KEGG   ORTHOLOGY: K00211
Entry
K00211                      KO                                     

Name
TYR1
Definition
prephenate dehydrogenase (NADP+) [EC:1.3.1.13]
Pathway
ko00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01230  Biosynthesis of amino acids
Module
M00025  Tyrosine biosynthesis, chorismate => HPP => tyrosine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K00211  TYR1; prephenate dehydrogenase (NADP+)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.13  prephenate dehydrogenase (NADP+)
     K00211  TYR1; prephenate dehydrogenase (NADP+)
Other DBs
RN: R01730
COG: COG0287
GO: 0004665
Genes
QSU: 112022044 112029155
SCE: YBR166C(TYR1)
AGO: AGOS_AGR219W
ERC: Ecym_7090
KLA: KLLA0_E24729g
KMX: KLMA_10819(TYR1)
LTH: KLTH0E13794g
VPO: Kpol_1048p32
ZRO: ZYRO0A10384g
CGR: CAGL0M06017g
NCS: NCAS_0B01830(NCAS0B01830)
NDI: NDAI_0C05850(NDAI0C05850)
TPF: TPHA_0I01630(TPHA0I01630)
TBL: TBLA_0E04010(TBLA0E04010)
TDL: TDEL_0A05400(TDEL0A05400)
KAF: KAFR_0G02120(KAFR0G02120)
PIC: PICST_52223(TYR1)
CAL: CAALFM_C401880WA(TYR1)
SLB: AWJ20_4481(TYR1)
NCR: NCU00468
NTE: NEUTE1DRAFT63778(NEUTE1DRAFT_63778)
MGR: MGG_05276
SSCK: SPSK_07157
MAW: MAC_01666
MAJ: MAA_02500
CMT: CCM_09467
BFU: BCIN_03g06980(Bctyr1)
MBE: MBM_07073
ANI: AN5959.2
ANG: ANI_1_840024(An02g06120)
ABE: ARB_05782
TVE: TRV_04459
PTE: PTT_08159
SPO: SPCC1494.04c(tyr1)
CNE: CNK03330
CNB: CNBK0170
TASA: A1Q1_03504
ABP: AGABI1DRAFT122388(AGABI1DRAFT_122388)
ABV: AGABI2DRAFT226049(AGABI2DRAFT_226049)
MRT: MRET_0865
MUC: MuYL_4319
MGOT: MgSA37_01016(tyrA)
LBY: Lbys_1216
 » show all
Reference
PMID:2697638
  Authors
Mannhaupt G, Stucka R, Pilz U, Schwarzlose C, Feldmann H
  Title
Characterization of the prephenate dehydrogenase-encoding gene, TYR1, from Saccharomyces cerevisiae.
  Journal
Gene 85:303-11 (1989)
DOI:10.1016/0378-1119(89)90422-8
  Sequence
[sce:YBR166C]

KEGG   ENZYME: 1.3.1.13
Entry
EC 1.3.1.13                 Enzyme                                 

Name
prephenate dehydrogenase (NADP+);
prephenate dehydrogenase (ambiguous);
prephenate (nicotinamide adenine dinucleotide phosphate) dehydrogenase;
prephenate dehydrogenase (NADP)
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
prephenate:NADP+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
prephenate + NADP+ = 4-hydroxyphenylpyruvate + CO2 + NADPH [RN:R01730]
Reaction(KEGG)
R01730
Substrate
prephenate [CPD:C00254];
NADP+ [CPD:C00006]
Product
4-hydroxyphenylpyruvate [CPD:C01179];
CO2 [CPD:C00011];
NADPH [CPD:C00005]
History
EC 1.3.1.13 created 1972
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00211  prephenate dehydrogenase (NADP+)
Genes
QSU: 112022044 112029155
SCE: YBR166C(TYR1)
AGO: AGOS_AGR219W
ERC: Ecym_7090
KLA: KLLA0_E24729g
KMX: KLMA_10819(TYR1)
LTH: KLTH0E13794g
VPO: Kpol_1048p32
ZRO: ZYRO0A10384g
CGR: CAGL0M06017g
NCS: NCAS_0B01830(NCAS0B01830)
NDI: NDAI_0C05850(NDAI0C05850)
TPF: TPHA_0I01630(TPHA0I01630)
TBL: TBLA_0E04010(TBLA0E04010)
TDL: TDEL_0A05400(TDEL0A05400)
KAF: KAFR_0G02120(KAFR0G02120)
PIC: PICST_52223(TYR1)
CAL: CAALFM_C401880WA(TYR1)
SLB: AWJ20_4481(TYR1)
NCR: NCU00468
NTE: NEUTE1DRAFT63778(NEUTE1DRAFT_63778)
MGR: MGG_05276
SSCK: SPSK_07157
MAW: MAC_01666
MAJ: MAA_02500
CMT: CCM_09467
BFU: BCIN_03g06980(Bctyr1)
MBE: MBM_07073
ANI: AN5959.2
ANG: ANI_1_840024(An02g06120)
ABE: ARB_05782
TVE: TRV_04459
PTE: PTT_08159
SPO: SPCC1494.04c(tyr1)
CNE: CNK03330
CNB: CNBK0170
TASA: A1Q1_03504
ABP: AGABI1DRAFT122388(AGABI1DRAFT_122388)
ABV: AGABI2DRAFT226049(AGABI2DRAFT_226049)
MRT: MRET_0865
MUC: MuYL_4319
MGOT: MgSA37_01016(tyrA)
LBY: Lbys_1216
 » show all
Reference
1  [PMID:4379953]
  Authors
Gamborg OL, Keeley FW.
  Title
Aromatic metabolism in plants. I. A study of the prephenate dehydrogenase from bean plants.
  Journal
Biochim Biophys Acta 115:65-72 (1966)
DOI:10.1016/0304-4165(66)90049-3
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.13
IUBMB Enzyme Nomenclature: 1.3.1.13
ExPASy - ENZYME nomenclature database: 1.3.1.13
BRENDA, the Enzyme Database: 1.3.1.13
CAS: 37251-11-9

KEGG   REACTION: R01730
Entry
R01730                      Reaction                               

Name
Prephenate:NADP+ oxidoreductase(decarboxylating)
Definition
Prephenate + NADP+ <=> 3-(4-Hydroxyphenyl)pyruvate + CO2 + NADPH + H+
Equation
Reaction class
RC00001  C00005_C00006
RC00125  C00254_C01179
Enzyme
Pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01230  Biosynthesis of amino acids
Module
M00025  Tyrosine biosynthesis, chorismate => HPP => tyrosine
Orthology
K00211  prephenate dehydrogenase (NADP+) [EC:1.3.1.13]
Other DBs
RHEA: 21643

DBGET integrated database retrieval system