KEGG   DRUG: Triprolidine hydrochloride
Entry
D01782                      Drug                                   
Name
Triprolidine hydrochloride (USP);
Triprolidine hydrochloride hydrate (JAN);
Venen (TN)
Formula
C19H22N2. HCl. H2O
Exact mass
332.1655
Mol weight
332.8676
Structure
Simcomp
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Remark
ATC code: R06AX07
Chemical structure group: DG01111
Efficacy
Antiallergic, Antipruritic, H1 receptor antagonist
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Interaction
Structure map
map07212  Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AX Other antihistamines for systemic use
     R06AX07 Triprolidine
      D01782  Triprolidine hydrochloride (USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for otolaryngologic use
  69 Oral medicine for nasal inflammation
   D01782  Triprolidine hydrochloride (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Triprolidine
    D01782  Triprolidine hydrochloride (USP)
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    DG01111  Triprolidine
     D01782  Triprolidine hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D01782  Triprolidine hydrochloride (USP)
Rx-to-OTC switch list in the USA [br08315.html]
 D01782
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    DG01111  Triprolidine
Other DBs
CAS: 6138-79-0
PubChem: 7848844
ChEBI: 32265
LigandBox: D01782
NIKKAJI: J1.591.795D
KCF data

ATOM        23
            1   X   Cl   29.7575  -15.7912
            2   C2b C    23.9165  -17.9663
            3   C1b C    22.7028  -17.2667
            4   N1y N    22.7018  -15.8660
            5   C1x C    21.5661  -15.0520
            6   C1x C    21.9980  -13.7193
            7   C1x C    23.3986  -13.7185
            8   C1x C    23.8326  -15.0503
            9   C8x C    20.2769  -20.0664
            10  C8y C    20.2769  -21.4672
            11  C8x C    21.4929  -22.1676
            12  C8x C    22.7018  -21.4672
            13  C8y C    22.7018  -20.0664
            14  C8x C    21.4929  -19.3660
            15  C2c C    23.9153  -19.3671
            16  C8y C    25.1280  -20.0683
            17  C8x C    25.1213  -21.4670
            18  C8x C    26.3340  -22.1684
            19  C8x C    27.5477  -21.4689
            20  C8x C    27.5487  -20.0681
            21  N5x N    26.3360  -19.3669
            22  C1a C    19.0641  -22.1683
            23  O0  O    30.1596  -17.6328
BOND        23
            1     4   5 1
            2     9  10 2
            3    10  11 1
            4    11  12 2
            5    12  13 1
            6    13  14 2
            7    14   9 1
            8     5   6 1
            9    13  15 1
            10    6   7 1
            11   15  16 1
            12    7   8 1
            13    8   4 1
            14    3   4 1
            15   16  17 2
            16   17  18 1
            17   18  19 2
            18   19  20 1
            19   20  21 2
            20   21  16 1
            21    2   3 1
            22   10  22 1
            23   15   2 2

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Ontology (6)   
   KEGG BRITE (6)   
Pathway (1)   
   KEGG PATHWAY (1)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (3)   
   PubChem (1)   
   ChEBI (1)   
   NIKKAJI (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (14)   

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