KEGG   DISEASE: AnaphylaxisHelp
Entry
H01359                      Disease                                

Name
Anaphylaxis
Description
Anaphylaxis is a severe, life-threatening, systemic allergic reaction that is almost always unanticipated and may lead to death by airway obstruction or vascular collapse. Anaphylaxis can be triggered by a broad range of triggers. Food is the commonest trigger in children and drugs the commonest in adults. In addition to the environmental influences, studies suggest that a complex of genes affects the anaphylactic response. Anaphylaxis occurs as the result of an allergen response, usually immunoglobulin E-mediated, which leads to mast cell and basophil activation and a combination of dermatologic, respiratory, cardiovascular, gastrointestinal, and neurologic symptoms.
Category
Immune system disease
Brite
Human diseases [BR:br08402]
 Immune system diseases
  Allergies and autoimmune diseases
   H01359  Anaphylaxis
Human diseases in ICD-11 classification [BR:br08403]
 04 Diseases of the immune system
  Allergic or hypersensitivity conditions
   4A84  Anaphylaxis
    H01359  Anaphylaxis
BRITE hierarchy
Gene
c-KIT (mutation) [HSA:3815] [KO:K05091]
NLRP3 (polymorphism) [HSA:114548] [KO:K12800]
IL-10 (polymorphism) [HSA:3586] [KO:K05443]
Env factor
Milk
Egg
Fish
Peanut
Tree nut
Sesame
Shellfish
Food additives
Penicillin [DR:D05411]
Cephalosporin [CPD:C00875]
Vanomycin
Bee
Wasp
Fire ants
Aspirin [DR:D00109]
Latex
Drug
Epinephrine [DR:D00095]
Other DBs
ICD-11: 4A84
MeSH: D000707
Reference
PMID:20560905 (gene, description, env_factor)
  Authors
Ben-Shoshan M, Clarke AE
  Title
Anaphylaxis: past, present and future.
  Journal
Allergy 66:1-14 (2011)
DOI:10.1111/j.1398-9995.2010.02422.x
Reference
PMID:22085665 (description, env_factor, drug)
  Authors
Arnold JJ, Williams PM
  Title
Anaphylaxis: recognition and management.
  Journal
Am Fam Physician 84:1111-8 (2011)
Reference
PMID:20236436 (description, env_factor)
  Authors
Younker J, Soar J
  Title
Recognition and treatment of anaphylaxis.
  Journal
Nurs Crit Care 15:94-8 (2010)
DOI:10.1111/j.1478-5153.2010.00366.x
Reference
PMID:20176258 (env_factor)
  Authors
Simons FE
  Title
Anaphylaxis.
  Journal
J Allergy Clin Immunol 125:S161-81 (2010)
DOI:10.1016/j.jaci.2009.12.981
Reference
PMID:21682750 (drug)
  Authors
Boden SR, Wesley Burks A
  Title
Anaphylaxis: a history with emphasis on food allergy.
  Journal
Immunol Rev 242:247-57 (2011)
DOI:10.1111/j.1600-065X.2011.01028.x

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