| Entry |
|
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| Name |
Tenofovir disoproxil fumarate (JAN/USAN);
Viread (TN) |
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| Abbr |
TDF |
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| Product |
|
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| Generic |
TENOFOVIR DISOPROXIL FUMARATE (Apotex Corp.), TENOFOVIR DISOPROXIL FUMARATE (Aurobindo Pharma Limited), TENOFOVIR DISOPROXIL FUMARATE (AvKARE), TENOFOVIR DISOPROXIL FUMARATE (AvPAK), TENOFOVIR DISOPROXIL FUMARATE (Camber Pharmaceuticals), TENOFOVIR DISOPROXIL FUMARATE (Cipla USA), TENOFOVIR DISOPROXIL FUMARATE (DOH CENTRAL PHARMACY), TENOFOVIR DISOPROXIL FUMARATE (NorthStar RxLLC), TENOFOVIR DISOPROXIL FUMARATE (Quinn Pharmaceuticals), TENOFOVIR DISOPROXIL FUMARATE (REMEDYREPACK), TENOFOVIR DISOPROXIL FUMARATE (REMEDYREPACK), TENOFOVIR DISOPROXIL FUMARATE (Strides Pharma Science Limited), TENOFOVIR DISPROXIL FUMARATE (Macleods Pharmaceuticals Limited), TENOFOVIR DISPROXIL FUMARATE (Major Pharmaceuticals) |
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| Formula |
C19H30N5O10P. C4H4O4
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| Exact mass |
635.184
|
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| Mol weight |
635.5149
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| Structure |
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| Simcomp |
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| Class |
Antiviral
DG01890 Nucleoside reverse transcriptase inhibitor (NRTI)
DG01656 HIV reverse transcriptase inhibitor
|
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| Remark |
| Therapeutic category: | 6250 |
| Product (DG01223): | D01982<JP/US> D10605<JP/US> |
| Product (mixture): | D02297<JP/US> D10571<US> D10756<JP/US> D10851<US> D11392<US> D11395<US> D11396<US> |
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| Efficacy |
Antiviral, Reverse transcriptase inhibitor |
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| Disease |
|
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| Comment |
Active form of prodrug: Tenofovir [CPD: C17407]
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| Target |
HBV reverse transcriptase [KO: K21037] HIV-1 reverse transcriptase [KO: K24802] |
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| Pathway |
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J05 ANTIVIRALS FOR SYSTEMIC USE
J05A DIRECT ACTING ANTIVIRALS
J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
J05AF07 Tenofovir disoproxil
D01982 Tenofovir disoproxil fumarate (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
Antivirals
Anti-hepatitis B (HBV) Agents
Tenofovir
D01982 Tenofovir disoproxil fumarate (JAN/USAN)
Anti-HIV Agents, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTI)
Tenofovir
D01982 Tenofovir disoproxil fumarate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
62 Chemotherapeutics
625 Antivirals
6250 Antivirals
D01982 Tenofovir disoproxil fumarate (JAN/USAN)
Antiinfectives [BR:br08307]
Antivirals
Genome replication inhibitor
HBV reverse transcriptase inhibitor
D01982 Tenofovir disoproxil fumarate (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D01982
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D01982
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D01982
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D01982
Prodrugs [br08324.html]
D01982
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| Other DBs |
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| KCF data |
ATOM 43
1 C6a C 30.8992 -18.5945
2 C2b C 32.1576 -19.2936
3 C2b C 33.3460 -18.5945
4 C6a C 34.5345 -19.2936
5 O6a O 35.7928 -18.5945
6 O6a O 29.7108 -19.2936
7 O6a O 30.8992 -17.1963
8 O6a O 34.5345 -20.6917
9 C8y C 26.5368 -16.8840
10 C8y C 26.5368 -15.4243
11 N4y N 25.2162 -17.3012
12 N5x N 27.7880 -17.5096
13 N5x N 25.2162 -15.0073
14 C8y C 27.7880 -14.7987
15 C8x C 24.3820 -16.1889
16 C8x C 28.9697 -16.8840
17 N5x N 28.9697 -15.4243
18 N1a N 27.7880 -13.4085
19 C1b C 25.2162 -18.6945
20 C1c C 24.0155 -19.3876
21 O2a O 22.8023 -18.6870
22 C1b C 21.5805 -19.3928
23 P1b P 20.3622 -18.6904
24 O2b O 19.1554 -17.9937
25 O2b O 19.6691 -19.8908
26 O3b O 21.0616 -17.4784
27 C1b C 19.1554 -16.5955
28 C1b C 19.6691 -21.2890
29 O7a O 17.9438 -15.8681
30 C7a C 16.7329 -16.5671
31 O7a O 15.5220 -15.8681
32 C1c C 14.3112 -16.5671
33 C1a C 13.1003 -15.8681
34 O7a O 18.4331 -22.0200
35 C7a C 17.2222 -21.3209
36 O7a O 16.0114 -22.0200
37 C1c C 14.8006 -21.3209
38 C1a C 13.5897 -22.0200
39 O6a O 16.7329 -17.9651
40 C1a C 14.3112 -17.9652
41 O6a O 17.2222 -19.9230
42 C1a C 14.8006 -19.9229
43 C1a C 24.0154 -20.7900
BOND 43
1 1 2 1
2 2 3 2
3 3 4 1
4 4 5 1
5 1 6 1
6 1 7 2
7 4 8 2
8 10 13 1
9 10 14 1
10 11 15 1
11 12 16 2
12 14 17 2
13 13 15 2
14 16 17 1
15 9 10 2
16 9 11 1
17 9 12 1
18 14 18 1
19 11 19 1
20 19 20 1
21 20 21 1
22 21 22 1
23 22 23 1
24 23 24 1
25 23 25 1
26 23 26 2
27 24 27 1
28 25 28 1
29 27 29 1
30 29 30 1
31 30 31 1
32 31 32 1
33 32 33 1
34 28 34 1
35 34 35 1
36 35 36 1
37 36 37 1
38 37 38 1
39 30 39 2
40 32 40 1
41 35 41 2
42 37 42 1
43 20 43 1 #Up
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