KEGG ENZYME: 1.1.1.146

ENZYME: 1.1.1.146

Entry

EC 1.1.1.146 Enzyme

Name

11beta-hydroxysteroid dehydrogenase;
corticosteroid 11beta-dehydrogenase;
beta-hydroxysteroid dehydrogenase;
11beta-hydroxy steroid dehydrogenase;
corticosteroid 11-reductase;
dehydrogenase, 11beta-hydroxy steroid

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

11beta-hydroxysteroid:NADP+ 11-oxidoreductase

Reaction(IUBMB)

an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+ [RN:R03203]

Reaction(KEGG)

R03203 > R02836 R03848 R04758 R04840;
(other) R09420

Substrate

11beta-hydroxysteroid [CPD:C01058];
NADP+ [CPD:C00006]

Product

11-oxosteroid [CPD:C01985];
NADPH [CPD:C00005];
H+ [CPD:C00080]

History

EC 1.1.1.146 created 1972

Pathway

ec00140

Steroid hormone biosynthesis

ec00980

Metabolism of xenobiotics by cytochrome P450

ec01100

Metabolic pathways

Orthology

K15680

corticosteroid 11-beta-dehydrogenase isozyme 1

K22418

11beta/17beta-hydroxysteroid dehydrogenase

Genes

HSA:	3290(HSD11B1)

PTR:	457698(HSD11B1)

PPS:	100981291(HSD11B1)

GGO:	101147766(HSD11B1)

PON:	100453076(HSD11B1)

NLE:	100593811(HSD11B1)

MCC:	574322(HSD11B1)

MCF:	101867467(HSD11B1)

CSAB:

103230154(HSD11B1)

RRO:	104664165(HSD11B1)

RBB:	108539553(HSD11B1)

CJC:	100401212(HSD11B1)

SBQ:	101040472(HSD11B1)

MMU:	15483(Hsd11b1)

MCAL:

110305040(Hsd11b1)

MPAH:

110322100(Hsd11b1)

RNO:	25116(Hsd11b1)

MUN:	110553509(Hsd11b1)

CGE:	100762502(Hsd11b1)

NGI:	103727028(Hsd11b1)

HGL:	101716800(Hsd11b1)

CCAN:

109681612(Hsd11b1)

OCU:	100342395(HSD11B1)

TUP:	102502602(HSD11B1)

CFA:	449023(HSD11B1)

VVP:	112907163(HSD11B1)

AML:	100466840(HSD11B1)

UMR:	103672488(HSD11B1)

UAH:	113262645(HSD11B1)

ORO:	101369340(HSD11B1)

ELK:

111162366

FCA:	100529248(HSD11B1)

PTG:	102967279(HSD11B1)

PPAD:

109255094(HSD11B1)

AJU:	106981789(HSD11B1)

BTA:	282589(HSD11B1)

BOM:	102275244(HSD11B1)

BIU:	109570467(HSD11B1)

BBUB:

102409054(HSD11B1)

CHX:	102168375(HSD11B1)

OAS:	443409(HSD11B1)

SSC:	397480(HSD11B1)

CFR:	102503994(HSD11B1)

CDK:	105099329(HSD11B1)

BACU:

103004239(HSD11B1)

LVE:	103086619(HSD11B1)

OOR:	101284098(HSD11B1)

DLE:	111184723(HSD11B1)

PCAD:

102992666(HSD11B1)

ECB:	100056429(HSD11B1)

EPZ:	103548673(HSD11B1)

EAI:	106827175(HSD11B1)

MYB:	102260050(HSD11B1)

MYD:	102771648(HSD11B1)

MNA:	107532934(HSD11B1)

DRO:	112297497(HSD11B1)

PALE:

102882377(HSD11B1)

RAY:	107517624(HSD11B1)

MJV:	108396749(HSD11B1)

LAV:	100667019(HSD11B1)

TMU:

101361858

SHR:	100923255(HSD11B1)

PCW:	110222669(HSD11B1)

OAA:	100079059(HSD11B1)

GGA:	419861(HSD11B1b) 771930(HSD11B1a)

MGP:	100550364(HSD11B1) 100550517

CJO:	107324848 107324849

NMEL:

110388207 110388337(HSD11B1)

APLA:

101803228(HSD11B1) 101804020

ACYG:

106041293 106041294

TGU:	100222111 100225021

LSR:	110475377 110475385

SCAN:

103823273 103823329

GFR:	102037915 102038088

FAB:	101815030 101815431

PHI:	102101549 102113769

PMAJ:

107214842 107214843(HSD11B1)

CCAE:

111922428 111939805(HSD11B1)

CCW:	104692327 104692500

ETL:	114063124(HSD11B1) 114063139

FPG:	101918372 101924921

FCH:	102051959 102053319(HSD11B1)

CLV:	102086357(HSD11B1) 102090135

EGZ:	104126798 104126829

NNI:	104010310 104010345

ACUN:

113488855 113488908 113489317

PADL:

103923566 103923602

AAM:	106486285 106490983 106490984

ASN:	102370220 102370459 102376675 102378118 102382863 102383966(HSD11B1)

AMJ:	102559578 102568341(HSD11B1)

PSS:	102459148 102459410 102459465

CMY:	102943559 102946690 102946915

CPIC:

101932631 101940528 101941697

ACS:	100555338(hsd11b1) 100555943

PVT:	110072366(HSD11B1) 110081926

PBI:	103052790 103059600(HSD11B1)

PMUR:

107292272(HSD11B1) 107301624 107301720

TSR:	106539582(HSD11B1)

PMUA:

114586681 114587149 114599353(HSD11B1)

GJA:	107126071(HSD11B1) 107126084

XLA:	108709376(hsd11b1.S) 379494(hsd11b1l.2.L) 379497(hsd11b1.L) 399012(hsd11b1l.L)

XTR:	100038278(hsd11b1l.2) 100489345(hsd11b1)

NPR:	108789677(HSD11B1) 108800094

DRE:	100333777(hsd11b1lb)

SRX:

107750927

CCAR:

109048452

LCM:	102345616(HSD11B1)

CMK:	103182506(hsd11b1)

BFO:

BRAFLDRAFT_121462 BRAFLDRAFT_210861 BRAFLDRAFT_210890 BRAFLDRAFT_210965 BRAFLDRAFT_216418 BRAFLDRAFT_232530 BRAFLDRAFT_264124(Hsd11b1D) BRAFLDRAFT_291087 BRAFLDRAFT_291098 BRAFLDRAFT_73210 BRAFLDRAFT_73306(Hsd11b1M) BRAFLDRAFT_73307 BRAFLDRAFT_84745 BRAFLDRAFT_84746 BRAFLDRAFT_84747 BRAFLDRAFT_86986 BRAFLDRAFT_92730 BRAFLDRAFT_96945 BRAFLDRAFT_96948

SPU:

764876

APLC:

110975185 110975957 110984537

SKO:	100371026 100373877 100374032 100374183 100374331 100374485 100374638 100374683 100374787

HRO:	HELRODRAFT_108742 HELRODRAFT_185224

LGI:	LOTGIDRAFT_138116

PCAN:

112558142

CRG:

105339932

MYI:	110457323 110463419

OBI:

106874424

LAK:	106155319 106155813 106174180 106174574 106174848 106176797 106176813 106176814 106178333 106179027

EPA:

ADF:

AMIL:

PDAM:

SPIS:

DGT:	114518992 114531929

AQU:

100631443

ATH:	AT5G50600(HSD1) AT5G50700(HSD1)

ALY:	ARALYDRAFT_323349 ARALYDRAFT_331461 ARALYDRAFT_495130 ARALYDRAFT_905956 ARALYDRAFT_918105

CRB:	111831663 17876456 17876693 17887259

CSAT:

104707290 104711192 104711193 104715359 104725306 104725315 104725355 104725571 104725572 104761049 104761058 104780532 104780534 104790944

EUS:	EUTSA_v10010570mg EUTSA_v10011076mg EUTSA_v10014225mg EUTSA_v10015475mg EUTSA_v10015936mg EUTSA_v10029315mg

BRP:	103849939 103852180 103852182 103858452 103858549 103860808 103873583 103873963

BNA:	106351766 106359814 106386200 106388429 106388464 106403171 106404886 106413163 106414656 106419234 106419247 106423434 106431760 106432240 106436433 106449447 106449448

BOE:	106305243 106317207 106325848 106326666 106328447 106333477

RSZ:	108808523 108833020 108833188 108836221 108840688 108841174 108846709 108846862 108850167 108850169 108850497 108858575

THJ:	104803153 104806756 104811572 104811573 104811575 104811576 104811579 104825026

CPAP:

110818740 110822949 110823028

CIT:	102624002 102624092 102624285 102626201

CIC:	CICLE_v10020750mg CICLE_v10031927mg CICLE_v10031969mg

TCC:	108661176 18592859 18605140 18605141 18605142 18605143

GRA:	105769707 105785979 105785986 105788663

GHI:	107886225 107926129 107926190 107943757 107949608 107953574 107960388

GAB:	108456673 108459329 108460577 108470900 108480637

DZI:	111277688 111289826 111290331 111290632 111313965

EGR:	104416667 104426137 104427794 104449815

GMX:	100780731 100787835 100808990

GSJ:	114375281 114413337 114421936 114425702

PVU:	PHAVU_002G285000g PHAVU_002G285100g PHAVU_002G2852000

VRA:	106755509 106765539 106766659 106771432 111242100

VAR:	108336671 108339276

VUN:	114175417 114177405

CCAJ:

109816434 109816455

MTR:	MTR_5g008850 MTR_8g096580 MTR_8g096610 MTR_8g096620

CAM:	101499223 101506110 101511685

LJA:	Lj4g3v2883360.1(Lj4g3v2883360.1) Lj4g3v2883370.1(Lj4g3v2883370.1) Lj4g3v2894400.1(Lj4g3v2894400.1)

ADU:	107480006 107480009 107480010 107480015 107488381

AIP:	107630833 107630834 107630836 107630837 107643145

LANG:

109332914 109361579 109362087 109362226

FVE:	101294757 101296282 101296562 101312540

RCN:	112175622 112176640 112176641 112177210 112180998

PPER:

18775747 18776959 18793216

PMUM:

103319342 103338099 103338101 103338102

PAVI:

110756009 110760364 110760365 110760366

MDM:	103416663 103431105 103441796 103455008 114820926

PXB:	103926811 103928181 103947939 103949983 103949984 103950092

ZJU:	107403456 107403458 107403459 107417985 107417986 107417988 107421274 112489546 112491572 112491725

CSV:	101206377 101219132 101220214 101220450

CMO:	103484591 103489041 103489048 103489056 103498693

MCHA:

111008744 111008745 111008746 111012094

CMAX:

111472594 111490135 111490142 111495256 111495641

CMOS:

111431382 111431503 111432789 111457123 111457313

CPEP:

111783265 111783304 111796926 111802527 111802532

RCU:	8264998 8269191 8269193 8269194

JCU:	105638172 105648767 105648769 105648770 105648902

HBR:	110640336 110671841 110671864

MESC:

110605769 110617032 110617033 110617034 110617039

POP:	112324469 112326118 18103815 18104344 7455255 7463142 7463143 7463144 7468944 7468945 7484858

PEU:	105112247 105119384 105125279 105125280 105131793 105131869 105131870 105133903 105139387

JRE:	108984079 109014117

QSU:	111986204 111990198 111991083 112001720 112001739 112001747 112001748 112016334 112025057 112025154 112028130 112028154 112028630

VVI:	100245367 100260124 100260981 100854734

SLY:	101249837 101260242 101262295 101264635

SPEN:

107013867 107019166 107022645 107022750 107024506

SOT:	102580177 102588345 102592042 102598438 102602596

CANN:

107862893 107862894 107877229 107879715

NTA:	107771906 107773055 107774779 107791177 107804825 107810593 107812296 107815400 107815629 107819900 107821747

NSY:	104212681 104217311 104227977 104232689 104243815 104245150

NTO:	104093056 104097570 104104406 104109582 104113522 104119679

NAU:	109207464 109216596 109221006 109223468 109236547 109243463

INI:	109148860 109166966 109166967 109180077

SIND:

105158152 105158154 105175113

OEU:	111379378 111380611 111391277 111409125

HAN:	110865158 110865159 110879936 110879937 110886113 110910969 110913196 110917343 110923335 110936058 110939301 110939564 110939567

LSV:	111895319 111895322 111895390 111913482 111914992 111919341 111919365 111920140 111920141 111920174

CCAV:

112509977 112509998 112511210 112511857 112514237 112527739 112528028 112528562

DCR:	108197095 108207713 108207714 108207944 108207945 108208389

BVG:	104897885 104908056 104908280 104908283

SOE:	110786004 110804634 110804643

CQI:	110694038 110696769 110704431 110723372 110723387 110723441 110739683 110739685 110739687

NNU:	104586100 104587416 104591773 104592001 104592833 104592834 104593267 104594949 104606984 104606986 104607243 104607815 104611822

PSOM:

113271698 113271701 113271703 113274407 113277380 113278022 113280998 113280999 113281001 113293405 113303512 113352158 113361375

OSA:	107275656 4329454 4335678 4350557 4352184

DOSA:

Os02t0511100-00(Os02g0511100) Os02t0511400-01(Os02g0511400) Os04t0390700-01(Os04g0390700) Os04t0390800-01(Os04g0390800) Os11t0499600-01(Os11g0499600) Os12t0464400-01(Os12g0464400)

OBR:	102707385 102716917 102718080 102718361 102720185 102721619 102721902

BDI:	100828565 100829729 100832888 100839980 100841594 100841883

ATS:	109743639(LOC109743639) 109747869(LOC109747869) 109752621(LOC109752621) 109752622(LOC109752622) 109764613(LOC109764613)

SBI:	8059587 8063011 8073089 8078395

ZMA:	100216664 100273792 100286255 103645429 103646566 103648012 113561368

SITA:

101760497 101773039 101776280 101781183

PDA:	103706421 103713735 103719497 103722549

EGU:	105036323 105036339 105038796 105049788 105051010

MUS:	103974695 103988363 103991124

DCT:	110104271 110110702

PEQ:	110021577 110024953

AOF:	109824580 109829474 109830604 109831004 109847060

ATR:	18427693 18434494

SMO:	SELMODRAFT_100351 SELMODRAFT_138761 SELMODRAFT_153443 SELMODRAFT_234271 SELMODRAFT_424474 SELMODRAFT_87233

PPP:	112272963 112282711

PFY:	PFICI_11194

PCO:	PHACADRAFT_85124

HIR:	HETIRDRAFT_240265

PSQ:	PUNSTDRAFT_117233

FME:	FOMMEDRAFT_27984

GTR:	GLOTRDRAFT_54160

LBC:	LACBIDRAFT_303996

ABV:	AGABI2DRAFT229948(AGABI2DRAFT_229948)

CPUT:

CONPUDRAFT_114262

SRE:	PTSG_01197 PTSG_02771

» show all

Reference

1 [PMID:2808402]

Authors

Agarwal AK, Monder C, Eckstein B, White PC.

Title

Cloning and expression of rat cDNA encoding corticosteroid 11 beta-dehydrogenase.

Journal

J Biol Chem 264:18939-43 (1989)

Sequence

[rno:25116]

Reference

2 [PMID:4384445]

Authors

Bush IE, Hunter SA, Meigs RA.

Title

Metabolism of 11-oxygenated steroids. Metabolism in vitro by preparations of liver.

Journal

Biochem J 107:239-58 (1968)

Reference

3 [PMID:3139396]

Authors

Lakshmi V, Monder C.

Title

Purification and characterization of the corticosteroid 11 beta-dehydrogenase component of the rat liver 11 beta-hydroxysteroid dehydrogenase complex.

Journal

Endocrinology 123:2390-8 (1988)
DOI:10.1210/endo-123-5-2390

Reference

4 [PMID:2661206]

Authors

Phillips DM, Lakshmi V, Monder C.

Title

Corticosteroid 11 beta-dehydrogenase in rat testis.

Journal

Endocrinology 125:209-16 (1989)
DOI:10.1210/endo-125-1-209

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