KEGG   ORTHOLOGY: K00028
Entry
K00028                      KO                                     

Name
E1.1.1.39
Definition
malate dehydrogenase (decarboxylating) [EC:1.1.1.39]
Pathway
ko00620  Pyruvate metabolism
ko00710  Carbon fixation in photosynthetic organisms
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00171  C4-dicarboxylic acid cycle, NAD - malic enzyme type
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    K00028  E1.1.1.39; malate dehydrogenase (decarboxylating)
  09102 Energy metabolism
   00710 Carbon fixation in photosynthetic organisms
    K00028  E1.1.1.39; malate dehydrogenase (decarboxylating)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.39  malate dehydrogenase (decarboxylating)
     K00028  E1.1.1.39; malate dehydrogenase (decarboxylating)
Other DBs
RN: R00214
COG: COG0281
GO: 0004471
Genes
ATH: AT2G13560(NAD-ME1) AT4G00570(NAD-ME2)
ALY: 9309009 9319868
CRB: 17882677 17890615
CSAT: 104705320 104712096 104737720 104748683 104766630 104793732
EUS: EUTSA_v10022600mg EUTSA_v10028520mg
BRP: 103836911 103837635 103858863
BNA: 106365524 106366363 106388718 106410651 106434956 106438600
BOE: 106318356 106318857 106328013
RSZ: 108827160 108828697 108828700 108847837
THJ: 104801455 104817017 104821820
LJA: Lj3g3v0618140.1(Lj3g3v0618140.1) Lj3g3v0618140.2(Lj3g3v0618140.2)
SOT: 102581802(NAD-ME) 102598070(NAD-ME)
DOSA: Os07t0496200-01(Os07g0496200) Os10t0503500-01(Os10g0503500)
ATS: 109740058(LOC109740058) 109765298(LOC109765298)
ZMA: 100501486
PPP: 112288778
CRE: CHLREDRAFT_196833(MME1)
MIS: MICPUN_55180(NAD-ME)
MPP: MICPUCDRAFT_43783(NADP-ME_2)
 » show all
Reference
  Authors
Tronconi MA, Fahnenstich H, Gerrard Weehler MC, Andreo CS, Flugge UI, Drincovich MF, Maurino VG
  Title
Arabidopsis NAD-malic enzyme functions as a homodimer and heterodimer and has a major impact on nocturnal metabolism.
  Journal
Plant Physiol 146:1540-52 (2008)
DOI:10.1104/pp.107.114975
  Sequence

KEGG   ENZYME: 1.1.1.39
Entry
EC 1.1.1.39                 Enzyme                                 

Name
malate dehydrogenase (decarboxylating);
'malic' enzyme (ambiguous);
pyruvic-malic carboxylase (ambiguous);
NAD-specific malic enzyme (ambiguous);
NAD-malic enzyme (ambiguous);
malate dehydrogenase (decarboxylating) (ambiguous)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(S)-malate:NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
(S)-malate + NAD+ = pyruvate + CO2 + NADH [RN:R00214]
Reaction(KEGG)
R00214
Substrate
(S)-malate [CPD:C00149];
NAD+ [CPD:C00003]
Product
pyruvate [CPD:C00022];
CO2 [CPD:C00011];
NADH [CPD:C00004]
Comment
There are several forms of malate dehydrogenases that differ in their use of substrates and cofactors. This particular form is found only in the plant kingdom. Unlike EC 1.1.1.38, which catalyses a similar reaction, this enzyme can not bind oxaloacetate, and thus does not decarboxylate exogeneously-added oxaloacetate. cf. EC 1.1.1.37, malate dehydrogenase; EC 1.1.1.38, malate dehydrogenase (oxaloacetate-decarboxylating); and EC 1.1.1.83, D-malate dehydrogenase (decarboxylating).
History
EC 1.1.1.39 created 1961
Pathway
ec00620  Pyruvate metabolism
ec00710  Carbon fixation in photosynthetic organisms
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00028  malate dehydrogenase (decarboxylating)
Genes
ATH: AT2G13560(NAD-ME1) AT4G00570(NAD-ME2)
ALY: 9309009 9319868
CRB: 17882677 17890615
CSAT: 104705320 104712096 104737720 104748683 104766630 104793732
EUS: EUTSA_v10022600mg EUTSA_v10028520mg
BRP: 103836911 103837635 103858863
BNA: 106365524 106366363 106388718 106410651 106434956 106438600
BOE: 106318356 106318857 106328013
RSZ: 108827160 108828697 108828700 108847837
THJ: 104801455 104817017 104821820
LJA: Lj3g3v0618140.1(Lj3g3v0618140.1) Lj3g3v0618140.2(Lj3g3v0618140.2)
SOT: 102581802(NAD-ME) 102598070(NAD-ME)
DOSA: Os07t0496200-01(Os07g0496200) Os10t0503500-01(Os10g0503500)
ATS: 109740058(LOC109740058) 109765298(LOC109765298)
ZMA: 100501486
PPP: 112288778
CRE: CHLREDRAFT_196833(MME1)
MIS: MICPUN_55180(NAD-ME)
MPP: MICPUCDRAFT_43783(NADP-ME_2)
 » show all
Reference
1  [PMID:4399380]
  Authors
Macrae AR
  Title
Isolation and properties of a 'malic' enzyme from cauliflower bud mitochondria.
  Journal
Biochem J 122:495-501 (1971)
DOI:10.1042/bj1220495
Reference
2  [PMID:7294802]
  Authors
Grover SD, Canellas PF, Wedding RT
  Title
Purification of NAD malic enzyme from potato and investigation of some physical and kinetic properties.
  Journal
Arch Biochem Biophys 209:396-407 (1981)
DOI:10.1016/0003-9861(81)90297-6
Reference
3  [PMID:16663114]
  Authors
Wedding RT, Black MK
  Title
Physical and Kinetic Properties and Regulation of the NAD Malic Enzyme Purified from Leaves of Crassula argentea.
  Journal
Plant Physiol 72:1021-8 (1983)
DOI:10.1104/pp.72.4.1021
Reference
4  [PMID:16666776]
  Authors
Wedding RT
  Title
Malic enzymes of higher plants: characteristics, regulation, and physiological function.
  Journal
Plant Physiol 90:367-71 (1989)
DOI:10.1104/pp.90.2.367
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.39
IUBMB Enzyme Nomenclature: 1.1.1.39
ExPASy - ENZYME nomenclature database: 1.1.1.39
BRENDA, the Enzyme Database: 1.1.1.39
CAS: 9028-46-0

KEGG   REACTION: R00214
Entry
R00214                      Reaction                               

Name
(S)-malate:NAD+ oxidoreductase (decarboxylating)
Definition
(S)-Malate + NAD+ <=> Pyruvate + CO2 + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00105  C00022_C00149
Enzyme
1.1.1.38        1.1.1.39
Pathway
rn00620  Pyruvate metabolism
rn00710  Carbon fixation in photosynthetic organisms
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00171  C4-dicarboxylic acid cycle, NAD - malic enzyme type
Orthology
K00027  malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38]
K00028  malate dehydrogenase (decarboxylating) [EC:1.1.1.39]
Other DBs
RHEA: 12656

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