KEGG   DISEASE: Nonalcoholic fatty liver diseaseHelp
Entry
H01333                      Disease                                

Name
Nonalcoholic fatty liver disease
Description
It has been reported that those patients with nonalcoholic fatty liver disease (NAFLD) are probably more common in those individuals with metabolic syndrome, which includes obesity and type 2 diabetes mellitus. The spectrum of NAFLD ranges from simple steatosis to steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepatitis (NASH). Of those with NASH, approximately 20% will go on to develop cirrhosis and hepatocellular carcinoma.
Category
Metabolic disease; Endocrine disease
Brite
Human diseases [BR:br08402]
 Digestive system diseases
  Liver diseases
   H01333  Nonalcoholic fatty liver disease
Human diseases in ICD-11 classification [BR:br08403]
 13 Diseases of the digestive system
  Diseases of liver
   DB92  Non-alcoholic fatty liver disease
    H01333  Nonalcoholic fatty liver disease
BRITE hierarchy
Pathway
hsa04932 Nonalcoholic fatty liver disease (NAFLD)   
hsa00561 Glycerolipid metabolism   
Gene
PNPLA3(polymorphism) [HSA:80339] [KO:K13534]
Other DBs
ICD-11: DB92
ICD-10: K75.8 K76.0
Reference
  Authors
Valenti L, Al-Serri A, Daly AK, Galmozzi E, Rametta R, Dongiovanni P, Nobili V, Mozzi E, Roviaro G, Vanni E, Bugianesi E, Maggioni M, Fracanzani AL, Fargion S, Day CP
  Title
Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease.
  Journal
Hepatology 51:1209-17 (2010)
DOI:10.1002/hep.23622
Reference
  Authors
Rotman Y, Koh C, Zmuda JM, Kleiner DE, Liang TJ
  Title
The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease.
  Journal
Hepatology 52:894-903 (2010)
DOI:10.1002/hep.23759
Reference
  Authors
Speliotes EK, Butler JL, Palmer CD, Voight BF, Hirschhorn JN
  Title
PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease.
  Journal
Hepatology 52:904-12 (2010)
DOI:10.1002/hep.23768

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