEN2271

SENA:

AU38_11480

SENO:

AU37_11490

SENV:

AU39_11490

SENQ:

AU40_12865

SENL:

IY59_11805

SEEC:

CFSAN002050_18370

SEEB:

SEEB0189_008125

SEEP:

I137_02775

SENB:

BN855_23700

SENE:

IA1_11400

SENC:

SEET0819_18535

SFX:

S2460

SFV:

SFV_2317

SFE:	SFxv_2569(yfaU)

SFN:

SFy_3311

SFS:

SFyv_3386

SFT:	NCTC1_02560(yfaU)

SSN:

SSON_2306

SBO:

SBO_2049

SDY:

SDY_2440

SDZ:	Asd1617_03289

SHQ:	A0259_15045

SHIG:

LXH19_07835(yfaU)

KPN:	KPN_02650(yfaU)

KPU:	KP1_3885(yfaU)

KPM:	KPHS_37160

KPP:

A79E_1453

KPH:	KPNIH24_10070

KPZ:	KPNIH27_17760

KPV:	KPNIH29_18550

KPW:	KPNIH30_18770

KPY:	KPNIH31_17700

KPG:	KPNIH32_19100

KPC:	KPNIH10_18140

KPQ:	KPR0928_18160

KPT:	VK055_4865

KPO:	KPN2242_16345

KPR:	KPR_2060(rhmA)

KPJ:

N559_1604

KPI:	D364_13505

KPA:	KPNJ1_01698

KPS:	KPNJ2_01666

KPX:	PMK1_00148(rhmA)

KPB:	FH42_09370

KPNE:

KU54_007825

KPNU:

LI86_07830

KPNK:

BN49_3867(rhmA)

KVA:

Kvar_1403

KPE:

KPK_1500

KPK:	A593_03110

KVD:	KR75_00770

KVQ:	SP68_07305

KQU:	AVR78_22520

KQV:	B8P98_08530

KOX:

KOX_26185

KOE:

A225_4137

KOY:	J415_11455

KOM:	HR38_24315

KOK:	KONIH1_20395

KOC:	AB185_15925

KLL:	BJF97_20360

KLW:	DA718_08655 DA718_10630

KAR:	LGL98_07530(yfaU)

KGR:	JJJ10_08360(yfaU)

KPAS:

LUW96_26825(yfaU)

KLC:	K7H21_08365(yfaU)

KLM:	BWI76_19980

KLP:	GUC22_07640

KLX:	GQR96_17210(yfaU)

ROR:	RORB6_01260

RON:	TE10_20120

RAO:	DSD31_07640

RTG:	NCTC13098_02025(rhmA)

CRO:

ROD_26581

CFQ:	C2U38_16750

CSED:

JY391_07570(yfaU)

CAMA:

F384_12025

CAF:	AL524_10870

CFAR:

CI104_17360 CI104_21505

CIR:	C2U53_27210

CTEL:

GBC03_08335 GBC03_13105

CITZ:

E4Z61_01500

CARS:

E1B03_18185

CIB:	HF677_007875(yfaU)

CENS:

P2W74_07565(yfaU)

CIY:	HAP28_17080(yfaU)

ESC:	Entcl_1475

KLE:	AO703_14490

ASUB:

NLZ15_15215(yfaU)

KIN:	AB182_07085

PDZ:	HHA33_10160(yfaU)

METY:

MRY16398_16460(rhmA)

IZH:	FEM41_11730

EBC:	C2U52_17620

EBU:	CUC76_23155

SERA:

Ser39006_021735

SERQ:

CWC46_21745

PROD:

PCO85_03745(yfaU)

PCAC:

OI450_03635(yfaU)

DDA:	Dd703_3301

BIZ:	HC231_20920(yfaU)

SLIG:

GTU79_10705(yfaU)

PANS:

FCN45_18205

PANE:

P6287_18155(yfaU)

PANZ:

NR302_18245(yfaU)

PPHI:

ACF2G4_17150(yfaU)

MINT:

C7M51_03756(rhmA)

MTHI:

C7M52_03270(rhmA)

MSU:	MS2103(pykF)

BSUN:

A4G13_07710

MVE:

X875_8900

ASU:

Asuc_1651

APOR:

DDU33_03045

BTO:

WQG_700

BTRE:

F542_20870

BTRH:

F543_23150

BTRA:

F544_720

PWI:	MWN52_01115

MRX:	MspRI1_33810(yfaU)

ABER:

BSR55_00525

TAU:

Tola_1177

GAQ:	RAM11_02400(yfaU)

NEI:	BG910_01270

NLS:	PJU73_03340

BGP:	BGL_2c06920

BPLA:

bpln_2g07770

PEW:	KZJ38_24500

SIX:	BSY16_5483

SSUM:

Q9314_26100

DEVD:

GHV40_13385

CMET:

K6K41_20475

MLUT:

JET14_17725

GYJ:	AADW23_10360

CCAQ:

CCAL_0714

ELUT:

CKA38_10250

TMV:	OH491_03655

RLC:	K227x_22900(rhmA)

AMOB:

HG15A2_21150(garL_2)

SDYN:

Mal52_00510(rhmA_1)

ABAC:

LuPra_05015(rhmA_2)

MCOS:

GM418_26085

CMR:	Cycma_2067

SPIB:

G8759_32850

SENF:

GJR95_28835

PSEZ:

HME7025_02113(rhmA)

DFE:

Dfer_4324

AALG:

AREALGSMS7_03944

AANR:

KCTC52924_02763(rhmA)

LYP:	MTP04_09330(rhmA)

PHJ:	LC071_18455

PKB:	B4V02_12650

PPAB:

KET34_18850

ANEU:

PP175_00385

CIU:	G4D55_19965

FPLA:

A4U99_15650

PFAA:

MM59RIKEN_19820(rhmA)

BPRO:

PMF13cell1_02925(rhmA)

BLAR:

LC508_25950

BACG:

D2962_11965

SEDM:

RBQ61_15430

VRM:	44547418_01808(rhmA)

ERB:	A4V01_00845

SLUO:

PS467_39005

BRI:	FDF13_04545

PAUS:

NCTC13651_02073(rhmA)

NRN:	SHK17_08985

ASG:	FB03_05450

ATIM:

CYJ17_0000960

BALA:

DSM104299_03708(garL)

LMAJ:

GKN94_06365 GKN94_07915

FVA:	FV113G1_31050(rhmA)

FUL:	C4N20_08390

HALY:

HYG82_19310

» show all

Reference

1 [PMID:18754693]

Authors

Rakus JF, Fedorov AA, Fedorov EV, Glasner ME, Hubbard BK, Delli JD, Babbitt PC, Almo SC, Gerlt JA

Title

Evolution of enzymatic activities in the enolase superfamily: L-rhamnonate dehydratase.

Journal

Biochemistry 47:9944-54 (2008)
DOI:10.1021/bi800914r

Sequence

[eco:b2245]

Reference

2 [PMID:18754683]

Authors

Rea D, Hovington R, Rakus JF, Gerlt JA, Fulop V, Bugg TD, Roper DI

Title

Crystal structure and functional assignment of YfaU, a metal ion dependent class II aldolase from Escherichia coli K12.

Journal

Biochemistry 47:9955-65 (2008)
DOI:10.1021/bi800943g

Sequence

[eco:b2245]

Other DBs

ExplorEnz - The Enzyme Database:

4.1.2.53

IUBMB Enzyme Nomenclature:

4.1.2.53

ExPASy - ENZYME nomenclature database:

4.1.2.53

BRENDA, the Enzyme Database:

4.1.2.53

All links

Gene (64)   
   MGENES (31)   
   RefGene (33)   
Protein sequence (2017)   
   UniProt (636)   
   SWISS-PROT (33)   
   RefSeq(pep) (1348)   
DNA sequence (99276)   
   RefSeq(nuc) (81025)   
   GenBank (9471)   
   EMBL (8780)   
Protein domain (5)   
   InterPro (5)   
All databases (101362)   

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