KEGG   DRUG: Metopimazine
Entry
D05010                      Drug                                   
Name
Metopimazine (USAN/INN)
Formula
C22H27N3O3S2
Exact mass
445.1494
Mol weight
445.5981
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
Gastrointestinal agent
 DG01762  Antiemetic
Remark
ATC code: A04AD05
Efficacy
Anti-emetic, Dopamine D2 receptor antagonist
Comment
Phenothiazine derivative
Target
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A04 ANTIEMETICS AND ANTINAUSEANTS
   A04A ANTIEMETICS AND ANTINAUSEANTS
    A04AD Other antiemetics
     A04AD05 Metopimazine
      D05010  Metopimazine (USAN/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    D05010  Metopimazine
 Gastrointestinal agent
  DG01762  Antiemetic
   D05010  Metopimazine
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D05010  Metopimazine (USAN/INN)
Other DBs
CAS: 14008-44-7
PubChem: 47206737
LigandBox: D05010
NIKKAJI: J8.471I
KCF data

ATOM        30
            1   C8y C    29.0698  -20.3857
            2   N1y N    30.2832  -19.6823
            3   C8y C    29.0698  -21.7751
            4   C8x C    27.8565  -19.6823
            5   C8y C    31.4908  -20.3857
            6   S2x S    30.2832  -22.4842
            7   C8x C    27.8565  -22.4842
            8   C8x C    26.6430  -20.3857
            9   C8y C    31.4908  -21.7751
            10  C8x C    32.6983  -19.6823
            11  C8x C    26.6430  -21.7751
            12  C8x C    32.6983  -22.4842
            13  C8y C    33.9058  -20.3857
            14  C8x C    33.9058  -21.7751
            15  S4a S    35.1229  -19.6861
            16  C1b C    30.2842  -17.7604
            17  C1b C    31.5188  -17.0486
            18  C1a C    36.3357  -18.9859
            19  O3c O    35.8233  -20.9022
            20  O3c O    34.4256  -18.4755
            21  C1b C    32.7299  -17.7488
            22  N1y N    33.9511  -17.0443
            23  C1x C    35.1475  -17.7352
            24  C1x C    36.3600  -17.0353
            25  C1y C    36.3601  -15.6353
            26  C1x C    35.1637  -14.9444
            27  C1x C    33.9512  -15.6443
            28  C5a C    37.5604  -14.9420
            29  N1a N    38.7806  -15.6465
            30  O5a O    37.5596  -13.5103
BOND        33
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     5   9 2
            9     5  10 1
            10    7  11 2
            11    9  12 1
            12   10  13 2
            13   12  14 2
            14    6   9 1
            15    8  11 1
            16   13  14 1
            17   13  15 1
            18    2  16 1
            19   16  17 1
            20   15  18 1
            21   15  19 2
            22   15  20 2
            23   17  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   22  27 1
            31   25  28 1
            32   28  29 1
            33   28  30 2

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Ontology (3)   
   KEGG BRITE (3)   
Drug (3)   
   KEGG DGROUP (2)   
   LigandBox (1)   
Chemical substance (6)   
   PubChem (1)   
   MASSBANK (4)   
   NIKKAJI (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (14)   

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