KEGG   DRUG: Doxifluridine
Entry
D01309                      Drug                                   

Name
Doxifluridine (JP17/INN);
Furtulon (TN)
Formula
C9H11FN2O5
Exact mass
246.0652
Mol weight
246.1924
Structure
Simcomp
Class
Antineoplastic
 DG01958  Nucleic acid derivative, antineoplastic
  DG01935  Fluoropyrimidine antineoplastic
 DG01935  Fluoropyrimidine antineoplastic
 DG02018  Antimetabolite
  DG01958  Nucleic acid derivative, antineoplastic
   DG01935  Fluoropyrimidine antineoplastic
Remark
Same as: C12739
Therapeutic category: 4223
Product: D01309<JP>
Efficacy
Antineoplastic, Antimetabolite
Comment
Active form of prodrug: Fluorouracil [DR:D00584]
Target
TYMS [HSA:7298] [KO:K00560]
  Pathway
hsa00240  Pyrimidine metabolism
hsa00670  One carbon pool by folate
Interaction
Structure map
map07041  Antineoplastics - antimetabolic agents
Other map
map00983  Drug metabolism - other enzymes
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   422  Antimetabolites
    4223  Fluorouracils
     D01309  Doxifluridine (JP17/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Methyltransferases
    TYMS
     D01309  Doxifluridine (JP17/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01309  Doxifluridine
  D01309  Doxifluridine capsules
Prodrugs [br08324.html]
 D01309
Other DBs
CAS: 3094-09-5
PubChem: 7848372
ChEBI: 31521
ChEMBL: CHEMBL1130
LigandBox: D01309
NIKKAJI: J7.679A
KCF data

ATOM        17
            1   C1y C    22.8703  -17.4990
            2   N4y N    24.5207  -16.9314
            3   O2x O    21.7034  -16.6238
            4   C1y C    22.4328  -18.8118
            5   C8y C    25.7785  -17.6293
            6   C8x C    24.4865  -15.5558
            7   C1y C    20.6094  -17.4261
            8   C1y C    21.0470  -18.8118
            9   O1a O    23.2350  -19.9058
            10  N4x N    26.9723  -16.9258
            11  O5x O    25.7354  -18.9679
            12  C8y C    25.7504  -14.8522
            13  O1a O    20.2448  -19.9058
            14  C8y C    26.9711  -15.4873
            15  O5x O    28.1650  -14.7838
            16  C1a C    19.2967  -17.0614
            17  X   F    25.7492  -13.4138
BOND        18
            1     1   3 1
            2     1   4 1
            3     2   5 1
            4     2   6 1
            5     3   7 1
            6     4   8 1
            7     4   9 1 #Down
            8     5  10 1
            9     5  11 2
            10    6  12 2
            11    8  13 1 #Down
            12   10  14 1
            13   14  15 2
            14    7   8 1
            15   12  14 1
            16    7  16 1 #Up
            17    1   2 1 #Up
            18   12  17 1

» Japanese version   » Back

KEGG   COMPOUND: C12739
Entry
C12739                      Compound                               

Name
5'-Deoxy-5-fluorouridine;
Doxifluridine
Formula
C9H11FN2O5
Exact mass
246.0652
Mol weight
246.1924
Structure
Remark
Same as: D01309
Reaction
Pathway
map00983  Drug metabolism - other enzymes
Enzyme
2.4.2.4         3.5.4.5
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   422  Antimetabolites
    4223  Fluorouracils
     D01309  Doxifluridine (JP17/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Methyltransferases
    TYMS
     D01309  Doxifluridine (JP17/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01309  Doxifluridine
  D01309  Doxifluridine capsules
Prodrugs [br08324.html]
 D01309
Other DBs
CAS: 3094-09-5
PubChem: 583128
ChEBI: 31521
ChEMBL: CHEMBL1130
NIKKAJI: J7.679A
KCF data

ATOM        17
            1   C1y C    23.0300  -17.7800
            2   N4y N    24.6400  -17.2200
            3   O2x O    21.9100  -16.9400
            4   C1y C    22.6100  -19.1100
            5   C8y C    25.9000  -17.9200
            6   C8x C    24.6400  -15.8900
            7   C1y C    20.7900  -17.7100
            8   C1y C    21.2100  -19.1100
            9   O1a O    23.3800  -20.1600
            10  N4x N    27.0900  -17.2200
            11  O5x O    25.9000  -19.2500
            12  C8y C    25.9000  -15.1900
            13  O1a O    20.4400  -20.1600
            14  C8y C    27.0900  -15.8200
            15  O5x O    28.2800  -15.1200
            16  C1a C    19.5300  -17.3600
            17  X   F    25.9000  -13.7200
BOND        18
            1     1   3 1
            2     1   4 1
            3     2   5 1
            4     2   6 1
            5     3   7 1
            6     4   8 1
            7     4   9 1 #Down
            8     5  10 1
            9     5  11 2
            10    6  12 2
            11    8  13 1 #Down
            12   10  14 1
            13   14  15 2
            14    7   8 1
            15   12  14 1
            16    7  16 1 #Up
            17    1   2 1 #Up
            18   12  17 1

» Japanese version

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