| Entry |
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| Name |
guluronate-specific alginate lyase;
alginase II;
guluronate lyase;
L-guluronan lyase;
L-guluronate lyase;
poly-alpha-L-guluronate lyase;
polyguluronate-specific alginate lyase;
poly(alpha-L-1,4-guluronide) exo-lyase;
poly(alpha-L-guluronate) lyase;
poly[(1->4)-alpha-L-guluronide] exo-lyase
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| Class |
Lyases;
Carbon-oxygen lyases;
Acting on polysaccharides
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| Sysname |
alginate alpha-L-guluronate---uronate lyase
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| Reaction(IUBMB) |
Eliminative cleavage of alginate to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non-reducing ends and alpha-L-guluronate at their reducing end.
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| Reaction(KEGG) |
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| Comment |
The enzyme catalyses the degradation of alginate by a beta-elimination reaction. It cleaves the (1->4) bond between alpha-L-guluronate and either alpha-L-guluronate or beta-D-mannuronate, generating oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non-reducing ends and alpha-L-guluronate at the reducing end. Depending on the composition of the substrate, the enzyme produces oligosaccharides ranging from two to six residues, with preference for shorter products. cf. EC 4.2.2.3, mannuronate-specific alginate lyase.
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| History |
EC 4.2.2.11 created 1990, modified 2015
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| Pathway |
| ec00051 | Fructose and mannose metabolism |
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| Reference |
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| Authors |
Boyd J, Turvey JR. |
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| Title |
Isolation of poly-alpha-L-guluronate lyase from Klebsiella aerogenes. |
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| Journal |
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| Reference |
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| Authors |
Davidson IW, Sutherland IW, Lawson CJ. |
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| Title |
Purification and properties of an alginate lyase from a marine bacterium. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.2.2.11 |
| ExPASy - ENZYME nomenclature database: | 4.2.2.11 |
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