KEGG   DRUG: Cefuroxime axetilHelp
Entry
D00914                      Drug                                   

Name
Cefuroxime axetil (JP17/USP/INN);
CXM-AX;
Ceftin (TN)
Product
  Generic
CEFUROXIME AXETIL (A-S Medication Solutions), CEFUROXIME AXETIL (A-S Medication Solutions), CEFUROXIME AXETIL (American Health Packaging), CEFUROXIME AXETIL (Ascend Laboratories), CEFUROXIME AXETIL (Aurobindo Pharma Limited), CEFUROXIME AXETIL (DIRECT RX), CEFUROXIME AXETIL (Denton Pharma), CEFUROXIME AXETIL (Direct_Rx), CEFUROXIME AXETIL (Golden State Medical Supply), CEFUROXIME AXETIL (Lake Erie Medical DBA Quality Care Products LLC), CEFUROXIME AXETIL (Lake Erie Medical DBA Quality Care Products LLC), CEFUROXIME AXETIL (Lupin Pharmaceuticals), CEFUROXIME AXETIL (NorthStar Rx LLC), CEFUROXIME AXETIL (NuCare Pharmaceuticals), CEFUROXIME AXETIL (NuCare Pharmaceuticals), CEFUROXIME AXETIL (NuCare Pharmaceuticals), CEFUROXIME AXETIL (PD-Rx Pharmaceuticals), CEFUROXIME AXETIL (PD-Rx Pharmaceuticals), CEFUROXIME AXETIL (PD-Rx Pharmaceuticals), CEFUROXIME AXETIL (PD-Rx Pharmaceuticals), CEFUROXIME AXETIL (PD-Rx Pharmaceuticals), CEFUROXIME AXETIL (PD-Rx Pharmaceuticals), CEFUROXIME AXETIL (Proficient Rx LP), CEFUROXIME AXETIL (Rising Health), CEFUROXIME AXETIL (Wockhardt USA LLC.)
Formula
C20H22N4O10S
Exact mass
510.1057
Mol weight
510.4745
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antibacterial
 DG01710  beta-Lactam antibiotic
  DG01714  Cephalosporin skeleton group
   DG01488  Cephem
 DG01775  Second-generation cephalosporin
 DG01804  Oxyimino beta-lactam
Remark
Same as: C08107
Therapeutic category: 6132
ATC code: J01DC02 S01AA27
Chemical structure group: DG00558
Product (DG00558): D00914<JP/US> D00915<US>
Efficacy
Antibacterial, Cell wall biosynthesis inhibitor
  Disease
Uncomplicated urinary tract infections [DS:H01176]
Gonorrhea [DS:H00315]
Lyme disease [DS:H00353]
Comment
Active form of prodrug: Cefuroxime [DR:D00262]
Target
penicillin binding protein
  Pathway
ko00550  Peptidoglycan biosynthesis
Interaction
Drug interaction
Structure map
map07012  Cephalosporins - parenteral agents
map07013  Cephalosporins - oral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01D OTHER BETA-LACTAM ANTIBACTERIALS
    J01DC Second-generation cephalosporins
     J01DC02 Cefuroxime
      D00914  Cefuroxime axetil (JP17/USP/INN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA27 Cefuroxime
      D00914  Cefuroxime axetil (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Beta-lactam, Cephalosporins
   Cefuroxime
    D00914  Cefuroxime axetil (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   613  Acting mainly on gram-positive and gram-negative bacteria
    6132  Cephem antibioitics
     D00914  Cefuroxime axetil (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00914  Cefuroxime axetil
Antiinfectives [br08350.html]
 Antibacterials
  D00914
Prodrugs [br08324.html]
 D00914
BRITE hierarchy
Other DBs
CAS: 64544-07-6
PubChem: 7847977
ChEBI: 3516
ChEMBL: CHEMBL1095930
DrugBank: DB01112
LigandBox: D00914
NIKKAJI: J111.110H
KCF data Show

ATOM        35
            1   C1y C    32.4830  -17.3815
            2   N1y N    32.4830  -18.7522
            3   C2y C    33.6704  -19.4375
            4   C2y C    34.8574  -18.7522
            5   C1x C    34.8574  -17.3815
            6   S2x S    33.6704  -16.6961
            7   C1y C    31.1122  -17.3815
            8   C5x C    31.1122  -18.7522
            9   N1b N    29.9252  -16.6961
            10  C5a C    28.7380  -17.3815
            11  O5a O    28.7380  -18.7522
            12  O5x O    29.9252  -19.4375
            13  C2c C    27.5508  -16.6961
            14  C1b C    36.0626  -19.4485
            15  C7a C    33.6704  -21.8391
            16  O7a O    32.4665  -22.5342
            17  O6a O    34.8407  -22.5150
            18  C8y C    26.3447  -17.3929
            19  O2x O    25.2137  -16.5965
            20  C8x C    24.1023  -17.4263
            21  C8x C    24.5479  -18.7397
            22  C8x C    25.9347  -18.7220
            23  N2b N    27.5507  -15.3044
            24  O7a O    37.2666  -18.7539
            25  C7a C    38.4302  -19.4263
            26  N1a N    39.6019  -18.7501
            27  O6a O    38.4298  -20.8040
            28  C1c C    31.2867  -21.8527
            29  O7a O    30.1305  -22.5200
            30  C7a C    28.9560  -21.8415
            31  C1a C    27.7902  -22.5142
            32  C1a C    31.2864  -20.4575
            33  O6a O    28.9562  -20.4574
            34  O2a O    28.7734  -14.5979
            35  C1a C    28.7734  -13.1979
BOND        37
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     2   8 1
            10    7   9 1 #Up
            11    9  10 1
            12   10  11 2
            13    8  12 2
            14   10  13 1
            15    4  14 1
            16    3  15 1
            17   15  16 1
            18   15  17 2
            19   13  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   18  22 2
            25   13  23 2
            26   14  24 1
            27   24  25 1
            28   25  26 1
            29   25  27 2
            30   16  28 1
            31   28  29 1
            32   29  30 1
            33   30  31 1
            34   28  32 1
            35   30  33 2
            36   23  34 1
            37   34  35 1

» Japanese version   » Back

DBGET integrated database retrieval system