KEGG   COMPOUND: C00064
Entry
C00064                      Compound                               

Name
L-Glutamine;
L-2-Aminoglutaramic acid
Formula
C5H10N2O3
Exact mass
146.0691
Mol weight
146.1445
Structure
Remark
Same as: D00015
Reaction
Pathway
map00220  Arginine biosynthesis
map00230  Purine metabolism
map00240  Pyrimidine metabolism
map00250  Alanine, aspartate and glutamate metabolism
map00471  D-Glutamine and D-glutamate metabolism
map00630  Glyoxylate and dicarboxylate metabolism
map00750  Vitamin B6 metabolism
map00910  Nitrogen metabolism
map00970  Aminoacyl-tRNA biosynthesis
map01060  Biosynthesis of plant secondary metabolites
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01230  Biosynthesis of amino acids
map01240  Biosynthesis of cofactors
map02010  ABC transporters
map02020  Two-component system
map04724  Glutamatergic synapse
map04727  GABAergic synapse
map04964  Proximal tubule bicarbonate reclamation
map04974  Protein digestion and absorption
map04978  Mineral absorption
map05230  Central carbon metabolism in cancer
Module
M00048  Inosine monophosphate biosynthesis, PRPP + glutamine => IMP
M00051  Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP
M00916  Pyridoxal-P biosynthesis, R5P + glyceraldehyde-3P + glutamine => pyridoxal-P
Enzyme
1.4.1.13        1.4.1.14        1.4.7.1         2.3.1.14        
2.3.1.68        2.3.2.1         2.3.2.14        2.4.2.14        
2.6.1.15        2.6.1.16        2.6.1.50        2.6.1.64        
2.6.1.85        2.6.1.86        2.6.1.100       2.6.1.101       
2.6.1.117       2.7.3.13        3.5.1.2         3.5.1.38        
3.5.1.133       4.1.3.27        4.3.2.10        4.3.3.6         
5.1.1.10        6.1.1.18        6.3.1.2         6.3.4.2         
6.3.5.1         6.3.5.2         6.3.5.3         6.3.5.4         
6.3.5.5         6.3.5.6         6.3.5.7         6.3.5.9         
6.3.5.10        6.3.5.11        6.3.5.12        6.3.5.13        
6.3.5.-
 » show all
Brite
Compounds with biological roles [BR:br08001]
 Peptides
  Amino acids
   Common amino acids
    C00064  Glutamine (Gln)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AA Amino acids and derivatives
     A16AA03 Glutamine
      D00015  Glutamine (USP) <JP/US>
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Gastrointestinal Agents, Other
   Short Bowel Syndrome Agents
    Glutamine
     D00015  Glutamine (USP)
 Genetic, Enzyme, or Protein Disorder: Replacement, Modifiers, Treatment
  Glutamine
   D00015  Glutamine (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   232  Peptic ulcer agents
    2322  Glutamines
     D00015  Glutamine (USP); L-Glutamine (JP17)
Risk category of Japanese OTC drugs [BR:br08312]
 Third-class OTC drugs
  Inorganic and organic chemicals
   L-Glutamine
    D00015  Glutamine (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00015  L-Glutamine
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D00015
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D00015
Other DBs
CAS: 56-85-9
PubChem: 3364
ChEBI: 18050
ChEMBL: CHEMBL930
KNApSAcK: C00001359
PDB-CCD: GLN[PDBj]
3DMET: B00017
NIKKAJI: J9.170G
KCF data

ATOM        10
            1   C1c C    23.8378  -17.4606
            2   C1b C    25.0254  -16.7178
            3   C6a C    22.6035  -16.7995
            4   N1a N    23.8787  -18.8587
            5   C1b C    26.2597  -17.3787
            6   O6a O    21.4451  -17.5952
            7   O6a O    22.6209  -15.4015
            8   C5a C    27.4472  -16.6416
            9   N1a N    28.6814  -17.3027
            10  O5a O    27.4704  -15.2435
BOND        9
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     3   6 1
            6     3   7 2
            7     5   8 1
            8     8   9 1
            9     8  10 2

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Chemical substance (46)   
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Chemical reaction (88)   
   KEGG ENZYME (40)   
   KEGG REACTION (48)   
Gene (159003)   
   KEGG GENES (159003)   
All databases (159165)   

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KEGG   COMPOUND: C00073
Entry
C00073                      Compound                               

Name
L-Methionine;
Methionine;
L-2-Amino-4methylthiobutyric acid
Formula
C5H11NO2S
Exact mass
149.051
Mol weight
149.2113
Structure
Remark
Same as: D00019
Reaction
Pathway
map00270  Cysteine and methionine metabolism
map00966  Glucosinolate biosynthesis
map00970  Aminoacyl-tRNA biosynthesis
map01060  Biosynthesis of plant secondary metabolites
map01070  Biosynthesis of plant hormones
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
map01240  Biosynthesis of cofactors
map01523  Antifolate resistance
map04974  Protein digestion and absorption
map04978  Mineral absorption
map05230  Central carbon metabolism in cancer
Module
M00017  Methionine biosynthesis, apartate => homoserine => methionine
M00034  Methionine salvage pathway
M00035  Methionine degradation
M00368  Ethylene biosynthesis, methionine => ethylene
M00609  Cysteine biosynthesis, methionine => cysteine
Enzyme
1.1.98.7        1.1.99.38       1.3.98.3        1.3.98.6        
1.4.3.2         1.8.4.11        1.8.4.13        1.8.4.14        
1.17.98.2       1.21.98.1       1.21.98.3       1.21.98.4       
1.97.1.4        2.1.1.3         2.1.1.5         2.1.1.10        
2.1.1.12        2.1.1.13        2.1.1.14        2.1.1.280       
2.1.1.308       2.1.1.326       2.1.1.342       2.1.1.350       
2.1.1.-         2.4.99.17       2.5.1.6         2.5.1.49        
2.5.1.63        2.5.1.94        2.5.1.120       2.5.1.147       
2.6.1.5         2.6.1.57        2.6.1.73        2.6.1.88        
2.6.1.117       2.6.1.-         2.8.1.6         2.8.1.8         
2.8.4.3         2.8.4.4         2.8.4.5         3.4.13.12       
3.5.1.31        3.13.1.8        4.1.1.57        4.1.3.44        
4.1.99.17       4.1.99.19       4.1.99.22       4.1.99.23       
4.3.1.30        4.3.1.32        4.4.1.11        4.7.1.1         
5.1.1.2         6.1.1.10
 » show all
Brite
Compounds with biological roles [BR:br08001]
 Peptides
  Amino acids
   Common amino acids
    C00073  Methionine (Met)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AB Antidotes
     V03AB26 Methionine
      D00019  Methionine (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Third-class OTC drugs
  Inorganic and organic chemicals
   Methionine
    D00019  Methionine (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00019  L-Methionine
Other DBs
CAS: 63-68-3
PubChem: 3373
ChEBI: 16643
ChEMBL: CHEMBL42336
KNApSAcK: C00001379
PDB-CCD: MET[PDBj]
3DMET: B01148
NIKKAJI: J9.174J
KCF data

ATOM        9
            1   C1c C    24.5047  -19.4197
            2   C6a C    23.3598  -18.6719
            3   C1b C    25.7313  -18.7361
            4   N1a N    24.5455  -20.8273
            5   O6a O    22.1332  -19.3553
            6   O6a O    23.3772  -17.2641
            7   C1b C    26.9405  -19.4546
            8   S2a S    28.1672  -18.7712
            9   C1a C    29.3647  -19.4896
BOND        8
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     7   8 1
            8     8   9 1

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Pathway (19)   
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Chemical substance (37)   
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Gene (99011)   
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KEGG   COMPOUND: C00123
Entry
C00123                      Compound                               

Name
L-Leucine;
2-Amino-4-methylvaleric acid;
(2S)-alpha-2-Amino-4-methylvaleric acid;
(2S)-alpha-Leucine
Formula
C6H13NO2
Exact mass
131.0946
Mol weight
131.1729
Structure
Remark
Same as: D00030
Reaction
Pathway
map00280  Valine, leucine and isoleucine degradation
map00290  Valine, leucine and isoleucine biosynthesis
map00966  Glucosinolate biosynthesis
map00970  Aminoacyl-tRNA biosynthesis
map01060  Biosynthesis of plant secondary metabolites
map01065  Biosynthesis of alkaloids derived from histidine and purine
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
map02010  ABC transporters
map04150  mTOR signaling pathway
map04974  Protein digestion and absorption
map04978  Mineral absorption
map05131  Shigellosis
map05230  Central carbon metabolism in cancer
Module
M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA
Enzyme
1.4.1.9         1.14.13.-       2.3.1.66        2.6.1.6         
2.6.1.42        2.6.1.67        3.5.1.64        5.4.3.7         
6.1.1.4         6.3.2.47
Brite
Compounds with biological roles [BR:br08001]
 Peptides
  Amino acids
   Common amino acids
    C00123  Leucine (Leu)
Risk category of Japanese OTC drugs [BR:br08312]
 Third-class OTC drugs
  Inorganic and organic chemicals
   L-Leucine
    D00030  Leucine (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00030  L-Leucine
Other DBs
CAS: 61-90-5
PubChem: 3423
ChEBI: 15603
ChEMBL: CHEMBL291962
KNApSAcK: C00001377
PDB-CCD: LEU[PDBj]
3DMET: B00034
NIKKAJI: J1.167C
KCF data

ATOM        9
            1   C1c C    25.0761  -19.4138
            2   C1b C    26.2633  -18.6769
            3   C6a C    23.8420  -18.7586
            4   N1a N    25.1229  -20.8173
            5   C1c C    27.4974  -19.3377
            6   O6a O    22.6841  -19.5483
            7   O6a O    23.8654  -17.3551
            8   C1a C    28.6846  -18.6007
            9   C1a C    27.5442  -20.7356
BOND        8
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     3   6 1
            6     3   7 2
            7     5   8 1
            8     5   9 1

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Network (5)   
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Drug (2)   
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