KEGG   DRUG: Acrivastine
Entry
D02760                      Drug                                   
Name
Acrivastine (USAN/INN)
Formula
C22H24N2O2
Exact mass
348.1838
Mol weight
348.4382
Structure
Simcomp
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Remark
ATC code: R06AX18
Efficacy
Antiallergic, H1 receptor antagonist
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Interaction
Structure map
map07212  Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AX Other antihistamines for systemic use
     R06AX18 Acrivastine
      D02760  Acrivastine (USAN/INN)
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    D02760  Acrivastine
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D02760  Acrivastine (USAN/INN)
Other DBs
CAS: 87848-99-5
PubChem: 17396918
ChEBI: 83168
LigandBox: D02760
NIKKAJI: J22.097C
KCF data

ATOM        26
            1   C2b C    18.1776  -14.7000
            2   C8y C    19.3900  -16.8000
            3   C8x C    19.3900  -18.2000
            4   C8x C    20.5800  -18.9000
            5   C8x C    21.8400  -18.2000
            6   C8y C    21.8400  -16.8000
            7   N5x N    20.5800  -16.1000
            8   C2b C    23.0300  -16.1000
            9   C2b C    24.2200  -16.8000
            10  C6a C    25.4800  -16.1000
            11  O6a O    26.6700  -16.8000
            12  O6a O    25.4800  -14.7000
            13  C2c C    18.1776  -16.1000
            14  C8y C    16.9651  -16.8000
            15  C8x C    16.9651  -18.2000
            16  C8x C    15.7527  -16.1000
            17  C8x C    14.5403  -16.8000
            18  C8y C    14.5403  -18.2000
            19  C8x C    15.7527  -18.9000
            20  C1a C    13.3278  -18.9000
            21  C1b C    16.9651  -14.0000
            22  N1y N    16.9651  -12.6000
            23  C1x C    18.1070  -11.7879
            24  C1x C    17.6898  -10.4515
            25  C1x C    16.2898  -10.4353
            26  C1x C    15.8419  -11.7618
BOND        28
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     6   8 1
            8     8   9 2
            9     9  10 1
            10   10  11 1
            11   10  12 2
            12    2  13 1
            13   13  14 1
            14   14  15 1
            15   14  16 2
            16   16  17 1
            17   17  18 2
            18   18  19 1
            19   19  15 2
            20   18  20 1
            21    1  13 2
            22    1  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   22  26 1

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (3)   
   PubChem (1)   
   ChEBI (1)   
   NIKKAJI (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (11)   

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