KEGG   DRUG: Ivermectin
Entry
D00804                      Drug                                   
Name
Ivermectin (JAN/USP/INN);
Sklice (TN);
Soolantra (TN);
Stromectol (TN)
Product
SOOLANTRA (Galderma Laboratories), STROMECTOL (Merck Sharp & Dohme LLC)
  Generic
IVERMECTIN (A-S Medication Solutions), IVERMECTIN (Actavis Pharma), IVERMECTIN (Asclemed USA), IVERMECTIN (Bryant Ranch Prepack), IVERMECTIN (Bryant Ranch Prepack), IVERMECTIN (Edenbridge Pharmaceuticals LLC.), IVERMECTIN (Mayne Pharma), IVERMECTIN (NuCare Pharmaceuticals), IVERMECTIN (Padagis Israel Pharmaceuticals), IVERMECTIN (Padagis US LLC), IVERMECTIN (Viona Pharmaceuticals), IVERMECTIN (Zydus Lifesciences Limited)
Formula
C47H71O14R
Structure
Simcomp
Class
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Transporter substrate
 DG01665  ABCB1 substrate
Remark
Therapeutic category: 6429
ATC code: D11AX22 P02CF01
Product: D00804<JP/US>
Efficacy
Antiparasitic
  Disease
Head lice infestation [DS:H01054]
Strongyloidiasis of the intestinal tract [DS:H01100]
Onchocerciasis [DS:H01043]
Comment
Avermectin derivative
Ivermectin B1a (CAS 70161-11-4) (R = -CH3)
Ivermectin B1b (CAS 70209-81-3) (R = -H)
Target
glutamate-gated chloride channel [KO:K05273]
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Transporter: ABCB1 [HSA:5243]
Interaction
Other map
map04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D11 OTHER DERMATOLOGICAL PREPARATIONS
   D11A OTHER DERMATOLOGICAL PREPARATIONS
    D11AX Other dermatologicals
     D11AX22 Ivermectin
      D00804  Ivermectin (JAN/USP/INN) <JP/US>
 P ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
  P02 ANTHELMINTICS
   P02C ANTINEMATODAL AGENTS
    P02CF Avermectines
     P02CF01 Ivermectin
      D00804  Ivermectin (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antiparasitics
  Anthelmintics
   Ivermectin
    D00804  Ivermectin (JAN/USP/INN)
 Dermatological Agents
  Pediculicides/Scabicides
   Ivermectin
    D00804  Ivermectin (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  64  Parasitics (systemic)
   642  Anthelmintics
    6429  Others
     D00804  Ivermectin (JAN/USP/INN)
Animal drugs in Japan [BR:br08331]
 97  Agents against pathogenic micro-organisms and parasites (except biological products and disinfectants)
  975  Anthelmintics for digestive organs
   9759  Other anthelmintics for digestive organs
    D00804  Ivermectin
 99  Agents for not mainly purpose of therapeutic
  993  Insecticides and insect-repellents
   9939  Other insecticides and insect repellents
    D00804  Ivermectin
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D00804  Ivermectin
 Transporter substrate
  DG01665  ABCB1 substrate
   D00804  Ivermectin
Antimicrobials [BR:br08307]
 Antiparasitics
  Antinematodal agents
   Avermectines
    D00804  Ivermectin (JAN/USP/INN) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00804
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00804
 Drug transporters
  D00804
Rx-to-OTC switch list in the USA [br08315.html]
 D00804
Other DBs
CAS: 70288-86-7
PubChem: 7847869
ChEBI: 6078
NIKKAJI: J529.802D
KCF data

ATOM        62
            1   C1z C    25.2552  -13.5058
            2   C1x C    25.2552  -14.8922
            3   O2x O    24.0733  -12.8183
            4   C1x C    26.4609  -14.2051
            5   O2x O    25.2552  -12.1312
            6   C1y C    24.0493  -15.5796
            7   C1y C    22.8677  -13.4935
            8   C1x C    27.6547  -13.5176
            9   C1y C    26.4609  -11.4438
            10  C1x C    22.8558  -14.8681
            11  O7x O    24.0374  -16.9542
            12  C1x C    21.6739  -12.7941
            13  C1y C    27.6666  -12.1312
            14  C7x C    22.8316  -17.6173
            15  C2x C    20.4682  -13.4817
            16  C1a C    28.8604  -11.4438
            17  C1y C    22.8316  -18.9918
            18  C2y C    19.2744  -12.7941
            19  C1z C    21.6620  -19.6674
            20  C2x C    24.0133  -19.6792
            21  C1y C    18.0806  -13.4817
            22  C1a C    19.2744  -11.4077
            23  C1y C    21.6620  -21.0419
            24  C2y C    20.4682  -18.9676
            25  O1a O    21.6498  -18.1987
            26  C2y C    24.0133  -21.0419
            27  C1y C    18.0806  -14.8681
            28  O2x O    19.2625  -21.0419
            29  C1y C    22.8316  -21.7172
            30  C1x C    19.2625  -19.6674
            31  C2x C    20.4682  -17.6173
            32  C1a C    25.2189  -21.7291
            33  C2x C    19.2744  -15.5556
            34  O1a O    22.8194  -23.1036
            35  C2x C    19.2744  -16.9301
            36  O6a O    24.0437  -18.3170
            37  O2a O    16.8679  -12.7815
            38  C1y C    15.6551  -13.4817
            39  O2x O    15.6551  -14.8681
            40  C1a C    16.8679  -15.5683
            41  C1x C    14.4423  -12.7815
            42  C1y C    13.2295  -13.4817
            43  C1y C    13.2295  -14.8681
            44  C1y C    14.4423  -15.5683
            45  C1a C    14.4421  -16.9455
            46  O2a O    12.0374  -12.7939
            47  O2a O    12.0331  -15.5586
            48  C1y C    12.0330  -16.9455
            49  C1x C    10.8312  -17.6393
            50  C1y C    10.8311  -19.0397
            51  C1y C    12.0439  -19.7400
            52  C1y C    13.2457  -19.0462
            53  O2x O    13.2457  -17.6458
            54  C1a C    10.8237  -13.4950
            55  O1a O    12.0439  -21.1468
            56  C1a C    14.4527  -19.7431
            57  O2a O     9.6354  -19.7303
            58  C1a C     8.4532  -19.0480
            59  C1c C    26.4606  -10.0136
            60  C1a C    25.2561   -9.3185
            61  C1b C    27.6817   -9.3083
            62  R   R    28.8710   -9.9950
BOND        68
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Up
            4     1   5 1 #Down
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     5   9 1
            9     6  10 1
            10    6  11 1 #Up
            11    7  12 1
            12    8  13 1
            13   11  14 1
            14   12  15 1
            15   13  16 1 #Up
            16   17  14 1 #Down
            17   15  18 2
            18   17  19 1
            19   17  20 1
            20   18  21 1
            21   18  22 1
            22   19  23 1
            23   19  24 1
            24   19  25 1 #Down
            25   20  26 2
            26   21  27 1
            27   23  28 1
            28   23  29 1
            29   24  30 1
            30   24  31 2
            31   26  32 1
            32   27  33 1
            33   29  34 1 #Up
            34   31  35 1
            35    7  10 1
            36    9  13 1
            37   26  29 1
            38   28  30 1
            39   33  35 2
            40   14  36 2
            41   21  37 1 #Down
            42   38  37 1 #Down
            43   38  39 1
            44   27  40 1 #Down
            45   38  41 1
            46   41  42 1
            47   42  43 1
            48   43  44 1
            49   39  44 1
            50   44  45 1 #Up
            51   42  46 1 #Up
            52   43  47 1 #Down
            53   48  47 1 #Down
            54   48  49 1
            55   49  50 1
            56   50  51 1
            57   51  52 1
            58   52  53 1
            59   48  53 1
            60   46  54 1
            61   51  55 1 #Down
            62   52  56 1 #Up
            63   50  57 1 #Up
            64   57  58 1
            65    9  59 1
            66   59  60 1 #Up
            67   59  61 1
            68   61  62 1

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