Entry |
|
Name |
Vindesine sulfate (JAN/USAN); Fildesin (TN) |
Formula |
C43H55N5O7. H2SO4
|
Exact mass |
851.3775
|
Mol weight |
852.0046
|
Structure |
|
Simcomp |
|
Class |
Antineoplastic
DG01965 Vinca alkaloid antineoplastic
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
|
Remark |
Therapeutic category: | 4240 |
Product (DG00691): | D01769<JP> |
|
Efficacy |
Antineoplastic, Tubulin polymerization inhibitor |
Comment |
Semisynthetic vinblastine derivative
|
Target |
|
Pathway |
|
Metabolism |
|
Interaction |
|
Structure map |
map07042 | Antineoplastics - agents from natural products |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01C PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
L01CA Vinca alkaloids and analogues
L01CA03 Vindesine
D01769 Vindesine sulfate (JAN/USAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
42 Antineoplastics
424 Plant extract preparations
4240 Plant extract preparations
D01769 Vindesine sulfate (JAN/USAN)
Drug groups [BR:br08330]
Antineoplastic
DG01965 Vinca alkaloid antineoplastic
DG00691 Vindesine
D01769 Vindesine sulfate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00691 Vindesine
D01769 Vindesine sulfate
Target-based classification of drugs [BR:br08310]
Not elsewhere classified
Cellular process
Cytoskeleton
TUBB
D01769 Vindesine sulfate (JAN/USAN) <JP>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01769
Drug groups [BR:br08330]
Antineoplastic
DG01965 Vinca alkaloid antineoplastic
DG00691 Vindesine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00691 Vindesine
|
Other DBs |
|
KCF data |
ATOM 60
1 S4a S 35.2967 -18.7069
2 O1d O 35.2898 -17.3138
3 O1d O 35.2898 -20.1001
4 O1d O 36.6898 -18.7069
5 O1d O 33.9036 -18.7000
6 C1z C 32.4769 -23.9191
7 C1y C 33.6075 -23.2524
8 C1y C 32.4827 -25.2239
9 C8y C 30.2271 -23.9191
10 C1x C 31.6420 -22.8407
11 C1z C 34.7500 -23.9134
12 N1y N 33.5959 -21.9303
13 C1z C 33.6191 -25.8733
14 N1y N 31.3462 -25.8733
15 C8y C 30.2271 -25.2239
16 C8x C 29.0905 -23.2697
17 C1x C 32.3030 -21.9250
18 C1y C 34.6916 -25.2297
19 C2x C 35.8807 -23.2408
20 C1b C 35.8459 -24.5455
21 C1x C 34.7441 -21.2693
22 C5a C 34.5122 -27.0521
23 O1a O 33.1263 -27.7753
24 C1a C 31.3326 -27.2491
25 C8x C 29.0905 -25.8792
26 C8y C 27.9830 -23.9134
27 O1a O 37.1932 -26.0776
28 C2x C 35.8864 -21.9187
29 C1a C 36.9591 -23.9077
30 N1a N 34.5014 -28.3220
31 C8y C 27.9830 -25.2239
32 C1z C 25.5581 -21.7439
33 O2a O 26.8697 -25.8617
34 C8y C 24.4333 -20.9843
35 C1x C 26.8221 -21.0076
36 C7a C 25.1986 -23.0429
37 C1a C 25.7565 -25.2122
38 C8y C 24.4333 -19.6391
39 N4x N 23.3083 -21.6570
40 C1y C 26.8221 -19.7203
41 O7a O 23.7607 -23.5010
42 O6a O 26.0277 -24.0751
43 C8y C 22.1196 -19.6391
44 C1x C 23.7084 -18.5373
45 C8y C 22.1196 -20.9843
46 C1x C 25.6857 -19.1057
47 C1x C 27.9060 -18.9027
48 C1a C 22.8908 -24.9216
49 C8x C 20.9773 -18.9724
50 C1x C 24.4795 -17.5516
51 C8x C 20.9773 -21.6570
52 N1y N 25.6857 -17.8647
53 C1z C 27.9471 -17.7605
54 C8x C 19.8988 -19.6391
55 C8x C 19.8988 -20.9843
56 C1x C 26.8164 -17.1110
57 C1b C 29.4548 -18.2881
58 O1a O 28.7879 -16.4673
59 C1a C 30.5158 -17.6503
60 O5a O 35.8176 -26.5198
BOND 67
1 1 2 2
2 1 3 2
3 1 4 1
4 1 5 1
5 6 7 1
6 6 8 1
7 6 9 1
8 6 10 1 #Up
9 7 11 1
10 7 12 1
11 8 13 1
12 8 14 1
13 9 15 2
14 9 16 1
15 10 17 1
16 11 18 1
17 11 19 1
18 11 20 1 #Down
19 12 21 1
20 13 22 1 #Down
21 13 23 1 #Up
22 14 24 1
23 15 25 1
24 16 26 2
25 18 27 1 #Up
26 19 28 2
27 20 29 1
28 22 30 1
29 25 31 2
30 32 26 1 #Down
31 31 33 1
32 32 34 1
33 32 35 1
34 32 36 1 #Up
35 33 37 1
36 34 38 2
37 34 39 1
38 35 40 1
39 36 41 1
40 36 42 2
41 38 43 1
42 38 44 1
43 39 45 1
44 40 46 1 #Down
45 40 47 1
46 41 48 1
47 43 49 1
48 44 50 1
49 45 51 1
50 52 46 1 #Down
51 47 53 1
52 49 54 2
53 51 55 2
54 52 56 1
55 53 57 1 #Down
56 53 58 1 #Up
57 57 59 1
58 12 17 1
59 13 18 1
60 14 15 1
61 21 28 1
62 26 31 1
63 43 45 2
64 50 52 1
65 53 56 1
66 54 55 1
67 22 60 2
|