| Entry |
|
|---|
| Name |
Paroxetine (USP/INN);
Paroxetine (TN) |
|---|
| Formula |
C19H20FNO3
|
|---|
| Exact mass |
329.1427
|
|---|
| Mol weight |
329.3654
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01659 Selective serotonin reuptake inhibitor (SSRI)
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
|
|---|
| Remark |
| Product (DG00944): | D02260<JP/US> D05374<US> D05375<US> |
|
|---|
| Efficacy |
Antidepressant, Selective serotonin reuptake inhibitor (SSRI) |
|---|
| Comment |
Fluoxetine derivative
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
|
|---|
| Structure map |
| map07234 | Neurotransmitter transporter inhibitors |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AB Selective serotonin reuptake inhibitors
N06AB05 Paroxetine
D02362 Paroxetine (USP/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01659 Selective serotonin reuptake inhibitor (SSRI)
DG00944 Paroxetine
D02362 Paroxetine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00944 Paroxetine
D02362 Paroxetine
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00944 Paroxetine
D02362 Paroxetine
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A4 (HTT)
D02362 Paroxetine (USP/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02362
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01659 Selective serotonin reuptake inhibitor (SSRI)
DG00944 Paroxetine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00944 Paroxetine
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00944 Paroxetine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 24
1 C1y C 24.7626 -18.6745
2 C1y C 23.5491 -19.3721
3 C8y C 24.7684 -17.3611
4 C1x C 25.9759 -19.3721
5 C1b C 22.3356 -18.6745
6 C1x C 23.5491 -20.7791
7 C8x C 25.9819 -16.6634
8 C8x C 23.5549 -16.6634
9 C1x C 25.9759 -20.7791
10 O2a O 21.1161 -19.3721
11 N1x N 24.7626 -21.4766
12 C8x C 25.9819 -15.2624
13 C8x C 23.5549 -15.2566
14 C8y C 19.9026 -18.6686
15 C8y C 24.7684 -14.5589
16 C8x C 19.9086 -17.2733
17 C8x C 18.6951 -19.3781
18 X F 24.7743 -13.2982
19 C8y C 18.7008 -16.5699
20 C8x C 17.4816 -18.6745
21 C8y C 17.4816 -17.2733
22 O2x O 18.4137 -15.1456
23 O2x O 16.4848 -16.2829
24 C1x C 16.9657 -14.8996
BOND 27
1 1 2 1
2 1 3 1 #Down
3 1 4 1
4 2 5 1 #Up
5 2 6 1
6 3 7 2
7 3 8 1
8 4 9 1
9 5 10 1
10 6 11 1
11 7 12 1
12 8 13 2
13 10 14 1
14 12 15 2
15 14 16 2
16 14 17 1
17 15 18 1
18 16 19 1
19 17 20 2
20 19 21 2
21 19 22 1
22 21 23 1
23 22 24 1
24 9 11 1
25 13 15 1
26 20 21 1
27 23 24 1
|
|---|
