| Entry |
|
|---|
| Name |
Levomethadone hydrochloride;
L-polamidon (TN) |
|---|
| Formula |
C21H27NO. HCl
|
|---|
| Exact mass |
345.1859
|
|---|
| Mol weight |
345.9061
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01498 NMDA receptor antagonist
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
Analgesic
DG01984 Opioid analgesics
|
|---|
| Remark |
|
|---|
| Efficacy |
Analgesic, Opioid receptor agonist, NMDA receptor antagonist |
|---|
| Comment |
Synthetic opioid
See Methadone [DR: D08195]
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07224 | Opioid receptor agonists/antagonists |
| map07235 | N-Methyl-D-aspartic acid (NMDA) receptor antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N07 OTHER NERVOUS SYSTEM DRUGS
N07B DRUGS USED IN ADDICTIVE DISORDERS
N07BC Drugs used in opioid dependence
N07BC05 Levomethadone
D08122 Levomethadone hydrochloride
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01498 NMDA receptor antagonist
DG01002 Levomethadone
D08122 Levomethadone hydrochloride
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG01002 Levomethadone
D08122 Levomethadone hydrochloride
Analgesic
DG01984 Opioid analgesics
DG01002 Levomethadone
D08122 Levomethadone hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D08122 Levomethadone hydrochloride
Ion channels
Ligand-gated ion channels
Glutamate (ionotropic), NMDA
GRIN (NMDAR)
D08122 Levomethadone hydrochloride
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01498 NMDA receptor antagonist
DG01002 Levomethadone
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG01002 Levomethadone
Analgesic
DG01984 Opioid analgesics
DG01002 Levomethadone
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 24
1 C8x C 21.0000 -19.2500
2 C8x C 21.0000 -20.6500
3 C8x C 22.1900 -21.3500
4 C8x C 23.3800 -20.6500
5 C8y C 23.3800 -19.2500
6 C8x C 22.1900 -18.6200
7 C8x C 25.6900 -20.6500
8 C8y C 25.6900 -19.2500
9 C1d C 24.5000 -18.6200
10 C8x C 26.8800 -21.3500
11 C8x C 28.0700 -20.6500
12 C8x C 28.0700 -19.2500
13 C8x C 26.8800 -18.6200
14 C1b C 24.5000 -17.2200
15 C1c C 25.6900 -16.5200
16 C5a C 22.5400 -17.5000
17 N1c N 25.6900 -15.2600
18 C1a C 26.8800 -14.5600
19 C1a C 24.5000 -14.5600
20 O5a O 22.5400 -16.1700
21 C1b C 21.3500 -18.2000
22 C1a C 20.2300 -17.5000
23 C1a C 26.8800 -17.2200
24 X Cl 31.3600 -17.9900
BOND 24
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 7 8 1
8 8 9 1
9 5 9 1
10 7 10 2
11 10 11 1
12 11 12 2
13 12 13 1
14 8 13 2
15 9 14 1
16 14 15 1
17 9 16 1
18 15 17 1
19 17 18 1
20 17 19 1
21 16 20 2
22 16 21 1
23 21 22 1
24 15 23 1 #Down
|
|---|
