KEGG   DRUG: Pravastatin sodium
Entry
D00893                      Drug                                   
Name
Pravastatin sodium (JP18/USP);
CS-514;
Pravachol (TN)
Product
  Generic
PRAVASTATIN SODIUM (A-S Medication Solutions), PRAVASTATIN SODIUM (A-S Medication Solutions), PRAVASTATIN SODIUM (A-S Medication Solutions), PRAVASTATIN SODIUM (A-S Medication Solutions), PRAVASTATIN SODIUM (A-S Medication Solutions), PRAVASTATIN SODIUM (A-S Medication Solutions), PRAVASTATIN SODIUM (A-S Medication Solutions), PRAVASTATIN SODIUM (A-S Medication Solutions), PRAVASTATIN SODIUM (A-S Medication Solutions), PRAVASTATIN SODIUM (A-S Medication Solutions), PRAVASTATIN SODIUM (Accord Healthcare), PRAVASTATIN SODIUM (American Health Packaging), PRAVASTATIN SODIUM (Aphena Pharma Solutions - Tennessee), PRAVASTATIN SODIUM (Aphena Pharma Solutions - Tennessee), PRAVASTATIN SODIUM (Apotex Corp.), PRAVASTATIN SODIUM (Aurobindo Pharma Limited), PRAVASTATIN SODIUM (AvKARE), PRAVASTATIN SODIUM (AvPAK), PRAVASTATIN SODIUM (BIOCON PHARMA INC.,), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Bryant Ranch Prepack), PRAVASTATIN SODIUM (Cardinal Health 107), PRAVASTATIN SODIUM (Cardinal Health 107), PRAVASTATIN SODIUM (DIRECT RX), PRAVASTATIN SODIUM (DIRECT RX), PRAVASTATIN SODIUM (DIRECT RX), PRAVASTATIN SODIUM (Denton Pharma), PRAVASTATIN SODIUM (Denton Pharma), PRAVASTATIN SODIUM (Direct_Rx), PRAVASTATIN SODIUM (Dr.Reddy's Laboratories Limited), PRAVASTATIN SODIUM (Glenmark Pharmaceuticals), PRAVASTATIN SODIUM (Lake Erie Medical DBA Quality Care Products LLC), PRAVASTATIN SODIUM (Lupin Pharmaceuticals), PRAVASTATIN SODIUM (Major Pharmaceuticals), PRAVASTATIN SODIUM (Mylan Institutional), PRAVASTATIN SODIUM (NCS HealthCare of KY), PRAVASTATIN SODIUM (NCS HealthCare of KY), PRAVASTATIN SODIUM (NorthStar RxLLC), PRAVASTATIN SODIUM (Northwind Pharmaceuticals), PRAVASTATIN SODIUM (Northwind Pharmaceuticals), PRAVASTATIN SODIUM (Northwind Pharmaceuticals), PRAVASTATIN SODIUM (Northwind Pharmaceuticals), PRAVASTATIN SODIUM (Northwind Pharmaceuticals), PRAVASTATIN SODIUM (Northwind Pharmaceuticals), PRAVASTATIN SODIUM (PD-Rx Pharmaceuticals), PRAVASTATIN SODIUM (PD-Rx Pharmaceuticals), PRAVASTATIN SODIUM (PD-Rx Pharmaceuticals), PRAVASTATIN SODIUM (PD-Rx Pharmaceuticals), PRAVASTATIN SODIUM (PD-Rx Pharmaceuticals), PRAVASTATIN SODIUM (PD-Rx Pharmaceuticals), PRAVASTATIN SODIUM (Preferred Pharmaceuticals Inc..), PRAVASTATIN SODIUM (Preferred Pharmaceuticals Inc..), PRAVASTATIN SODIUM (Preferred Pharmaceuticals), PRAVASTATIN SODIUM (Preferred Pharmaceuticals), PRAVASTATIN SODIUM (Preferred Pharmaceuticals), PRAVASTATIN SODIUM (Proficient Rx LP), PRAVASTATIN SODIUM (Proficient Rx LP), PRAVASTATIN SODIUM (Proficient Rx LP), PRAVASTATIN SODIUM (Proficient Rx LP), PRAVASTATIN SODIUM (Proficient Rx LP), PRAVASTATIN SODIUM (Proficient Rx LP), PRAVASTATIN SODIUM (Quality Care Products), PRAVASTATIN SODIUM (Quallent), PRAVASTATIN SODIUM (REMEDYREPACK), PRAVASTATIN SODIUM (REMEDYREPACK), PRAVASTATIN SODIUM (REMEDYREPACK), PRAVASTATIN SODIUM (REMEDYREPACK), PRAVASTATIN SODIUM (REMEDYREPACK), PRAVASTATIN SODIUM (REMEDYREPACK), PRAVASTATIN SODIUM (REMEDYREPACK), PRAVASTATIN SODIUM (St. Mary's Medical Park Pharmacy), PRAVASTATIN SODIUM (Teva Pharmaceuticals USA), PRAVASTATIN SODIUM (Teva Pharmaceuticals USA), PRAVASTATIN SODIUM (Teva Pharmaceuticals), PRAVASTATIN SODIUM (Zydus Lifesciences Limited), PRAVASTATIN SODIUM (Zydus Pharmaceuticals USA)
Formula
C23H35O7. Na
Exact mass
446.228
Mol weight
446.5096
Structure
Simcomp
Class
Hypolipidemic agent
 DG01946  Hypolipidemic agent
  DG01660  HMG-CoA reductase inhibitor
Transporter substrate
 DG02861  ABCC2 substrate
 DG02856  SLCO1B1 substrate
 DG02933  SLCO2B1 substrate
Remark
Therapeutic category: 2189
ATC code: C10AA03
Chemical structure group: DG00353
Product (DG00353): D00893<JP/US>
Efficacy
Antihyperlipidemic, HMG-CoA reductase inhibitor
  Disease
Hyperlipidemia [DS:H01635 H00155]
Target
HMGCR [HSA:3156] [KO:K00021]
  Pathway
hsa00900  Terpenoid backbone biosynthesis
hsa04976  Bile secretion
Metabolism
Transporter: ABCC2 [HSA:1244], SLCO1B1 [HSA:10599], SLCO2B1 [HSA:11309]
Interaction
Structure map
map07024  HMG-CoA reductase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AA HMG CoA reductase inhibitors
     C10AA03 Pravastatin
      D00893  Pravastatin sodium (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, HMG CoA Reductase Inhibitors
   Pravastatin
    D00893  Pravastatin sodium (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   218  Hyperlipidemia agents
    2189  Others
     D00893  Pravastatin sodium (JP18/USP)
Drug groups [BR:br08330]
 Hypolipidemic agent
  DG01946  Hypolipidemic agent
   DG01660  HMG-CoA reductase inhibitor
    DG00353  Pravastatin
     D00893  Pravastatin sodium
 Transporter substrate
  DG02861  ABCC2 substrate
   DG00353  Pravastatin
    D00893  Pravastatin sodium
  DG02856  SLCO1B1 substrate
   DG00353  Pravastatin
    D00893  Pravastatin sodium
  DG02933  SLCO2B1 substrate
   DG00353  Pravastatin
    D00893  Pravastatin sodium
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01946  Hypolipidemic agent
   D00893  Pravastatin sodium
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Dehydrogenases
    HMGCR
     D00893  Pravastatin sodium (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00893  Pravastatin sodium
  D00893  Pravastatin sodium tablets
  D00893  Pravastatin sodium fine granules
  D00893  Pravastatin sodium solution
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D00893
Drug groups [BR:br08330]
 Hypolipidemic agent
  DG01946  Hypolipidemic agent
   DG01660  HMG-CoA reductase inhibitor
    DG00353  Pravastatin
 Transporter substrate
  DG02861  ABCC2 substrate
   DG00353  Pravastatin
  DG02856  SLCO1B1 substrate
   DG00353  Pravastatin
  DG02933  SLCO2B1 substrate
   DG00353  Pravastatin
Other DBs
CAS: 81131-70-6
PubChem: 7847957
ChEBI: 8361
LigandBox: D00893
NIKKAJI: J227.579A
KCF data

ATOM        31
            1   C1y C    23.0209  -21.3559
            2   C1y C    24.2277  -20.6597
            3   C1y C    21.8141  -20.6540
            4   C2y C    23.0152  -22.7543
            5   C1y C    25.4345  -21.3675
            6   C1b C    24.2335  -19.2674
            7   C1x C    20.6014  -21.3559
            8   O7a O    21.7444  -18.9309
            9   C2x C    21.8141  -23.4447
            10  C2x C    24.2161  -23.4506
            11  C2x C    25.4288  -22.7600
            12  C1a C    26.6471  -20.6713
            13  C1b C    25.4460  -18.5768
            14  C1y C    20.6014  -22.7543
            15  C7a C    20.6536  -18.2287
            16  O1a O    19.3947  -23.4447
            17  C1c C    19.4469  -18.9250
            18  O6a O    20.6536  -16.8362
            19  C1b C    18.2402  -18.2287
            20  C1a C    19.4469  -20.3174
            21  C1a C    17.0276  -18.9250
            22  C1c C    25.4276  -17.1575
            23  C1b C    24.2075  -16.4743
            24  O1a O    26.6293  -16.4427
            25  C1c C    24.2156  -15.0601
            26  C1b C    25.4307  -14.3679
            27  O1a O    23.0087  -14.3541
            28  C6a C    26.8259  -14.3609
            29  O6a O    27.5310  -15.5685 #-
            30  O6a O    27.5189  -13.1465
            31  Z   Na   29.1409  -15.4559 #+
BOND        31
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1 #Up
            6     3   7 1
            7     3   8 1 #Down
            8     4   9 2
            9     4  10 1
            10    5  11 1
            11    5  12 1 #Up
            12    6  13 1
            13    7  14 1
            14    8  15 1
            15   14  16 1 #Up
            16   15  17 1
            17   15  18 2
            18   17  19 1
            19   17  20 1 #Up
            20   19  21 1
            21    9  14 1
            22   10  11 2
            23   22  13 1 #Down
            24   22  23 1
            25   22  24 1
            26   23  25 1
            27   25  26 1
            28   25  27 1 #Up
            29   26  28 1
            30   28  29 1
            31   28  30 2

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Ontology (8)   
   KEGG BRITE (8)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (2)   
   KEGG DISEASE (2)   
Drug (3)   
   KEGG DGROUP (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (3)   
   PubChem (1)   
   ChEBI (1)   
   NIKKAJI (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
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