KEGG ORTHOLOGY: K00037

ORTHOLOGY: K00037

Entry

K00037                      KO

Symbol

AKR1C4

Name

3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase [EC:1.1.1.50 1.1.1.357 1.1.1.225]

Pathway

map00120

Primary bile acid biosynthesis

map00140

Steroid hormone biosynthesis

map01100

Metabolic pathways

map05208

Chemical carcinogenesis - reactive oxygen species

Module

M00104

Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate

Disease

H00607

46,XY gonadal dysgenesis

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    K00037  AKR1C4; 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
   00140 Steroid hormone biosynthesis
    K00037  AKR1C4; 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K00037  AKR1C4; 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.50  3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
     K00037  AKR1C4; 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
    1.1.1.225  chlordecone reductase
     K00037  AKR1C4; 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     K00037  AKR1C4; 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase

Other DBs

RN:	R02476 R02477 R04309 R04310 R04818 R04819 R04824 R04825 R04829 R04830 R04832 R04833 R04835 R04836 R04837 R04838 R04842 R04843 R04845 R04846 R08963

GO:	0047042 0047743

Genes

HSA:	1109(AKR1C4)

PTR:	450274(AKR1C4)

PPS:	100987989(AKR1C4)

GGO:

101148343

PON:	100434557(AKR1C4)

NLE:

100605385

HMH:	116461800(AKR1C4)

MCC:	722483 722490(AKR1C4)

MCF:	102116844 102117205(AKR1C4)

MTHB:

MNI:

CSAB:

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:	117082119 117082359

CANG:

105521699 105521705

CJC:	100405255 100405615(AKR1C4)

SBQ:

101041915

CIMI:

108292324(AKR1C4) 108292325

OGA:

GVR:

ECB:

EPZ:

EAI:

LAV:

DNM:

XLA:	108712557(akr1c4.S)

XTR:	496490(akr1c4)

NPR:

RTEM:

BBUF:

BGAR:

Reference

PMID:3479982

Authors

Penning TM, Sharp RB

Title

Prostaglandin dehydrogenase activity of purified rat liver 3 alpha-hydroxysteroid dehydrogenase.

Journal

Biochem Biophys Res Commun 148:646-52 (1987)
DOI:10.1016/0006-291X(87)90925-9

Reference

PMID:8172617

Authors

Deyashiki Y, Ogasawara A, Nakayama T, Nakanishi M, Miyabe Y, Sato K, Hara A

Title

Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder.

Journal

Biochem J 299 ( Pt 2):545-52 (1994)
DOI:10.1042/bj2990545

Sequence

[hsa:1109]

Reference

PMID:2187532

Authors

Winters CJ, Molowa DT, Guzelian PS

Title

Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase.

Journal

Biochemistry 29:1080-7 (1990)
DOI:10.1021/bi00456a034

Sequence

[hsa:1109]

All links

Ontology (4)   
   KEGG BRITE (2)   
   GO (2)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (25)   
   KEGG ENZYME (3)   
   KEGG REACTION (21)   
   KEGG RCLASS (1)   
Gene (44)   
   KEGG GENES (43)   
   OC (1)   
Literature (3)   
   PubMed (3)   
All databases (86)   

Download RDF

DBGET integrated database retrieval system