KEGG   COMPOUND: C00079
Entry
C00079                      Compound                               

Name
L-Phenylalanine;
(S)-alpha-Amino-beta-phenylpropionic acid
Formula
C9H11NO2
Exact mass
165.079
Mol weight
165.1891
Structure
Remark
Same as: D00021
Reaction
Pathway
map00360  Phenylalanine metabolism
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis
map00460  Cyanoamino acid metabolism
map00940  Phenylpropanoid biosynthesis
map00960  Tropane, piperidine and pyridine alkaloid biosynthesis
map00966  Glucosinolate biosynthesis
map00970  Aminoacyl-tRNA biosynthesis
map00998  Biosynthesis of various secondary metabolites - part 2
map01060  Biosynthesis of plant secondary metabolites
map01061  Biosynthesis of phenylpropanoids
map01063  Biosynthesis of alkaloids derived from shikimate pathway
map01064  Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
map01070  Biosynthesis of plant hormones
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
map02010  ABC transporters
map04974  Protein digestion and absorption
map04978  Mineral absorption
map05230  Central carbon metabolism in cancer
Module
M00024  Phenylalanine biosynthesis, chorismate => phenylpyruvate => phenylalanine
M00039  Monolignol biosynthesis, phenylalanine/tyrosine => monolignol
M00137  Flavanone biosynthesis, phenylalanine => naringenin
M00891  Ditryptophenaline biosynthesis, tryptophan + phenylalanine => ditryptophenaline
M00910  Phenylalanine biosynthesis, chorismate => arogenate => phenylalanine
Enzyme
1.4.1.20        1.4.3.2         1.11.1.21       1.13.12.9       
1.14.14.40      1.14.16.1       1.14.16.7       2.3.1.53        
2.6.1.1         2.6.1.5         2.6.1.9         2.6.1.28        
2.6.1.57        2.6.1.58        2.6.1.64        2.6.1.70        
2.6.1.-         3.4.17.23       4.1.1.28        4.1.1.53        
4.1.1.109       4.2.1.51        4.2.1.91        4.3.1.24        
4.3.1.25        5.1.1.11        5.4.3.10        5.4.3.11        
6.1.1.20        6.3.2.40        6.3.2.-
Brite
Compounds with biological roles [BR:br08001]
 Peptides
  Amino acids
   Common amino acids
    C00079  Phenylalanine (Phe)
Risk category of Japanese OTC drugs [BR:br08312]
 Third-class OTC drugs
  Inorganic and organic chemicals
   L-Phenylalanine
    D00021  Phenylalanine (USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00021  L-Phenylalanine
Other DBs
CAS: 63-91-2
PubChem: 3379
ChEBI: 17295
ChEMBL: CHEMBL301523
KNApSAcK: C00001386
PDB-CCD: PHE[PDBj]
3DMET: B01151
NIKKAJI: J9.175H
KCF data

ATOM        12
            1   C8y C    25.3400  -16.0300
            2   C8x C    25.3400  -17.5000
            3   C8x C    24.0800  -18.2000
            4   C8x C    22.8900  -17.5000
            5   C8x C    22.8900  -16.0300
            6   C8x C    24.0800  -15.3300
            7   C1b C    26.5300  -15.3300
            8   C1c C    27.7200  -16.0300
            9   C6a C    28.9100  -15.3300
            10  O6a O    30.1000  -16.0300
            11  O6a O    28.9100  -13.9300
            12  N1a N    27.7200  -17.5000
BOND        12
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    9  11 2
            12    8  12 1 #Up

» Japanese version

KEGG   COMPOUND: C00082
Entry
C00082                      Compound                               

Name
L-Tyrosine;
(S)-3-(p-Hydroxyphenyl)alanine;
(S)-2-Amino-3-(p-hydroxyphenyl)propionic acid;
Tyrosine
Formula
C9H11NO3
Exact mass
181.0739
Mol weight
181.1885
Structure
Remark
Same as: D00022
Reaction
Pathway
map00130  Ubiquinone and other terpenoid-quinone biosynthesis
map00261  Monobactam biosynthesis
map00350  Tyrosine metabolism
map00360  Phenylalanine metabolism
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis
map00401  Novobiocin biosynthesis
map00460  Cyanoamino acid metabolism
map00680  Methane metabolism
map00730  Thiamine metabolism
map00940  Phenylpropanoid biosynthesis
map00950  Isoquinoline alkaloid biosynthesis
map00965  Betalain biosynthesis
map00966  Glucosinolate biosynthesis
map00970  Aminoacyl-tRNA biosynthesis
map00998  Biosynthesis of various secondary metabolites - part 2
map01055  Biosynthesis of vancomycin group antibiotics
map01059  Biosynthesis of enediyne antibiotics
map01060  Biosynthesis of plant secondary metabolites
map01063  Biosynthesis of alkaloids derived from shikimate pathway
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
map01240  Biosynthesis of cofactors
map04728  Dopaminergic synapse
map04916  Melanogenesis
map04917  Prolactin signaling pathway
map04974  Protein digestion and absorption
map05012  Parkinson disease
map05030  Cocaine addiction
map05031  Amphetamine addiction
map05034  Alcoholism
map05230  Central carbon metabolism in cancer
Module
M00025  Tyrosine biosynthesis, chorismate => HPP => tyrosine
M00039  Monolignol biosynthesis, phenylalanine/tyrosine => monolignol
M00040  Tyrosine biosynthesis, chorismate => arogenate => tyrosine
M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
M00043  Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine
M00044  Tyrosine degradation, tyrosine => homogentisate
M00127  Thiamine biosynthesis, prokaryotes, AIR (+ DXP/tyrosine) => TMP/TPP
M00369  Cyanogenic glycoside biosynthesis, tyrosine => dhurrin
M00827  C-1027 beta-amino acid moiety biosynthesis, tyrosine => 3-chloro-4,5-dihydroxy-beta-phenylalanyl-PCP
M00828  Maduropeptin beta-hydroxy acid moiety biosynthesis, tyrosine => 3-(4-hydroxyphenyl)-3-oxopropanoyl-PCP
M00889  Puromycin biosynthesis, ATP => puromycin
M00935  Methanofuran biosynthesis
Enzyme
1.2.1.101       1.3.1.43        1.3.1.78        1.3.1.79        
1.4.1.20        1.4.3.2         1.10.3.1        1.11.1.8        
1.11.2.6        1.14.14.36      1.14.16.1       1.14.16.2       
1.14.18.1       1.21.1.1        2.1.1.304       2.5.1.122       
2.5.1.147       2.6.1.1         2.6.1.5         2.6.1.9         
2.6.1.57        2.6.1.58        2.6.1.103       4.1.1.25        
4.1.1.28        4.1.1.108       4.1.99.2        4.1.99.19       
4.1.99.24       4.3.1.23        4.3.1.25        5.4.3.6         
6.1.1.1         6.3.2.24        6.3.2.25
Brite
Compounds with biological roles [BR:br08001]
 Peptides
  Amino acids
   Common amino acids
    C00082  Tyrosine (Tyr)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00022  L-Tyrosine
Other DBs
CAS: 60-18-4
PubChem: 3382
ChEBI: 17895
ChEMBL: CHEMBL925
KNApSAcK: C00001397
PDB-CCD: TYR[PDBj]
3DMET: B01154
NIKKAJI: J9.173A
KCF data

ATOM        13
            1   C8y C    25.0600  -15.8200
            2   C8x C    25.0600  -17.2200
            3   C8x C    23.8700  -17.9200
            4   C8y C    22.6800  -17.2200
            5   C8x C    22.6800  -15.8200
            6   C8x C    23.8700  -15.1200
            7   C1b C    26.3200  -15.1200
            8   O1a O    21.4200  -17.9900
            9   C1c C    27.5100  -15.8200
            10  C6a C    28.7000  -15.1200
            11  O6a O    29.8900  -15.8200
            12  O6a O    28.7000  -13.7200
            13  N1a N    27.5100  -17.2200
BOND        13
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     4   8 1
            9     7   9 1
            10    9  10 1
            11   10  11 1
            12   10  12 2
            13    9  13 1 #Up

» Japanese version

KEGG   COMPOUND: C00078
Entry
C00078                      Compound                               

Name
L-Tryptophan;
Tryptophan;
(S)-alpha-Amino-beta-(3-indolyl)-propionic acid
Formula
C11H12N2O2
Exact mass
204.0899
Mol weight
204.2252
Structure
Remark
Same as: D00020
Reaction
Pathway
map00260  Glycine, serine and threonine metabolism
map00380  Tryptophan metabolism
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis
map00404  Staurosporine biosynthesis
map00901  Indole alkaloid biosynthesis
map00966  Glucosinolate biosynthesis
map00970  Aminoacyl-tRNA biosynthesis
map00998  Biosynthesis of various secondary metabolites - part 2
map01060  Biosynthesis of plant secondary metabolites
map01061  Biosynthesis of phenylpropanoids
map01063  Biosynthesis of alkaloids derived from shikimate pathway
map01070  Biosynthesis of plant hormones
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
map01240  Biosynthesis of cofactors
map04361  Axon regeneration
map04726  Serotonergic synapse
map04974  Protein digestion and absorption
map04978  Mineral absorption
map05143  African trypanosomiasis
map05230  Central carbon metabolism in cancer
Module
M00023  Tryptophan biosynthesis, chorismate => tryptophan
M00037  Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin
M00038  Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate
M00370  Glucosinolate biosynthesis, tryptophan => glucobrassicin
M00786  Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A
M00789  Rebeccamycin biosynthesis, tryptophan => rebeccamycin
M00790  Pyrrolnitrin biosynthesis, tryptophan => pyrrolnitrin
M00805  Staurosporine biosynthesis, tryptophan => staurosporine
M00808  Violacein biosynthesis, tryptophan => violacein
M00891  Ditryptophenaline biosynthesis, tryptophan + phenylalanine => ditryptophenaline
M00901  Fumiquinazoline biosynthesis, tryptophan + alanine + anthranilate => fumiquinazoline
M00912  NAD biosynthesis, tryptophan => quinolinate => NAD
M00936  Melatonin biosynthesis, plants, tryptophan => serotonin => melatonin
Enzyme
1.3.3.10        1.4.1.19        1.4.3.2         1.4.3.-         
1.13.11.11      1.13.11.52      1.13.12.3       1.13.99.3       
1.14.14.156     1.14.16.4       1.14.19.9       1.14.19.58      
1.14.19.59      2.1.1.106       2.5.1.34        2.5.1.80        
2.6.1.27        2.6.1.28        2.6.1.99        2.6.1.-         
3.5.1.57        4.1.1.28        4.1.1.105       4.1.99.1        
4.1.99.25       4.2.1.20        4.2.1.122       4.3.1.31        
6.1.1.2         6.3.2.-
Brite
Compounds with biological roles [BR:br08001]
 Peptides
  Amino acids
   Common amino acids
    C00078  Tryptophan (Trp)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX02 Tryptophan
      D00020  Tryptophan (USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Third-class OTC drugs
  Inorganic and organic chemicals
   L-Tryptophan
    D00020  Tryptophan (USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00020  L-Tryptophan
Other DBs
CAS: 73-22-3
PubChem: 3378
ChEBI: 16828
ChEMBL: CHEMBL54976
KNApSAcK: C00001396
PDB-CCD: TRP[PDBj]
3DMET: B01150
NIKKAJI: J9.181B
KCF data

ATOM        15
            1   C8y C    17.0958  -16.0419
            2   C8y C    18.4268  -16.3221
            3   C8y C    16.3953  -17.2327
            4   C8x C    16.3953  -14.7810
            5   C1b C    19.4775  -15.4815
            6   N4x N    17.2359  -18.2835
            7   C8x C    14.9243  -17.2327
            8   C8x C    14.9943  -14.7810
            9   C1c C    20.7384  -16.1120
            10  C8x C    14.2238  -16.0419
            11  N1a N    20.7384  -17.5830
            12  C6a C    21.9292  -15.4815
            13  O6a O    23.1201  -16.1820
            14  O6a O    21.9292  -14.0805
            15  C8x C    18.4268  -17.7221
BOND        16
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     5   9 1
            9     7  10 2
            10    9  11 1 #Up
            11    9  12 1
            12   12  13 1
            13   12  14 2
            14    8  10 1
            15    2  15 2
            16   15   6 1

» Japanese version

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