KEGG   DRUG: Ciclesonide
Entry
D01703                      Drug                                   
Name
Ciclesonide (JAN/USAN/INN);
Alvesco (TN);
Omnaris (TN);
Zetonna (TN)
Product
ALVESCO (Covis Pharma US), OMNARIS (Covis Pharma US), ZETONNA (Covis Pharma US)
Formula
C32H44O7
Exact mass
540.3087
Mol weight
540.69
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2290
ATC code: R01AD13 R03BA08
Product: D01703<JP/US>
Efficacy
Antiasthmatic, Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Allergic rhinitis [DS:H01360]
Asthma [DS:H00079]
Comment
Glucocorticoid, acetal derivative
Treatment of asthma as prophylactic therapy in adults and adolescents
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD13 Ciclesonide
      D01703  Ciclesonide (JAN/USAN/INN) <JP/US>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA08 Ciclesonide
      D01703  Ciclesonide (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Anti-inflammatories, Inhaled Corticosteroids
   Ciclesonide
    D01703  Ciclesonide (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   229  Miscellaneous
    2290  Miscellaneous
     D01703  Ciclesonide (JAN/USAN/INN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    D01703  Ciclesonide
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D01703  Ciclesonide
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D01703  Ciclesonide
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01703  Ciclesonide (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01703
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01703
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01703
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01703
Other DBs
CAS: 126544-47-6
PubChem: 7848766
ChEBI: 31397
LigandBox: D01703
NIKKAJI: J561.842H
KCF data

ATOM        39
            1   C2x C    14.0700  -23.5900
            2   C5x C    14.0700  -24.9900
            3   C2x C    15.2600  -25.6900
            4   C2y C    16.5200  -24.9900
            5   C1z C    16.5200  -23.5900
            6   C2x C    15.2600  -22.8900
            7   C1x C    17.7100  -25.6900
            8   C1x C    18.9000  -24.9900
            9   C1y C    18.9000  -23.5900
            10  C1y C    17.7100  -22.8900
            11  C1y C    20.1600  -22.8900
            12  C1z C    20.1600  -21.4900
            13  C1x C    18.9000  -20.7900
            14  C1y C    17.7100  -21.4900
            15  C1x C    22.5400  -22.8900
            16  C1y C    22.5400  -21.4900
            17  C1z C    21.3500  -20.7900
            18  O5x O    12.8800  -25.6900
            19  C1a C    16.5200  -22.1900
            20  C1a C    20.1600  -20.0900
            21  O1a O    16.5200  -20.7900
            22  C5a C    21.3500  -19.3900
            23  O5a O    22.5400  -18.6900
            24  C1b C    20.1600  -18.6900
            25  O7a O    20.1600  -17.2900
            26  C7a C    18.9700  -16.5900
            27  C1c C    17.7800  -17.2900
            28  O6a O    18.9700  -15.1900
            29  C1a C    16.5900  -16.5900
            30  C1a C    17.7800  -18.6900
            31  O2x O    22.5400  -20.0900
            32  O2x O    23.9400  -21.1400
            33  C1y C    23.9400  -20.0900
            34  C1x C    25.1300  -17.9900
            35  C1y C    25.1300  -19.3900
            36  C1x C    26.3200  -20.0900
            37  C1x C    27.5800  -19.3900
            38  C1x C    27.5800  -17.9900
            39  C1x C    26.3200  -17.2900
BOND        44
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   12  20 1 #Up
            24   14  21 1 #Up
            25   17  22 1 #Up
            26   22  23 2
            27   22  24 1
            28   24  25 1
            29   25  26 1
            30   26  27 1
            31   26  28 2
            32   27  29 1
            33   27  30 1
            34   17  31 1
            35   16  32 1
            36   31  33 1
            37   32  33 1
            38   34  35 1
            39   35  36 1
            40   36  37 1
            41   37  38 1
            42   38  39 1
            43   34  39 1
            44   33  35 1 #Down

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