KEGG   ORTHOLOGY: K00026
Entry
K00026                      KO                                     
Symbol
MDH2
Name
malate dehydrogenase [EC:1.1.1.37]
Pathway
map00020  Citrate cycle (TCA cycle)
map00270  Cysteine and methionine metabolism
map00620  Pyruvate metabolism
map00630  Glyoxylate and dicarboxylate metabolism
map00710  Carbon fixation in photosynthetic organisms
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
M00012  Glyoxylate cycle
M00168  CAM (Crassulacean acid metabolism), dark
M00171  C4-dicarboxylic acid cycle, NAD - malic enzyme type
Disease
H00606  Early infantile epileptic encephalopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    K00026  MDH2; malate dehydrogenase
   00620 Pyruvate metabolism
    K00026  MDH2; malate dehydrogenase
   00630 Glyoxylate and dicarboxylate metabolism
    K00026  MDH2; malate dehydrogenase
  09102 Energy metabolism
   00710 Carbon fixation in photosynthetic organisms
    K00026  MDH2; malate dehydrogenase
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    K00026  MDH2; malate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.37  malate dehydrogenase
     K00026  MDH2; malate dehydrogenase
Other DBs
RN: R00342 R07136
GO: 0030060
Genes
HSA: 4191(MDH2)
PTR: 463484(MDH2)
PPS: 100991112(MDH2)
GGO: 101137732(MDH2)
PON: 100174759(MDH2)
NLE: 100602020(MDH2)
MCC: 719983(MDH2)
MCF: 101867276(MDH2)
MTHB: 126950379
CSAB: 103246656(MDH2)
CATY: 105593377(MDH2)
PANU: 101002779(MDH2)
TGE: 112620393(MDH2)
RRO: 104663627 104681214(MDH2)
RBB: 108518918(MDH2)
PTEH: 111527791 111547066(MDH2)
CJC: 100407619(MDH2)
SBQ: 101035915(MDH2)
CSYR: 103260393(MDH2)
MMUR: 105868340(MDH2)
LCAT: 123632594(MDH2) 123642951
OGA: 100960074(MDH2)
MMU: 17448(Mdh2)
MCAL: 110294957(Mdh2)
MPAH: 110312755(Mdh2)
RNO: 81829(Mdh2)
MCOC: 116068547(Mdh2)
MUN: 110555866(Mdh2)
CGE: 100763194(Mdh2)
MAUA: 101844686(Mdh2)
PLEU: 114710306(Mdh2)
MORG: 121446527(Mdh2)
MFOT: 126492731
AAMP: 119825340(Mdh2)
NGI: 103733471(Mdh2)
HGL: 101713764(Mdh2)
CPOC: 100723643(Mdh2)
CCAN: 109700987(Mdh2)
DORD: 105997386(Mdh2)
DSP: 122113803(Mdh2)
NCAR: 124970814
OCU: 100354776(MDH2)
OPI: 101517825(MDH2)
TUP: 102499069(MDH2)
AML: 100464508(MDH2)
UMR: 103670144(MDH2)
UAH: 113267810(MDH2)
UAR: 123784758(MDH2)
ELK: 111145638
LLV: 125090971
MPUF: 101674447(MDH2)
NSU: 110582490 110589923(MDH2)
FCA: 101084845(MDH2)
PYU: 121017706(MDH2)
PBG: 122471349(MDH2)
LRUF: 124519253
PTG: 102972029(MDH2)
PPAD: 109250575(MDH2)
AJU: 106980706(MDH2)
HHV: 120239292(MDH2)
BTA: 281306(MDH2)
BOM: 102282724(MDH2)
BIU: 109578485(MDH2)
BBUB: 102404946(MDH2)
CHX: 102174799(MDH2)
OAS: 443091(MDH2)
ODA: 120878765(MDH2)
CCAD: 122433041(MDH2)
SSC: 397039(MDH2)
CFR: 102509576(MDH2)
CBAI: 105082709(MDH2)
CDK: 105089651(MDH2)
VPC: 102526097(MDH2)
BACU: 103008368(MDH2)
LVE: 103084096(MDH2)
OOR: 101287547(MDH2)
DLE: 111182024(MDH2)
PCAD: 102985021(MDH2)
PSIU: 116740764(MDH2)
ECB: 100061046(MDH2)
EPZ: 103560973(MDH2)
EAI: 106839275(MDH2)
MYB: 102253136(MDH2)
MYD: 102765341(MDH2)
MMYO: 118656408(MDH2)
MLF: 102438191(MDH2)
MNA: 107526526(MDH2)
PKL: 118703303(MDH2)
HAI: 109385021(MDH2)
DRO: 112314910(MDH2)
SHON: 118992816(MDH2)
PDIC: 114504476(MDH2)
PHAS: 123806435(MDH2)
MMF: 118642527(MDH2)
RFQ: 117021232 117024791(MDH2)
PALE: 102894928(MDH2)
PGIG: 120591708(MDH2)
PVP: 105299694(MDH2)
RAY: 107511802(MDH2)
MJV: 108393301(MDH2)
TOD: 119241535(MDH2)
SARA: 101553995(MDH2)
LAV: 100654242(MDH2)
TMU: 101345659
DNM: 101422462(MDH2)
MDO: 100018146(MDH2)
GAS: 123247524(MDH2)
SHR: 100927693(MDH2)
PCW: 110221172(MDH2)
OAA: 100082520(MDH2)
GGA: 417517(MDH2)
PCOC: 116228146(MDH2)
MGP: 100544516(MDH2)
CJO: 107322573(MDH2)
NMEL: 110407568(MDH2)
APLA: 101804610(MDH2)
ACYG: 106041498(MDH2)
AFUL: 116497339(MDH2)
TGU: 100190484(MDH2)
LSR: 110482062(MDH2)
SCAN: 103820076(MDH2)
PMOA: 120507832(MDH2)
OTC: 121345894(MDH2)
PRUF: 121361641(MDH2)
GFR: 102031464(MDH2)
FAB: 101806190(MDH2)
PHI: 102108401(MDH2)
PMAJ: 107212730(MDH2)
CCAE: 111937933(MDH2)
CCW: 104691227(MDH2)
CBRC: 103621539(MDH2)
ETL: 114065033(MDH2)
ZAB: 102062976(MDH2)
ACHL: 103808167(MDH2)
FPG: 101923367(MDH2)
FCH: 102051253(MDH2)
CLV: 102096727(MDH2)
EGZ: 104131800(MDH2)
NNI: 104016135(MDH2)
PLET: 104628435(MDH2)
PCRI: 104036347(MDH2)
ACUN: 113487190(MDH2)
TALA: 104359845(MDH2)
PADL: 103918697(MDH2)
AFOR: 103905655(MDH2)
ACHC: 115347339(MDH2)
HALD: 104311313(MDH2)
CCRI: 104160969(MDH2)
CSTI: 104550940(MDH2)
CMAC: 104486060(MDH2)
MUI: 104546475(MDH2)
FGA: 104077868(MDH2)
GSTE: 104257226(MDH2)
LDI: 104351284(MDH2)
MNB: 103777056(MDH2)
OHA: 104333649(MDH2)
NNT: 104405365(MDH2)
DPUB: 104301793(MDH2)
PGUU: 104466107(MDH2)
ACAR: 104520946(MDH2)
AVIT: 104271961(MDH2)
CVF: 104286591(MDH2)
AAM: 106497338(MDH2)
AROW: 112964998(MDH2)
NPD: 112945372(MDH2)
TGT: 104574384(MDH2)
DNE: 112987366(MDH2)
SCAM: 104151219(MDH2)
ASN: 102383144(MDH2)
AMJ: 102569347(MDH2)
CPOO: 109316998(MDH2)
GGN: 109293425(MDH2)
PSS: 102446255
CMY: 102930226(MDH2)
CPIC: 101934562(MDH2)
TST: 117867427(MDH2)
CABI: 116830246(MDH2)
MRV: 120387255(MDH2)
ACS: 100563761(mdh2)
PVT: 110085149(MDH2)
SUND: 121916832(MDH2)
PBI: 103048702(MDH2)
PMUR: 107290031(MDH2)
CTIG: 120304261(MDH2)
TSR: 106549627(MDH2)
PGUT: 117667780(MDH2)
VKO: 123036729(MDH2)
PMUA: 114585377(MDH2)
ZVI: 118097150(MDH2)
GJA: 107107697(MDH2)
STOW: 125445989(MDH2)
XLA: 443751(mdh2.S) 446263(mdh2.L)
XTR: 496892(mdh2)
NPR: 108791073(MDH2)
RTEM: 120926703(MDH2)
BBUF: 120995478(MDH2)
BGAR: 122931977(MDH2)
DRE: 406405(mdh2)
PPRM: 120482849(mdh2)
MAMB: 125262223(mdh2)
IPU: 100528931(mdh2)
PHYP: 113523716(mdh2)
SMEO: 124393746(mdh2)
TFD: 113650282(mdh2)
AMEX: 103036822(mdh2)
EEE: 113576348(mdh2)
TRU: 101064979(mdh2)
LCO: 104926207(mdh2)
NCC: 104955197(mdh2)
CGOB: 115021094(mdh2)
ELY: 117265908(mdh2)
EFO: 125892830(mdh2)
PLEP: 121945612(mdh2)
SLUC: 116035224(mdh2)
ECRA: 117946795(mdh2)
ESP: 116690746(mdh2)
PFLV: 114556749(mdh2)
GAT: 120810185(mdh2)
PPUG: 119197152(mdh2)
MSAM: 119897930(mdh2)
CUD: 121513319(mdh2)
ALAT: 119005751(mdh2)
MZE: 101483745(mdh2)
ONL: 100712273(mdh2)
OAU: 116322576(mdh2)
OLA: 101166000(mdh2)
OML: 112143314(mdh2)
XMA: 102231838(mdh2)
XCO: 114141831(mdh2)
XHE: 116717262(mdh2)
PRET: 103478336(mdh2)
PLAI: 106939839(mdh2)
GAF: 122831584(mdh2)
CVG: 107089625(mdh2)
CTUL: 119777049(mdh2)
GMU: 124865748(mdh2)
NFU: 107378788(mdh2)
KMR: 108232189(mdh2)
ALIM: 106536790(mdh2)
NWH: 119410192(mdh2)
AOCE: 111562480(mdh2)
MCEP: 125015753(mdh2)
CSEM: 103388600(mdh2)
POV: 109632147(mdh2)
SSEN: 122774403(mdh2)
HHIP: 117776389(mdh2)
HSP: 118113563(mdh2)
LCF: 108888566
SDU: 111227633(mdh2)
SLAL: 111658021(mdh2)
XGL: 120784038(mdh2)
HCQ: 109531051(mdh2)
BPEC: 110171587(mdh2)
MALB: 109958229(mdh2)
BSPL: 114843038(mdh2)
SASA: 100194641(MDHM) 100196673(MDHM)
ELS: 105011098(mdh2)
SFM: 108928129(mdh2)
PKI: 111844697 111847838(mdh2)
AANG: 118236092(mdh2)
LOC: 102688410(mdh2)
PSPA: 121305094(mdh2)
ARUT: 117430371(mdh2)
LCM: 102351122(MDH2)
CMK: 103186901(mdh2)
RTP: 109918471(mdh2)
BFO: 118425725
BBEL: 109464586
CIN: 100178529
SCLV: 120340711
APLC: 110980666
SKO: 100374306
DME: Dmel_CG10748(CG10748) Dmel_CG10749(CG10749) Dmel_CG7998(Mdh2)
DSI: Dsimw501_GD12684(Dsim_GD12684) Dsimw501_GD14416(Dsim_GD14416) Dsimw501_GD19217(Dsim_GD19217)
DAN: 6505717
DVI: 6630367
SCAC: 106089244
ACOZ: 120961320
AARA: 120895411
ASTE: 118506617
AAG: 5570233
CPII: 120414329
CNS: 116351157
ACEP: 105623235
HST: 105186315
CFO: 105251203
OBO: 105276920
MDL: 103571949
CGLO: 123260903
LHT: 122511337
NVL: 108563167
CFEL: 113377602
API: 100145825
DNX: 107161319
AGS: 114126059
RMD: 113552113
BTAB: 109035578
DCI: 103509286
TPAL: 117643149
ZNE: 110840229
CSEC: 111869430
DPX: DAPPUDRAFT_301215(MDHM)
DMK: 116921449
PVM: 113811537
PJA: 122256849
PCHN: 125046792
HAME: 121862434
PCLA: 123767656
PTRU: 123509426
HAZT: 108670244
EAF: 111696441
LSM: 121121272
PPOI: 119110232
DSV: 119445834
RSAN: 119390244
RMP: 119172964
VDE: 111250056
VJA: 111267735
DPTE: 113791514
DFR: 124496931
CSCU: 111624020
PTEP: 107454667
SDM: 118192135
CEL: CELE_F20H11.3(mdh-2)
CBR: CBG_15213(Cbr-mdh-2)
BMY: BM_BM13855(Bma-mdh-2)
PCAN: 112561063
BGT: 106067662
GAE: 121367379
HRF: 124120256
HRJ: 124280863
CRG: 105333137
MYI: 110446880
PMAX: 117332894
OBI: 106872209
OSN: 115212957
LAK: 106159255
SHX: MS3_00010820(MDH2)
EGL: EGR_07010
NVE: 5500904
EPA: 110236455
ATEN: 116287870
ADF: 107341339
PDAM: 113686005
SPIS: 111336554
DGT: 114523664
HMG: 100210170
AQU: 100641593
ATH: AT1G53240(mMDH1) AT2G22780(PMDH1) AT3G15020(mMDH2) AT3G47520(MDH) AT5G09660(PMDH2)
LJA: Lj0g3v0169339.1(Lj0g3v0169339.1) Lj0g3v0292959.1(Lj0g3v0292959.1) Lj2g3v1984320.1(Lj2g3v1984320.1) Lj3g3v0428550.1(Lj3g3v0428550.1) Lj3g3v0428550.2(Lj3g3v0428550.2) Lj3g3v0428550.3(Lj3g3v0428550.3) Lj4g3v1635340.1(Lj4g3v1635340.1)
DOSA: Os01t0649100-01(Os01g0649100) Os01t0829800-01(Os01g0829800) Os03t0773800-01(Os03g0773800) Os05t0574400-01(Os05g0574400) Os07t0630800-01(Os07g0630800) Os08t0434300-01(Os08g0434300) Os12t0632700-01(Os12g0632700)
SCE: YDL078C(MDH3) YKL085W(MDH1) YOL126C(MDH2)
KMX: KLMA_40055(MDH3) KLMA_40391(MDH2) KLMA_60167(MDH1)
NCS: NCAS_0A04020(NCAS0A04020) NCAS_0C04560(NCAS0C04560) NCAS_0H03320(NCAS0H03320)
NDI: NDAI_0C00340(NDAI0C00340) NDAI_0E01670(NDAI0E01670) NDAI_0G03940(NDAI0G03940)
TPF: TPHA_0A00460(TPHA0A00460) TPHA_0G02100(TPHA0G02100) TPHA_0L01990(TPHA0L01990) TPHA_0P01350(TPHA0P01350)
TBL: TBLA_0A07800(TBLA0A07800) TBLA_0B08630(TBLA0B08630) TBLA_0B09220(TBLA0B09220) TBLA_0C00860(TBLA0C00860)
TDL: TDEL_0B07350(TDEL0B07350) TDEL_0E00560(TDEL0E00560) TDEL_0G03230(TDEL0G03230)
KAF: KAFR_0C01710(KAFR0C01710) KAFR_0C03960(KAFR0C03960) KAFR_0F02690(KAFR0F02690)
KNG: KNAG_0A01340(KNAG0A01340) KNAG_0A05930(KNAG0A05930) KNAG_0H00310(KNAG0H00310)
PIC: PICST_40132(MDHM) PICST_66451(MDH1) PICST_78343(MDH2)
SLB: AWJ20_2901(MDH1) AWJ20_411(MDH1)
NCR: NCU04899(tca-15) NCU06211(tca-16)
NTE: NEUTE1DRAFT116885(NEUTE1DRAFT_116885) NEUTE1DRAFT59383(NEUTE1DRAFT_59383)
ANG: ANI_1_12134(An15g00070) ANI_1_2230094(An11g07190) ANI_1_268064(An07g02160)
ACHE: ACHE_31300S ACHE_50264S(MDH1_1) ACHE_60976S(MDH1_2)
ABP: AGABI1DRAFT115666(AGABI1DRAFT_115666) AGABI1DRAFT119105(AGABI1DRAFT_119105)
ABV: AGABI2DRAFT187815(AGABI2DRAFT_187815) AGABI2DRAFT192140(AGABI2DRAFT_192140)
SCM: SCHCO_02638923(SCHCODRAFT_02638923) SCHCO_02645782(SCHCODRAFT_02645782)
MSYM: MSY001_0149(Mala_s_4) MSY001_1828
EHI: EHI_067860(8.t00059)
SMIN: v1.2.016412.t1(symbB.v1.2.016412.t1) v1.2.017877.t2(symbB.v1.2.017877.t2) v1.2.023331.t1(symbB.v1.2.023331.t1) v1.2.023511.t1(symbB.v1.2.023511.t1) v1.2.028119.t1(symbB.v1.2.028119.t1)
PTI: PHATRDRAFT_51297(MDH)
TPS: THAPSDRAFT_20726(MDH1)
SPAR: SPRG_12496
 » show all
Reference
  Authors
Minarik P, Tomaskova N, Kollarova M, Antalik M
  Title
Malate dehydrogenases--structure and function.
  Journal
Gen Physiol Biophys 21:257-65 (2002)
Reference
PMID:7849603
  Authors
Goward CR, Nicholls DJ
  Title
Malate dehydrogenase: a model for structure, evolution, and catalysis.
  Journal
Protein Sci 3:1883-8 (1994)
DOI:10.1002/pro.5560031027
Reference
  Authors
Madern D
  Title
Molecular evolution within the L-malate and L-lactate dehydrogenase super-family.
  Journal
J Mol Evol 54:825-40 (2002)
DOI:10.1007/s00239-001-0088-8
Reference
PMID:3072021
  Authors
Thompson LM, Sutherland P, Steffan JS, McAlister-Henn L
  Title
Gene sequence and primary structure of mitochondrial malate dehydrogenase from Saccharomyces cerevisiae.
  Journal
Biochemistry 27:8393-400 (1988)
DOI:10.1021/bi00422a015
  Sequence
[sce:YKL085W]

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