KEGG   ORTHOLOGY: K00192
Entry
K00192                      KO                                     

Name
cdhA
Definition
anaerobic carbon-monoxide dehydrogenase, CODH/ACS complex subunit alpha [EC:1.2.7.4]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00422  Acetyl-CoA pathway, CO2 => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K00192  cdhA; anaerobic carbon-monoxide dehydrogenase, CODH/ACS complex subunit alpha
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.7  With an iron-sulfur protein as acceptor
    1.2.7.4  anaerobic carbon monoxide dehydrogenase
     K00192  cdhA; anaerobic carbon-monoxide dehydrogenase, CODH/ACS complex subunit alpha
Other DBs
RN: R07157
COG: COG1152
GO: 0043885
Genes
DAU: Daud_0105
MJA: MJ_0153
MFE: Mefer_0203
MVU: Metvu_1187
MFS: MFS40622_0120
MIF: Metin_1030
MJH: JH146_0004
MIG: Metig_1381
MMP: MMP0985(cdhA)
MMQ: MmarC5_0805
MMD: GYY_05750
MMAK: MMKA1_10980(cdhA) MMKA1_11410(cdhA)
MMAO: MMOS7_10770(cdhA)
MMAD: MMJJ_00060
METF: CFE53_02830(cdhA)
MTH: MTH_1708
MMG: MTBMA_c02870(cdhA1) MTBMA_c14200(cdhA2) MTBMA_c14210(cdhA3)
METC: MTCT_1561
MWO: MWSIV6_0249(cdhA1) MWSIV6_0986(cdhA3)
MTHM: FZP57_01125(cdhA)
METH: MBMB1_1565(cdhA)
MFC: BRM9_0801(cdhA)
MFI: DSM1535_0763(cdhA)
MCUB: MCBB_1821(cdhA)
METT: CIT01_07270(cdhA)
METO: CIT02_10120(cdhA)
MFV: Mfer_0527
MKA: MK0717(cdhA_1) MK0719(cdhA_1)
FPL: Ferp_0731
GAC: GACE_0359
GAH: GAH_01139
MAC: MA_1016(cdhA) MA_3860(cdhA) MA_4399(cdhA)
MTHR: MSTHT_2340
MTHE: MSTHC_0940
MFZ: AOB57_003735(cdhA)
MBU: Mbur_0858
MMET: MCMEM_0990
MMH: Mmah_1166
MPY: Mpsy_2895
MZI: HWN40_08225(cdhA)
MTP: Mthe_0292
MCJ: MCON_1332(cdhA)
MHU: Mhun_0690
MBN: Mboo_1373
RCI: LRC456(cdhA)
BARC: AOA65_0464(cdhA2)
BARB: AOA66_1428(cdhA2)
AG: AAC44650(cdhA)
 » show all
Reference
PMID:8955306
  Authors
Maupin-Furlow JA, Ferry JG
  Title
Analysis of the CO dehydrogenase/acetyl-coenzyme A synthase operon of Methanosarcina thermophila.
  Journal
J Bacteriol 178:6849-56 (1996)
DOI:10.1128/JB.178.23.6849-6856.1996
  Sequence

KEGG   ORTHOLOGY: K00195
Entry
K00195                      KO                                     

Name
cdhB
Definition
anaerobic carbon-monoxide dehydrogenase, CODH/ACS complex subunit epsilon
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00422  Acetyl-CoA pathway, CO2 => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K00195  cdhB; anaerobic carbon-monoxide dehydrogenase, CODH/ACS complex subunit epsilon
Other DBs
RN: R07157
COG: COG1880
Genes
DAU: Daud_0106
ROO: G5S37_21600
MJA: MJ_0154
MFE: Mefer_0202
MVU: Metvu_1186
MFS: MFS40622_0119
MIF: Metin_1031
MJH: JH146_0003
MIG: Metig_1380
MMP: MMP0984(cdh)
MMD: GYY_05745
MMAK: MMKA1_10970(cdhB) MMKA1_11400(cdhB)
MMAO: MMOS7_10760(cdhB)
MMAD: MMJJ_00070
MTH: MTH_1709
MMG: MTBMA_c02880(cdhB1) MTBMA_c14190(cdhB2)
METC: MTCT_1562
MWO: MWSIV6_0250(cdhB_1) MWSIV6_0989(cdhB_3)
METH: MBMB1_1564(cdhB)
MFC: BRM9_0800(cdhB)
MFI: DSM1535_0762(cdhB)
MCUB: MCBB_1820(cdhB)
MFV: Mfer_0526
MKA: MK0718(cdhB)
FPL: Ferp_0732
GAC: GACE_0358
GAH: GAH_01140
MAC: MA_1015(cdhB) MA_3861(cdhB)
MTHR: MSTHT_2339
MTHE: MSTHC_0941
MFZ: AOB57_003740(cdhB)
MBU: Mbur_0859
MMET: MCMEM_0991
MMH: Mmah_1167
MPY: Mpsy_2894
MZI: HWN40_08230(cdhB)
MTP: Mthe_0291
MCJ: MCON_1331(cdhB)
MHU: Mhun_0689
MBN: Mboo_1372
RCI: LRC458(cdhB)
BARC: AOA65_0453(cdhB)
BARB: AOA66_1429(cdhB)
LOKI: Lokiarch_15810(cdhB2)
AG: AAC44651(cdhB)
 » show all
Reference
PMID:8955306
  Authors
Maupin-Furlow JA, Ferry JG
  Title
Analysis of the CO dehydrogenase/acetyl-coenzyme A synthase operon of Methanosarcina thermophila.
  Journal
J Bacteriol 178:6849-56 (1996)
DOI:10.1128/JB.178.23.6849-6856.1996
  Sequence

KEGG   ORTHOLOGY: K00196
Entry
K00196                      KO                                     

Name
cooF
Definition
anaerobic carbon-monoxide dehydrogenase iron sulfur subunit
Pathway
ko00633  Nitrotoluene degradation
ko00680  Methane metabolism
ko00720  Carbon fixation pathways in prokaryotes
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00720 Carbon fixation pathways in prokaryotes
    K00196  cooF; anaerobic carbon-monoxide dehydrogenase iron sulfur subunit
   00680 Methane metabolism
    K00196  cooF; anaerobic carbon-monoxide dehydrogenase iron sulfur subunit
  09111 Xenobiotics biodegradation and metabolism
   00633 Nitrotoluene degradation
    K00196  cooF; anaerobic carbon-monoxide dehydrogenase iron sulfur subunit
Other DBs
RN: R07157 R08034
COG: COG1142
Genes
CAMA: F384_12625
AVN: Avin_04500(cooF)
AVL: AvCA_04500(cooF)
AVD: AvCA6_04500(cooF)
ACX: Achr_4460(cooF)
MAH: MEALZ_0764
MBUR: EQU24_17605
SEDS: AAY24_06510
EBA: ebA5004
RBH: B4966_01400
AZO: azo2931
AOA: dqs_3071
AZA: AZKH_1615
SMUL: SMUL_1306
SHAL: SHALO_1293
GSU: GSU1238 GSU2096(cooF)
GME: Gmet_1755
GBM: Gbem_0071(cooF) Gbem_0313
GEO: Geob_1048(cooF) Geob_3278
GEB: GM18_1820
PCA: Pcar_0059(cooF-2) Pcar_0887(cooF-1)
DVU: DVU2293(cooF)
DVL: Dvul_0962
DVM: DvMF_3187
DDE: Dde_0476
DDS: Ddes_1887
DGG: DGI_2741
DTR: RSDT_0226(cooF)
DAS: Daes_1525
DPI: BN4_20191(cooF)
PPRF: DPRO_0386
DBA: Dbac_2008
DRT: Dret_1841
DML: Dmul_02410(hydN) Dmul_19110(cooF)
SFU: Sfum_2874
RPC: RPC_4499
RRU: Rru_A1426
MAG: amb2921
MAGX: XM1_2181
HTL: HPTL_1472
CPE: CPE1796
CPF: CPF_2051(narB)
CPR: CPR_1766(narB)
CBO: CBO1332
CBA: CLB_1360
CBH: CLC_1370
CBY: CLM_1507
CBL: CLK_0776
CBB: CLD_3225
CBI: CLJ_B1447
CBF: CLI_1427
CBM: CBF_1403
CPAS: Clopa_1483
CPAT: CLPA_c34380(cooF)
CPAE: CPAST_c34380(cooF)
HHW: NCTC503_01566(cooF)
CTH: Cthe_0199
ESR: ES1_07080
ESU: EUS_23830
CCEL: CCDG5_0793
RCH: RUM_02430
BPRO: PMF13cell1_02126(ydhY_1) PMF13cell1_02406(dmsB_1) PMF13cell1_04202(dmsB_3)
CSCI: HDCHBGLK_01916(ydhY)
PHX: KGNDJEFE_00544(padI)
SLP: Slip_1564
SALQ: SYNTR_0028
PTH: PTH_0486(HycB) PTH_0609(HycB)
TTE: TTE1707(HybA)
THX: Thet_0615
TIT: Thit_1268
TKI: TKV_c20110(cooF)
CHY: CHY_0086(cooF1) CHY_0735(cooF2) CHY_1713 CHY_1825(cooF3)
MTA: Moth_1291
MTHO: MOTHE_c12740(cooF)
MTHZ: MOTHA_c13600(cooF)
TTM: Tthe_0616
TSH: Tsac_1233
TAE: TepiRe1_0597(cooF)
MANA: MAMMFC1_02735(cooF)
STED: SPTER_01620(cooF_1)
DET: DET1133
DEH: cbdbA1061
DEV: DhcVS_951
DMC: btf_1034
DMD: dcmb_1018
DMG: GY50_0966
DUC: UCH007_09120(hydN)
DEW: DGWBC_0687(cooF)
KST: KSMBR1_2434(cooF)
EPO: Epro_0363
ETI: RSTT_138
RSD: TGRD_160
TTK: TST_0011
TMA: TM0396
TMW: THMA_0401
TMQ: THMB_0401
TMX: THMC_0401
TPT: Tpet_0524
TRQ: TRQ2_0538
TNA: CTN_0273
TNP: Tnap_0188
MMP: MMP1502(porF) MMP1503(porE)
MMAK: MMKA1_17260(porF) MMKA1_17270(porE)
MMAO: MMOS7_16080(porF) MMOS7_16090(porE)
MMAD: MMJJ_13350(hyfA_2) MMJJ_13360(cooF)
MTH: MTH_1737
METE: tca_01000(cooF_1) tca_01682(cooF_3) tca_01683(hyfA)
MRU: mru_0552(porE) mru_0553(porF)
MSI: Msm_0561
MEB: Abm4_1436(porE) Abm4_1437(porF)
MMIL: sm9_0403(porE)
MEYE: TL18_02100
MFC: BRM9_0773(porE) BRM9_0774(porF)
MKA: MK0084
AFU: AF_0950
TON: TON_1017
TGA: TGAM_0823
THE: GQS_04550
PPAC: PAP_00975
MBAR: MSBR2_0096
MBAK: MSBR3_0094
MAC: MA_3283(cooF)
MMA: MM_0122
MMAC: MSMAC_2549
METM: MSMTP_1178
MTHR: MSTHT_0127
MTHE: MSTHC_0601
MHOR: MSHOH_2497
MTP: Mthe_1340
MCJ: MCON_2866
MHI: Mhar_1629
MHU: Mhun_1271
MPL: Mpal_0841
MEZ: Mtc_2234
POG: Pogu_1050
ASC: ASAC_0693
ACIA: SE86_00625
BARC: AOA65_0065(hmeA_1) AOA65_0447(hmeA_2) AOA65_1877
BARB: AOA66_0230(mvhB_1) AOA66_1499(mvhB_2)
PSYT: DSAG12_02801(hmeA)
 » show all
Reference
  Authors
Gonzalez JM, Robb FT
  Title
Genetic analysis of Carboxydothermus hydrogenoformans carbon monoxide dehydrogenase genes cooF and cooS.
  Journal
FEMS Microbiol Lett 191:243-7 (2000)
DOI:10.1111/j.1574-6968.2000.tb09346.x
  Sequence
[chy:CHY_0086]

KEGG   ORTHOLOGY: K00198
Entry
K00198                      KO                                     

Name
cooS, acsA
Definition
anaerobic carbon-monoxide dehydrogenase catalytic subunit [EC:1.2.7.4]
Pathway
ko00633  Nitrotoluene degradation
ko00680  Methane metabolism
ko00720  Carbon fixation pathways in prokaryotes
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00377  Reductive acetyl-CoA pathway (Wood-Ljungdahl pathway)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00720 Carbon fixation pathways in prokaryotes
    K00198  cooS, acsA; anaerobic carbon-monoxide dehydrogenase catalytic subunit
   00680 Methane metabolism
    K00198  cooS, acsA; anaerobic carbon-monoxide dehydrogenase catalytic subunit
  09111 Xenobiotics biodegradation and metabolism
   00633 Nitrotoluene degradation
    K00198  cooS, acsA; anaerobic carbon-monoxide dehydrogenase catalytic subunit
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.7  With an iron-sulfur protein as acceptor
    1.2.7.4  anaerobic carbon monoxide dehydrogenase
     K00198  cooS, acsA; anaerobic carbon-monoxide dehydrogenase catalytic subunit
Other DBs
RN: R07157 R08034
COG: COG1151
GO: 0043885
Genes
CAMA: F384_12620
AVN: Avin_04490(cooS)
AVL: AvCA_04490(cooS)
AVD: AvCA6_04490(cooS)
ACX: Achr_4450(cooS)
TMB: Thimo_0223
CCV: CCV52592_1131(codH)
CCO: CCC13826_0236(codH)
CGRA: CGRAC_1999
SULT: FA592_03290(cooS)
GSU: GSU2098(cooS)
GME: Gmet_1902(cooS)
GUR: Gura_0618
GBM: Gbem_0072(cooS-2) Gbem_1736(cooS-1)
GEO: Geob_0362(cooS-1) Geob_1046(cooS-2)
PCA: Pcar_0057(cooS-2) Pcar_0888(cooS-1)
DES: DSOUD_1182(cooS)
DEU: DBW_0138
DVU: DVU2098(cooS)
DVL: Dvul_1133
DVM: DvMF_2233
DDE: Dde_3028
DDS: Ddes_0382
DMA: DMR_25780
DEF: CNY67_12835(cooS)
DFL: DFE_2686
DCB: C3Y92_11905(cooS)
DMS: E8L03_07465(cooS)
DSD: GD606_18530(cooS)
DAS: Daes_0529
DPI: BN4_11760(cooS) BN4_20190(cooS)
PPRF: DPRO_1606(cooS) DPRO_3530
DSX: GD604_08985(cooS)
DBA: Dbac_0934
DRT: Dret_1234
DML: Dmul_09300(cooS1) Dmul_19100(cooS2) Dmul_30840(cdhA)
DAT: HRM2_16670(cdhA) HRM2_41010(cdh1) HRM2_43440(cdh2)
DTO: TOL2_C00990(cdh1) TOL2_C11820(cdhA) TOL2_C38110(cooS)
DOV: DSCO28_32360(cooS_1) DSCO28_36040(cooS_2) DSCO28_44770 DSCO28_59740(cooS_3)
DWD: DSCW_28520(cooS_1) DSCW_41580(cooS_2) DSCW_47510(cooS_3)
DALK: DSCA_26710(cooS_1) DSCA_27610(cooS_2) DSCA_28100(cooS_3)
DAX: FDQ92_02155(cooS) FDQ92_06245(cooS)
DBR: Deba_0241
RPC: RPC_4498
RRU: Rru_A1427
RRF: F11_07370
BBEV: BBEV_2326(cooS1)
CAE: SMB_G0117(cooS) SMB_G2533
CTC: CTC_01156
CNO: NT01CX_0669(cooS)
CBH: CLC_1369
CBN: CbC4_2402(cooS)
CKL: CKL_2148
CKR: CKR_1887
CLJ: CLJU_c09110(cooS1) CLJU_c17910(cooS2) CLJU_c37670(codH)
CSR: Cspa_c16740(cooS1) Cspa_c21120(cooS2) Cspa_c57670(cooS3)
CPAT: CLPA_c05080(cooS) CLPA_c34390(cooS1)
CPAE: CPAST_c05080(cooS) CPAST_c34390(cooS1)
CSB: CLSA_c11710(cooS1) CLSA_c14830(cooS2)
CLD: CLSPO_c13520(cooS1) CLSPO_c22620(cooS2)
CTYK: CTK_C21760(cooS)
CDY: F3K33_15405(cooS) F3K33_25905(cooS)
CCOH: SAMEA4530647_0946(cooS1_1)
HHW: NCTC503_01567(cooS1)
CAZO: G3A45_00240(cooS)
SARJ: HH195_01185(cooS)
CTH: Cthe_2801
CSS: Cst_c19650(cooS1)
CSD: Clst_1883
CTHD: CDO33_08275(cooS)
RUM: CK1_12690
ROB: CK5_28700
BHAN: CGC63_06525(cooS) CGC63_07980(cooS)
BLAU: DQQ01_10205(cooS)
BPRO: PMF13cell1_00639(cooS1_1) PMF13cell1_04203(cooS) PMF13cell1_04285(cooS1_2)
BLAB: EYS05_16735(cooS)
EHL: EHLA_2243
RGN: RGna_12250(cooS)
CBOL: CGC65_03955(cooS) CGC65_24000(cooS)
CDF: CD630_01740(cooS) CD630_07160(cooS)
PDF: CD630DERM_01740(cooS) CD630DERM_07160(cooS1)
ROC: HF520_11320(cooS)
PHX: KGNDJEFE_00543(cooS)
DRM: Dred_0652
DAU: Daud_0870
SGY: Sgly_2814
DED: DHBDCA_p230(cooS1)
DEC: DCF50_p290(cooS1)
TFR: BR63_06565(cooS)
ELM: ELI_3603
EMT: CPZ25_018705(cooS)
AWO: Awo_c10740(acsA) Awo_c19050(cooS)
AMIJ: EQM06_02755(cooS)
TTE: TTE1708
TKI: TKV_c08080(cooS) TKV_c20100(acsA)
CHY: CHY_0034(cooSV) CHY_0085(cooSII) CHY_0736(cooSIV) CHY_1824(cooSI)
ADG: Adeg_0335
TPZ: Tph_c05730(cooS1) Tph_c15180(acsB)
CSC: Csac_0400
TACI: TDSAC_0035
TAE: TepiRe1_0598(cooS)
HALS: D7D81_07270(cooS) D7D81_07945(cooS)
CAD: Curi_c06440(cooS)
VPR: Vpar_0209
VRM: 44547418_00230(cooS2)
VDN: NCTC11831_00196(cooS1)
KST: KSMBR1_1326(cdh_acsA) KSMBR1_3765(acsA_2)
TAZ: TREAZ_1535(cooS_2) TREAZ_1650(cooS_1)
TPI: TREPR_3069(cooS)
TOH: BCB71_06635(cooS)
CPC: Cpar_1193
PMX: PERMA_0106(cooS)
CTHI: THC_1754
TAV: G4V39_00810(cooS) G4V39_01690(cooS)
TMAI: FVE67_00270(cooS)
MJA: MJ_0728
MVO: Mvol_0200
MKA: MK0536
AFU: AF_1849
GAC: GACE_0127
GAH: GAH_01577
TON: TON_1018
TGA: TGAM_0824(cooS)
THS: TES1_1211
THH: CDI07_07345(cooS)
MBAK: MSBR3_0095
MAC: MA_1309(cooS) MA_3282(cooS)
MTHR: MSTHT_0128
MTHE: MSTHC_0600
MPY: Mpsy_0694
MZI: HWN40_01045(cooS)
MCJ: MCON_2865(cooS)
MHI: Mhar_1630
MHU: Mhun_1272
MBG: BN140_2260(cooS)
MEMA: MMAB1_2986(cooS)
MPI: Mpet_0907
MBN: Mboo_0884
MPL: Mpal_0842
HDF: AArcSl_0878(cooS)
KCR: Kcr_0762
BARC: AOA65_1716(cdhA)
 » show all
Reference
  Authors
Gonzalez JM, Robb FT
  Title
Genetic analysis of Carboxydothermus hydrogenoformans carbon monoxide dehydrogenase genes cooF and cooS.
  Journal
FEMS Microbiol Lett 191:243-7 (2000)
DOI:10.1111/j.1574-6968.2000.tb09346.x
  Sequence
[chy:CHY_0085]
Reference
  Authors
Doukov TI, Iverson TM, Seravalli J, Ragsdale SW, Drennan CL
  Title
A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase.
  Journal
Science 298:567-72 (2002)
DOI:10.1126/science.1075843
  Sequence
[mta:Moth_1203]

KEGG   ENZYME: 1.2.7.4
Entry
EC 1.2.7.4                  Enzyme                                 

Name
anaerobic carbon monoxide dehydrogenase;
Ni-CODH;
carbon-monoxide dehydrogenase (ferredoxin)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With an iron-sulfur protein as acceptor
Sysname
carbon-monoxide,water:ferredoxin oxidoreductase
Reaction(IUBMB)
CO + H2O + 2 oxidized ferredoxin = CO2 + 2 reduced ferredoxin + 2 H+ [RN:R07157]
Reaction(KEGG)
R07157;
(other) R08034 R09317
Substrate
CO [CPD:C00237];
H2O [CPD:C00001];
oxidized ferredoxin [CPD:C00139]
Product
CO2 [CPD:C00011];
reduced ferredoxin [CPD:C00138];
H+ [CPD:C00080]
Comment
This prokaryotic enzyme catalyses the reversible reduction of CO2 to CO. The electrons are transferred to redox proteins such as ferredoxin. In purple sulfur bacteria and methanogenic archaea it catalyses the oxidation of CO to CO2, which is incorporated by the Calvin-Benson-Basham cycle or released, respectively. In acetogenic and sulfate-reducing microbes it catalyses the reduction of CO2 to CO, which is incorporated into acetyl CoA by EC 2.3.1.169, CO-methylating acetyl-CoA synthase, with which the enzyme forms a tight complex in those organisms. The enzyme contains five metal clusters per homodimeric enzyme: two nickel-iron-sulfur clusters called the C-Clusters, one [4Fe-4S] D-cluster; and two [4Fe-4S] B-clusters. In methanogenic archaea additional [4Fe-4S] clusters exist, presumably as part of the electron transfer chain. In purple sulfur bacteria the enzyme forms complexes with the Ni-Fe-S protein EC 1.12.7.2, ferredoxin hydrogenase, which catalyse the overall reaction: CO + H2O = CO2 + H2. cf. EC 1.2.5.3, aerobic carbon monoxide dehydrogenase.
History
EC 1.2.7.4 created 2003 (EC 1.2.99.2 created 1982, modified 1990, modified 2003, incorporated 2015), modified 2016
Pathway
ec00633  Nitrotoluene degradation
ec00680  Methane metabolism
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00192  anaerobic carbon-monoxide dehydrogenase, CODH/ACS complex subunit alpha
K00198  anaerobic carbon-monoxide dehydrogenase catalytic subunit
Genes
CAMA: F384_12620
AVN: Avin_04490(cooS)
AVL: AvCA_04490(cooS)
AVD: AvCA6_04490(cooS)
ACX: Achr_4450(cooS)
TMB: Thimo_0223
CCV: CCV52592_1131(codH)
CCO: CCC13826_0236(codH)
CGRA: CGRAC_1999
SULT: FA592_03290(cooS)
GSU: GSU2098(cooS)
GME: Gmet_1902(cooS)
GUR: Gura_0618
GBM: Gbem_0072(cooS-2) Gbem_1736(cooS-1)
GEO: Geob_0362(cooS-1) Geob_1046(cooS-2)
PCA: Pcar_0057(cooS-2) Pcar_0888(cooS-1)
DES: DSOUD_1182(cooS)
DEU: DBW_0138
DVU: DVU2098(cooS)
DVL: Dvul_1133
DVM: DvMF_2233
DDE: Dde_3028
DDS: Ddes_0382
DMA: DMR_25780
DEF: CNY67_12835(cooS)
DFL: DFE_2686
DCB: C3Y92_11905(cooS)
DMS: E8L03_07465(cooS)
DSD: GD606_18530(cooS)
DAS: Daes_0529
DPI: BN4_11760(cooS) BN4_20190(cooS)
PPRF: DPRO_1606(cooS) DPRO_3530
DSX: GD604_08985(cooS)
DBA: Dbac_0934
DRT: Dret_1234
DML: Dmul_09300(cooS1) Dmul_19100(cooS2) Dmul_30840(cdhA)
DAT: HRM2_16670(cdhA) HRM2_41010(cdh1) HRM2_43440(cdh2)
DTO: TOL2_C00990(cdh1) TOL2_C11820(cdhA) TOL2_C38110(cooS)
DOV: DSCO28_32360(cooS_1) DSCO28_36040(cooS_2) DSCO28_44770 DSCO28_59740(cooS_3)
DWD: DSCW_28520(cooS_1) DSCW_41580(cooS_2) DSCW_47510(cooS_3)
DALK: DSCA_26710(cooS_1) DSCA_27610(cooS_2) DSCA_28100(cooS_3)
DAX: FDQ92_02155(cooS) FDQ92_06245(cooS)
DBR: Deba_0241
RPC: RPC_4498
RRU: Rru_A1427
RRF: F11_07370
BBEV: BBEV_2326(cooS1)
CAE: SMB_G0117(cooS) SMB_G2533
CTC: CTC_01156
CNO: NT01CX_0669(cooS)
CBH: CLC_1369
CBN: CbC4_2402(cooS)
CKL: CKL_2148
CKR: CKR_1887
CLJ: CLJU_c09110(cooS1) CLJU_c17910(cooS2) CLJU_c37670(codH)
CSR: Cspa_c16740(cooS1) Cspa_c21120(cooS2) Cspa_c57670(cooS3)
CPAT: CLPA_c05080(cooS) CLPA_c34390(cooS1)
CPAE: CPAST_c05080(cooS) CPAST_c34390(cooS1)
CSB: CLSA_c11710(cooS1) CLSA_c14830(cooS2)
CLD: CLSPO_c13520(cooS1) CLSPO_c22620(cooS2)
CTYK: CTK_C21760(cooS)
CDY: F3K33_15405(cooS) F3K33_25905(cooS)
CCOH: SAMEA4530647_0946(cooS1_1)
HHW: NCTC503_01567(cooS1)
CAZO: G3A45_00240(cooS)
SARJ: HH195_01185(cooS)
CTH: Cthe_2801
CSS: Cst_c19650(cooS1)
CSD: Clst_1883
CTHD: CDO33_08275(cooS)
RUM: CK1_12690
ROB: CK5_28700
BHAN: CGC63_06525(cooS) CGC63_07980(cooS)
BLAU: DQQ01_10205(cooS)
BPRO: PMF13cell1_00639(cooS1_1) PMF13cell1_04203(cooS) PMF13cell1_04285(cooS1_2)
BLAB: EYS05_16735(cooS)
EHL: EHLA_2243
RGN: RGna_12250(cooS)
CBOL: CGC65_03955(cooS) CGC65_24000(cooS)
CDF: CD630_01740(cooS) CD630_07160(cooS)
PDF: CD630DERM_01740(cooS) CD630DERM_07160(cooS1)
ROC: HF520_11320(cooS)
PHX: KGNDJEFE_00543(cooS)
DRM: Dred_0652
SGY: Sgly_2814
DED: DHBDCA_p230(cooS1)
DEC: DCF50_p290(cooS1)
TFR: BR63_06565(cooS)
ELM: ELI_3603
EMT: CPZ25_018705(cooS)
AWO: Awo_c10740(acsA) Awo_c19050(cooS)
AMIJ: EQM06_02755(cooS)
TTE: TTE1708
TKI: TKV_c08080(cooS) TKV_c20100(acsA)
CHY: CHY_0034(cooSV) CHY_0085(cooSII) CHY_0736(cooSIV) CHY_1824(cooSI)
ADG: Adeg_0335
TPZ: Tph_c05730(cooS1) Tph_c15180(acsB)
CSC: Csac_0400
TACI: TDSAC_0035
TAE: TepiRe1_0598(cooS)
HALS: D7D81_07270(cooS) D7D81_07945(cooS)
CAD: Curi_c06440(cooS)
VPR: Vpar_0209
VRM: 44547418_00230(cooS2)
VDN: NCTC11831_00196(cooS1)
KST: KSMBR1_1326(cdh_acsA) KSMBR1_3765(acsA_2)
TAZ: TREAZ_1535(cooS_2) TREAZ_1650(cooS_1)
TPI: TREPR_3069(cooS)
TOH: BCB71_06635(cooS)
CPC: Cpar_1193
PMX: PERMA_0106(cooS)
CTHI: THC_1754
TAV: G4V39_00810(cooS) G4V39_01690(cooS)
TMAI: FVE67_00270(cooS)
MMP: MMP0985(cdhA)
MMD: GYY_05750
MMAK: MMKA1_10980(cdhA) MMKA1_11410(cdhA)
MMAO: MMOS7_10770(cdhA)
MMAD: MMJJ_00060
MVO: Mvol_0200
METF: CFE53_02830(cdhA)
MTH: MTH_1708
MMG: MTBMA_c02870(cdhA1) MTBMA_c14200(cdhA2) MTBMA_c14210(cdhA3)
METC: MTCT_1561
MWO: MWSIV6_0249(cdhA1) MWSIV6_0986(cdhA3)
MTHM: FZP57_01125(cdhA)
METH: MBMB1_1565(cdhA)
MFC: BRM9_0801(cdhA)
MFI: DSM1535_0763(cdhA)
MCUB: MCBB_1821(cdhA)
METT: CIT01_07270(cdhA)
METO: CIT02_10120(cdhA)
MFV: Mfer_0527
MKA: MK0536 MK0717(cdhA_1) MK0719(cdhA_1)
TON: TON_1018
TGA: TGAM_0824(cooS)
THS: TES1_1211
THH: CDI07_07345(cooS)
MAC: MA_1016(cdhA) MA_1309(cooS) MA_3282(cooS) MA_3860(cdhA) MA_4399(cdhA)
MFZ: AOB57_003735(cdhA)
MBU: Mbur_0858
MMET: MCMEM_0990
MMH: Mmah_1166
MZI: HWN40_01045(cooS) HWN40_08225(cdhA)
MCJ: MCON_1332(cdhA) MCON_2865(cooS)
MBG: BN140_2260(cooS)
MEMA: MMAB1_2986(cooS)
MPI: Mpet_0907
MPL: Mpal_0842
RCI: LRC456(cdhA)
HDF: AArcSl_0878(cooS)
KCR: Kcr_0762
BARC: AOA65_0464(cdhA2) AOA65_1716(cdhA)
BARB: AOA66_1428(cdhA2)
 » show all
Reference
1  [PMID:6687389]
  Authors
Ragsdale SW, Clark JE, Ljungdahl LG, Lundie LL, Drake HL.
  Title
Properties of purified carbon monoxide dehydrogenase from Clostridium thermoaceticum, a nickel, iron-sulfur protein.
  Journal
J Biol Chem 258:2364-9 (1983)
Reference
2  [PMID:6687458]
  Authors
Diekert G, Ritter M.
  Title
Purification of the nickel protein carbon monoxide dehydrogenase of Clostridium thermoaceticum.
  Journal
FEBS Lett 151:41-4 (1983)
DOI:10.1016/0014-5793(83)80338-X
Reference
3  [PMID:3029096]
  Authors
Bonam D, Ludden PW.
  Title
Purification and characterization of carbon monoxide dehydrogenase, a nickel, zinc, iron-sulfur protein, from Rhodospirillum rubrum.
  Journal
J Biol Chem 262:2980-7 (1987)
Reference
4  [PMID:11593006]
  Authors
Drennan CL, Heo J, Sintchak MD, Schreiter E, Ludden PW.
  Title
Life on carbon monoxide: X-ray structure of Rhodospirillum rubrum Ni-Fe-S carbon monoxide dehydrogenase.
  Journal
Proc Natl Acad Sci U S A 98:11973-8 (2001)
DOI:10.1073/pnas.211429998
  Sequence
[rru:Rru_A1427]
Reference
5  [PMID:11509720]
  Authors
Dobbek H, Svetlitchnyi V, Gremer L, Huber R, Meyer O.
  Title
Crystal structure of a carbon monoxide dehydrogenase reveals a [Ni-4Fe-5S] cluster.
  Journal
Science 293:1281-5 (2001)
DOI:10.1126/science.1061500
  Sequence
[chy:CHY_0085]
Reference
6  [PMID:12386327]
  Authors
Doukov TI, Iverson TM, Seravalli J, Ragsdale SW, Drennan CL
  Title
A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase.
  Journal
Science 298:567-72 (2002)
DOI:10.1126/science.1075843
  Sequence
[mta:Moth_1203]
Reference
7  [PMID:24521136]
  Authors
Can M, Armstrong FA, Ragsdale SW
  Title
Structure, function, and mechanism of the nickel metalloenzymes, CO dehydrogenase, and acetyl-CoA synthase.
  Journal
Chem Rev 114:4149-74 (2014)
DOI:10.1021/cr400461p
Other DBs
ExplorEnz - The Enzyme Database: 1.2.7.4
IUBMB Enzyme Nomenclature: 1.2.7.4
ExPASy - ENZYME nomenclature database: 1.2.7.4
BRENDA, the Enzyme Database: 1.2.7.4

KEGG   REACTION: R07157
Entry
R07157                      Reaction                               

Name
carbon-monoxide,water:ferredoxin oxidoreductase
Definition
CO + H2O + 2 Oxidized ferredoxin <=> CO2 + 2 Reduced ferredoxin + 2 H+
Equation
C00237 + C00001 + 2 C00139 <=> C00011 + 2 C00138 + 2 C00080
Reaction class
RC02800  C00011_C00237
Enzyme
Pathway
rn00680  Methane metabolism
rn00720  Carbon fixation pathways in prokaryotes
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00377  Reductive acetyl-CoA pathway (Wood-Ljungdahl pathway)
M00422  Acetyl-CoA pathway, CO2 => acetyl-CoA
Orthology
K00192  anaerobic carbon-monoxide dehydrogenase, CODH/ACS complex subunit alpha [EC:1.2.7.4]
K00195  anaerobic carbon-monoxide dehydrogenase, CODH/ACS complex subunit epsilon
K00196  anaerobic carbon-monoxide dehydrogenase iron sulfur subunit
K00198  anaerobic carbon-monoxide dehydrogenase catalytic subunit [EC:1.2.7.4]
Other DBs
RHEA: 21043

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