KEGG   ORTHOLOGY: K00157
Entry
K00157                      KO                                     

Name
AOX
Definition
aldehyde oxidase [EC:1.2.3.1]
Pathway
ko00280  Valine, leucine and isoleucine degradation
ko00350  Tyrosine metabolism
ko00380  Tryptophan metabolism
ko00750  Vitamin B6 metabolism
ko00760  Nicotinate and nicotinamide metabolism
ko00830  Retinol metabolism
ko00982  Drug metabolism - cytochrome P450
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko04630  JAK-STAT signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K00157  AOX; aldehyde oxidase
   00350 Tyrosine metabolism
    K00157  AOX; aldehyde oxidase
   00380 Tryptophan metabolism
    K00157  AOX; aldehyde oxidase
  09108 Metabolism of cofactors and vitamins
   00750 Vitamin B6 metabolism
    K00157  AOX; aldehyde oxidase
   00760 Nicotinate and nicotinamide metabolism
    K00157  AOX; aldehyde oxidase
   00830 Retinol metabolism
    K00157  AOX; aldehyde oxidase
  09111 Xenobiotics biodegradation and metabolism
   00982 Drug metabolism - cytochrome P450
    K00157  AOX; aldehyde oxidase
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K00157  AOX; aldehyde oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.3  With oxygen as acceptor
    1.2.3.1  aldehyde oxidase
     K00157  AOX; aldehyde oxidase
Other DBs
RN: R01709 R02125 R02657 R03871 R04085 R04904 R08349 R08384 R08408
GO: 0004031
Genes
HSA: 316(AOX1)
PTR: 459863(AOX1) 747025
PPS: 100968717(AOX1)
GGO: 101125522(AOX1) 115933782
PON: 100451794(AOX4) 100939468(AOX1)
NLE: 100583419 100583754(AOX1)
MCC: 701024(AOX1) 701502(AOX4) 701613(AOX2)
MCF: 102131116(AOX1) 102134468(AOX2) 102134825(AOX4)
CSAB: 103217611 103217617 103217619
RRO: 104670351 104670357 104670457
CJC: 100393665(AOX1) 100394388(AOX2)
MMU: 11761(Aox1) 213043(Aox2) 71724(Aox3) 71872(Aox4)
RNO: 316421(Aox2) 316424(Aox4) 493909(Aox3) 54349(Aox1)
HGL: 101710340 101722324(Aox4) 101722898(Aox1)
OCU: 100008601(AOX1) 100345417(AOX2) 100345675(AOX3) 100354428(AOX4)
CFA: 488467(AOX4) 608849(AOX2)
AML: 100470835(AOX4) 100471086(AOX2) 100474367(AOX1)
FCA: 101085487(AOX1)
PTG: 102949513(AOX1) 102967431
PPAD: 109254456
AJU: 106979979(AOX1)
BTA: 338074(AOX1) 518393(AOX4) 531699(AOX2)
CHX: 102171556 102187632(AOX1) 102188176(AOX1)
SSC: 100523701(AOX1) 100525616(AOX2) 100623394(AOX4)
OOR: 101285123(AOX1)
DLE: 111171714
PCAD: 102987494 102992680(AOX1)
EPZ: 103541147(AOX1) 103543311
MYB: 102249846 102257951(AOX1)
MYD: 102755298(AOX1) 102771691
DRO: 112307752
MDO: 100016433(AOX2) 100029977(AOX1) 100030014(AOX4) 107648868
OAA: 100092481(AOX1)
GGA: 424071(AOX1) 424072(AOX2)
MGP: 100548803(AOX1) 100549268
CJO: 107316537(AOX1)
NMEL: 110400687(AOX1)
APLA: 101795737(AOX1)
ACYG: 106039970(AOX1)
TGU: 100217503(AOX1)
LSR: 110484579(AOX1)
SCAN: 103814515(AOX1)
GFR: 102031924(AOX1)
FAB: 101818190(AOX1)
PHI: 102105114(AOX1)
PMAJ: 107207425
CCAE: 111931979(AOX1)
CCW: 104693769(AOX1)
ETL: 114055687 114055700(AOX1)
FPG: 101915658(AOX1)
FCH: 102057814(AOX1)
CLV: 102097486(AOX1)
EGZ: 104130522
NNI: 104010254(AOX1)
ACUN: 113480959
PADL: 103923316(AOX1)
PSS: 102452808(AOX1) 102453236
CPIC: 101949373(AOX1)
PVT: 110089018 110089019(AOX1)
PBI: 103048615(AOX1)
PMUR: 107291766(AOX1)
PMUA: 114607773 114607791(AOX1)
XTR: 100379890(aox1) 100493336 100495429(aox1)
DRE: 570457(aox6) 64265(aox5)
CCAR: 109060027
IPU: 108259545
PHYP: 113524277
EEE: 113585478
TRU: 101069055(aox1)
LCO: 104937222(aox1)
MZE: 101479847(aox1)
ONL: 100708434(aox1)
OLA: 101168436(aox1)
XMA: 102223145(aox1)
XCO: 114140277(aox1)
PRET: 103457351(aox1)
CVG: 107082806(aox1)
NFU: 107384677(aox1)
AOCE: 111570749(aox1)
POV: 109639006 109639051(aox1)
LCF: 108873170(aox1)
SLAL: 111670357(aox1)
HCQ: 109520227(aox1)
BPEC: 110175588(aox1) 110175628
MALB: 109955752(aox1)
ELS: 105022540(aox1)
PKI: 111856671(aox1)
LCM: 102354789(AOX1) 102358967
RTP: 109935677(aox1)
CEL: CELE_B0222.9(gad-3)
CBR: CBG19218
 » show all
Reference
  Authors
Huang DY, Furukawa A, Ichikawa Y
  Title
Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse livers and functional expression of recombinant mouse retinal oxidase cDNA in Escherichia coli.
  Journal
Arch Biochem Biophys 364:264-72 (1999)
DOI:10.1006/abbi.1999.1129
  Sequence
[mmu:11761] [ocu:100008601]
Reference
  Authors
Garattini E, Fratelli M, Terao M
  Title
The mammalian aldehyde oxidase gene family.
  Journal
Hum Genomics 4:119-30 (2009)
DOI:10.1186/1479-7364-4-2-119

KEGG   ENZYME: 1.2.3.1
Entry
EC 1.2.3.1                  Enzyme                                 

Name
aldehyde oxidase;
quinoline oxidase;
retinal oxidase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With oxygen as acceptor
Sysname
aldehyde:oxygen oxidoreductase
Reaction(IUBMB)
an aldehyde + H2O + O2 = a carboxylate + H2O2 [RN:R00635]
Reaction(KEGG)
Substrate
aldehyde [CPD:C00071];
H2O [CPD:C00001];
O2 [CPD:C00007]
Product
carboxylate [CPD:C00060];
H2O2 [CPD:C00027]
Comment
Contains molybdenum, [2Fe-2S] centres and FAD. The enzyme from liver exhibits a broad substrate specificity, and is involved in the metabolism of xenobiotics, including the oxidation of N-heterocycles and aldehydes and the reduction of N-oxides, nitrosamines, hydroxamic acids, azo dyes, nitropolycyclic aromatic hydrocarbons, and sulfoxides [4,6].
The enzyme is also responsible for the oxidation of retinal, an activity that was initially attributed to a distinct enzyme (EC 1.2.3.11, retinal oxidase) [5,7].
History
EC 1.2.3.1 created 1961, modified 2002, modified 2004, modified 2012
Pathway
ec00280  Valine, leucine and isoleucine degradation
ec00350  Tyrosine metabolism
ec00380  Tryptophan metabolism
ec00750  Vitamin B6 metabolism
ec00760  Nicotinate and nicotinamide metabolism
ec00830  Retinol metabolism
ec00982  Drug metabolism - cytochrome P450
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00157  aldehyde oxidase
Genes
HSA: 316(AOX1)
PTR: 459863(AOX1) 747025
PPS: 100968717(AOX1)
GGO: 101125522(AOX1) 115933782
PON: 100451794(AOX4) 100939468(AOX1)
NLE: 100583419 100583754(AOX1)
MCC: 701024(AOX1) 701502(AOX4) 701613(AOX2)
MCF: 102131116(AOX1) 102134468(AOX2) 102134825(AOX4)
CSAB: 103217611 103217617 103217619
RRO: 104670351 104670357 104670457
CJC: 100393665(AOX1) 100394388(AOX2)
MMU: 11761(Aox1) 213043(Aox2) 71724(Aox3) 71872(Aox4)
RNO: 316421(Aox2) 316424(Aox4) 493909(Aox3) 54349(Aox1)
HGL: 101710340 101722324(Aox4) 101722898(Aox1)
OCU: 100008601(AOX1) 100345417(AOX2) 100345675(AOX3) 100354428(AOX4)
CFA: 488467(AOX4) 608849(AOX2)
AML: 100470835(AOX4) 100471086(AOX2) 100474367(AOX1)
FCA: 101085487(AOX1)
PTG: 102949513(AOX1) 102967431
PPAD: 109254456
AJU: 106979979(AOX1)
BTA: 338074(AOX1) 518393(AOX4) 531699(AOX2)
CHX: 102171556 102187632(AOX1) 102188176(AOX1)
SSC: 100523701(AOX1) 100525616(AOX2) 100623394(AOX4)
OOR: 101285123(AOX1)
DLE: 111171714
PCAD: 102987494 102992680(AOX1)
EPZ: 103541147(AOX1) 103543311
MYB: 102249846 102257951(AOX1)
MYD: 102755298(AOX1) 102771691
DRO: 112307752
MDO: 100016433(AOX2) 100029977(AOX1) 100030014(AOX4) 107648868
OAA: 100092481(AOX1)
GGA: 424071(AOX1) 424072(AOX2)
MGP: 100548803(AOX1) 100549268
CJO: 107316537(AOX1)
NMEL: 110400687(AOX1)
APLA: 101795737(AOX1)
ACYG: 106039970(AOX1)
TGU: 100217503(AOX1)
LSR: 110484579(AOX1)
SCAN: 103814515(AOX1)
GFR: 102031924(AOX1)
FAB: 101818190(AOX1)
PHI: 102105114(AOX1)
PMAJ: 107207425
CCAE: 111931979(AOX1)
CCW: 104693769(AOX1)
ETL: 114055687 114055700(AOX1)
FPG: 101915658(AOX1)
FCH: 102057814(AOX1)
CLV: 102097486(AOX1)
EGZ: 104130522
NNI: 104010254(AOX1)
ACUN: 113480959
PADL: 103923316(AOX1)
PSS: 102452808(AOX1) 102453236
CPIC: 101949373(AOX1)
PVT: 110089018 110089019(AOX1)
PBI: 103048615(AOX1)
PMUR: 107291766(AOX1)
PMUA: 114607773 114607791(AOX1)
XTR: 100379890(aox1) 100493336 100495429(aox1)
DRE: 570457(aox6) 64265(aox5)
CCAR: 109060027
IPU: 108259545
PHYP: 113524277
EEE: 113585478
TRU: 101069055(aox1)
LCO: 104937222(aox1)
MZE: 101479847(aox1)
ONL: 100708434(aox1)
OLA: 101168436(aox1)
XMA: 102223145(aox1)
XCO: 114140277(aox1)
PRET: 103457351(aox1)
CVG: 107082806(aox1)
NFU: 107384677(aox1)
AOCE: 111570749(aox1)
POV: 109639006 109639051(aox1)
LCF: 108873170(aox1)
SLAL: 111670357(aox1)
HCQ: 109520227(aox1)
BPEC: 110175588(aox1) 110175628
MALB: 109955752(aox1)
ELS: 105022540(aox1)
PKI: 111856671(aox1)
LCM: 102354789(AOX1) 102358967
RTP: 109935677(aox1)
CEL: CELE_B0222.9(gad-3)
CBR: CBG19218
 » show all
Reference
1  [PMID:16747217]
  Authors
Gordon AH, Green DE, Subrahmanyan V
  Title
Liver aldehyde oxidase.
  Journal
Biochem J 34:764-74 (1940)
DOI:10.1042/bj0340764
Reference
2  [PMID:20985642]
  Authors
KNOX WE
  Title
The quinine-oxidizing enzyme and liver aldehyde oxidase.
  Journal
J Biol Chem 163:699-711 (1946)
Reference
3  [PMID:13201608]
  Authors
MAHLER HR, MACKLER B, GREEN DE.
  Title
Studies on metalloflavoproteins. III. Aldehyde oxidase: a molybdoflavoprotein.
  Journal
J Biol Chem 210:465-80 (1954)
Reference
4  [PMID:5044040]
  Authors
Krenitsky TA, Neil SM, Elion GB, Hitchings GH
  Title
A comparison of the specificities of xanthine oxidase and aldehyde oxidase.
  Journal
Arch Biochem Biophys 150:585-99 (1972)
DOI:10.1016/0003-9861(72)90078-1
Reference
5  [PMID:8262244]
  Authors
Tomita S, Tsujita M, Ichikawa Y
  Title
Retinal oxidase is identical to aldehyde oxidase.
  Journal
FEBS Lett 336:272-4 (1993)
DOI:10.1016/0014-5793(93)80818-F
Reference
6  [PMID:9015384]
  Authors
Yoshihara S, Tatsumi K
  Title
Purification and characterization of hepatic aldehyde oxidase in male and female  mice.
  Journal
Arch Biochem Biophys 338:29-34 (1997)
DOI:10.1006/abbi.1996.9774
Reference
7  [PMID:10190983]
  Authors
Huang DY, Furukawa A, Ichikawa Y.
  Title
Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse livers and functional expression of recombinant mouse retinal oxidase cDNA in Escherichia coli.
  Journal
Arch Biochem Biophys 364:264-72 (1999)
DOI:10.1006/abbi.1999.1129
  Sequence
[mmu:11761] [ocu:100008601]
Reference
8  [PMID:14659539]
  Authors
Uchida H, Kondo D, Yamashita A, Nagaosa Y, Sakurai T, Fujii Y, Fujishiro K, Aisaka K, Uwajima T.
  Title
Purification and characterization of an aldehyde oxidase from Pseudomonas sp. KY 4690.
  Journal
FEMS Microbiol Lett 229:31-6 (2003)
DOI:10.1016/S0378-1097(03)00781-X
Other DBs
ExplorEnz - The Enzyme Database: 1.2.3.1
IUBMB Enzyme Nomenclature: 1.2.3.1
ExPASy - ENZYME nomenclature database: 1.2.3.1
UM-BBD (Biocatalysis/Biodegradation Database): 1.2.3.1
BRENDA, the Enzyme Database: 1.2.3.1
CAS: 9029-07-6

KEGG   REACTION: R01709
Entry
R01709                      Reaction                               

Name
pyridoxal:oxygen 4-oxidoreductase
Definition
Pyridoxal + Oxygen + H2O <=> 4-Pyridoxate + Hydrogen peroxide
Equation
Reaction class
RC00075  C00250_C00847
RC02755  C00007_C00027
Enzyme
1.2.3.1         1.2.3.8
Pathway
rn00750  Vitamin B6 metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K00157  aldehyde oxidase [EC:1.2.3.1]
Other DBs
RHEA: 23727

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