KEGG   DRUG: Budesonide and formoterol fumarate dihydrate
Entry
D09595            Mixture   Drug                                   
Name
Budesonide and formoterol fumarate dihydrate;
Symbicort (TN);
Budeforu (TN)
Product
SYMBICORT (A-S Medication Solutions), SYMBICORT (AstraZeneca Pharmaceuticals LP)
  Generic
BREYNA (Mylan Pharmaceuticals), BUDESONIDE AND FORMOTEROL FUMARATE DIHYDRATE (A-S Medication Solutions), BUDESONIDE AND FORMOTEROL FUMARATE DIHYDRATE (A-S Medication Solutions), BUDESONIDE AND FORMOTEROL FUMARATE DIHYDRATE (AstraZeneca Pharmaceuticals LP), BUDESONIDE AND FORMOTEROL FUMARATE DIHYDRATE (RPK Pharmaceuticals)
Component
Budesonide [DR:D00246], Formoterol fumarate [DR:D05277]
Class
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
 DG02924  UGT substrate
Remark
Therapeutic category: 2290
ATC code: R03AK07
Product: D09595<JP/US>
Efficacy
Antiasthmatic
  Disease
Asthma [DS:H00079]
Chronic obstructive pulmonary disease [DS:H01714]
Comment
Budesonide is primarily metabolized by CYP3A4.
Formoterol is primarily metabolized by UDP-glucuronosyltransferase (UGT).
Metabolism
Enzyme: CYP3A4 [HSA:1576], UGT [KO:K00699]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03A ADRENERGICS, INHALANTS
    R03AK Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
     R03AK07 Formoterol and budesonide
      D09595  Budesonide and formoterol fumarate dihydrate <JP/US>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Bronchodilator Combinations
   Budesonide/ Formoterol Fumarate Dihydrate
    D09595  Budesonide and formoterol fumarate dihydrate
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   229  Miscellaneous
    2290  Miscellaneous
     D09595  Budesonide and formoterol fumarate dihydrate
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D09595  Budesonide and formoterol fumarate dihydrate
  DG02924  UGT substrate
   D09595  Budesonide and formoterol fumarate dihydrate
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09595
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D09595
Other DBs
PubChem: 124490335

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Ontology (6)   
   KEGG BRITE (6)   
Disease (2)   
   KEGG DISEASE (2)   
Drug (2)   
   KEGG DGROUP (2)   
Chemical substance (1)   
   PubChem (1)   
All databases (11)   

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