| Entry |
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| Name |
formylmethanofuran dehydrogenase;
formylmethanofuran:acceptor oxidoreductase
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| Class |
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With an iron-sulfur protein as acceptor
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| Sysname |
formylmethanofuran:ferredoxin oxidoreductase
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| Reaction(IUBMB) |
a formylmethanofuran + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster = CO2 + a methanofuran + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ [RN: R11743]
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| Reaction(KEGG) |
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| Substrate |
formylmethanofuran [CPD: C01001];
H2O [CPD: C00001];
oxidized ferredoxin [iron-sulfur] cluster [CPD: C00139]
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| Product |
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| Comment |
Contains a molybdopterin cofactor and numerous [4Fe-4S] clusters. In some organisms an additional subunit enables the incorporation of tungsten when molybdenum availability is low. The enzyme catalyses a reversible reaction in methanogenic archaea, and is involved in methanogenesis from CO2 as well as the oxidation of coenzyme M to CO2. The reaction is endergonic, and is driven by coupling with the soluble CoB-CoM heterodisulfide reductase via electron bifurcation.
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| History |
EC 1.2.7.12 created 1992 as EC 1.2.99.5, transferred 2017 to EC 1.2.7.12
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| Pathway |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K00200 | formylmethanofuran dehydrogenase subunit A |
| K00201 | formylmethanofuran dehydrogenase subunit B |
| K00202 | formylmethanofuran dehydrogenase subunit C |
| K00203 | formylmethanofuran dehydrogenase subunit D |
| K11261 | formylmethanofuran dehydrogenase subunit E |
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| Genes |
» show all
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| Reference |
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| Authors |
Karrasch M, Borner G, Enssle M, Thauer RK. |
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| Title |
The molybdoenzyme formylmethanofuran dehydrogenase from Methanosarcina barkeri contains a pterin cofactor. |
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| Journal |
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| Reference |
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| Authors |
Bertram PA, Schmitz RA, Linder D, Thauer RK |
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| Title |
Tungstate can substitute for molybdate in sustaining growth of Methanobacterium thermoautotrophicum. Identification and characterization of a tungsten isoenzyme of formylmethanofuran dehydrogenase. |
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| Journal |
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| Reference |
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| Authors |
Bertram PA, Karrasch M, Schmitz RA, Bocher R, Albracht SP, Thauer RK |
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| Title |
Formylmethanofuran dehydrogenases from methanogenic Archaea. Substrate specificity, EPR properties and reversible inactivation by cyanide of the molybdenum or tungsten iron-sulfur proteins. |
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| Journal |
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| Reference |
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| Authors |
Vorholt JA, Thauer RK |
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| Title |
The active species of 'CO2' utilized by formylmethanofuran dehydrogenase from methanogenic Archaea. |
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| Journal |
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| Reference |
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| Authors |
Meuer J, Kuettner HC, Zhang JK, Hedderich R, Metcalf WW |
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| Title |
Genetic analysis of the archaeon Methanosarcina barkeri Fusaro reveals a central role for Ech hydrogenase and ferredoxin in methanogenesis and carbon fixation. |
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| Journal |
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| Reference |
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| Authors |
Kaster AK, Moll J, Parey K, Thauer RK |
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| Title |
Coupling of ferredoxin and heterodisulfide reduction via electron bifurcation in hydrogenotrophic methanogenic archaea. |
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| Journal |
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| Reference |
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| Authors |
Wagner T, Ermler U, Shima S |
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| Title |
The methanogenic CO2 reducing-and-fixing enzyme is bifunctional and contains 46 [4Fe-4S] clusters. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.2.7.12 |
| ExPASy - ENZYME nomenclature database: | 1.2.7.12 |
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