KEGG   DRUG: Droperidol and fentanyl citrateHelp
Entry
D03852            Mixture   Drug                                   

Name
Droperidol and fentanyl citrate;
Innovar (TN)
Formula
C22H28N2O. C6H8O7. C22H22FN3O2
Exact mass
907.4168
Mol weight
908.0214
Structure
Mol fileKCF fileDB search
Component
Droperidol [DR:D00308], Fentanyl citrate [DR:D01399]
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG02027  General anesthetics
 DG02027  General anesthetics
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Remark
Therapeutic category: 8219
ATC code: N01AH51
Product: D03852<JP>
Efficacy
Anesthetic (intravenous)
Comment
neuroleptanalgesia
Fentanyl is primarily metabolized by CYP3A4.
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01A ANESTHETICS, GENERAL
    N01AH Opioid anesthetics
     N01AH51 Fentanyl, combinations
      D03852  Droperidol and fentanyl citrate <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 8  Narcotics
  82  Non-alkaloidal narcotics
   821  Synthetic narcotics
    8219  Others
     D03852  Droperidol and fentanyl citrate
BRITE hierarchy
Other DBs
CAS: 8067-59-2
PubChem: 47205893
LigandBox: D03852
KCF data Show

ATOM        66
            1   N4y N    34.5158  -10.6492
            2   C8y C    35.8311  -11.0790
            3   C2y C    33.3222  -11.3512
            4   C8y C    34.5137   -9.2374
            5   C8y C    36.7019   -9.9314
            6   C8x C    36.4555  -12.3562
            7   C1x C    33.3222  -12.7555
            8   C2x C    32.0584  -10.6492
            9   N4x N    35.8821   -8.8153
            10  O5x O    33.3733   -8.4363
            11  C8x C    38.0647  -10.1452
            12  C8x C    37.8182  -12.5699
            13  C1x C    32.0584  -13.4576
            14  C1x C    30.8648  -11.3512
            15  C8x C    38.6192  -11.4295
            16  N1y N    30.8648  -12.7555
            17  C1b C    29.6712  -13.4576
            18  C1b C    28.4074  -12.7555
            19  C1b C    27.2138  -13.4576
            20  C5a C    26.0201  -12.7555
            21  C8y C    24.7562  -13.4576
            22  O5a O    26.0201  -11.3512
            23  C8x C    23.5627  -12.7555
            24  C8x C    24.7562  -14.8619
            25  C8x C    22.3691  -13.4576
            26  C8x C    23.5627  -15.5640
            27  C8y C    22.3691  -14.8619
            28  X   F    21.1755  -15.5640
            29  C8x C    18.9750  -21.2095
            30  C8x C    18.9750  -22.6137
            31  C8x C    20.1911  -23.3159
            32  C8x C    21.4073  -22.6137
            33  C8y C    21.4073  -21.2095
            34  C8x C    20.1911  -20.5073
            35  C1b C    22.6420  -20.4963
            36  C1b C    23.8509  -21.1941
            37  N1y N    25.0367  -20.5092
            38  C1x C    26.2344  -21.2007
            39  C1x C    27.4505  -20.4985
            40  C1y C    27.4505  -19.0942
            41  C1x C    26.2529  -18.4029
            42  C1x C    25.0367  -19.1050
            43  N1c N    28.6777  -18.3855
            44  C8y C    29.8904  -19.0856
            45  C8x C    29.8909  -20.5069
            46  C8x C    31.1072  -21.2087
            47  C8x C    32.3230  -20.5061
            48  C8x C    32.3225  -19.0848
            49  C8x C    31.1063  -18.3830
            50  C5a C    28.6775  -16.9968
            51  C1b C    27.4512  -16.2891
            52  O5a O    29.8835  -16.3002
            53  C1a C    26.2475  -16.9845
            54  C1d C    37.9470  -19.4909
            55  C1b C    36.6894  -20.1895
            56  C1b C    39.1348  -20.1895
            57  C6a C    38.5758  -18.3031
            58  O1a O    37.2484  -18.3031
            59  C6a C    35.5017  -19.4909
            60  C6a C    39.1348  -21.5870
            61  O6a O    37.8772  -17.1154
            62  O6a O    39.9732  -18.3031
            63  O6a O    34.3139  -20.1895
            64  O6a O    35.5017  -18.0935
            65  O6a O    40.3225  -22.2857
            66  O6a O    37.8772  -22.2857
BOND        70
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     4  10 2
            10    5  11 1
            11    6  12 2
            12    7  13 1
            13    8  14 1
            14   11  15 2
            15   13  16 1
            16   16  17 1
            17   17  18 1
            18   18  19 1
            19   19  20 1
            20   20  21 1
            21   20  22 2
            22   21  23 2
            23   21  24 1
            24   23  25 1
            25   24  26 2
            26   25  27 2
            27   27  28 1
            28    5   9 1
            29   12  15 1
            30   14  16 1
            31   26  27 1
            32   29  30 2
            33   30  31 1
            34   31  32 2
            35   32  33 1
            36   33  34 2
            37   29  34 1
            38   33  35 1
            39   35  36 1
            40   36  37 1
            41   37  38 1
            42   38  39 1
            43   39  40 1
            44   40  41 1
            45   41  42 1
            46   37  42 1
            47   40  43 1
            48   43  44 1
            49   44  45 2
            50   45  46 1
            51   46  47 2
            52   47  48 1
            53   48  49 2
            54   44  49 1
            55   43  50 1
            56   50  51 1
            57   50  52 2
            58   51  53 1
            59   54  55 1
            60   54  56 1
            61   54  57 1
            62   54  58 1
            63   55  59 1
            64   56  60 1
            65   57  61 1
            66   57  62 2
            67   59  63 1
            68   59  64 2
            69   60  65 1
            70   60  66 2
BRACKET     1    18.3400  -23.5200   18.3400  -16.0300
            1    41.4400  -16.0300   41.4400  -23.5200
            1  1 #GEN

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