KEGG   ENZYME: 1.1.1.284Help
Entry
EC 1.1.1.284                Enzyme                                 

Name
S-(hydroxymethyl)glutathione dehydrogenase;
NAD-linked formaldehyde dehydrogenase (incorrect);
formaldehyde dehydrogenase (incorrect);
formic dehydrogenase (incorrect);
class III alcohol dehydrogenase;
ADH3;
chi-ADH;
FDH (incorrect);
formaldehyde dehydrogenase (glutathione) (incorrect);
GS-FDH (incorrect);
glutathione-dependent formaldehyde dehydrogenase (incorrect);
NAD-dependent formaldehyde dehydrogenase;
GD-FALDH;
NAD- and glutathione-dependent formaldehyde dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
S-(hydroxymethyl)glutathione:NAD+ oxidoreductase
Reaction(IUBMB)
S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+ [RN:R06983 R07140]
Reaction(KEGG)
Substrate
S-(hydroxymethyl)glutathione [CPD:C14180];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
S-formylglutathione [CPD:C01031];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The substrate, S-(hydroxymethyl)glutathione, forms spontaneously from glutathione and formaldehyde; its rate of formation is increased in some bacteria by the presence of EC 4.4.1.22, S-(hydroxymethyl)glutathione synthase. This enzyme forms part of the pathway that detoxifies formaldehyde, since the product is hydrolysed by EC 3.1.2.12, S-formylglutathione hydrolase. The human enzyme belongs to the family of zinc-dependent alcohol dehydrogenases. Also specifically reduces S-nitrosylglutathione.
History
EC 1.1.1.284 created 2005 (EC 1.2.1.1 created 1961, modified 1982, modified 2002, part transferred 2005 to EC 1.1.1.284)
Pathway
ec00680  Methane metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K00121  S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase
Genes
HSA: 128(ADH5)
PTR: 743928(ADH5)
PPS: 100969269(ADH5)
GGO: 101133633(ADH5)
PON: 100450815(ADH5)
NLE: 100592499(ADH5)
MCC: 707258(ADH5)
MCF: 102122307(ADH5)
CSAB: 103236693(ADH5)
RRO: 104664094(ADH5)
RBB: 108531854(ADH5)
CJC: 100395052(ADH5) 100411335
SBQ: 101042901(ADH5)
MMU: 11532(Adh5)
RNO: 100145871(Adh5)
CGE: 100767929(Adh5)
NGI: 103728053(Adh5)
HGL: 101707720 101717353(Adh5)
CCAN: 109693545(Adh5)
OCU: 100009307(ADH5)
TUP: 102485893(ADH5)
CFA: 609781(ADH5)
AML: 100466093(ADH5)
UMR: 103677920(ADH5)
ORO: 101369556(ADH5)
FCA: 101101307(ADH5)
PTG: 102971488(ADH5)
AJU: 106972170(ADH5)
BTA: 505515(ADH5)
BOM: 102283691(ADH5)
BIU: 109560322(ADH5)
CHX: 102186197(ADH5)
OAS: 101112223
SSC: 100513555(ADH5)
CFR: 102522598(ADH5)
CDK: 105089539(ADH5)
BACU: 102999923(ADH5)
LVE: 103087112(ADH5) 103087442
ECB: 111772846
EPZ: 103553731(ADH5)
EAI: 106846359(ADH5)
MYB: 102256132(ADH5)
MYD: 102752786(ADH5)
HAI: 109392931(ADH5)
PALE: 102877891(ADH5)
LAV: 100670136
TMU: 101351658
MDO: 100618327(ADH5)
SHR: 100921013(ADH5)
GGA: 422705(ADH5)
MGP: 100544708
CJO: 107313656
ACYG: 106048949(ADH5)
GFR: 102031372(ADH5)
FAB: 101819625(ADH5)
PHI: 102104321(ADH5)
PMAJ: 107202992
CCW: 104697283
FPG: 101920409(ADH5)
FCH: 102055955(ADH5)
CLV: 102094939
EGZ: 104122606
AAM: 106491822
ASN: 102387010(ADH5)
AMJ: 106737174
PSS: 102463576(ADH3)
CMY: 102946787(ADH5)
CPIC: 101949414(ADH5)
ACS: 100557775(adh5)
PVT: 110083974
PBI: 103067637
GJA: 107114471
XLA: 445841(adh5.L)
XTR: 497007(adh5)
NPR: 108795102
DRE: 116517(adh5)
SASA: 100195992(adhx) 106600509 106611602(ADHX)
CMK: 103188743
CIN: 445671(adh3)
APLC: 110977545
SKO: 100374330
DME: Dmel_CG6598(Fdh)
DSI: Dsimw501_GD20694(Dsim_GD20694)
MDE: 101888268
AAG: 5568019
AME: 409773(Fdh)
BIM: 100744734
BTER: 100643155
SOC: 105194743
AEC: 105151776
ACEP: 105627769
PBAR: 105422074
HST: 105182327
CFO: 105255139
LHU: 105673697
PGC: 109854874
NVI: 100118368
TCA: 654905(Fdh)
DPA: 109537737
NVL: 108557853
BMOR: 733095
PMAC: 106720760
PRAP: 111003443
PXY: 105397287
API: 100164837
DNX: 107173845
ZNE: 110834779
FCD: 110856129
CEL: CELE_H24K24.3(H24K24.3)
CBR: CBG17892
BMY: Bm1_52445
CRG: 105336470
MYI: 110465605
OBI: 106880206
SHX: MS3_08826
EPA: 110240232
HMG: 100208817
AQU: 100641833
LJA: Lj0g3v0062349.1(Lj0g3v0062349.1) Lj0g3v0062349.2(Lj0g3v0062349.2) Lj0g3v0071329.1(Lj0g3v0071329.1) Lj0g3v0135859.1(Lj0g3v0135859.1) Lj0g3v0135859.2(Lj0g3v0135859.2) Lj0g3v0135859.3(Lj0g3v0135859.3) Lj0g3v0135859.4(Lj0g3v0135859.4) Lj0g3v0207999.2(Lj0g3v0207999.2) Lj1g3v4528570.1(Lj1g3v4528570.1) Lj2g3v2970670.1(Lj2g3v2970670.1) Lj2g3v2971690.1(Lj2g3v2971690.1) Lj3g3v3639170.1(Lj3g3v3639170.1) Lj3g3v3639170.2(Lj3g3v3639170.2) Lj3g3v3639170.3(Lj3g3v3639170.3)
DOSA: Os02t0815500-01(Os02g0815500) Os03t0189400-01(Os03g0189400) Os03t0189600-01(Os03g0189600) Os07t0621800-01(Os07g0621800)
ATS: 109734537(LOC109734537) 109738642(LOC109738642) 109756018(LOC109756018) 109779034(LOC109779034) 109784312(LOC109784312)
ZMA: 100193894 100273217(pco147721a) 542459(fdh1)
CRE: CHLREDRAFT_129874(FDH1)
MNG: MNEG_0974
OLU: OSTLU_27414(ADHX)
APRO: F751_6614
SCE: YDL168W(SFA1)
ERC: Ecym_4723
KMX: KLMA_50315(SFA1)
NCS: NCAS_0A14160(NCAS0A14160)
NDI: NDAI_0A01890(NDAI0A01890)
TPF: TPHA_0F02970(TPHA0F02970)
TBL: TBLA_0E00390(TBLA0E00390)
TDL: TDEL_0C01980(TDEL0C01980)
KAF: KAFR_0B00880(KAFR0B00880)
PIC: PICST_29252(FDH1)
CAL: CAALFM_CR10250CA(FDH3)
CDU: CD36_35225(FDH1)
CAUR: QG37_07051
SLB: AWJ20_4461(SFA1)
NCR: NCU06652
NTE: NEUTE1DRAFT115811(NEUTE1DRAFT_115811)
MGR: MGG_06011
TRE: TRIREDRAFT_22633(fld1)
MAW: MAC_03913
MAJ: MAA_02901
CMT: CCM_09050
BFU: BCIN_14g01030(Bcsfa1)
MBE: MBM_09978
ANI: AN7632.2
ANG: ANI_1_58174(An10g00510)
ABE: ARB_06379
TVE: TRV_07407
PTE: PTT_05481
CNE: CNM01690
CNB: CNBM1570
ABP: AGABI1DRAFT113598(AGABI1DRAFT_113598)
ABV: AGABI2DRAFT191754(AGABI2DRAFT_191754)
MGL: MGL_0044
DDI: DDB_G0281865(adh5)
DFA: DFA_11040(adh5)
SMIN: v1.2.015428.t1(symbB.v1.2.015428.t1) v1.2.026659.t1(symbB.v1.2.026659.t1) v1.2.041717.t1(symbB.v1.2.041717.t1)
FCY: FRACYDRAFT_277191(ADH2)
ECO: b0356(frmA)
ECJ: JW0347(frmA)
ECD: ECDH10B_0311(frmA)
EBW: BWG_0245(frmA)
ECOK: ECMDS42_0278(frmA)
ECE: Z0456(adhC)
ECS: ECs0411
ECF: ECH74115_0431(adhC)
ETW: ECSP_0420(frmA)
EOJ: ECO26_0392(frmA)
EOI: ECO111_0392(frmA)
EOH: ECO103_0338(frmA)
ECG: E2348C_0303(frmA)
EOK: G2583_0469(frmA)
ECC: c0465(adhC)
ECP: ECP_0421
ECI: UTI89_C0376(adhC)
ECV: APECO1_1645(adhC)
ECX: EcHS_A0421(adhC)
ECM: EcSMS35_0387(adhC)
ECY: ECSE_0381
ECR: ECIAI1_0357(frmA)
ECQ: ECED1_0384(frmA)
ECK: EC55989_0365(frmA)
ECT: ECIAI39_0322(frmA)
EOC: CE10_0324(frmA)
EUM: ECUMN_0399(frmA)
ECZ: ECS88_0356(frmA)
ELO: EC042_0393(adhC)
ELH: ETEC_0412
ESE: ECSF_0327
ESO: O3O_05600
ESM: O3M_19680
ESL: O3K_19695
EBR: ECB_00310(frmA)
EBD: ECBD_3301
EKF: KO11_21800(frmA)
EAB: ECABU_c04390(frmA)
EDJ: ECDH1ME8569_0343(frmA)
EIH: ECOK1_0340(adhC)
ENA: ECNA114_0339(adhC)
ELW: ECW_m0434(frmA)
ELL: WFL_02135(frmA)
ELC: i14_0447(adhC)
ELD: i02_0447(adhC)
ELP: P12B_c0378(adhC)
EBL: ECD_00310(frmA)
EBE: B21_00314(frmA)
ELF: LF82_0737(frmA)
ECOI: ECOPMV1_00350(frmA)
ECOJ: P423_01870
ECOO: ECRM13514_0490(adhC)
ECOH: ECRM13516_0336(adhC)
ECOS: EC958_0501(adhC)
EFE: EFER_1582(frmA)
EAL: EAKF1_ch1074(adhC)
STM: STM1627
SEY: SL1344_1557(adhC)
SEF: UMN798_1704(adhC)
SENR: STMDT2_15501(adhC)
SEND: DT104_15981(adhC)
SENI: CY43_08305
SEI: SPC_2108
SEC: SCH_1622(adh3)
SHB: SU5_02239
SENS: Q786_07070
SED: SeD_A1715
SEG: SG1492
SEL: SPUL_1442
SET: SEN1425
SENA: AU38_07365
SENO: AU37_07360
SENV: AU39_07370
SENQ: AU40_08290
SENL: IY59_07550
SEEP: I137_06510
SENE: IA1_08060
SBG: SBG_1455
SBZ: A464_1664
SSN: SSON_0335(adhC)
SBC: SbBS512_E0271(adhC)
ENC: ECL_02059
ECLO: ENC_11200
EEC: EcWSU1_02119(frmA)
ENF: AKI40_3245(adhC)
ESA: ESA_01709
CSK: ES15_1892(frmA)
CTU: CTU_22450(frmA)
KPU: KP1_3020
KPP: A79E_2296
KPE: KPK_2397(adhC)
KPR: KPR_2990
KPJ: N559_2335
KPX: PMK1_04295(frmA) PMK1_a00028(frmA)
KPNU: LI86_11615
KPNK: BN49_3048
KVA: Kvar_2351
KOX: KOX_19595
KOE: A225_2789
EAE: EAE_20315
EAR: CCG29816
CKO: CKO_01455
CRO: ROD_16171(adhC)
CAMA: F384_07555
EBF: D782_2308
PSTS: E05_24130(adhC) E05_24140
YPE: YPO1502
YPK: y2667(adhC)
YPA: YPA_0797
YPN: YPN_2477
YPM: YP_1392(adhC)
YPZ: YPZ3_1369(adhC)
YPD: YPD4_1335(adhC)
YPX: YPD8_1613(adhC)
YPH: YPC_2652
YPW: CH59_336
YPJ: CH55_1035
YPV: BZ15_2051
YPL: CH46_3624
YPS: YPTB1517
YPO: BZ17_998
YPY: YPK_2571
YPB: YPTS_1627
YPQ: DJ40_695
YPU: BZ21_855
YPR: BZ20_447
YPC: BZ23_1134
YPF: BZ19_955
YEN: YE2821
YEY: Y11_17241
YEW: CH47_2172
YET: CH48_3052
YAL: AT01_3930
YFR: AW19_631
YIN: CH53_3264
YKR: CH54_1031
YRO: CH64_4
YRU: BD65_3136
SPE: Spro_1557
SRL: SOD_c14260(frmA)
SPLY: Q5A_007725(frmA)
SMAF: D781_1465
SMW: SMWW4_v1c15410(frmA)
SMAR: SM39_0991
SERF: L085_20795
RAA: Q7S_06810
ECA: ECA2714(adhC)
PATR: EV46_13260
PATO: GZ59_18460(adhC)
PCT: PC1_1667
PEC: W5S_1884
SOD: Sant_1424
DDD: Dda3937_00069(adhC)
DDQ: DDI_1641
ETA: ETA_12850(adhC)
EPY: EpC_13460(adhC)
EPR: EPYR_01434(adhC)
EAM: EAMY_2294(adhC1)
EAY: EAM_2212(adhC)
EBI: EbC_23190 EbC_29900(adhC)
ERJ: EJP617_33510(adhC)
EGE: EM595_2438(frmA)
PAM: PANA_2547(adhC)
PLF: PANA5342_1529(adhC)
PAJ: PAJ_1841(adhC)
PVA: Pvag_2032(adhc1)
PSTW: DSJ_16345
PLU: plu4332(adhC)
PAY: PAU_03905(adhC)
PMR: PMI0450(adhC)
PMIB: BB2000_0596(adhC)
XBO: XBJ1_3896(adhC)
XBV: XBW1_4096(frmA)
XNE: XNC1_2054(adhC)
XNM: XNC2_1987(adhC)
XDO: XDD1_2291(frmA)
PSI: S70_20825
PSX: DR96_3064
MMK: MU9_1071
ETE: ETEE_p1050(frmA)
HIN: HI0185(adhC)
HIU: HIB_02360
HIE: R2846_0454(frmA)
HIZ: R2866_0404(frmA)
HIK: HifGL_000868(frmA)
HIA: H733_0069
HIW: NTHI477_01216(frmA)
HIC: NTHIC486_00847(frmA)
HIX: NTHI723_01520(frmA)
MSU: MS1386(adhC)
MVE: X875_2590
APL: APL_1208(adhC)
APJ: APJL_1221(adh1)
APA: APP7_1259(adhC)
ASU: Asuc_0067
AAT: D11S_0481
AAN: D7S_01140
AACN: AANUM_0855
XCC: XCC3389 XCC3475(adhC)
XAC: XAC0652(adhC) XAC0734
XCI: XCAW_03848(adhC) XCAW_03929(adhC)
XOO: XOO3867(AdhC)
XOM: XOO3647(XOO3647)
XOP: PXO_04416
XOR: XOC_0794
XAL: XALC_0862
XPH: XppCFBP6546_08360(XppCFBP6546P_08360) XppCFBP6546_16600(XppCFBP6546P_16600)
SML: Smlt3978(adhC)
SMT: Smal_3387
SMZ: SMD_3577(adhC)
SACZ: AOT14_07450(adhC)
PSUW: WQ53_09655
PSD: DSC_00215
LEZ: GLE_4842
LEM: LEN_4602
DKO: I596_2121
VVU: VV1_0344
VVY: VV0841
VPA: VPA0071
VAG: N646_3525
VSP: VS_II1327
VNI: VIBNI_A0638(frmA)
VAN: VAA_01187
VTA: A2409(frmA)
VFI: VF_0645(frmA) VF_0648
VSA: VSAL_I0746(adhC)
AWD: AWOD_I_0623(adhC) AWOD_I_0627(adhC)
PPR: PBPRA0784(PA3629) PBPRA1480(PA3629)
PAE: PA3629(adhC)
PAEV: N297_3753
PAEI: N296_3753
PAU: PA14_17400(adhC)
PAG: PLES_14061(adhC)
PAF: PAM18_1317(adhC)
PNC: NCGM2_4760(adhC)
PAEP: PA1S_07265
PAEM: U769_06745
PAEL: T223_06980
PAEU: BN889_04017(adhC_1) BN889_04018(adhC_2) BN889_06862(adhC-1)
PAEG: AI22_26640
PAEC: M802_3750
PAEO: M801_3618
PMY: Pmen_3028
PRE: PCA10_45100(adhC)
PPSE: BN5_2809(adhC)
PCQ: PcP3B5_47450(frmA)
PPU: PP_1616(frmA)
PPF: Pput_4161
PPI: YSA_02538
PPX: T1E_4967 T1E_5518(adhC)
PPUH: B479_06130
PPUN: PP4_41520(adhC)
PMON: X969_04225
PMOT: X970_04200
PST: PSPTO_1558(adhC)
PSYR: N018_18870
PSP: PSPPH_3816(adhC)
PFL: PFL_1200
PPRC: PFLCHA0_c12210(frmA)
PPRO: PPC_1239
PFS: PFLU_1295(adhC)
PFB: VO64_4456
PMAN: OU5_2273(adhC)
PEN: PSEEN2613(adhC-1) PSEEN4196(adhC-2)
PSA: PST_1563(adhC)
PSZ: PSTAB_1467(adhC)
PSR: PSTAA_1587(adhC)
PSTT: CH92_06480
PKC: PKB_1243(frmA)
PSES: PSCI_3177(frmA)
PSEM: TO66_06015
PSEC: CCOS191_1140(frmA)
PSOS: POS17_1205
PANR: A7J50_1431
PSET: THL1_4546
PAR: Psyc_1671(adhC)
PALI: A3K91_2162
PSYC: DABAL43B_2235(adhC)
PSYA: AOT82_1217
ABY: ABAYE1861(frmA) p3ABAYE0024(adhC)
ABN: AB57_2002
ABX: ABK1_2267
ABH: M3Q_2161
ABAD: ABD1_17650(adhC)
ABAZ: P795_8335
ABAU: IX87_19820
ABAA: IX88_10825
ACC: BDGL_001145(adhC)
ACI: ACIAD1879(frmA)
ASJ: AsACE_CH01515(frmA-1) AsACE_p100121(frmA-2)
MCT: MCR_0444(adhC)
MCS: DR90_1463
MCAT: MC25239_00459(frmA)
SON: SO_2054(frmA) SO_A0161
SDN: Sden_3767
SAZ: Sama_0004
SBL: Sbal_2419
SLO: Shew_1540
SSE: Ssed_4227
SWD: Swoo_0375
SWP: swp_2093
SVO: SVI_3328(adhC)
SPSW: Sps_04287
ILO: IL1773(adhC)
CPS: CPS_0817
PHA: PSHAa1386(adhC) PSHAa2213(adhC)
PSM: PSM_A1422(adhC)
PSEO: OM33_21195
PTN: PTRA_a1748(frmA) PTRA_a2684(frmA) PTRA_b0476(frmA)
PEA: PESP_a1787(frmA)
PSPO: PSPO_b1562(frmA)
PART: PARC_a2204(frmA) PARC_a2244(frmA)
PTU: PTUN_a1904(frmA)
PNG: PNIG_a1849(frmA) PNIG_a2881(frmA)
PTD: PTET_a1648(frmA)
MHC: MARHY0268(frmA) MARHY0975(frmA)
MAD: HP15_4017
MBS: MRBBS_0274(frmA)
AMAL: I607_14735
AMAE: I876_15030
AMAO: I634_14975
AMAD: I636_14835
AMAI: I635_15410
AMAG: I533_14555
AMAC: MASE_14560
AAUS: EP12_15335
ASP: AOR13_374
GNI: GNIT_0810(frmA)
PIN: Ping_3530
FBL: Fbal_2057
MVS: MVIS_0167(adhC)
CJA: CJA_3340(adhC)
SDE: Sde_0052
SAGA: M5M_04025
MICC: AUP74_00267(frmA)
LLO: LLO_2480(frmA)
LFA: LFA_0064(adhI)
TMC: LMI_2558(adhI)
FTM: FTM_0472
FTN: FTN_0409(adhC)
FTX: AW25_1625
FTD: AS84_291
FTY: CH70_1668
FPH: Fphi_0427
FPT: BZ13_1627
FPI: BF30_619
FPM: LA56_1750
FPX: KU46_935
FPZ: LA55_405
FPJ: LA02_33
CYQ: Q91_0456(adhC)
CZA: CYCME_2188(adhC)
PSAL: PSLF89_732
NOC: Noc_1394
NWA: Nwat_1687
NTT: TAO_1182
GAI: IMCC3135_23765(flhA_2)
HCH: HCH_01446(adhC)
CSA: Csal_0985
HEL: HELO_3466(frmA)
HAM: HALO1300
HCO: LOKO_02165(frmA)
HBE: BEI_0781(frmA)
ABO: ABO_0117(adhC)
ADI: B5T_00248(adhC)
APAC: S7S_01975
AXE: P40_01235
KKO: Kkor_2048
KGE: TQ33_0996
TOL: TOL_3015
AHA: AHA_0214
ASA: ASA_4180(adhC)
AVR: B565_3859
AMED: B224_5428
ACAV: VI35_20330
TAU: Tola_2876
OCE: GU3_14840
TBN: TBH_C0219
PSPI: PS2015_948
GPB: HDN1F_08500(adhC)
NME: NMB1304
NMP: NMBB_1436
NMQ: NMBM04240196_0898(adhC)
NMZ: NMBNZ0533_1293(adhC)
NMA: NMA1518
NMW: NMAA_1035
NMX: NMA510612_1678(adhC)
NMC: NMC1241(adhC)
NMN: NMCC_1217(adhC)
NMT: NMV_1092
NMI: NMO_1145(adhC)
NLA: NLA_11390(adhC)
CVI: CV_0740(adhC)
LHK: LHK_02379(fdhG)
PSE: NH8B_1367
RSO: RSc0605(adhC2) RSp0069(adhC1)
RSC: RCFBP_20867(adhI)
RSL: RPSI07_2746(adhI)
RSN: RSPO_c02756(adhC2)
RSM: CMR15_30292(adhI)
RSE: F504_619
RPI: Rpic_0535
REH: H16_B1195(adhC) H16_B2470(h16_B2470)
CNC: CNE_1c00190(flhA) CNE_2c11700(flhA2) CNE_BB1p12270(flhA)
RME: Rmet_0545 Rmet_4784(frmA)
CGD: CR3_3508(adhC) CR3_4536(adhC)
BMA: BMA0324
BMAL: DM55_1719
BMAE: DM78_275
BMAQ: DM76_1695
BMAI: DM57_2350
BMAF: DM51_119
BMAZ: BM44_2904
BMAB: BM45_642
BPS: BPSL0820(flhA)
BPM: BURPS1710b_1025(flhA)
BPSE: BDL_1207
BPSM: BBQ_2628
BPSU: BBN_2751
BPSD: BBX_3154
BPZ: BP1026B_I2731(flhA)
BPK: BBK_687
BPSH: DR55_300
BPSA: BBU_1360
BPSO: X996_3382
BUT: X994_1916
BTE: BTH_I0686
BTQ: BTQ_704
BTJ: BTJ_1740
BTZ: BTL_3018
BTD: BTI_3001
BTV: BTHA_3235
BTHE: BTN_1694
BTHM: BTRA_3330
BTHA: DR62_1881
BTHL: BG87_3210
BOK: DM82_212
BOC: BG90_812
BVE: AK36_5894
BCN: Bcen_1994
BCJ: BCAL2817(flhA)
BCEW: DM40_5771
BCEO: I35_2674
BAM: Bamb_6311
BMJ: BMULJ_02567(adhC) BMULJ_05877(adhC)
BMUL: NP80_2745
BDL: AK34_485
BCON: NL30_26090
BUB: BW23_2290
BLAT: WK25_19040
BTEI: WS51_28960
BSEM: WJ12_13050
BMEC: WJ16_13360
BSTG: WT74_13835
BGU: KS03_409
BGO: BM43_801
BUK: MYA_5857
BUL: BW21_3143
BXE: Bxe_A0713(flhA)
BXB: DR64_2881
BPH: Bphy_0483
BFN: OI25_2165
PPNO: DA70_20165
PPNM: LV28_10220
PPUL: RO07_04520
PSPU: NA29_00220
PAPI: SG18_04550
BPE: BP3751(adhI)
BPC: BPTD_3696(adhI)
BPER: BN118_3549(adhI)
BPET: B1917_3763(adhI)
BPEU: Q425_1420(adhI)
BPA: BPP4251(adhI)
BPAR: BN117_4384(adhI)
BBR: BB4838(adhI)
BBM: BN115_4507(adhI)
BBH: BN112_3592(adhI)
BBX: BBS798_4614(adhI)
BPT: Bpet0155
BAV: BAV3289(adhC)
BHO: D560_1594
BHM: D558_1583
BHZ: ACR54_04477(flhA_2)
BTRM: SAMEA390648701043(adhC)
AXY: AXYL_00280(adhC)
AXX: ERS451415_00288(frmA)
PUT: PT7_2764
AMIM: MIM_c14310 MIM_c29020(frmA)
AFQ: AFA_17610
ODI: ODI_R3570
RFR: Rfer_0121
POL: Bpro_3129
PNA: Pnap_1230
AAV: Aave_2195
AJS: Ajs_2800
AAA: Acav_2947
ACRA: BSY15_261
VEI: Veis_4025
DAC: Daci_2414
RTA: Rta_01030(adhC)
HYB: Q5W_15050
MMS: mma_0221(adhC) mma_1172(adhI)
JAG: GJA_4575
HSE: Hsero_2713(adhC)
HRB: Hrubri_2804(adhC) Hrubri_4318(adhC2)
CFU: CFU_2422
CARE: LT85_2198
LCH: Lcho_3255
TIN: Tint_1602
RGE: RGE_11350(frmA)
PBH: AAW51_2650(frmA) AAW51_3543(frmA)
NEU: NE0907(adhC1)
NET: Neut_1385
EBA: ebA5713(fdhG)
AZO: azo3623(adhC)
AOA: dqs_3766
TCL: Tchl_0785
BPRC: D521_1788
MXA: MXAN_7094
CCX: COCOR_03877(adh1)
SCL: sce2769(adh2)
CCRO: CMC5_036950(adhP)
HOH: Hoch_5737
BBA: Bd0898(adhC)
BBAT: Bdt_0860(adhC)
BBW: BDW_05780
BBAC: EP01_14620
BMX: BMS_1185
MLO: mlr0872
MES: Meso_2671
AMIH: CO731_01630(flhA_1) CO731_01952(flhA_2) CO731_03658(flhA_4)
SME: SM_b20170(fdh) SMa2113(adhC2) SMc01270(adhC1)
SMX: SM11_chr2178(adhC1) SM11_pD1433(fdh)
SMI: BN406_01125(adhI) BN406_06487(adhI)
RHI: NGR_b14640(adhC2) NGR_b16470(adhC3) NGR_b23560(adhC4) NGR_c12280(adhC6) NGR_c20470(adhC5)
SFD: USDA257_c26150(adhI1) USDA257_c30920(adhI2) USDA257_c54280(adhI3)
EAD: OV14_2450(adhC6)
ATU: Atu1670(adhC)
ARA: Arad_2510
ATF: Ach5_16000(adhC)
AVI: Avi_2506(adhC)
AGR: AGROH133_06548(adhC)
RET: RHE_CH02227(adhCch) RHE_PF00402(adhCf)
REL: REMIM1_CH02236(adhI-1) REMIM1_PF00506(adhI-2)
REI: IE4771_CH02367(adhI-1) IE4771_PD00412(adhI-2)
REP: IE4803_CH02281(adhI-1) IE4803_PC00394(adhI-2)
RLE: pRL120524(adhI)
RLG: Rleg_4830
RIR: BN877_I1633(adhC)
RHL: LPU83_2361(adhC) LPU83_2619(adhI)
RGA: RGR602_CH02029(adhI-1) RGR602_PC00928(adhI-2) RGR602_PC01673(adhI-3) RGR602_PC02294(adhI-4)
RHN: AMJ98_CH02280(adhI-1) AMJ98_PE00479(adhI-2)
RPHA: AMC79_CH02366(adhI-1) AMC79_PD00609(adhI-2)
RHT: NT26_1727(adhC) NT26_3259(adhC)
RHX: AMK02_CH02296(adhI-2) AMK02_PD00342(adhI-1)
BME: BMEI1819
BMEL: DK63_1669
BMEE: DK62_1280
BMF: BAB1_0128
BABO: DK55_147
BABR: DO74_1735
BABT: DK49_1996
BABB: DK48_1979
BABU: DK53_142
BABS: DK51_1321
BABC: DO78_58
BSZ: DK67_67
BCAR: DK60_235
BCAS: DA85_00635
BMR: BMI_I133
BPP: BPI_I131
BPV: DK65_1236
OAN: Oant_0144
OAH: DR92_103
BJA: bll7898 bll7981 blr6215(adhC)
BRA: BRADO0921(adh) BRADO5486(adhC)
BBT: BBta_5970(adhC) BBta_7131(adh)
BRS: S23_08870 S23_20800(adhC)
RPA: RPA1955
RPB: RPB_3418
RPC: RPC_0101
RPD: RPD_2034
RPE: RPE_4678
NWI: Nwi_1739
NHA: Nham_2168
VGO: GJW-30_1_03530(flhA)
AZC: AZC_0105
SNO: Snov_2400
MOR: MOC_0294
MAQU: Maq22A_c21490(adhC)
BID: Bind_2495
RVA: Rvan_0682
MMED: Mame_02773(flhA)
RBM: TEF_01790
PZU: PHZ_c0845(adhI) PHZ_c2025
RSP: RSP_2576(adhI)
RCP: RCAP_rcc00869(adhC)
JAN: Jann_0044
RDE: RD1_0887(flhA) RD1_3806(flhA)
RLI: RLO149_c006390(flhA1) RLO149_c037730(flhA2)
PDE: Pden_0016
DSH: Dshi_0103(adhI)
KVU: EIO_0283(adhC)
KVL: KVU_2476(adhC)
KRO: BVG79_00155(adhC)
PSF: PSE_p0014
PGA: PGA1_c02510(frmA)
PGL: PGA2_c02100(frmA)
PGD: Gal_03255
PHP: PhaeoP97_00193(frmA)
PPIC: PhaeoP14_00170(frmA_1) PhaeoP14_03706(frmA_2) PhaeoP14_03721(frmA_3)
OAT: OAN307_c20620(adhI)
OAR: OA238_c26640(adhI)
PTP: RCA23_c04970(adhI)
MALG: MALG_01134
RSU: NHU_03562(adhCc)
RHC: RGUI_0958
LVS: LOKVESSMR4R_02887(flhA)
HNE: HNE_0560
HBA: Hbal_2865
ZMO: ZMO1722
ZMN: Za10_1498
ZMM: Zmob_1418
ZMB: ZZ6_1396
ZMI: ZCP4_1441
NAR: Saro_0874
SAL: Sala_3073
SGI: SGRAN_1123(adhI) SGRAN_3519 SGRAN_4066(adhC2)
SPMI: K663_00335
SPHR: BSY17_3820
AAY: WYH_02781(flhA_1) WYH_03282(frmA) WYH_03283
ANH: A6F65_00758(flhA)
ADO: A6F68_00167(flhA) A6F68_01656(adhD)
GOX: GOX2018
GOY: GLS_c21300(adhI)
ACR: Acry_2794
GDI: GDI1852(frmA)
GDJ: Gdia_0079
GXY: GLX_06680
KEU: S101446_01056(adhP) S101446_03508(frmA)
APK: APA386B_105(adhC) APA386B_1P121(adhC) APA386B_1P92(adhC)
ASZ: ASN_1303(adhC) ASN_1465(frmA) ASN_2313(adhC) ASN_2447(adhI) ASN_2453(adhC)
RRU: Rru_A3405
RRF: F11_17450
RCE: RC1_0269(adhC)
ALI: AZOLI_p30144(frmA)
ABS: AZOBR_p130213(frmA)
TMO: TMO_3459
TXI: TH3_18205
MAGQ: MGMAQ_0501(frmA)
AFR: AFE_0697
BSU: BSU26970(adhB)
BSR: I33_2738(adhB)
BSL: A7A1_0338
BSH: BSU6051_26970(adhB)
BSUT: BSUB_02878(adhB)
BSUL: BSUA_02878(adhB)
BSUS: Q433_14505
BSS: BSUW23_12995(adhB)
BST: GYO_2928(adhB)
BSO: BSNT_09084(adhB)
BSQ: B657_26970(adhB)
BSX: C663_2530(adhB)
BLI: BL02473(adhB)
BLD: BLi03831(adhB)
BLH: BaLi_c38430(adhB)
BAQ: BACAU_0296(adhB1) BACAU_0505(adhB3)
BYA: BANAU_0298(adhB1) BANAU_0505(adhB3)
BAML: BAM5036_0315(adhB) BAM5036_0516(adhB)
BAMA: RBAU_0330 RBAU_0548(adhB)
BAMN: BASU_0314 BASU_0540(adhB)
BAMB: BAPNAU_0299(adhB1) BAPNAU_0512(adhB3)
BAMY: V529_03190 V529_05170(adhB)
BMP: NG74_00338(fdhA) NG74_00561(fdm)
BAO: BAMF_0303(RBAM_003560) BAMF_0490(adhB)
BQL: LL3_00311 LL3_00523(adhB)
BQY: MUS_0317(fdh) MUS_0554(adhB)
BHA: BH1829(adhB)
BAN: BA_3131
BAR: GBAA_3131
BAT: BAS2912
BAI: BAA_3180
BANT: A16_31580
BANR: A16R_32000
BANS: BAPAT_3004
BANV: DJ46_1885
BCE: BC3092
BCA: BCE_3145(adhB)
BCZ: BCE33L2838(adhB)
BCQ: BCQ_2941(adhB) BCQ_PI181
BCX: BCA_3189
BAL: BACI_c30760(adhB2)
BCF: bcf_15220
BCER: BCK_19335
BTK: BT9727_2881(adhB)
BTL: BALH_2794
BTT: HD73_2858
BTHI: BTK_14165
BTI: BTG_03760
BTW: BF38_4289
BCL: ABC3413 ABC3428(adhB)
BPU: BPUM_0237
BPUS: UP12_01515
BPF: BpOF4_03860(bfaD) BpOF4_05195(adhB)
BMQ: BMQ_1767
BCOA: BF29_2872
BJS: MY9_2680
BACW: QR42_01475
BACO: OXB_0569
BACY: QF06_11670
BACL: BS34A_29430(adhB)
BALM: BsLM_2649
BEO: BEH_05980
BGY: BGLY_4229(adhB)
BKW: BkAM31D_07320(fdm) BkAM31D_07355(fdhA_1) BkAM31D_11910(fdhA_2) BkAM31D_16215(fdhA_3) BkAM31D_23195(frmA)
GEA: GARCT_00951(fdhA)
AFL: Aflv_1185(gutB)
ANL: GFC29_133
SSP: SSP1623
MCL: MCCL_1471(adhC)
MCAK: MCCS_00660
ESI: Exig_2206
EAN: Eab7_2052
BBE: BBR47_08010(adhB)
PPY: PPE_02400
PPM: PPSC2_24890(adhB3)
PPO: PPM_4947(adhB3)
PPOY: RE92_12390
PMS: KNP414_00819(adhB) KNP414_05429(adhB2) KNP414_05608(adhB3)
PSAB: PSAB_05550
PRI: PRIO_4985(adhB)
PSWU: SY83_01940
SMU: SMU_119(adh)
SMJ: SMULJ23_0099(adh1)
SMUA: SMUFR_0098(frmA)
EFU: HMPREF0351_10336(fdh)
EFM: M7W_507
ECAS: ECBG_00351
EMU: EMQU_0315(fdh) EMQU_0525
CRN: CAR_c01200(adhB) CAR_c01530(tdh) CAR_c23690(gutB)
CML: BN424_366(adhC)
CARC: NY10_1567
JDA: BW727_101169(frmA)
CAC: CA_C3375
CAE: SMB_G3412(adhB)
CAY: CEA_G3378
CBEI: LF65_01713
CPAT: CLPA_c05130(adhB)
CPAE: CPAST_c05130(adhB)
CSB: CLSA_c28950(adhB)
DSY: DSY3044
DHD: Dhaf_4212
CAD: Curi_c26880(adhB)
LPIL: LIP_2323
MTU: Rv0761c(adhB) Rv3086(adhD)
MRA: MRA_0771(adhB) MRA_3118(adhD)
MTUR: CFBS_0800(adhB) CFBS_3254(adhD)
MTO: MTCTRI2_0780(adhB)
MTD: UDA_0761c(adhB) UDA_3086(adhD)
MTN: ERDMAN_0843(adhB) ERDMAN_3377(adhD)
MTUH: I917_21670
MTUT: HKBT1_0800(adhB) HKBT1_3241(adhD)
MTUU: HKBT2_0801(adhB) HKBT2_3246(adhD)
MTQ: HKBS1_0800(adhB) HKBS1_3252(adhD)
MBO: BQ2027_MB0784C(adhB) BQ2027_MB3113(adhD)
MBB: BCG_0813c(adhB) BCG_3111(adhD)
MBT: JTY_0783(adhB) JTY_3106(adhD)
MBM: BCGMEX_0784c(adhB) BCGMEX_3108(adhD)
MAF: MAF_07730(adhB) MAF_30930(adhD)
MCE: MCAN_07651(adhB) MCAN_31121(adhD)
MCQ: BN44_10831(adhB) BN44_60602(adhD)
MCV: BN43_20196(adhB) BN43_60078(adhD)
MCX: BN42_20519(adhB) BN42_41103(adhD)
MCZ: BN45_20030(adhB) BN45_60074(adhD)
MPA: MAP_0595c(adhB)
MUL: MUL_0470(adhB)
MMI: MMAR_0127(adhD_1) MMAR_3150 MMAR_4935(adhB)
MMAE: MMARE11_01140(adhD_1) MMARE11_47450(adhB)
MLI: MULP_00112(adhD_1) MULP_05179(adhB)
MHAD: B586_05040
MSG: MSMEI_0210(adhB) MSMEI_3308(adhD) MSMEI_4069(adhD) MSMEI_5707(adhB)
MCHE: BB28_23280
MSTE: MSTE_04614(adhB) MSTE_04732
MJD: JDM601_0149(adhB) JDM601_2351(adhD_1) JDM601_3610(adhB)
CAQU: CAQU_03945
TPR: Tpau_2883
SCO: SCO1705(SCI30A.26c)
SHY: SHJG_3154
SALB: XNR_5118
SALS: SLNWT_6186
SRW: TUE45_02169 TUE45_02893(adhD_1) TUE45_04279(adhD_2)
SLE: sle_54110(sle_54110)
STRD: NI25_30655
SALF: SMD44_01787(frmA) SMD44_02532(frmA) SMD44_03713(frmA)
SALJ: SMD11_3924(frmA) SMD11_4784(frmA)
ARX: ARZXY2_1492(adh) ARZXY2_4684(adh)
BLIN: BLSMQ_0326
NDK: I601_0646 I601_0649(frmA)
TFU: Tfu_1270
NDA: Ndas_2247
TCU: Tcur_4959
GOB: Gobs_4948
BSD: BLASA_0307(adhB) BLASA_4819(adhB2)
MMAR: MODMU_0391(adhB) MODMU_2922(adhB) MODMU_2924(adhB) MODMU_2938(adh) MODMU_5408(adh)
KRA: Krad_2224
AOI: AORI_4731(adh)
KAL: KALB_3416
SAQ: Sare_2799
MIL: ML5_2392
AHE: Arch_0038
BAST: BAST_0427
BCOR: BCOR_0370
TBI: Tbis_2878
RXY: Rxyl_3153
CWO: Cwoe_3280
SYN: sll0990
SYZ: MYO_15950
SYY: SYNGTS_0589(sll0990)
SYT: SYNGTI_0589(sll0990)
SYS: SYNPCCN_0589(sll0990)
SYQ: SYNPCCP_0589(sll0990)
SYC: syc1059_d
SYG: sync_1463
SYX: SynWH7803_0877(adhC)
CYI: CBM981_2131(frmA)
PMM: PMM1234
PMB: A9601_14521(adhC)
AMR: AM1_2463
MAR: MAE_21280
MPK: VL20_5043
CYL: AA637_09520(frmA)
GEN: GM3709_62
CYT: cce_1588
TER: Tery_2840
GVI: glr4425
GLJ: GKIL_1446(frmA)
ANA: all2810
AVA: Ava_1089
NAZ: Aazo_4639
CALH: IJ00_03030
CTHE: Chro_1599
CAA: Caka_0892
FAE: FAES_5031(gutB)
FLM: MY04_2091
GFO: GFO_1717
MARM: YQ22_01780
CBAL: M667_11690
CBAT: M666_11735
ZGA: ZOBELLIA_4674(adhI)
 » show all
Taxonomy
Reference
1
  Authors
Jakoby, W.B.
  Title
Aldehyde dehydrogenases.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
Reference
2
  Authors
Rose, Z.B. and Racker, E.
  Title
Formaldehyde dehydrogenase.
  Journal
Methods Enzymol 9:357-360 (1966)
Reference
3  [PMID:11260719]
  Authors
Liu L, Hausladen A, Zeng M, Que L, Heitman J, Stamler JS.
  Title
A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans.
  Journal
Nature 410:490-4 (2001)
DOI:10.1038/35068596
Reference
4  [PMID:10978156]
  Authors
Sanghani PC, Stone CL, Ray BD, Pindel EV, Hurley TD, Bosron WF.
  Title
Kinetic mechanism of human glutathione-dependent formaldehyde dehydrogenase.
  Journal
Biochemistry 39:10720-9 (2000)
DOI:10.1021/bi9929711
Reference
5
  Authors
van Ophem, P.W. and Duine, J.A.
  Title
NAD- and co-substrate (GSH or factor)-dependent formaldehyde dehydrogenases from methylotrophic microorganisms act as a class III alcohol dehydrogenase.
  Journal
FEMS Microbiol Lett 116:87-94 (1994)
Reference
6  [PMID:7798140]
  Authors
Ras J, Van Ophem PW, Reijnders WN, Van Spanning RJ, Duine JA, Stouthamer AH, Harms N.
  Title
Isolation, sequencing, and mutagenesis of the gene encoding NAD- and glutathione-dependent formaldehyde dehydrogenase (GD-FALDH) from Paracoccus denitrificans, in which GD-FALDH is essential for methylotrophic growth.
  Journal
J Bacteriol 177:247-51 (1995)
DOI:10.1128/JB.177.1.247-251.1995
  Sequence
Reference
7  [PMID:8631716]
  Authors
Barber RD, Rott MA, Donohue TJ.
  Title
Characterization of a glutathione-dependent formaldehyde dehydrogenase from Rhodobacter sphaeroides.
  Journal
J Bacteriol 178:1386-93 (1996)
DOI:10.1128/JB.178.5.1386-1393.1996
  Sequence
[rsp:RSP_2576]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.284
IUBMB Enzyme Nomenclature: 1.1.1.284
ExPASy - ENZYME nomenclature database: 1.1.1.284
UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.284
BRENDA, the Enzyme Database: 1.1.1.284

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