| Entry |
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| Name |
aminobutyraldehyde dehydrogenase;
gamma-guanidinobutyraldehyde dehydrogenase (ambiguous);
ABAL dehydrogenase;
4-aminobutyraldehyde dehydrogenase;
4-aminobutanal dehydrogenase;
gamma-aminobutyraldehyde dehydroganase;
1-pyrroline dehydrogenase;
ABALDH;
YdcW
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| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
4-aminobutanal:NAD+ 1-oxidoreductase
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| Reaction(IUBMB) |
4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+ [RN: R02549]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme from some species exhibits broad substrate specificity and has a marked preference for straight-chain aldehydes (up to 7 carbon atoms) as substrates [9]. The plant enzyme also acts on 4-guanidinobutanal (cf. EC 1.2.1.54 gamma-guanidinobutyraldehyde dehydrogenase). As 1-pyrroline and 4-aminobutanal are in equilibrium and can be interconverted spontaneously, 1-pyrroline may act as the starting substrate. The enzyme forms part of the arginine-catabolism pathway [8] and belongs in the aldehyde dehydrogenase superfamily [9].
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| History |
EC 1.2.1.19 created 1965, modified 1989 (EC 1.5.1.35 created 2006, incorporated 2007)
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| Pathway |
| ec00330 | Arginine and proline metabolism |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K00137 | aminobutyraldehyde dehydrogenase |
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| Genes |
» show all
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| Reference |
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| Authors |
Callewaert DM, Rosemblatt MS, Tchen TT. |
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| Title |
Purification and properties of 4-aminobutanal dehydrogenase from a Pseudomonas species. |
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| Journal |
J Biol Chem 249:1737-41 (1974) |
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| Reference |
2 |
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| Authors |
Jakoby, W.B. |
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| Title |
Aldehyde dehydrogenases. |
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| Journal |
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221. |
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| Reference |
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| Authors |
JAKOBY WB, FREDERICKS J. |
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| Title |
Pyrrolidine and putrescine metabolism: gamma-aminobutyraldehyde dehydrogenase. |
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| Journal |
J Biol Chem 234:2145-50 (1959) |
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| Reference |
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| Authors |
Matsuda H, Suzuki Y. |
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| Title |
gamma-Guanidinobutyraldehyde Dehydrogenase of Vicia faba Leaves. |
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| Journal |
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| Reference |
5 |
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| Authors |
Yorifuji, T., Koike, K., Sakurai, T. and Yokoyama, K. |
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| Title |
4-Aminobutyraldehyde and 4-guanidinobutyraldehyde dehydrogenases for arginine degradation in Pseudomonas putida. |
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| Journal |
Agric Biol Chem 50:2009-2016 (1986) |
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| Reference |
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| Authors |
Prieto-Santos MI, Martin-Checa J, Balana-Fouce R, Garrido-Pertierra A. |
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| Title |
A pathway for putrescine catabolism in Escherichia coli. |
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| Journal |
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| Reference |
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| Authors |
Prieto MI, Martin J, Balana-Fouce R, Garrido-Pertierra A. |
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| Title |
Properties of gamma-aminobutyraldehyde dehydrogenase from Escherichia coli. |
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| Journal |
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| Reference |
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| Authors |
Samsonova NN, Smirnov SV, Novikova AE, Ptitsyn LR |
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| Title |
Identification of Escherichia coli K12 YdcW protein as a gamma-aminobutyraldehyde dehydrogenase. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Gruez A, Roig-Zamboni V, Grisel S, Salomoni A, Valencia C, Campanacci V, Tegoni M, Cambillau C |
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| Title |
Crystal structure and kinetics identify Escherichia coli YdcW gene product as a medium-chain aldehyde dehydrogenase. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.2.1.19 |
| ExPASy - ENZYME nomenclature database: | 1.2.1.19 |
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