KEGG   DISEASE: Allergic rhinitisHelp
Entry
H01360                      Disease                                

Name
Allergic rhinitis
Description
Allergic rhinitis (AR) is an inflammation of nasal mucosa mediated by IgE-associated processes, which is characterised by pruritus, sneezing, rhinorrhoea, and nasal congestion. The development of AR entails a complex interaction between genetic predisposition and environmental exposure to different factors, of which the most important is the implicated allergen. Single-nucleotide polymorphism studies involving genes encoding for molecules implicated in the pathogenesis of AR have also been made. Such molecules comprise chemokines and their receptors, interleukins and their receptors, eosinophil peroxidase and leukotrienes, among others.
Category
Immune system disease
Brite
Human diseases [BR:br08402]
 Immune system diseases
  Allergies and autoimmune diseases
   H01360  Allergic rhinitis
Human diseases in ICD-11 classification [BR:br08403]
 12 Diseases of the respiratory system
  Upper respiratory tract disorders
   CA08  Vasomotor or allergic rhinitis
    H01360  Allergic rhinitis
BRITE hierarchy
Gene
GATA3 (polymorphism) [HSA:2625] [KO:K17895]
IL-13 (polymorphism) [HSA:3596] [KO:K05435]
IL-18 (polymorphism) [HSA:3606] [KO:K05482]
IL-28RA (polymorphism) [HSA:163702] [KO:K05140]
EPO (polymorphism) [HSA:2056] [KO:K05437]
CCXCR1 (polymorphism) [HSA:2829] [KO:K04193]
CCR1 (polymorphism) [HSA:1230] [KO:K04176]
CCR2 (polymorphism) [HSA:729230] [KO:K04177]
CCR3 (polymorphism) [HSA:1232] [KO:K04178]
CCR5 (polymorphism) [HSA:1234] [KO:K04180]
SDAD1 (polymorphism) [HSA:55153] [KO:K14856]
CXCL9 (polymorphism) [HSA:4283] [KO:K05416]
CXCL10 (polymorphism) [HSA:3627] [KO:K12671]
CXCL11 (polymorphism) [HSA:6373] [KO:K12672]
RANTES (polymorphism) [HSA:6352] [KO:K12499]
Eotaxin-3 (polymorphism) [HSA:10344] [KO:K21096]
CD14 (polymorphism) [HSA:929] [KO:K04391]
FOXJ1 (polymorphism) [HSA:2302] [KO:K09402]
FCGR2A (polymorphism) [HSA:2212] [KO:K06472]
Env factor
Dust mite
Mold
Animal dander
Cockroach
Tree, Grass, and weed pollens
Drug
Triamcinolone acetonide [DR:D00983]
Dexamethasone [DR:D00292]
Dexamethasone sodium phosphate [DR:D00975]
Hydrocortisone [DR:D00088]
Hydrocortisone sodium succinate [DR:D00978]
Prednisolone [DR:D00472]
Prednisolone sodium phosphate [DR:D00981]
Prednisone [DR:D00473]
Budesonide [DR:D00246]
Beclomethasone dipropionate [DR:D00689]
Promethazine hydrochloride [DR:D00480]
Clemastine fumarate [DR:D00666]
Methylprednisolone [DR:D00407]
Methylprednisolone sodium succinate [DR:D00751]
Methylprednisolone acetate [DR:D00979]
Mometasone furoate [DR:D00690]
Fluticasone furoate [DR:D06315]
Cortisone acetate [DR:D00973]
Azithromycin [DR:D06390]
Azelastine hydrochloride [DR:D00659]
Olopatadine hydrochloride [DR:D01192]
Ciclesonide [DR:D01703]
Fexofenadine hydrochloride - pseudoephedorine hydrochloride mixt [DR:D10252]
Desloratadine - pseudoephedrine sulfate mixt [DR:D10850]
Montelukast sodium [DR:D00529]
Carbinoxamine maleate [DR:D01336]
Dexchlorpheniramine maleate [DR:D00668]
Levocetirizine dihydrochloride [DR:D08118]
Cyproheptadine hydrochloride [DR:D02234]
Fexofenadine hydrochloride [DR:D00671]
Desloratadine [DR:D03693]
Other DBs
ICD-11: CA08.0
ICD-10: J30
MeSH: C567078
OMIM: 607154
Reference
  Authors
Davila I, Mullol J, Ferrer M, Bartra J, del Cuvillo A, Montoro J, Jauregui I, Sastre J, Valero A
  Title
Genetic aspects of allergic rhinitis.
  Journal
J Investig Allergol Clin Immunol 19 Suppl 1:25-31 (2009)
Reference
  Authors
Pawankar R, Mori S, Ozu C, Kimura S
  Title
Overview on the pathomechanisms of allergic rhinitis.
  Journal
Asia Pac Allergy 1:157-67 (2011)
DOI:10.5415/apallergy.2011.1.3.157
Reference
PMID:21913195 (env_factor)
  Authors
Mucci T, Govindaraj S, Tversky J
  Title
Allergic rhinitis.
  Journal
Mt Sinai J Med 78:634-44 (2011)
DOI:10.1002/msj.20287
Reference
PMID:21783242 (description, env_factor, drug)
  Authors
Greiner AN, Hellings PW, Rotiroti G, Scadding GK
  Title
Allergic rhinitis.
  Journal
Lancet 378:2112-22 (2011)
DOI:10.1016/S0140-6736(11)60130-X
Reference
PMID:21784174 (description, env_factor, drug)
  Authors
Mandhane SN, Shah JH, Thennati R
  Title
Allergic rhinitis: an update on disease, present treatments and future prospects.
  Journal
Int Immunopharmacol 11:1646-62 (2011)
DOI:10.1016/j.intimp.2011.07.005
Reference
PMID:18360551 (env_factor)
  Authors
Wang DY
  Title
Risk factors of allergic rhinitis: genetic or environmental?
  Journal
Ther Clin Risk Manag 1:115-23 (2005)
DOI:10.2147/tcrm.1.2.115.62907
Reference
PMID:24535140 (drug)
  Authors
Braido F, Arcadipane F, Marugo F, Hayashi M, Pawankar R
  Title
Allergic rhinitis: current options and future perspectives.
  Journal
Curr Opin Allergy Clin Immunol 14:168-76 (2014)
DOI:10.1097/ACI.0000000000000043

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