KEGG   ORTHOLOGY: K00166
Entry
K00166                      KO                                     

Name
BCKDHA, bkdA1
Definition
2-oxoisovalerate dehydrogenase E1 component alpha subunit [EC:1.2.4.4]
Pathway
ko00280  Valine, leucine and isoleucine degradation
ko00640  Propanoate metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA
Disease
H00172  Maple syrup urine disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00640 Propanoate metabolism
    K00166  BCKDHA, bkdA1; 2-oxoisovalerate dehydrogenase E1 component alpha subunit
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K00166  BCKDHA, bkdA1; 2-oxoisovalerate dehydrogenase E1 component alpha subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.4  3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
     K00166  BCKDHA, bkdA1; 2-oxoisovalerate dehydrogenase E1 component alpha subunit
Other DBs
RN: R01701 R01702 R04225 R07599 R07600 R07601 R07602 R07603 R07604 R10996 R10997
COG: COG1071
GO: 0003863
Genes
HSA: 593(BCKDHA)
PTR: 468889(BCKDHA)
PPS: 100980379(BCKDHA)
PON: 100462553(BCKDHA)
NLE: 100583180(BCKDHA)
MCC: 106994773(BCKDHA) 704978
MCF: 102134149(BCKDHA)
CSAB: 103234732(BCKDHA)
RRO: 104676082(BCKDHA)
RBB: 108536156(BCKDHA)
CJC: 100407780(BCKDHA)
SBQ: 101049760(BCKDHA)
MMU: 12039(Bckdha)
MCAL: 110298425(Bckdha)
MPAH: 110336437(Bckdha)
RNO: 25244(Bckdha)
MUN: 110561191(Bckdha)
CGE: 100774234(Bckdha)
NGI: 103751518(Bckdha)
HGL: 101705928(Bckdha)
OCU: 100352048(BCKDHA)
TUP: 102488938(BCKDHA)
CFA: 484488(BCKDHA)
VVP: 112928345(BCKDHA)
AML: 100484116(BCKDHA)
UMR: 103677383(BCKDHA)
UAH: 113243532(BCKDHA)
ORO: 101363773(BCKDHA)
ELK: 111161410
FCA: 101087186(BCKDHA)
PTG: 102960450(BCKDHA)
PPAD: 109257969(BCKDHA)
AJU: 106987684(BCKDHA)
BTA: 282149(BCKDHA)
BOM: 102284478(BCKDHA)
BIU: 109572632(BCKDHA)
BBUB: 102412125(BCKDHA)
CHX: 102171539(BCKDHA)
OAS: 100145857(BCKDHA)
SSC: 100142666(BCKDHA)
CFR: 102504954(BCKDHA)
CDK: 105093370(BCKDHA)
BACU: 103004548(BCKDHA)
LVE: 103074708(BCKDHA)
OOR: 101285178(BCKDHA)
DLE: 111180820(BCKDHA)
PCAD: 102976890(BCKDHA)
ECB: 100068678(BCKDHA)
EPZ: 103562535(BCKDHA)
EAI: 106843817(BCKDHA)
MYB: 102240537(BCKDHA)
MYD: 102774136(BCKDHA)
MNA: 107534219(BCKDHA)
HAI: 109376595(BCKDHA)
DRO: 112320080(BCKDHA)
PALE: 102880923(BCKDHA)
RAY: 107505492(BCKDHA)
MJV: 108383692(BCKDHA)
LAV: 100654926(BCKDHA)
TMU: 101343046
MDO: 100019333(BCKDHA)
PCW: 110202383(BCKDHA)
OAA: 100088094(BCKDHA)
GGA: 374210(BCKDHA)
CJO: 107307112(BCKDHA)
APLA: 113841943(BCKDHA)
LSR: 110478789(BCKDHA)
PHI: 102103341
FPG: 101913651(BCKDHA)
FCH: 102056420(BCKDHA)
ASN: 102371000(BCKDHA)
AMJ: 102576924(BCKDHA)
CMY: 102933976(BCKDHA)
CPIC: 101937607(BCKDHA)
ACS: 100554302(bckdha)
PVT: 110088527(BCKDHA)
PBI: 103048497(BCKDHA)
PMUR: 107295271(BCKDHA)
TSR: 106554144(BCKDHA)
PMUA: 114603299(BCKDHA)
GJA: 107119235(BCKDHA)
XLA: 108698630(bckdha.L) 108700580(bckdha.S)
XTR: 100036656(bckdha)
NPR: 108786664(BCKDHA)
DRE: 554124(bckdha)
SRX: 107705067(bckdha) 107758241
IPU: 108264709(bckdha)
PHYP: 113526699(bckdha)
AMEX: 103041479(bckdha)
EEE: 113589579(bckdha)
TRU: 101069065(bckdha)
LCO: 104925937(bckdha)
NCC: 104941573(bckdha)
MZE: 101474711(bckdha)
ONL: 100706080(bckdha)
OLA: 101166649(bckdha)
XMA: 102219548(bckdha)
PRET: 103475058(bckdha)
CVG: 107090653(bckdha)
NFU: 107380153(bckdha)
KMR: 108248794(bckdha)
ALIM: 106529845(bckdha)
AOCE: 111579603(bckdha)
CSEM: 103377990(bckdha)
POV: 109630405(bckdha)
LCF: 108876199(bckdha)
SDU: 111216769(bckdha)
SLAL: 111662265(bckdha)
HCQ: 109510859(bckdha)
BPEC: 110163607(bckdha)
MALB: 109963278(bckdha)
SASA: 106613373(bckdha)
OTW: 112238969(bckdha)
SALP: 112075107
ELS: 105029594(bckdha)
SFM: 108924819(bckdha)
LCM: 102364931(BCKDHA)
CMK: 103172759(bckdha)
RTP: 109926907(bckdha)
CIN: 100184456
SPU: 583728
APLC: 110990587
DME: Dmel_CG8199(CG8199)
DER: 6551999
DSE: 6607094
DSI: Dsimw501_GD18623(Dsim_GD18623)
DAN: 6501250
DSR: 110185355
DPE: 6591427
DMN: 108155459
DWI: 6647904
DAZ: 108613323
DNV: 108658035
DHE: 111603403
DVI: 6633002
MDE: 101897400
LCQ: 111690289
AAG: 5570559
AALB: 109419256
AME: 412548
BIM: 100747488
BTER: 100651520
CCAL: 108624648
OBB: 114877384
SOC: 105197789
MPHA: 105831601
AEC: 105145500
ACEP: 105626358
PBAR: 105427685
VEM: 105559755
HST: 105184189
DQU: 106751875
CFO: 105254270
LHU: 105668893
PGC: 109857306
OBO: 105277128
PCF: 106792148
CSOL: 105361133
MDL: 103577874
TCA: 660327
DPA: 109541365
ATD: 109598484
NVL: 108563261
BMOR: 101746491
BMAN: 114252978
PMAC: 106714627
PRAP: 110999699
HAW: 110372912
TNL: 113500278
PXY: 105381551
API: 100164806
AGS: 114119055
RMD: 113555805
BTAB: 109031226
CLEC: 106667514
ZNE: 110831859
FCD: 110859291
PVM: 113829155
TUT: 107361956
CSCU: 111639232
PTEP: 107446536
CEL: CELE_Y39E4A.3(bckd-1A)
BMY: Bm1_00280
PCAN: 112570590
CRG: 105326289
MYI: 110464293
OBI: 106879837
LAK: 106166723
NVE: 5514960
EPA: 110240377
ADF: 107331174
AMIL: 114956585
PDAM: 113676686
SPIS: 111341496
DGT: 114519959
HMG: 100209249
AQU: 100633338
LJA: Lj1g3v0912020.1(Lj1g3v0912020.1) Lj1g3v1340510.1(Lj1g3v1340510.1)
AIP: 107623646
FVE: 101315378
PPER: 18780924
PMUM: 103327122
PAVI: 110751189
PXB: 103946828
OEU: 111397063
OSA: 4351684
DOSA: Os12t0183100-01(Os12g0183100)
OBR: 102700387
BDI: 100845243
ATS: 109734458(LOC109734458)
SBI: 110429745
ZMA: 100191513(pco079304)
SITA: 101765211
PDA: 103720523
EGU: 105051761
MUS: 103979408
DCT: 110097954
PEQ: 110029901
AOF: 109824176
ATR: 18436937
PPP: 112284577
APRO: F751_1234
SLB: AWJ20_2913(PDA1)
NCR: NCU09864
NTE: NEUTE1DRAFT124643(NEUTE1DRAFT_124643)
MGR: MGG_03840
SSCK: SPSK_01178
MAW: MAC_03390
MAJ: MAA_01990
CMT: CCM_00361
MBE: MBM_07396
ANI: AN1726.2
ANG: ANI_1_1232084(An09g02700)
ABE: ARB_01968
TVE: TRV_07197
PTE: PTT_01849
CNE: CNE02620
CNB: CNBE2640
TASA: A1Q1_07686
ABP: AGABI1DRAFT40547(AGABI1DRAFT_40547)
ABV: AGABI2DRAFT206891(AGABI2DRAFT_206891)
DDI: DDB_G0286335(bkdA)
DFA: DFA_07500(bkdA)
PCB: PCHAS_141300(PC000407.01.0)
TAN: TA10340
TPV: TP04_0719
BBO: BBOV_III008200(17.m07717)
SMIN: v1.2.015623.t1(symbB.v1.2.015623.t1)
FCY: FRACYDRAFT_186364(BCKDE1-A)
NGD: NGA_0175701(BKDA1) NGA_0175702(BKDA1)
SPAR: SPRG_14335
VNI: VIBNI_A0968(bkdA1)
PAE: PA2247(bkdA1)
PAEV: N297_2320(bkdA1)
PAEI: N296_2320(bkdA1)
PAU: PA14_35530(bkdA1)
PAP: PSPA7_2994(bkdA1)
PAG: PLES_30571(bkdA1)
PAF: PAM18_2793(bkdA1)
PNC: NCGM2_3256(bkdA1)
PAEB: NCGM1900_4284(bkdA1)
PAEP: PA1S_14385
PAEM: U769_13970
PAEL: T223_15615
PAEU: BN889_02451(bkdA1)
PAEG: AI22_19470
PAEC: M802_2317(bkdA1)
PAEO: M801_2319(bkdA1)
PCQ: PcP3B5_35980(bkdA1)
PPU: PP_4401(bkdAA)
PPF: Pput_1453
PPT: PPS_3805
PPI: YSA_07994
PPX: T1E_5099(bkdA1)
PPUH: B479_18910
PPUT: L483_24350
PPUN: PP4_13600(bkdA1)
PPUD: DW66_4238
PMON: X969_18285
PMOT: X970_17920
PFL: PFL_2534(bkdA1)
PPRC: PFLCHA0_c25970(bkdA2)
PPRO: PPC_2578(bkdA1)
PFS: PFLU_3964
PFC: PflA506_3337(bkdA1)
PFB: VO64_1045
PMAN: OU5_6091
PFW: PF1751_v1c34230(bkdA1)
PEN: PSEEN3853(bkdA1)
PPUU: PputUW4_02962(bkdA1)
PKC: PKB_2848(bkdA1)
PSEM: TO66_12340
PSEC: CCOS191_1452(bkdA1)
PSOS: POS17_2536(bkdA1)
PANR: A7J50_3619
PSIL: PMA3_15760
SON: SO_2339(bkdA1)
SDN: Sden_1786
SFR: Sfri_1935
SAZ: Sama_1709
SLO: Shew_1925
SSE: Ssed_2329
SPL: Spea_2246
SHL: Shal_2234
SWD: Swoo_2278
SWP: swp_2606
SVO: SVI_2042
SPSW: Sps_00789
SKH: STH12_01386(pdhA)
ILO: IL1680
CPS: CPS_1582
PHA: PSHAa1632(BckdhA)
PTN: PTRA_a2027(bkdA1)
PAT: Patl_2036
PSM: PSM_A1605(bckdhA)
PSEO: OM33_10875
PEA: PESP_a2048(bkdA1)
PSPO: PSPO_a1577(bkdA1)
PART: PARC_a1890(bkdA1)
PTU: PTUN_a2016(bkdA1)
PNG: PNIG_a2139(bkdA1)
PTD: PTET_a1856(bkdA1)
PSEN: PNC201_08390(bkdA1)
PAGA: PAGA_a1866(bkdA1)
MAQ: Maqu_1382
MHC: MARHY2009(bckdhA)
MBS: MRBBS_2856(bkdA)
AMAL: I607_09630
AMAE: I876_10095
AMAO: I634_10040
AMAD: I636_10240
AMAI: I635_10635
AMAG: I533_09865
AMAC: MASE_09530
AAUS: EP12_10195
GNI: GNIT_1901(bkdA1)
GPS: C427_2947
FBL: Fbal_2358
SAGA: M5M_15975
HCH: HCH_03687
HEL: HELO_2370(bkdA1)
HAM: HALO2324
HCO: LOKO_01414(bfmBAA)
HBE: BEI_1740
OCE: GU3_06465
BMA: BMAA2013
BMAL: DM55_3786(bkdA1)
BMAE: DM78_4393(bkdA1)
BMAQ: DM76_4483(bkdA1)
BMAI: DM57_06035
BMAF: DM51_3688(bkdA1)
BMAZ: BM44_3745(bkdA1)
BMAB: BM45_4521(bkdA1)
BPS: BPSS2273(bkdA1)
BPM: BURPS1710b_A1411(bkdA1)
BPSE: BDL_5748(bkdA1)
BPSM: BBQ_3831(bkdA1)
BPSU: BBN_5769(bkdA1)
BPSD: BBX_4916(bkdA1)
BPZ: BP1026B_II2449(bkdA1)
BPK: BBK_5053(bkdA1)
BPSH: DR55_5457(bkdA1)
BPSA: BBU_3716(bkdA1)
BPSO: X996_5228(bkdA1)
BUT: X994_4776(bkdA1)
BTQ: BTQ_5591(bkdA1)
BTJ: BTJ_4246(bkdA1)
BTZ: BTL_5056(bkdA1)
BTD: BTI_4842(bkdA1)
BTV: BTHA_5166(bkdA1)
BTHE: BTN_4714(bkdA1)
BTHM: BTRA_4980(bkdA1)
BTHA: DR62_4821
BTHL: BG87_5048(bkdA1)
BOK: DM82_4058(bkdA1)
BOC: BG90_3970(bkdA1)
BCN: Bcen_0762
BCJ: BCAL1212(bkdA1)
BCEN: DM39_6353(bkdA1)
BCEW: DM40_1898(bkdA1)
BCEO: I35_1123(bkdA1)
BAM: Bamb_1123
BCT: GEM_2217
BCED: DM42_479(bkdA1)
BCON: NL30_09480
BUB: BW23_5908(bkdA1)
BLAT: WK25_06215
BTEI: WS51_16570
BSEM: WJ12_06065
BPSL: WS57_16600
BMEC: WJ16_05840
BSTG: WT74_18525
BGU: KS03_3387(bkdA1)
BGO: BM43_7059(bkdA1)
BUL: BW21_4368(bkdA1)
BGP: BGL_2c02400(bkdA1)
BPT: Bpet3511(bkdA1)
AXX: ERS451415_02352(bkdA1)
PUT: PT7_0836
RFR: Rfer_3554
POL: Bpro_0273
VPD: VAPA_1c10760(bkdA1)
RTA: Rta_10480(bkdA1)
ADE: Adeh_1827
MXA: MXAN_4564
CCX: COCOR_04759(bfmBAA)
SCL: sce1571(pdhA) sce8001
HOH: Hoch_3237
MLO: mll4473
MHUA: MCHK_5643
AMIH: CO731_01638(bkdA1)
SME: SMc03201(bkdAa)
SMX: SM11_chr3104(bkdAa)
SMI: BN406_02789(bkdA1)
SMEL: SM2011_c03201(bkdAa)
SMER: DU99_16160
SMD: Smed_2826
RHI: NGR_c29890(bkdA1)
SFH: SFHH103_02998(bkdA1)
SFD: USDA257_c54050(bkdA1)
SAME: SAMCFNEI73_Ch3362(bkdA)
EAD: OV14_0458(bkdA1)
ATU: Atu3473(bkdA1)
ATF: Ach5_33320(bkdA1)
RET: RHE_PC00070(bkDa1)
REL: REMIM1_PB00071(bkdA1)
REP: IE4803_PD00070(bkdA1)
REI: IE4771_PE00070(bkdA1)
RLE: pRL100303
RLG: Rleg_6503
RIR: BN877_II0489(bkdA1)
RHL: LPU83_pLPU83d0281(bkdA1)
RGA: RGR602_PC01283(bkdA1)
RHN: AMJ98_PB00088(bkdA1)
RPHA: AMC79_PA00095(bkdA1)
RHT: NT26_2594(bkdAa)
RHX: AMK02_PB00087(bkdA1)
RHK: Kim5_PD00070(bkdA1)
REZ: AMJ99_PA00088(bkdA1)
SHZ: shn_32700
BME: BMEII0748
BMEL: DK63_2497(bkdA1)
BMEE: DK62_2908(bkdA1)
BMF: BAB2_0715
BABO: DK55_2682(bkdA1)
BABR: DO74_3099(bkdA1)
BABT: DK49_2556(bkdA1)
BABB: DK48_3115(bkdA1)
BABU: DK53_2685(bkdA1)
BABS: DK51_2168(bkdA1)
BABC: DO78_2371(bkdA1)
BMS: BRA0524
BSZ: DK67_2521(bkdA1)
BOV: BOV_A0455
BCAR: DK60_2238(bkdA1)
BCAS: DA85_12980
BMR: BMI_II518
BPP: BPI_II505
BPV: DK65_3106(bkdA1)
OAN: Oant_3551
OAH: DR92_2936(bkdA1)
BJA: blr6331(bkdA1)
BOS: BSY19_710
MAQU: Maq22A_c19015(acoA)
PHL: KKY_1077
CAK: Caul_1870
BVY: NCTC9239_00232(bkdA1)
PDE: Pden_4757
PAMN: pAMV3p0449(odbA)
LAQU: R2C4_00535
MALG: MALG_04598
SPSE: SULPSESMR1_00014(bkdA1)
RID: RIdsm_00820(bkdA1)
HBA: Hbal_1614
GAK: X907_0931
NAR: Saro_1976
SAL: Sala_1331
SPHK: SKP52_08350(bkdA1)
SPHP: LH20_11275
SMAZ: LH19_09665
SGI: SGRAN_2143(bkdA1)
SPHU: SPPYR_0632(bkdA) SPPYR_1442(bkdA) SPPYR_2050(bkdA)
SPHM: G432_01725
STAX: MC45_11230
SPHI: TS85_18125
SSAN: NX02_27220
SPKC: KC8_03345
SECH: B18_23310
SJP: SJA_C1-12990(bkdA1)
SSY: SLG_09650(bkdA1)
SPMI: K663_11035
SPHR: BSY17_191
SINB: SIDU_07795
SPHT: K426_07820
SFLA: SPHFLASMR4Y_01144(bkdA1)
BLAS: BSY18_845
SMIC: SmB9_02010(bkdA1)
ELI: ELI_05155
ERF: FIU90_09170(bkdA1)
AAY: WYH_00347(bkdA1)
ANH: A6F65_01538(bkdA1)
ADO: A6F68_02030(bkdA1)
ALB: AEB_P1787
SHUM: STHU_18050
SVC: STVA_35220(bkdAa)
TMO: TMO_b0190
BBA: Bd0972
BBAT: Bdt_0917
BBW: BDW_03325
BBAC: EP01_14960
BEX: A11Q_794
BSU: BSU24050(bkdAA)
BSR: I33_2483
BSL: A7A1_3638
BSH: BSU6051_24050(bkdAA)
BSUT: BSUB_02579(bkdAA)
BSUL: BSUA_02579(bkdAA)
BSUS: Q433_13150
BSS: BSUW23_11890(bkdAA)
BST: GYO_2650
BSO: BSNT_08837(bkdAA)
BSQ: B657_24050(bkdAA)
BSX: C663_2286(bkdAA)
BLI: BL01504(bkdAA)
BLD: BLi02582(bkdAA)
BLH: BaLi_c26660(bkdAA)
BAQ: BACAU_2246(bkdAA)
BYA: BANAU_2385(bkdAA)
BAMP: B938_11540
BAML: BAM5036_2156(bkdAA)
BAMA: RBAU_2369(bkdAA)
BAMN: BASU_2158(bkdAA)
BAMB: BAPNAU_1352(bkdAA)
BAMT: AJ82_12650
BAMY: V529_25060(bkdAA)
BMP: NG74_02338(bfmBAA)
BAO: BAMF_2302(bkdAA)
BAZ: BAMTA208_12330(bkdAA)
BQL: LL3_02591(bkdA)
BXH: BAXH7_02514(bkdAA)
BQY: MUS_2695(bkdAA)
BAMI: KSO_008230
BAMC: U471_23080
BAMF: U722_12165
BAN: BA_4384(bfmbAa)
BAR: GBAA_4384(bfmbAa)
BAT: BAS4067
BAH: BAMEG_4421(bfmbAa)
BAI: BAA_4403(bfmbAa)
BANT: A16_43810
BANR: A16R_44350
BANS: BAPAT_4205
BANV: DJ46_3070(bfmBAA)
BCE: BC4159
BCA: BCE_4234(bfmbAa)
BCZ: BCE33L3914(bfmbAa)
BCR: BCAH187_A4292(bfmbAa)
BCB: BCB4264_A4272(bfmbAa)
BCU: BCAH820_4182(bfmbAa)
BCG: BCG9842_B0962(bfmbAa)
BCQ: BCQ_3949(bfmbAa)
BCX: BCA_4271(bfmbAa)
BAL: BACI_c41280(bfmbAa)
BNC: BCN_4075
BCF: bcf_20685
BCER: BCK_14370
BTK: BT9727_3905(bfmbAa)
BTL: BALH_3772(bfmbAa)
BTB: BMB171_C3822(bfmbAa)
BTT: HD73_4464
BTHI: BTK_21980
BTC: CT43_CH4175(bfmbAa)
BTM: MC28_3453(bfmBAA)
BTG: BTB_c43030(bfmBAA)
BTI: BTG_28590
BTW: BF38_5330(bfmBAA)
BWW: bwei_0784(bfmBAA)
BMYO: BG05_1859(bfmBAA)
BMYC: DJ92_1261(bfmBAA)
BTRO: FJR70_14575(bfmBAA)
BPU: BPUM_2144
BPUM: BW16_11635
BPUS: UP12_10890
BMQ: BMQ_4439(bkdAA)
BMD: BMD_4425(bkdAA)
BMH: BMWSH_0796(bfmbAa)
BMEG: BG04_1357(bfmBAA)
BAG: Bcoa_2875
BCOA: BF29_693(bfmBAA)
BJS: MY9_2423
BMET: BMMGA3_11325(bfmBAA)
BACW: QR42_10840
BACP: SB24_17560
BACB: OY17_14435
BACO: OXB_2731
BACY: QF06_10215
BACL: BS34A_26410(bkdAA)
BALM: BsLM_2359
BEO: BEH_19430
BGY: BGLY_2860(bfmBAA)
BBEV: BBEV_1321(bfmBAA)
BFD: NCTC4823_01912(bfmbAa)
BHA: BH2763(bfmBAA)
BCL: ABC2451(bkdA1)
BPF: BpOF4_01420(bfmBAA)
BKW: BkAM31D_16790(bfmBAA)
OIH: OB1866
GKA: GK2378
GTN: GTNG_2307
GGH: GHH_c24510(bkdAA)
GEA: GARCT_02357(bfmBAA)
AFL: Aflv_0962(bkdAA)
AAMY: GFC30_2567
AXL: AXY_11870(bkdA)
LSP: Bsph_3494
HLI: HLI_19570
VPN: A21D_03291(bfmBAA)
PASA: BAOM_3646
PSYO: PB01_11455
BSE: Bsel_2253
SAU: SA1348(bfmBAA)
SAV: SAV1517(bfmBAA)
SAW: SAHV_1505(bfmBAA)
SAM: MW1470(bfmBAA)
SAS: SAS1456
SAR: SAR1595(bfmBAA)
SAC: SACOL1562
SAX: USA300HOU_1519(odpA)
SAE: NWMN_1423
SAD: SAAV_1510
SUE: SAOV_1518
SUJ: SAA6159_01453(acoA)
SUK: SAA6008_01487(acoA)
SUZ: MS7_1535(bfmBAA)
SUX: SAEMRSA15_14380(bfmBAA)
SUW: SATW20_15140(bfmBAA)
SUG: SAPIG1583
SUF: SARLGA251_14240(bfmBAA)
SAUA: SAAG_01432
SAUS: SA40_1389(bfmBAA)
SAUU: SA957_1472(bfmBAA)
SAUG: SA268_1476(bfmBAA)
SAUZ: SAZ172_1532(bfmBAA)
SAUT: SAI1T1_2011030(bfmBAA)
SAUJ: SAI2T2_1011050(bfmBAA)
SAUK: SAI3T3_1011030(bfmBAA)
SAUQ: SAI4T8_1011040(bfmBAA)
SAUV: SAI7S6_1011050(bfmBAA)
SAUW: SAI5S5_1011000(bfmBAA)
SAUX: SAI6T6_1011010(bfmBAA)
SAUY: SAI8T7_1011040(bfmBAA)
SAUF: X998_1529
SAB: SAB1390c
SUY: SA2981_1476(bfmBAA)
SAUB: C248_1560(bfmBAA)
SAUC: CA347_1515
SAUR: SABB_00440
SAUI: AZ30_07740
SAUD: CH52_11480
SAMS: NI36_08195
SER: SERP1078
SEP: SE1198
SEPP: SEB_01218
SEPS: DP17_157
SHA: SH1398(bfmBAA)
SHH: ShL2_01282(acoA_2)
SSP: SSP1238
SCA: SCA_1139(bfmBAA)
SLN: SLUG_13950(bfmBAA)
SDT: SPSE_1283
SPAS: STP1_0093
SCAP: AYP1020_0816(bfmBAA)
SSCH: LH95_06205
SSCZ: RN70_06385
SAGQ: EP23_03415
SDP: NCTC12225_01498(bfmBAA)
LMO: lmo1372
LMOC: LMOSLCC5850_1431(bfmBAA)
LMOD: LMON_1435
LMOW: AX10_00935
LMOQ: LM6179_2115(bkdAA)
LMR: LMR479A_1459(bkdAA)
LMOM: IJ09_03150
LMOG: BN389_13960(bfmBAA)
LMP: MUO_07080
LMOL: LMOL312_1368(bfmBAA)
LMOX: AX24_04320
LMQ: LMM7_1457(bkdA1)
LML: lmo4a_1429(bfmBAA)
LMS: LMLG_1958
LMW: LMOSLCC2755_1374(bfmBAA)
LMX: LMOSLCC2372_1433(bfmBAA)
LMZ: LMOSLCC2482_1424(bfmBAA)
LMON: LMOSLCC2376_1326(bfmBAA)
LMOS: LMOSLCC7179_1342(bfmBAA)
LMOO: LMOSLCC2378_1385(bfmBAA)
LMOY: LMOSLCC2479_1432(bfmBAA)
LMOT: LMOSLCC2540_1422(bfmBAA)
LMOA: LMOATCC19117_1379(bfmBAA)
LMOK: CQ02_07050
LIN: lin1409
LWE: lwe1387
LSG: lse_1288
LIV: LIV_1323
LGZ: NCTC10812_01310(bfmBAA)
ESI: Exig_0919
EAN: Eab7_0889
BBE: BBR47_23690(bkdA1)
PPY: PPE_02822
PPM: PPSC2_14970(bckE1)
PPO: PPM_3009(bckE1)
PPOL: X809_31380
PPOY: RE92_21745
PMS: KNP414_02694(bfmBAA)
PMW: B2K_14915
PLV: ERIC2_c12560(bfmBAA)
PSAB: PSAB_16490
PRI: PRIO_4647(bfmBAA)
PSWU: SY83_19070
ASOC: CB4_03317(bfmBAA)
COHN: KCTCHS21_25040(bfmBAA)
BTS: Btus_1309
SIV: SSIL_1715
JEO: JMA_20780
KZO: NCTC404_02395(bfmBAA)
LCA: LSEI_1445
LCS: LCBD_1648
LCE: LC2W_1615
LPAP: LBPC_1368
LCB: LCABL_16680(bkdA)
EFA: EF1660(bkdA)
EFL: EF62_2038(bkdA)
EFI: OG1RF_11372(bkdA)
EFS: EFS1_1416(bkdA)
EFN: DENG_01832(bkdA1)
EFQ: DR75_659(bfmBAA)
ENE: ENT_10640
JDA: BW727_101907(bfmBAA)
SAY: TPY_3788(bkdA1) TPY_3789(bkdA1)
LPIL: LIP_0823
NDK: I601_1188(pdhA)
RXY: Rxyl_2480
AYM: YM304_17900(bkdA1)
RCA: Rcas_3063
CAU: Caur_1693
CAG: Cagg_2095
HAU: Haur_2591
STI: Sthe_3477
ABAT: CFX1CAM_0234(bfmBAA)
DRA: DR_0029
DGE: Dgeo_2338
DFC: DFI_13665
TRA: Trad_0746
TTH: TT_C1757
TTJ: TTHA0229
TSC: TSC_c02400(acoA)
TAQ: TO73_0140
MRB: Mrub_2320
TTR: Tter_0093
PUV: PUV_02590(bkdA)
WCH: wcw_0464(pdhA1)
GES: VT84_03820(bfmBAA)
IPA: Isop_0418
CDIV: CPM_0222
 » show all
Reference
PMID:283398
  Authors
Pettit FH, Yeaman SJ, Reed LJ
  Title
Purification and characterization of branched chain alpha-keto acid dehydrogenase complex of bovine kidney.
  Journal
Proc Natl Acad Sci U S A 75:4881-5 (1978)
DOI:10.1073/pnas.75.10.4881
  Sequence
[bta:282149]

KEGG   ORTHOLOGY: K00167
Entry
K00167                      KO                                     

Name
BCKDHB, bkdA2
Definition
2-oxoisovalerate dehydrogenase E1 component beta subunit [EC:1.2.4.4]
Pathway
ko00280  Valine, leucine and isoleucine degradation
ko00640  Propanoate metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA
Disease
H00172  Maple syrup urine disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00640 Propanoate metabolism
    K00167  BCKDHB, bkdA2; 2-oxoisovalerate dehydrogenase E1 component beta subunit
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K00167  BCKDHB, bkdA2; 2-oxoisovalerate dehydrogenase E1 component beta subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.4  3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
     K00167  BCKDHB, bkdA2; 2-oxoisovalerate dehydrogenase E1 component beta subunit
Other DBs
RN: R01701 R01702 R04225 R07599 R07600 R07601 R07602 R07603 R07604 R10996 R10997
COG: COG0022
GO: 0003863
Genes
HSA: 594(BCKDHB)
PTR: 462845(BCKDHB)
PPS: 100970081(BCKDHB)
GGO: 101132793(BCKDHB)
PON: 100173401(BCKDHB)
NLE: 100597493(BCKDHB)
MCC: 718472(BCKDHB)
MCF: 102136327(BCKDHB)
CSAB: 103239988(BCKDHB)
RRO: 104682059(BCKDHB)
RBB: 108512608(BCKDHB)
CJC: 100402568(BCKDHB)
SBQ: 101033639(BCKDHB)
MMU: 12040(Bckdhb)
MCAL: 110302385(Bckdhb)
MPAH: 110327310(Bckdhb)
RNO: 29711(Bckdhb)
MUN: 110546461(Bckdhb)
CGE: 100774277(Bckdhb)
HGL: 101725476(Bckdhb)
CCAN: 109698015(Bckdhb)
OCU: 100353682(BCKDHB)
TUP: 102478510(BCKDHB)
CFA: 474978(BCKDHB)
VVP: 112926383(BCKDHB)
AML: 100476045(BCKDHB)
UMR: 103657422(BCKDHB)
UAH: 113261078(BCKDHB)
ELK: 111147848
FCA: 101080635(BCKDHB)
PTG: 102961522(BCKDHB)
PPAD: 109263332(BCKDHB)
AJU: 106976576(BCKDHB)
BTA: 282150(BCKDHB)
BOM: 102284531(BCKDHB)
BIU: 109563728(BCKDHB)
BBUB: 102399961(BCKDHB)
CHX: 102171071(BCKDHB)
OAS: 101113939(BCKDHB)
SSC: 100142669(BCKDHB)
CFR: 102512847(BCKDHB)
CDK: 105103856(BCKDHB)
BACU: 103010716(BCKDHB)
LVE: 103084139(BCKDHB)
OOR: 101282899(BCKDHB)
DLE: 111183211(BCKDHB)
PCAD: 102993749(BCKDHB)
ECB: 100065300(BCKDHB)
EPZ: 103548489(BCKDHB)
EAI: 106842946(BCKDHB)
MYB: 102251028(BCKDHB)
MYD: 102772900(BCKDHB)
MNA: 107532843(BCKDHB)
HAI: 109387808(BCKDHB)
DRO: 112319233(BCKDHB)
PALE: 102897408(BCKDHB)
RAY: 107513203(BCKDHB)
LAV: 100658914(BCKDHB)
TMU: 101359226
MDO: 100023799(BCKDHB)
SHR: 100929078(BCKDHB)
PCW: 110200281(BCKDHB)
OAA: 100081828(BCKDHB)
GGA: 395375(BCKDHB)
MGP: 100546491(BCKDHB)
CJO: 107312019(BCKDHB)
NMEL: 110395994(BCKDHB)
APLA: 101790102(BCKDHB)
ACYG: 106048592(BCKDHB)
TGU: 100229803(BCKDHB)
LSR: 110476540(BCKDHB)
SCAN: 103819615(BCKDHB)
GFR: 102035852(BCKDHB)
FAB: 101817399(BCKDHB)
PHI: 102114644(BCKDHB)
PMAJ: 107202246(BCKDHB)
CCAE: 111925781(BCKDHB)
CCW: 104692725(BCKDHB)
ETL: 114070040(BCKDHB)
FPG: 101918832(BCKDHB)
FCH: 102056703(BCKDHB)
CLV: 102097651(BCKDHB)
EGZ: 104132743(BCKDHB)
NNI: 104021975(BCKDHB)
ACUN: 113478223(BCKDHB)
PADL: 103924589(BCKDHB)
AAM: 106489720(BCKDHB)
ASN: 102373010(BCKDHB)
AMJ: 102573276(BCKDHB)
PSS: 102445517(BCKDHB)
CMY: 102938690(BCKDHB)
CPIC: 101944574(BCKDHB)
ACS: 100558130(bckdhb)
PVT: 110080851(BCKDHB)
PBI: 103061299(BCKDHB)
PMUR: 107288223(BCKDHB)
TSR: 106542266(BCKDHB)
PMUA: 114593900(BCKDHB)
GJA: 107109437(BCKDHB)
XLA: 100137712(bckdhb.S) 108704172(bckdhb.L)
XTR: 100496384(bckdhb)
NPR: 108783998(BCKDHB)
DRE: 569980(bckdhb)
SRX: 107713906 107726253(bckdhb)
CCAR: 109048510
IPU: 108270547(bckdhb)
PHYP: 113526938(bckdhb)
AMEX: 103035891(bckdhb)
EEE: 113572547(bckdhb)
TRU: 101068467(bckdhb)
LCO: 104929947(bckdhb)
MZE: 101482476(bckdhb)
ONL: 100693722(bckdhb)
OLA: 101170333(bckdhb)
XMA: 102217625(bckdhb)
XCO: 114144908(bckdhb)
PRET: 103478247(bckdhb)
CVG: 107096762(bckdhb)
NFU: 107378906(bckdhb)
KMR: 108234210(bckdhb)
ALIM: 106533401(bckdhb)
AOCE: 111566637(bckdhb)
CSEM: 103388676(bckdhb)
POV: 109632021(bckdhb)
LCF: 108887582(bckdhb)
SDU: 111227756(bckdhb)
SLAL: 111658083(bckdhb)
HCQ: 109529677(bckdhb)
BPEC: 110171699(bckdhb)
MALB: 109972616(bckdhb)
ELS: 105030455(bckdhb)
SFM: 108937150(bckdhb)
PKI: 111844565(bckdhb)
LCM: 102353777(BCKDHB)
CMK: 103186186(bckdhb)
RTP: 109932311(bckdhb)
BFO: 118422807
CIN: 100179963
APLC: 110974428
SKO: 100367645
DME: Dmel_CG17691(CG17691)
DER: 6541787
DSE: 6620766
DSI: Dsimw501_GD17911(Dsim_GD17911)
DAN: 6498492
DSR: 110188784
DPE: 6597984
DAZ: 108610092
DNV: 108658064
DHE: 111594685
DVI: 6629175
MDE: 101899884
LCQ: 111680010
AAG: 23687479
AALB: 109418091
AME: 409306
BIM: 100742658
BTER: 100644396
CCAL: 108632813
OBB: 114872504
SOC: 105193267
MPHA: 105836687
AEC: 105143319
ACEP: 105624994
PBAR: 105425985
VEM: 105560259
HST: 105192268
DQU: 106742952
CFO: 105259501
LHU: 105673874
PGC: 109858256
OBO: 105277981
PCF: 106787820
NVI: 100119698
CSOL: 105362793
MDL: 103577021
TCA: 663575
ATD: 109602051
NVL: 108557424
BMOR: 101739671
BMAN: 114251703
PMAC: 106720197
PRAP: 111002787
HAW: 110378583
TNL: 113500866
PXY: 105386601
API: 100165320
DNX: 107171294
AGS: 114120843
BTAB: 109032819
CLEC: 106665018
ZNE: 110833988
FCD: 110862199
PVM: 113826872
TUT: 107363634
DPTE: 113790813
CSCU: 111628196
PTEP: 107436294
CEL: CELE_F27D4.5(bckd-1B)
CBR: CBG00293 CBG00294(Cbr-tag-173)
BMY: Bm1_56495
TSP: Tsp_11960
PCAN: 112565560
CRG: 105348639
MYI: 110452582
OBI: 106875153
LAK: 106160310
NVE: 5499764
EPA: 110234578
ADF: 107343196
AMIL: 114954656
PDAM: 113665641
SPIS: 111322504
DGT: 114535070
HMG: 100204367
ATH: AT1G55510(BCDH_BETA1) AT3G13450(DIN4)
CRB: 17899006
BNA: 106360358
BOE: 106336164
CPAP: 110809588
CIT: 102626842
TCC: 18589127
GRA: 105768044
GAB: 108466884
DZI: 111286735
EGR: 104422272
VRA: 106754885
VAR: 108346238
VUN: 114165058
CCAJ: 109803250
CAM: 101489657
LJA: Lj3g3v1591670.1(Lj3g3v1591670.1)
LANG: 109351461
FVE: 101311948
RCN: 112203450
PPER: 18771997
PMUM: 103321304
PAVI: 110759005
ZJU: 107419342
CSV: 101216174
CMO: 103492412
MCHA: 111016561
CMAX: 111484908
CMOS: 111461465
CPEP: 111779935
RCU: 8282158
JCU: 105640999
HBR: 110632317
MESC: 110602490
POP: 7461342
PEU: 105126074
JRE: 109003661
VVI: 100248427
SLY: 101254327
SPEN: 107008312
SOT: 102584009
NSY: 104243639
NAU: 109215342
INI: 109152449
SIND: 105170579
OEU: 111384935
HAN: 110908658
LSV: 111898616
CCAV: 112521519
DCR: 108211788
BVG: 104889831
SOE: 110790429
NNU: 104597693
OSA: 4342508
DOSA: Os07t0170100-01(Os07g0170100)
OBR: 102722510
BDI: 100822469
ATS: 109764102(LOC109764102)
SBI: 110432906
ZMA: 100273293(pco118301)
SITA: 101770216
PDA: 103718364
EGU: 105035247
MUS: 103995099
DCT: 110102598
PEQ: 110024247
AOF: 109832959
ATR: 18421443
PPP: 112273577
MNG: MNEG_8236
APRO: F751_4000
SLB: AWJ20_885(PDB1)
NCR: NCU03913
NTE: NEUTE1DRAFT88048(NEUTE1DRAFT_88048)
MGR: MGG_06511
SSCK: SPSK_09224
MAW: MAC_03510
MAJ: MAA_02197
CMT: CCM_04631
MBE: MBM_06483
ANI: AN8559.2
ANG: ANI_1_400114(An13g03150)
ABE: ARB_07981
TVE: TRV_04270
PTE: PTT_13322
CNE: CNA03850
CNB: CNBA3660
ABP: AGABI1DRAFT34834(AGABI1DRAFT_34834)
ABV: AGABI2DRAFT63983(AGABI2DRAFT_63983)
DDI: DDB_G0268020(bkdB)
DFA: DFA_02206(bkdB)
PCB: PCHAS_110390(PC000864.02.0)
TAN: TA06600
TPV: TP01_0956
BBO: BBOV_IV008190(23.m06335)
SPAR: SPRG_04186
VNI: VIBNI_A0969(bkdA2)
PAE: PA2248(bkdA2)
PAEV: N297_2321(bkdA2)
PAEI: N296_2321(bkdA2)
PAU: PA14_35520(bkdA2)
PAP: PSPA7_2993(bkdA2)
PAG: PLES_30561(bkdA2)
PAF: PAM18_2792(bkdA2)
PNC: NCGM2_3257(bkdA2)
PAEB: NCGM1900_4283(bkdA2)
PAEP: PA1S_14380
PAEM: U769_13965
PAEL: T223_15610
PAEU: BN889_02452(bkdA2)
PAEG: AI22_19475
PAEC: M802_2318(bkdA2)
PAEO: M801_2320(bkdA2)
PCQ: PcP3B5_35990(bkdA2)
PPU: PP_4402(bkdAB)
PPF: Pput_1452
PPT: PPS_3806
PPI: YSA_07992
PPX: T1E_5100(bkdA2)
PPUH: B479_18915
PPUT: L483_24355
PPUN: PP4_13590(bkdA2)
PPUD: DW66_4239
PMON: X969_18290
PMOT: X970_17925
PFL: PFL_2533(bkdA2)
PPRC: PFLCHA0_c25960(bkdA1)
PPRO: PPC_2577(bkdA2)
PFS: PFLU_3965
PFE: PSF113_2345(bkdA2)
PFC: PflA506_3338(bkdA2)
PFB: VO64_1046
PMAN: OU5_6090
PFW: PF1751_v1c34240(bkdA2)
PEN: PSEEN3854(bkdA2)
PPUU: PputUW4_02963(bkdA2)
PKC: PKB_2849(bkdA2)
PSEM: TO66_12335
PSEC: CCOS191_1451(bkdA2)
PSOS: POS17_2535(bkdA2)
PANR: A7J50_3620
PSIL: PMA3_15765
SON: SO_2340(bkdA2)
SDN: Sden_1787
SFR: Sfri_1936
SAZ: Sama_1710
SLO: Shew_1926
SSE: Ssed_2328
SPL: Spea_2245
SHL: Shal_2233
SWD: Swoo_2279
SWP: swp_2605
SVO: SVI_2043
SPSW: Sps_00790
ILO: IL1679
CPS: CPS_1583
PHA: PSHAa1631(bkdA2)
PTN: PTRA_a2026(bkdA2)
PAT: Patl_2037
PSM: PSM_A1604(bkdA2)
PSEO: OM33_10870
PEA: PESP_a2047(bkdA2)
PSPO: PSPO_a1578(bkdA2)
PART: PARC_a1891(bkdA2)
PTU: PTUN_a2017(bkdA2)
PNG: PNIG_a2138(bkdA2)
PTD: PTET_a1855(bkdA2)
PSEN: PNC201_08395(bkdA2)
PAGA: PAGA_a1867(bkdA2)
MAQ: Maqu_1381
MHC: MARHY2010(bkdA2)
MBS: MRBBS_2857(bkdB)
AMAL: I607_09635
AMAE: I876_10100
AMAO: I634_10045
AMAD: I636_10245
AMAI: I635_10640
AMAG: I533_09870
AMAC: MASE_09535
AAUS: EP12_10200
GNI: GNIT_1900(bkdA2)
GPS: C427_2946(bkdA2)
FBL: Fbal_2357
SAGA: M5M_15970
HCH: HCH_03686
HEL: HELO_2371(bkdA2)
HAM: HALO2325
HBE: BEI_1741
HOL: HORIV_33820(bkdA2)
HAXI: HAALTHF_36480n(bkdA2)
OCE: GU3_06470
BMA: BMAA2012
BMAL: DM55_3787(bkdA2)
BMAE: DM78_4392(bkdA2)
BMAQ: DM76_4484(bkdA2)
BMAI: DM57_06040
BMAF: DM51_3687(bkdA2)
BMAZ: BM44_3746(bkdA2)
BMAB: BM45_4522(bkdA2)
BPS: BPSS2272(bkdA2)
BPM: BURPS1710b_A1410(bkdA2)
BPSE: BDL_5747(bkdA2)
BPSM: BBQ_3832(bkdA2)
BPSU: BBN_5768(bkdA2)
BPSD: BBX_4915(bkdA2)
BPZ: BP1026B_II2447(bkdA2)
BPK: BBK_5052(bkdA2)
BPSH: DR55_5458(bkdA2)
BPSA: BBU_3717(bkdA2)
BPSO: X996_5229(bkdA2)
BUT: X994_4777(bkdA2)
BTQ: BTQ_5590(bkdA2)
BTJ: BTJ_4245(bkdA2)
BTZ: BTL_5055(bkdA2)
BTD: BTI_4843(bkdA2)
BTV: BTHA_5167(bkdA2)
BTHE: BTN_4713(bkdA2)
BTHM: BTRA_4979(bkdA2)
BTHA: DR62_4820
BTHL: BG87_5047(bkdA2)
BOK: DM82_4059(bkdA2)
BOC: BG90_3969(bkdA2)
BCN: Bcen_0763
BCJ: BCAL1213(bkdA2)
BCEN: DM39_6352(bkdA2)
BCEW: DM40_1899(bkdA2)
BCEO: I35_1124(bkdA2)
BAM: Bamb_1124
BCT: GEM_2216
BCED: DM42_478(bkdA2)
BCON: NL30_09475
BUB: BW23_5909(bkdA2)
BLAT: WK25_06220
BTEI: WS51_16575
BSEM: WJ12_06070
BPSL: WS57_16595
BMEC: WJ16_05845
BSTG: WT74_18530
BGU: KS03_3386(bkdA2)
BGO: BM43_7060(bkdA2)
BUL: BW21_4369(bkdA2)
BGP: BGL_2c02410(bkdA2)
BPT: Bpet3510(bkdA2)
AXY: AXYL_02630(bkdA)
AXX: ERS451415_02353(bkdA2)
PUT: PT7_0837
RFR: Rfer_3553
POL: Bpro_0274
VPD: VAPA_1c10770(bkdA2)
RTA: Rta_10490(bkdA2)
ADE: Adeh_1826
MXA: MXAN_4565
CCX: COCOR_04760(bkdA2)
SUR: STAUR_4870 STAUR_4887(esg1b)
SCL: sce1570(pdhB1)
CCRO: CMC5_066690(bkdA2)
HOH: Hoch_3236
MLO: mll4472
MHUA: MCHK_5642
AMIH: CO731_01639(bkdA2)
SME: SMc03202(bkdAb)
SMX: SM11_chr3105(bkdAb)
SMI: BN406_02790(bkdA2)
SMEL: SM2011_c03202(bkdAb)
SMER: DU99_16165
SMD: Smed_2827
RHI: NGR_c29900(bkdA2)
SFD: USDA257_c54060(bkdA2)
SAME: SAMCFNEI73_Ch3363(bkdA)
EAD: OV14_0459(bkdA2)
ATU: Atu3472(bkdA2)
ATF: Ach5_33310(bkdA2)
RET: RHE_PC00071(bkDa2)
REL: REMIM1_PB00072(bkdA2)
REP: IE4803_PD00071(bkdA2)
REI: IE4771_PE00071(bkdA2)
RLE: pRL100304
RLG: Rleg_6502
RIR: BN877_II0488(bkdA2)
RHL: LPU83_pLPU83d0280(bkdA2)
RGA: RGR602_PC01284(bkdA2)
RHN: AMJ98_PB00089(bkdA2)
RPHA: AMC79_PA00096(bkdA2)
RHT: NT26_2593(bkdAb)
RHX: AMK02_PB00088(bkdA2)
RHK: Kim5_PD00071(bkdA2)
REZ: AMJ99_PA00089(bkdA2)
SHZ: shn_32695
BME: BMEII0747
BMEL: DK63_2498(bkdA2)
BMEE: DK62_2907(bkdA2)
BMF: BAB2_0714
BABO: DK55_2681(bkdA2)
BABR: DO74_3098(bkdA2)
BABT: DK49_2557(bkdA2)
BABB: DK48_3116(bkdA2)
BABU: DK53_2684(bkdA2)
BABS: DK51_2167(bkdA2)
BABC: DO78_2372(bkdA2)
BMS: BRA0525
BSZ: DK67_2522(bkdA2)
BOV: BOV_A0456
BCAR: DK60_2239(bkdA2)
BCAS: DA85_12985
BMR: BMI_II519
BPP: BPI_II506
BPV: DK65_3105(bkdA2)
OAN: Oant_3552
OAH: DR92_2935(bkdA2)
OCH: CES85_4238(bkdA2)
BJA: blr6332(bkdA2)
BOS: BSY19_711
MAQU: Maq22A_c19020(acoB)
PHL: KKY_1078
CAK: Caul_1871
BVY: NCTC9239_00231(bkdA2)
PDE: Pden_4758
PAMN: pAMV3p0450(odbB)
LAQU: R2C4_00530
MALG: MALG_04599
SPSE: SULPSESMR1_00015(bkdA2)
RID: RIdsm_00821(bkdA2_1)
HBA: Hbal_1615
GAK: X907_0932
NAR: Saro_1975
SAL: Sala_1330
SPHK: SKP52_08355(bkdA2)
SPHP: LH20_11280
SMAZ: LH19_09660
SGI: SGRAN_2144(pdhB)
SPHU: SPPYR_0633(bkdA) SPPYR_1441(bkdA) SPPYR_2049(bkdA)
SPHM: G432_01720
STAX: MC45_11225
SPHI: TS85_18135
SSAN: NX02_27215
SPKC: KC8_03340
SECH: B18_23315
SJP: SJA_C1-13000(bkdA2)
SSY: SLG_09660(bkdA2)
SPMI: K663_11025
SPHB: EP837_02341(bkdA)
SPHR: BSY17_190
SINB: SIDU_07790
SPHT: K426_07825
SFLA: SPHFLASMR4Y_01143(bkdA2)
BLAS: BSY18_846
SMIC: SmB9_02020(bkdA2)
ELI: ELI_05160
ERF: FIU90_09175(bkdA2)
AAY: WYH_00348(bkdA2)
ANH: A6F65_01539(bkdA2)
ADO: A6F68_02031(bkdA2)
ALB: AEB_P1788
SHUM: STHU_18060
TMO: TMO_b0191
BBA: Bd0974
BBAT: Bdt_0918
BBW: BDW_03330
BBAC: EP01_14965
BEX: A11Q_795
BSU: BSU24040(bkdAB)
BSR: I33_2482
BSL: A7A1_3639
BSH: BSU6051_24040(bkdAB)
BSUT: BSUB_02578(bkdAB)
BSUL: BSUA_02578(bkdAB)
BSUS: Q433_13145
BSS: BSUW23_11885(bkdAB)
BST: GYO_2649
BSO: BSNT_08836(bkdAB)
BSQ: B657_24040(bkdAB)
BSX: C663_2285(bkdAB)
BLI: BL01505(bkdAB)
BLD: BLi02581(bkdAB)
BLH: BaLi_c26650(bkdAB)
BAQ: BACAU_2245(bkdAB)
BYA: BANAU_2384(bkdAB)
BAMP: B938_11535
BAML: BAM5036_2155(bkdAB)
BAMA: RBAU_2368(bkdAB)
BAMN: BASU_2157(bkdAB)
BAMB: BAPNAU_1353(bkdAB)
BAMT: AJ82_12645
BAMY: V529_25050(bkdAB)
BMP: NG74_02337(bfmBAB)
BAO: BAMF_2301(bkdAB)
BAZ: BAMTA208_12325(bkdAB)
BQL: LL3_02590(bkdA)
BXH: BAXH7_02513(bkdAB)
BQY: MUS_2694(bkdAB)
BAMI: KSO_008235
BAMC: U471_23070
BAMF: U722_12160
BAN: BA_4383(bfmbAb)
BAR: GBAA_4383(bfmbAb)
BAT: BAS4066
BAH: BAMEG_4420(bfmbAb)
BAI: BAA_4402(bfmbAb)
BANT: A16_43800
BANR: A16R_44340
BANS: BAPAT_4204
BANV: DJ46_3069(bfmBAB)
BCE: BC4158
BCA: BCE_4233(bfmbAb)
BCZ: BCE33L3913(bfmbAb)
BCR: BCAH187_A4291(bfmbAb)
BCB: BCB4264_A4271(bfmbAb)
BCU: BCAH820_4181(bfmbAb)
BCG: BCG9842_B0963(bfmbAb)
BCQ: BCQ_3948(bfmbAb)
BCX: BCA_4270(bfmbAb)
BAL: BACI_c41270(bfmbAb)
BNC: BCN_4074
BCF: bcf_20680
BCER: BCK_14375
BTK: BT9727_3904(bfmbAb)
BTL: BALH_3771(bfmbAb)
BTB: BMB171_C3821(bfmbAb)
BTT: HD73_4463
BTHI: BTK_21975
BTC: CT43_CH4174(bfmbAb)
BTM: MC28_3452(bfmBAB)
BTG: BTB_c43020(bfmBAB)
BTI: BTG_28595
BTW: BF38_5329(bfmBAB)
BWW: bwei_0785(bfmBAB)
BMYO: BG05_1860(bfmBAB)
BMYC: DJ92_1260(bfmBAB)
BTRO: FJR70_14570(bfmBAB)
BPU: BPUM_2143
BPUM: BW16_11630
BPUS: UP12_10885
BMQ: BMQ_4438(bkdAB)
BMD: BMD_4424(bkdAB)
BMH: BMWSH_0797(bkdAB)
BMEG: BG04_1356(bfmBAB)
BAG: Bcoa_2876
BCOA: BF29_692(bfmBAB)
BMET: BMMGA3_11320(bfmBAB)
BACW: QR42_10835
BACP: SB24_17565
BACB: OY17_14430
BACO: OXB_2730
BACY: QF06_10210
BACL: BS34A_26400(bkdAB)
BALM: BsLM_2358
BEO: BEH_19425
BGY: BGLY_2859(bfmBAB)
BBEV: BBEV_1322(bfmBAB)
BFD: NCTC4823_01913(bkdAB)
BHA: BH2762(bfmBAB)
BCL: ABC2450(bkdA2)
BPF: BpOF4_01415(bfmBAB)
BKW: BkAM31D_16785(bfmBAB_2)
OIH: OB1865
GKA: GK2377
GTN: GTNG_2306
GGH: GHH_c24500(bkdAB)
GEA: GARCT_02356(bfmBAB)
AFL: Aflv_0963(bkdAB)
ANM: GFC28_3799(bfmBAB)
AAMY: GFC30_2566(bfmBAB)
ANL: GFC29_1634(bfmBAB)
AXL: AXY_11880(bkdB)
LSP: Bsph_3493
HLI: HLI_19575
VPN: A21D_03292(bfmBAB)
PASA: BAOM_3645
PSYO: PB01_11450
BSE: Bsel_2252
SAU: SA1347(bfmBAB)
SAV: SAV1516(bfmBAB)
SAW: SAHV_1504(bfmBAB)
SAM: MW1469(bfmBAB)
SAS: SAS1455
SAR: SAR1594(bfmBAB)
SAC: SACOL1561
SAE: NWMN_1422
SAD: SAAV_1509
SUE: SAOV_1517
SUJ: SAA6159_01452(bfmBAB)
SUK: SAA6008_01486(bfmBAB)
SUZ: MS7_1534(bfmBAB)
SUX: SAEMRSA15_14370(bfmBAB)
SUW: SATW20_15130(bfmBAB)
SUG: SAPIG1582
SUF: SARLGA251_14230(bfmBAB)
SAUA: SAAG_01431
SAUS: SA40_1388(bfmBAB)
SAUU: SA957_1471(bfmBAB)
SAUG: SA268_1475(bfmBAB)
SAUZ: SAZ172_1531(bfmBAB)
SAUT: SAI1T1_2011020(bfmBAB)
SAUJ: SAI2T2_1011040(bfmBAB)
SAUK: SAI3T3_1011020(bfmBAB)
SAUQ: SAI4T8_1011030(bfmBAB)
SAUV: SAI7S6_1011040(bfmBAB)
SAUW: SAI5S5_1010990(bfmBAB)
SAUX: SAI6T6_1011000(bfmBAB)
SAUY: SAI8T7_1011030(bfmBAB)
SAUF: X998_1528
SAB: SAB1389c
SUY: SA2981_1475(bfmBAB)
SAUB: C248_1559(bfmBAB)
SAUC: CA347_1514(bfmBAB)
SAUR: SABB_00439
SAUI: AZ30_07735
SAUD: CH52_11485
SAMS: NI36_08190
SER: SERP1077
SEP: SE1197
SEPP: SEB_01217
SEPS: DP17_156
SHA: SH1399(bfmBAB)
SHH: ShL2_01283(bfmBAB_2)
SSP: SSP1239
SCA: SCA_1138(bfmBAB)
SLN: SLUG_13960(bfmBAB)
SDT: SPSE_1284
SPAS: STP1_0092
SCAP: AYP1020_0815(bfmBAB)
SSCH: LH95_06210
SSCZ: RN70_06390
SAGQ: EP23_03410
SDP: NCTC12225_01499(bfmBAB)
LMO: lmo1373
LMOC: LMOSLCC5850_1432(bfmBAB)
LMOD: LMON_1436
LMOW: AX10_00940
LMOQ: LM6179_2116(bkdAB)
LMR: LMR479A_1460(bkdAB)
LMOM: IJ09_03145
LMOG: BN389_13970(bfmBAB)
LMP: MUO_07085
LMOL: LMOL312_1369(bfmBAB)
LMOX: AX24_04325
LMQ: LMM7_1458(bkdA2)
LML: lmo4a_1430(bfmBAB)
LMS: LMLG_2976
LMW: LMOSLCC2755_1375(bfmBAB)
LMX: LMOSLCC2372_1434(bfmBAB)
LMZ: LMOSLCC2482_1425(bfmBAB)
LMON: LMOSLCC2376_1327(bfmBAB)
LMOS: LMOSLCC7179_1343(bfmBAB)
LMOO: LMOSLCC2378_1386(bfmBAB)
LMOY: LMOSLCC2479_1433(bfmBAB)
LMOT: LMOSLCC2540_1423(bfmBAB)
LMOA: LMOATCC19117_1380(bfmBAB)
LMOK: CQ02_07055
LIN: BfmBAB
LWE: lwe1388
LSG: lse_1289
LIV: LIV_1324
LGZ: NCTC10812_01311(bfmBAB)
ESI: Exig_0920
EAN: Eab7_0890
PPY: PPE_02821
PPM: PPSC2_14965(dxpS)
PPO: PPM_3008(dxpS)
PPOL: X809_31375
PPOY: RE92_21750
PMS: KNP414_02695(bfmBAB)
PMW: B2K_14920
PLV: ERIC2_c12570(bfmBAB)
PSAB: PSAB_16485
PRI: PRIO_4646(bfmBAB)
PSWU: SY83_19065
PBK: Back11_24210(bfmbAb)
ASOC: CB4_03316(bfmBAB)
COHN: KCTCHS21_25050(bfmbAb)
BTS: Btus_1310
SIV: SSIL_1716
JEO: JMA_20770
KUR: ASO14_1284(bfmBAB)
KZO: NCTC404_02394(bfmBAB)
LCA: LSEI_1444
LCS: LCBD_1647
LCE: LC2W_1614
LCW: BN194_16390(bfmBAB)
LPAP: LBPC_1367
LCB: LCABL_16670(bkdB)
EFA: EF1659(bkdB)
EFL: EF62_2037(bkdB)
EFI: OG1RF_11371(bkdB)
EFS: EFS1_1415(bkdB)
EFN: DENG_01831(bkdA2)
EFQ: DR75_658(bfmBAB)
JDA: BW727_101908(bfmBAB)
STH: STH2161
SAY: TPY_3787(bkdA2)
LPIL: LIP_0824
RXY: Rxyl_2479
AYM: YM304_17910(bkdA2)
RCA: Rcas_3062
CAU: Caur_1692
CAG: Cagg_2096
HAU: Haur_2592
STI: Sthe_3476
ABAT: CFX1CAM_0235(bfmBAB)
DRA: DR_0030
DGE: Dgeo_2339
DFC: DFI_13670
TRA: Trad_0747
TTH: TT_C1756
TTJ: TTHA0230
TSC: TSC_c02390(acoB)
TAQ: TO73_0139
MRB: Mrub_2321
TTR: Tter_0094
PUV: PUV_02580(bkdB-B)
WCH: wcw_0465(pdhB1)
GES: VT84_03815(bfmBAB)
IPA: Isop_0417
KST: KSMBR1_3307(pdh)
SUS: Acid_0353
GBA: J421_3597
NDE: NIDE3114
NMV: NITMOv2_0059(bkdAB)
NJA: NSJP_0544(bfmBAB)
 » show all

KEGG   ORTHOLOGY: K11381
Entry
K11381                      KO                                     

Name
bkdA
Definition
2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4]
Pathway
ko00280  Valine, leucine and isoleucine degradation
ko00640  Propanoate metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00640 Propanoate metabolism
    K11381  bkdA; 2-oxoisovalerate dehydrogenase E1 component
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K11381  bkdA; 2-oxoisovalerate dehydrogenase E1 component
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.4  3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
     K11381  bkdA; 2-oxoisovalerate dehydrogenase E1 component
Other DBs
RN: R01701 R01702 R04225 R07599 R07600 R07601 R07602 R07603 R07604 R10996 R10997
GO: 0003863
Genes
PLU: plu1883 plu2795
PLUM: A4R40_09435 A4R40_13935
PAY: PAU_02673
PTT: VY86_21735
XNE: XNC1_1758
XNM: XNC2_1709
SML: Smlt3207
SMT: Smal_2640
BUJ: BurJV3_2657
SMZ: SMD_2785
PSUW: WQ53_14705
LEZ: GLE_3052(tkB)
LEM: LEN_1986
DKO: I596_3224
RBD: ALSL_1588
SDN: Sden_3017
SAZ: Sama_2795
SLO: Shew_0901
SWD: Swoo_1035
SVO: SVI_0813
SPSW: Sps_04622
ILO: IL0177(acoA)
GPS: C427_1074
PIN: Ping_2782
MICC: AUP74_00234(bfmBAB_1)
LPN: lpg2581
LPH: LPV_2911
LPO: LPO_2846
LPM: LP6_2613
LPF: lpl2503
LPP: lpp2633
LPC: LPC_0566
LPA: lpa_03775
LPE: lp12_2574
LLO: LLO_0636
LFA: LFA_2505
LHA: LHA_2872
LOK: Loa_00611
LCD: clem_02070(pdhB_1)
LLG: 44548918_02381(pdhB_2)
LJR: NCTC11533_02551(pdhB_2)
LCJ: NCTC11976_01391(pdhB_1)
LWA: SAMEA4504053_3062(pdhB_2)
TMC: LMI_0355
METL: U737_21135
HCH: HCH_06123
HCO: LOKO_03072(pdhB)
KKO: Kkor_1768
KGE: TQ33_0687
AXX: ERS451415_05624(acoB)
TCL: Tchl_1479
GSU: GSU3019
HOH: Hoch_2652
MHUA: MCHK_6040
RPOD: E0E05_16370(pdhA)
SME: SM_b20020(pdh)
SMX: SM11_pD0027(pdh)
SMEL: SM2011_b20020(pdh)
SMER: DU99_25595
SMD: Smed_4110
SFH: SFHH103_06013(pdh)
ARA: Arad_3395(bkdA2)
RLE: pRL80083
SHZ: shn_32490
BMF: BAB2_0031
BMS: BRA0032
BOV: BOV_A0029
BPV: DK65_2424
XAU: Xaut_1571
PLEO: OHA_2_00074(acoB)
MMED: Mame_01542(pdhB)
BRN: D1F64_18965(pdhA)
SIL: SPO0585
RUT: FIU92_18270(pdhB)
RSP: RSP_1294
JAN: Jann_3081
RDE: RD1_2926(pdhB)
DSH: Dshi_2566
PGD: Gal_03423
OCT: FTO60_06210(pdhA)
LAQU: R2C4_18820
RSU: NHU_04397
RID: RIdsm_04372(pdhB)
ROH: FIU89_00840(bfmBAB1)
ROT: FIV09_09055(pdhB)
MALU: KU6B_35060(bkdA)
TGL: HFZ77_16950(pdhA)
NAR: Saro_1045
SAL: Sala_2962
SPHP: LH20_21640
SMAZ: LH19_24970
SGI: SGRAN_0415(mfs)
SPHU: SPPYR_3770
SMIC: SmB9_16910
MAG: amb0073
MAGX: XM1_2654
MAGN: WV31_20215
HTQ: FRZ44_43250(bkdA)
HADH: FRZ61_41140(bkdA)
MAI: MICA_1997
MAN: A11S_1918
BMX: BMS_1223 BMS_3178(pdhAB)
CSS: Cst_c08650(acoB1)
CSD: Clst_0830(pdhE)
OVA: OBV_27000
CSC: Csac_0874
ATE: Athe_0704
MMC: Mmcs_1976
MKM: Mkms_2022
MJL: Mjls_1956
MVQ: MYVA_2369
MTHN: 4412656_03742(acoB)
MHAS: MHAS_01025(bfmBAB)
MDU: MDUV_29300(bkdA)
ASD: AS9A_2449
NFA: NFA_35780
NFR: ERS450000_00478(pdhB)
NSR: NS506_04175(bkdA)
NAD: NCTC11293_04914(pdhB)
RER: RER_04420(acoA_acoB)
ROP: ROP_28430
RHB: NY08_1992
RRT: 4535765_04190(pdhB)
GOM: D7316_02551(acoA)
BCV: Bcav_3854
MPH: MLP_13240
NCA: Noca_4454
KFL: Kfla_0894
PSIM: KR76_25410
SRO: Sros_6420
SEN: SACE_3884
AMD: AMED_7122(bkdA)
AMN: RAM_36570
AMM: AMES_7014(bkdA)
AMZ: B737_7014(bkdA)
AMQ: AMETH_1829(bkdA)
KAL: KALB_2837
ACTI: UA75_21855
ACAD: UA74_21380
AHG: AHOG_18860(pdhB)
SAQ: Sare_3610
MIL: ML5_3598
ASE: ACPL_1533
ACTN: L083_1776
AFS: AFR_08790
ACTS: ACWT_1412
TBI: Tbis_2156
CWO: Cwoe_0566
GVI: gll1094
CAP: CLDAP_19200(acoA_acoB) CLDAP_34870
CTR: CT_340(pdhA_B)
CTD: CTDEC_0340(pdhA_B)
CTF: CTDLC_0340(pdhA_B)
CTA: CTA_0369(pdhA_2)
CTY: CTR_3381
CRA: CTO_0369
CTRQ: A363_00363
CTB: CTL0594
CTO: CTL2C_951
CTJ: JALI_3381
CTZ: CTB_3381
CSW: SW2_3451
CES: ESW3_3451
CTRB: BOUR_00360
CTEC: EC599_3501
CFS: FSW4_3451
CFW: FSW5_3451
CTFW: SWFP_3661
CTCH: O173_01855
CTRI: BN197_3431
CTRA: BN442_3431
CTCT: CTW3_01855
CMU: TC_0618
CMUR: Y015_03255
CMX: DNC_03135
CMZ: TAC_03255
CPN: CPn0033(pdhA_pdhB)
CPA: CP_0743
CPJ: pdhA_pdhB(pdhA_pdhB)
CPT: CpB0037
CPM: G5S_0669
CPEC: CPE3_0322
CPEO: CPE1_0322
CPER: CPE2_0322
CHB: G5O_0359
CHR: Cpsi_3261
CPSC: B711_0381
CPSN: B712_0357
CPSB: B595_0380
CPSG: B598_0360
CPSM: B602_0357
CPSI: B599_0356
CPSV: B600_0382
CPSW: B603_0363
CPST: B601_0358
CPSD: BN356_3251
CPSA: AO9_01720
CCA: CCA_00324(pdhA_pdhB)
CAB: CAB319
CABO: AB7_3581
CFE: CF0679(pdhAB)
CHLA: C834K_0349(bfmBAB_1)
SNG: SNE_A05470(bfmBAB)
OTE: Oter_4204
OBG: Verru16b_01586(bfmBAB)
CAA: Caka_2205
MFF: MFFC18_09840(bfmBAB)
GES: VT84_03185(acoA_1)
PBAS: SMSP2_02972(acoA_2)
ALUS: STSP2_02442(acoA_1)
ACA: ACP_3156
ABAS: ACPOL_4126
ABAC: LuPra_05932(bfmBAB)
BTH: BT_0312
BTHO: Btheta7330_03065(bfmBAB)
BFR: BF1622
BXY: BXY_15220
BOA: Bovatus_00157(bfmBAB)
BCEL: BcellWH2_03587(bfmBAB)
PMUC: ING2E5A_1160(acoB1) ING2E5A_1267(acoB3)
PSAC: PSM36_2182
PDI: BDI_0687
BLQ: L21SP5_00503(bkdA2)
MBAS: ALGA_0753
SRM: SRM_00667(acoA_pdhA) SRM_02182(bkdA2)
PHE: Phep_3824
SMIZ: 4412673_02991(pdhB)
MUC: MuYL_0745
MGOT: MgSA37_00323(bfmBAB_1)
CHU: CHU_3183(dxs)
DFE: Dfer_3632
SLI: Slin_4914
LBY: Lbys_3002
FAE: FAES_5448
PSEZ: HME7025_00518(tktA)
GFO: GFO_1616
GFL: GRFL_3286
FPS: FP1028(bfmBA)
FJO: Fjoh_2840
FJG: BB050_03756(bfmBAB)
FIN: KQS_06850(bfmBA)
FSN: GS03_00110(dxs_1) GS03_02105(dxs_4)
ZPR: ZPR_2696
MARM: YQ22_18220
CBAL: M667_15670
CBAT: M666_15670
DDO: I597_1121(bfmBAB_2) I597_1939(bfmBAB_3)
ZGA: ZOBELLIA_4392(bkdA1)
MLT: VC82_2847
MPW: MPR_1189
KOS: KORDIASMS9_01974(bfmBAB) KORDIASMS9_03561(bfmBAB)
KAN: IMCC3317_04280(bfmBAB_1) IMCC3317_21600(bfmBAB_2)
MARF: CJ739_3508
MESQ: C7H62_2430
FBA: FIC_01383
RAI: RA0C_0601
RAR: RIA_1891
RAG: B739_1688
RAE: G148_1238
RAT: M949_2069
EAO: BD94_2725
ELB: VO54_03939(bfmBAB_2)
CHZ: CHSO_1586(pdhA2)
CTAK: 4412677_00824(bfmBAB)
IAL: IALB_1650(bkdA)
MRO: MROS_2258
CABY: Cabys_3508
DTU: Dtur_0419
HTU: Htur_2793
NVR: FEJ81_04080(pdhA)
 » show all

KEGG   ENZYME: 1.2.4.4
Entry
EC 1.2.4.4                  Enzyme                                 

Name
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring);
2-oxoisocaproate dehydrogenase;
2-oxoisovalerate (lipoate) dehydrogenase;
3-methyl-2-oxobutanoate dehydrogenase (lipoamide);
3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating);
alpha-keto-alpha-methylvalerate dehydrogenase;
alpha-ketoisocaproate dehydrogenase;
alpha-ketoisocaproic dehydrogenase;
alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase;
alpha-ketoisovalerate dehydrogenase;
alpha-oxoisocaproate dehydrogenase;
BCKDH (ambiguous);
BCOAD;
branched chain keto acid dehydrogenase;
branched-chain (-2-oxoacid) dehydrogenase (BCD);
branched-chain 2-keto acid dehydrogenase;
branched-chain 2-oxo acid dehydrogenase;
branched-chain alpha-keto acid dehydrogenase;
branched-chain alpha-oxo acid dehydrogenase;
branched-chain keto acid dehydrogenase;
branched-chain ketoacid dehydrogenase;
dehydrogenase, 2-oxoisovalerate (lipoate);
dehydrogenase, branched chain alpha-keto acid
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With a disulfide as acceptor
Sysname
3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)
Reaction(IUBMB)
3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2 [RN:R01701]
Reaction(KEGG)
Substrate
3-methyl-2-oxobutanoate [CPD:C00141];
[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine
Product
[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine [CPD:C15977];
CO2 [CPD:C00011]
Comment
Contains thiamine diphosphate. It acts not only on 3-methyl-2-oxobutanaoate, but also on 4-methyl-2-oxopentanoate and (S)-3-methyl-2-oxopentanoate, so that it acts on the 2-oxo acids that derive from the action of transaminases on valine, leucine and isoleucine. It is a component of the multienzyme 3-methyl-2-oxobutanoate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.168, dihydrolipoyllysine-residue (2-methylpropanoyl)transferase, which also binds multiple copies of EC 1.8.1.4, dihydrolipoyl dehydrogenase. It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.168.
History
EC 1.2.4.4 created 1972 (EC 1.2.4.3 created 1972, incorporated 1978), modified 2003
Pathway
ec00280  Valine, leucine and isoleucine degradation
ec00640  Propanoate metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00166  2-oxoisovalerate dehydrogenase E1 component alpha subunit
K00167  2-oxoisovalerate dehydrogenase E1 component beta subunit
K11381  2-oxoisovalerate dehydrogenase E1 component
Genes
HSA: 593(BCKDHA) 594(BCKDHB)
PTR: 462845(BCKDHB) 468889(BCKDHA)
PPS: 100970081(BCKDHB) 100980379(BCKDHA)
GGO: 101132793(BCKDHB)
PON: 100173401(BCKDHB) 100462553(BCKDHA)
NLE: 100583180(BCKDHA) 100597493(BCKDHB)
MCC: 106994773(BCKDHA) 704978 718472(BCKDHB)
MCF: 102134149(BCKDHA) 102136327(BCKDHB)
CSAB: 103234732(BCKDHA) 103239988(BCKDHB)
RRO: 104676082(BCKDHA) 104682059(BCKDHB)
RBB: 108512608(BCKDHB) 108536156(BCKDHA)
CJC: 100402568(BCKDHB) 100407780(BCKDHA)
SBQ: 101033639(BCKDHB) 101049760(BCKDHA)
MMU: 12039(Bckdha) 12040(Bckdhb)
MCAL: 110298425(Bckdha) 110302385(Bckdhb)
MPAH: 110327310(Bckdhb) 110336437(Bckdha)
RNO: 25244(Bckdha) 29711(Bckdhb)
MUN: 110546461(Bckdhb) 110561191(Bckdha)
CGE: 100774234(Bckdha) 100774277(Bckdhb)
NGI: 103751518(Bckdha)
HGL: 101705928(Bckdha) 101725476(Bckdhb)
OCU: 100352048(BCKDHA) 100353682(BCKDHB)
TUP: 102478510(BCKDHB) 102488938(BCKDHA)
CFA: 474978(BCKDHB) 484488(BCKDHA)
VVP: 112926383(BCKDHB) 112928345(BCKDHA)
AML: 100476045(BCKDHB) 100484116(BCKDHA)
UMR: 103657422(BCKDHB) 103677383(BCKDHA)
UAH: 113243532(BCKDHA) 113261078(BCKDHB)
ORO: 101363773(BCKDHA)
FCA: 101080635(BCKDHB) 101087186(BCKDHA)
PTG: 102960450(BCKDHA) 102961522(BCKDHB)
PPAD: 109257969(BCKDHA) 109263332(BCKDHB)
AJU: 106976576(BCKDHB) 106987684(BCKDHA)
BTA: 282149(BCKDHA) 282150(BCKDHB)
BOM: 102284478(BCKDHA) 102284531(BCKDHB)
BIU: 109563728(BCKDHB) 109572632(BCKDHA)
BBUB: 102399961(BCKDHB) 102412125(BCKDHA)
CHX: 102171071(BCKDHB) 102171539(BCKDHA)
OAS: 100145857(BCKDHA) 101113939(BCKDHB)
SSC: 100142666(BCKDHA) 100142669(BCKDHB)
CFR: 102504954(BCKDHA) 102512847(BCKDHB)
CDK: 105093370(BCKDHA) 105103856(BCKDHB)
BACU: 103004548(BCKDHA) 103010716(BCKDHB)
LVE: 103074708(BCKDHA) 103084139(BCKDHB)
OOR: 101282899(BCKDHB) 101285178(BCKDHA)
DLE: 111180820(BCKDHA) 111183211(BCKDHB)
PCAD: 102976890(BCKDHA) 102993749(BCKDHB)
ECB: 100065300(BCKDHB) 100068678(BCKDHA)
EPZ: 103548489(BCKDHB) 103562535(BCKDHA)
EAI: 106842946(BCKDHB) 106843817(BCKDHA)
MYB: 102240537(BCKDHA) 102251028(BCKDHB)
MYD: 102772900(BCKDHB) 102774136(BCKDHA)
MNA: 107532843(BCKDHB) 107534219(BCKDHA)
HAI: 109376595(BCKDHA) 109387808(BCKDHB)
DRO: 112319233(BCKDHB) 112320080(BCKDHA)
PALE: 102880923(BCKDHA) 102897408(BCKDHB)
RAY: 107505492(BCKDHA) 107513203(BCKDHB)
MJV: 108383692(BCKDHA)
LAV: 100654926(BCKDHA) 100658914(BCKDHB)
MDO: 100019333(BCKDHA) 100023799(BCKDHB)
SHR: 100929078(BCKDHB)
PCW: 110200281(BCKDHB) 110202383(BCKDHA)
OAA: 100081828(BCKDHB) 100088094(BCKDHA)
GGA: 374210(BCKDHA) 395375(BCKDHB)
MGP: 100546491(BCKDHB)
CJO: 107307112(BCKDHA) 107312019(BCKDHB)
NMEL: 110395994(BCKDHB)
APLA: 101790102(BCKDHB) 113841943(BCKDHA)
ACYG: 106048592(BCKDHB)
TGU: 100229803(BCKDHB)
LSR: 110476540(BCKDHB) 110478789(BCKDHA)
SCAN: 103819615(BCKDHB)
GFR: 102035852(BCKDHB)
FAB: 101817399(BCKDHB)
PHI: 102103341 102114644(BCKDHB)
PMAJ: 107202246(BCKDHB)
CCAE: 111925781(BCKDHB)
CCW: 104692725(BCKDHB)
ETL: 114070040(BCKDHB)
FPG: 101913651(BCKDHA) 101918832(BCKDHB)
FCH: 102056420(BCKDHA) 102056703(BCKDHB)
CLV: 102097651(BCKDHB)
EGZ: 104132743(BCKDHB)
NNI: 104021975(BCKDHB)
ACUN: 113478223(BCKDHB)
PADL: 103924589(BCKDHB)
AAM: 106489720(BCKDHB)
ASN: 102371000(BCKDHA) 102373010(BCKDHB)
AMJ: 102573276(BCKDHB) 102576924(BCKDHA)
PSS: 102445517(BCKDHB)
CMY: 102933976(BCKDHA) 102938690(BCKDHB)
CPIC: 101937607(BCKDHA) 101944574(BCKDHB)
ACS: 100554302(bckdha) 100558130(bckdhb)
PVT: 110080851(BCKDHB) 110088527(BCKDHA)
PBI: 103048497(BCKDHA) 103061299(BCKDHB)
PMUR: 107288223(BCKDHB) 107295271(BCKDHA)
TSR: 106542266(BCKDHB) 106554144(BCKDHA)
PMUA: 114593900(BCKDHB) 114603299(BCKDHA)
GJA: 107109437(BCKDHB) 107119235(BCKDHA)
XLA: 100137712(bckdhb.S) 108698630(bckdha.L) 108700580(bckdha.S) 108704172(bckdhb.L)
XTR: 100036656(bckdha) 100496384(bckdhb)
NPR: 108783998(BCKDHB) 108786664(BCKDHA)
DRE: 554124(bckdha) 569980(bckdhb)
SRX: 107705067(bckdha) 107713906 107726253(bckdhb) 107758241
IPU: 108264709(bckdha) 108270547(bckdhb)
PHYP: 113526699(bckdha) 113526938(bckdhb)
AMEX: 103035891(bckdhb) 103041479(bckdha)
EEE: 113572547(bckdhb) 113589579(bckdha)
TRU: 101068467(bckdhb) 101069065(bckdha)
LCO: 104925937(bckdha) 104929947(bckdhb)
NCC: 104941573(bckdha)
MZE: 101474711(bckdha) 101482476(bckdhb)
ONL: 100693722(bckdhb) 100706080(bckdha)
OLA: 101166649(bckdha) 101170333(bckdhb)
XMA: 102217625(bckdhb) 102219548(bckdha)
PRET: 103475058(bckdha) 103478247(bckdhb)
CVG: 107090653(bckdha) 107096762(bckdhb)
NFU: 107378906(bckdhb) 107380153(bckdha)
KMR: 108234210(bckdhb) 108248794(bckdha)
ALIM: 106529845(bckdha) 106533401(bckdhb)
AOCE: 111566637(bckdhb) 111579603(bckdha)
CSEM: 103377990(bckdha) 103388676(bckdhb)
POV: 109630405(bckdha) 109632021(bckdhb)
LCF: 108876199(bckdha) 108887582(bckdhb)
SDU: 111216769(bckdha) 111227756(bckdhb)
SLAL: 111658083(bckdhb) 111662265(bckdha)
HCQ: 109510859(bckdha) 109529677(bckdhb)
BPEC: 110163607(bckdha) 110171699(bckdhb)
MALB: 109963278(bckdha) 109972616(bckdhb)
ELS: 105029594(bckdha) 105030455(bckdhb)
SFM: 108924819(bckdha) 108937150(bckdhb)
PKI: 111837928 111841455(bckdha) 111841457 111844565(bckdhb)
LCM: 102353777(BCKDHB) 102364931(BCKDHA)
CMK: 103172759(bckdha) 103186186(bckdhb)
RTP: 109926907(bckdha) 109932311(bckdhb)
DME: Dmel_CG17691(CG17691) Dmel_CG8199(CG8199)
DSI: Dsimw501_GD17911(Dsim_GD17911) Dsimw501_GD18623(Dsim_GD18623)
CEL: CELE_F27D4.5(bckd-1B) CELE_Y39E4A.3(bckd-1A)
CBR: CBG00293 CBG00294(Cbr-tag-173) CBG15770 CBG15799
TSP: Tsp_11960
AQU: 100633338
LJA: Lj1g3v0912020.1(Lj1g3v0912020.1) Lj1g3v1340510.1(Lj1g3v1340510.1) Lj3g3v1591670.1(Lj3g3v1591670.1)
DOSA: Os07t0170100-01(Os07g0170100) Os12t0183100-01(Os12g0183100)
ATS: 109734458(LOC109734458) 109764102(LOC109764102)
ZMA: 100191513(pco079304) 100273293(pco118301)
MNG: MNEG_8236
SLB: AWJ20_2913(PDA1) AWJ20_885(PDB1)
NTE: NEUTE1DRAFT124643(NEUTE1DRAFT_124643) NEUTE1DRAFT88048(NEUTE1DRAFT_88048)