KEGG ENZYME: 4.3.1.2

ENZYME: 4.3.1.2

Entry

EC 4.3.1.2                  Enzyme

Name

methylaspartate ammonia-lyase;
beta-methylaspartase;
3-methylaspartase;
L-threo-3-methylaspartate ammonia-lyase

Class

Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases

Sysname

L-threo-3-methylaspartate ammonia-lyase (mesaconate-forming)

Reaction(IUBMB)

L-threo-3-methylaspartate = mesaconate + NH3 [RN:R03696]

Reaction(KEGG)

R03696

Substrate

L-threo-3-methylaspartate [CPD:C03618]

Product

mesaconate [CPD:C01732];
NH3 [CPD:C00014]

Comment

A cobalamin protein.

History

EC 4.3.1.2 created 1961

Pathway

ec00630

Glyoxylate and dicarboxylate metabolism

ec00660

C5-Branched dibasic acid metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K04835

methylaspartate ammonia-lyase

Genes

AFM:	AFUA_3G00790

NFI:	NFIA_001410

AOR:	AO090010000710

AFV:	AFLA_014211

ACHE:

ACHE_70014S

PDP:	PDIP_33520

ECE:

Z0892

ECS:

ECs_0761

ECF:	ECH74115_0829

ETW:

ECSP_0779

ELX:	CDCO157_0741

ECOO:

ECRM13514_0750

ECOH:

ECRM13516_0697

EOK:	G2583_0892

ELR:	ECO55CA74_04340

ECM:	EcSMS35_0749

EUM:	ECUMN_0814

ECT:	ECIAI39_0701

EOC:

CE10_0730

ELO:	EC042_0753

EFE:

EFER_2378

EMA:	C1192_08695

ESZ:	FEM44_18110

ESF:	ACK8NJ_16265

SES:	SARI_02201

SDY:

SDY_0673

SDZ:	Asd1617_00848

SHIG:

LXH19_15265

ESH:	C1N69_07900

EPU:	QVH39_07900

EAX:	AAHF05_07650

ENTE:

GXP72_07970

KOX:

KOX_14665

KOE:

A225_1756

KOY:	J415_22870

KOM:	HR38_13440

KOK:	KONIH1_08640

KOC:	AB185_27495

KLL:	BJF97_09010

KLW:	DA718_19620

KGR:	JJJ10_19550

KPAS:

LUW96_15420

KLC:	K7H21_19535

KLM:	BWI76_08475

KLP:	GUC22_18805

CKO:

CKO_02419

CFD:	CFNIH1_13770

CBRA:

A6J81_09350

CWE:	CO701_15165

CYO:	CD187_16565

CPOT:

FOB25_04015

CFQ:	C2U38_07700

CSED:

JY391_14750

CAMA:

F384_03285

CAF:	AL524_19000

CIF:	AL515_08250

CFAR:

CI104_08015

CIR:	C2U53_17235

CIE:	AN232_22705

CPAR:

CUC49_03400

CTEL:

GBC03_21985

CITZ:

E4Z61_09960

CARS:

E1B03_08815

CIX:	M4I31_15970

CIB:	HF677_016175

CENS:

P2W74_15920

CITR:

GUC46_16240

CIQ:	FD428_14755

CIY:	HAP28_08240

ESC:	Entcl_1732

KLE:	AO703_13285

BUF:	D8682_20785

BFT:	MNO13_05010

BSEL:

RHD99_04810

YRE:	HEC60_20895

PVJ:	LMA04_06040

YEN:

YE4043

YEP:	YE105_C3763

YEY:

Y11_31521

YEW:

CH47_3688

YET:

CH48_1495

YEF:	FORC2_0151

YEE:	YE5303_38771

YAL:

AT01_1098

YIN:

CH53_313

YRO:

CH64_1340

YHI:	D5F51_21360

YEL:	LC20_00182

YCA:	F0T03_21045

YAS:	N0H69_09490

YFE:	ACF3VQ_00650

MMK:

MU9_1023

HAV:	AT03_08650

OPO:	DSM2777_13860

PFLX:

THUN1379_32010

PPUL:

RO07_15990

BPE:	BP0806 BP3177

BPC:	BPTD_0804 BPTD_3139

BPER:

BN118_0709

BPET:

B1917_0643 B1917_2973

BPEU:

Q425_31590 Q425_7420

BPAR:

BN117_3385 BN117_3938

BPA:	BPP3422 BPP3864

BBH:	BN112_4085 BN112_4543

BBR:	BB3872 BB4337

BBM:	BN115_3544 BN115_4013

BBX:	BBS798_3652 BBS798_4114

BFZ:	BAU07_20575

BOH:	AKI39_19475

BGM:	CAL15_20690

XYK:	GT347_12540

MLO:

mlr6095

MLN:	A9174_31760

MCI:	Mesci_5690

MCIC:

A4R28_21445

MOP:	Mesop_6269

MAM:	Mesau_05741

MAMO:

A6B35_31635 A6B35_31710

MESW:

A9K65_030880

MESM:

EJ066_12585

MJR:	EB229_32430

MERD:

EB233_30065

MMEI:

LRP31_10480

MESJ:

MJ8_14450

MEWS:

QAZ47_06665

MEWM:

QAZ22_06695

MEOR:

ACIU1A_01930

RSUL:

N2599_36735

BIC:	LMTR13_26000

PPAN:

ESD82_15275

GFU:	KM031_18930

ALH:	G6N82_05195

ELQ:	Ga0102493_112996

MTAR:

DF168_01552

LBV:	JYG24_01975

TDE:

TDE_2235

TPI:	TREPR_1304

TPED:

TPE_1176

TPK:	JO40_01075

SCD:	Spica_1659

PAH:	Poras_1170

PCRE:

NCTC12858_01580

PSOE:

CE91St14_10350

PET:	PEIBARAKI_4288

PROJ:

KDN43_05785

TOH:	BCB71_00035

PIT:	PIN17_0467

PNI:	J5A59_01360

DTH:	DICTH_1229

DTU:

Dtur_1344

CTC:

CTC_02563

CTET:

BN906_02814

CLJ:	CLJU_c40610

CAH:	CAETHG_1904

CSQ:

CSCA_4328

CCK:	Ccar_17555 Ccar_19615

CEU:	A7L45_08020

CARG:

RSJ17_03855

CDRK:

B9W14_23400

CCOH:

SAMEA4530647_2259

CLOS:

DMR38_20135

CCAA:

KQH81_15280

CTAG:

LL095_20705

CLOO:

RCG18_03800 RCG18_05855

HHW:	NCTC503_02397

CALE:

FDN13_04640

OCW:	OW730_04540

PROQ:

P6M73_02460

PETR:

QKW49_11540

DSY:

DSY3233

DHD:

Dhaf_4400

DDH:	Desde_3779

DMT:	DESME_13810

DNS:	ACHOLT_06155

DESD:

AusDCA_0126

DELO:

DESULF6_05890

DOR:	Desor_5275

DAI:	Desaci_4373

DMI:	Desmer_4259

DCA:	Desca_0604

DRM:

Dred_2689

DRU:	Desru_0927

DFG:	B0537_13815

FWA:	DCMF_09590

AACX:

DEACI_0128

ACAE:

HYG86_02375

CTHM:

CFE_0619

FMS:	M1R53_04075

PROM:

QO263_09920

BYL:	A4V09_10270

BHAN:

CGC63_11295

BPRO:

PMF13cell1_03217

BCOC:

BLCOC_23090

BLAR:

LC508_07905

VGU:	HYG85_02135

VPY:	HZI73_09950

EMJ:	V1225_12890

EUU:	ADJ67_05945

AMT:

Amet_3414

CACE:

CACET_c34410

CFM:	BJL90_02575

TEM:	JW646_17970

TGC:	L0P85_10055

TMY:	TEMA_08780

TPET:

TPHSE_23060

TVT:	TVTCOM_20070

PBQ:	C3V37_01025

EAC:	EAL2_808p05890

CHY:	CHY_0484 CHY_0582

TPZ:	Tph_c20250

TEP:	TepRe1_0115

TAE:	TepiRe1_0120

HOR:	Hore_15430

HPK:	Hprae_1850

HALS:

D7D81_15595

IFN:	GM661_12735

AAR:	Acear_0480

HHL:	Halha_1649

AFT:	BBF96_08380

MFOM:

VZL98_10615

TIS:	P3962_02615

ECOU:

M1R54_02150

PUF:

UFO1_3073

PFT:

JBW_01516

MANA:

MAMMFC1_00632

STED:

SPTER_10690

SSPH:

SPSPH_031600

SOVA:

SOV_11890

SSID:

SPSIL_016820

SACV:

SPACI_017830

SCAO:

SCACP_11170

MANR:

MPAN_001680

XCL:	G4Z02_00740

MBJ:	KQ51_00879

TBK:	HF295_06620

TBM:	BK010_00845

TBZ:	BK011_00735

MSED:

E3O41_00265

FRP:	AX769_17710

NMES:

H9L09_01760

MHAI:

OHB01_26590

MMAR:

MODMU_4014

MOM:	KUM42_03575

KAL:

KALB_5717

MTUA:

CSH63_31865

BSOL:

FSW04_00285

BALA:

DSM104299_03890

ABAO:

BEQ56_05600

CPOR:

BED41_14050

APRP:

KIH16_11020

FVA:	FV113G1_25160

FUL:	C4N20_01145

FMO:	C4N19_13190

FHO:	H9Q81_10155

IPO:	Ilyop_0556

CSOM:

MKD34_06450

HAL:	VNG_2289G(mal)

HSL:	OE_4207F(mal)

HANR:

LJ422_09240

HAGS:

JT689_10590

HABO:

JRZ79_08965

HALX:

M0R89_18080

HAXY:

NGM07_04610

SALI:

L593_04670

HMA:	rrnAC0687(mal)

HSIN:

KDQ40_06775

HHI:	HAH_1339(mal)

HHN:	HISP_06855

HAB:	SG26_14700

HTA:	BVU17_06525

HALJ:

G9465_08575

HSAA:

ACOZ4I_04500

HMU:

Hmuk_2982

HALZ:

E5139_02185

HALL:

LC1Hm_2319(mal)

HAZP:

GBQ70_02185

HRR:	HZS55_19995

HPEL:

HZS54_23495

HGI:	ABY42_16395

HTU:

Htur_1592

HSAL:

JMJ58_00675

HAKZ:

J0X25_14770

NMG:	Nmag_3336(mal)

HXA:	Halxa_3157

NAT:

NJ7G_3291

NPE:	Natpe_2592

NVR:	FEJ81_11890

NPL:	FGF80_10930

NAY:	HYG81_14700

HALY:

HYG82_17320

HJT:	DVR14_02945

HLO:	J0X27_02305

NGE:	Natgr_2182 Natgr_3386

HLC:	CHINAEXTREME16085

HRU:	Halru_1550

SAWL:

NGM29_08780

HALV:

NGM15_00945

NOU:	Natoc_1511

HLR:	HALLA_00800 HALLA_10845

NAJ:	B1756_12015

NAG:	AArcMg_1647

NAN:	AArc1_1992

NARA:

QQ977_05690

NBG:	DV706_12990

NAS:	GCU68_13735

HDA:	BB347_04020

» show all

Reference

1 [PMID:13618029]

Authors

BARKER HA, SMYTH RD, WAWSZKIEWICZ EJ, LEE MN, WILSON RM.

Title

Enzymic preparation and characterization of an alpha-L-beta-methylaspartic acid.

Journal

Arch Biochem Biophys 78:468-76 (1958)
DOI:10.1016/0003-9861(58)90371-0

Reference

Authors

Bright HJ, Ingraham LL.

Title

The preparation of crystalline beta-methylaspartase.

Journal

Biochim Biophys Acta 44:586-588 (1960)

Other DBs

ExplorEnz - The Enzyme Database:

4.3.1.2

IUBMB Enzyme Nomenclature:

4.3.1.2

ExPASy - ENZYME nomenclature database:

4.3.1.2

BRENDA, the Enzyme Database:

4.3.1.2

CAS:

9033-26-5

All links

Gene (1110)   
   MGENES (986)   
   RefGene (124)   
Protein sequence (3214)   
   UniProt (591)   
   SWISS-PROT (5)   
   RefSeq(pep) (2606)   
   PDBSTR (12)   
DNA sequence (29724)   
   RefSeq(nuc) (23670)   
   GenBank (3044)   
   EMBL (3010)   
3D Structure (6)   
   PDB (6)   
Protein domain (5)   
   InterPro (3)   
   Pfam (2)   
All databases (34059)   

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