KEGG   DISEASE: Chronic lymphocytic leukemia (CLL)Help
Entry
H00005                      Disease                                

Name
Chronic lymphocytic leukemia (CLL)
Description
Chronic lymphocytic leukemia (CLL) is caused by the abnormal progressive accumulation of functionally incompetent monoclonal B-lymphocytes in blood, bone marrow, lymph nodes and spleen. It is the most common adult leukemia in Western countries, accounting for about 30% of total leukaemias. Worldwide there are approximately 180,000 new cases every year. A main focus in CLL research involved the evaluation of genetic features related to somatic gene mutation or deletions that disrupt apoptosis and enhance tumor cell proliferation. The best characterized genes are TP53 (also known as p53) and ATM, for which mutations and/or deletions have been described that predict rapid disease progression, resistance to conventional therapies and poor survival.
Category
Cancer
Brite
Human diseases [BR:br08402]
 Cancers
  Cancers of haematopoietic and lymphoid tissues
   H00005  Chronic lymphocytic leukemia (CLL)
Human diseases in ICD-11 classification [BR:br08403]
 02 Neoplasms
  Neoplasms of haematopoietic or lymphoid tissues
   Mature B-cell neoplasms
    2A82  Mature B-cell neoplasm with leukaemic behaviour
     H00005  Chronic lymphocytic leukemia (CLL)
Tumor markers [br08442.html]
 H00005
Cancer-accociated carbohydrates [br08441.html]
 H00005
BRITE hierarchy
Gene
Bcl-2 (overexpression) [HSA:596] [KO:K02161]
p53 (mutation) [HSA:7157] [KO:K04451]
ATM (germline and somatic mutation) [HSA:472] [KO:K04728]
Fas (absent) [HSA:355] [KO:K04390]
Carcinogen
1,3-Butadiene [CPD:C16450]
Ethylene oxide [CPD:C06548]
Rubber industry
Drug
Cyclophosphamide [DR:D00287]
Chlorambucil [DR:D00266]
Mechlorethamine hydrochloride [DR:D04872]
Bendamustine hydrochloride [DR:D07085]
Carmustine [DR:D00254]
Fludarabine phosphate [DR:D01907]
Doxorubicin hydrochloride [DR:D01275]
Rituximab [DR:D02994] (CD20-positive)
Ofatumumab [DR:D09314]
Obinutuzumab [DR:D09321]
Ibrutinib [DR:D10223]
Idelalisib [DR:D10560]
Venetoclax [DR:D10679] (chromosome 17p deletion)
Alemtuzumab [DR:D02802]
Sodium phosphate P 32 [DR:D05870]
Ibritumomab tiuxetan [DR:D04489]
Comment
ICD-O: 9823/3, Tumor type: Chronic lymphocytic leukemia
Other DBs
ICD-11: 2A82.0
ICD-10: C91.1
MeSH: D015451
Reference
PMID:18059180 (description, gene, marker)
  Authors
Chen J, McMillan NA
  Title
Molecular basis of pathogenesis, prognosis and therapy in chronic lymphocytic leukaemia.
  Journal
Cancer Biol Ther 7:174-9 (2008)
DOI:10.4161/cbt.7.2.5262
Reference
  Authors
Plass C, Byrd JC, Raval A, Tanner SM, de la Chapelle A
  Title
Molecular profiling of chronic lymphocytic leukaemia: genetics meets epigenetics to identify predisposing genes.
  Journal
Br J Haematol 139:744-52 (2007)
DOI:10.1111/j.1365-2141.2007.06875.x
Reference
PMID:10687725 (gene, tumor type)
  Authors
Bannerji R, Byrd JC.
  Title
Update on the biology of chronic lymphocytic leukemia.
  Journal
Curr Opin Oncol 12:22-9 (2000)
Reference
PMID:11491097 (gene, tumor type)
  Authors
Caligaris-Cappio F.
  Title
Biology of chronic lymphocytic leukemia.
  Journal
Rev Clin Exp Hematol 4:5-21 (2000)
DOI:10.1046/j.1468-0734.2000.00001.x
Reference
PMID:9498905 (carcinogen)
  Authors
Blair A, Kazerouni N.
  Title
Reactive chemicals and cancer.
  Journal
Cancer Causes Control 8:473-90 (1997)
Reference
PMID:16155477 (carcinogen)
  Authors
Graff JJ, Sathiakumar N, Macaluso M, Maldonado G, Matthews R, Delzell E.
  Title
Chemical exposures in the synthetic rubber industry and lymphohematopoietic cancer mortality.
  Journal
J Occup Environ Med 47:916-32 (2005)
Reference
PMID:15660110 (carcinogen)
  Authors
Luch A.
  Title
Nature and nurture - lessons from chemical carcinogenesis.
  Journal
Nat Rev Cancer 5:113-25 (2005)
DOI:10.1038/nrc1546
Reference
PMID:12464351 (carcinogen)
  Authors
Kolman A, Chovanec M, Osterman-Golkar S.
  Title
Genotoxic effects of ethylene oxide, propylene oxide and epichlorohydrin in humans: update review (1990-2001).
  Journal
Mutat Res 512:173-94 (2002)
DOI:10.1016/S1383-5742(02)00067-4
Reference
PMID:16873420 (carcinogen)
  Authors
Alder N, Fenty J, Warren F, Sutton AJ, Rushton L, Jones DR, Abrams KR.
  Title
Meta-analysis of mortality and cancer incidence among workers in the synthetic rubber-producing industry.
  Journal
Am J Epidemiol 164:405-20 (2006)
DOI:10.1093/aje/kwj252
Reference
PMID:16299089 (carcinogen)
  Authors
Sathiakumar N, Graff J, Macaluso M, Maldonado G, Matthews R, Delzell E.
  Title
An updated study of mortality among North American synthetic rubber industry workers.
  Journal
Occup Environ Med 62:822-9 (2005)
DOI:10.1136/oem.2004.018176

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