| Entry |
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| Name |
isocitrate dehydrogenase (NAD+);
isocitric dehydrogenase;
beta-ketoglutaric-isocitric carboxylase;
isocitric acid dehydrogenase;
NAD dependent isocitrate dehydrogenase;
NAD isocitrate dehydrogenase;
NAD-linked isocitrate dehydrogenase;
NAD-specific isocitrate dehydrogenase;
NAD isocitric dehydrogenase;
isocitrate dehydrogenase (NAD);
IDH (ambiguous);
nicotinamide adenine dinucleotide isocitrate dehydrogenase
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
isocitrate:NAD+ oxidoreductase (decarboxylating)
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| Reaction(IUBMB) |
isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH [RN: R00709]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Requires Mn2+ or Mg2+ for activity. Unlike EC 1.1.1.42, isocitrate dehydrogenase (NADP+), oxalosuccinate cannot be used as a substrate. In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD+-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP+-linked enzyme that is found in both mitochondria and cytoplasm [7]. The enzyme from some species can also use NADP+ but much more slowly [9].
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| History |
EC 1.1.1.41 created 1961, modified 2005
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K00030 | isocitrate dehydrogenase (NAD+) |
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| Genes |
» show all
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| Reference |
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| Authors |
HATHAWAY JA, ATKINSON DE. |
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| Title |
THE EFFECT OF ADENYLIC ACID ON YEAST NICOTINAMIDE ADENINE DINUCLEOTIDE ISOCITRATE DEHYDROGENASE, A POSSIBLE METABOLIC CONTROL MECHANISM. |
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| Journal |
J Biol Chem 238:2875-81 (1963) |
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| Reference |
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| Authors |
KORNBERG A, PRICER WE Jr. |
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| Title |
Di- and triphosphopyridine nucleotide isocitric dehydrogenases in yeast. |
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| Journal |
J Biol Chem 189:123-36 (1951) |
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| Reference |
3 |
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| Authors |
Plaut, G.W.E. |
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| Title |
Isocitrate dehydrogenases. |
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| Journal |
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 105-126. |
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| Reference |
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| Authors |
PLAUT GW, SUNG SC. |
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| Title |
Diphosphopyridine nucleotide isocitric dehydrogenase from animal tissues. |
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| Journal |
J Biol Chem 207:305-14 (1954) |
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| Reference |
5 |
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| Authors |
Ramakrishnan, C.V. and Martin, S.M. |
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| Title |
Isocitric dehydrogenase in Aspergillus niger. |
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| Journal |
Arch Biochem Biophys 55:403-407 (1955) |
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| Reference |
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| Authors |
VICKERY HB. |
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| Title |
A suggested new nomenclature for the isomers of isocitric acid. |
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| Journal |
J Biol Chem 237:1739-41 (1962) |
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| Reference |
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| Authors |
Camacho ML, Brown RA, Bonete MJ, Danson MJ, Hough DW |
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| Title |
Isocitrate dehydrogenases from Haloferax volcanii and Sulfolobus solfataricus: enzyme purification, characterisation and N-terminal sequence. |
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| Journal |
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| Reference |
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| Authors |
Kim YO, Koh HJ, Kim SH, Jo SH, Huh JW, Jeong KS, Lee IJ, Song BJ, Huh TL |
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| Title |
Identification and functional characterization of a novel, tissue-specific NAD(+)-dependent isocitrate dehydrogenase beta subunit isoform. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Inoue H, Tamura T, Ehara N, Nishito A, Nakayama Y, Maekawa M, Imada K, Tanaka H, Inagaki K |
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| Title |
Biochemical and molecular characterization of the NAD(+)-dependent isocitrate dehydrogenase from the chemolithotroph Acidithiobacillus thiooxidans. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.1.1.41 |
| ExPASy - ENZYME nomenclature database: | 1.1.1.41 |
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