KEGG ORTHOLOGY: K00212

ORTHOLOGY: K00212

Entry

K00212                      KO

Symbol

AKR1C1

Name

20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase [EC:1.1.1.149 1.1.1.357 1.3.1.20]

Pathway

map00140

Steroid hormone biosynthesis

map00980

Metabolism of xenobiotics by cytochrome P450

map01100

Metabolic pathways

map05208

Chemical carcinogenesis - reactive oxygen species

Reaction

R02207

20alpha-hydroxy-4-pregnen-3-one:NAD+ 20-oxidoreductase

R02209

20alpha-hydroxy-4-pregnen-3-one:NADP+ 20-oxidoreductase

R03325

17alpha,20alpha-dihydroxypregn-4-en-3-one:NADP+ 20-oxidoreductase

R07015

1,2-dihydronaphthalene-1,2-diol dehydrogenase

R08958

5alpha-pregnan-20alpha-ol-3-one:NADP+ 20-oxidoreductase

R08959

5alpha-pregnane-3alpha,20alpha-diol:NADP+ 20-oxidoreductase

R09420

carbonyl reductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00212  AKR1C1; 20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K00212  AKR1C1; 20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K00212  AKR1C1; 20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.149  20alpha-hydroxysteroid dehydrogenase
     K00212  AKR1C1; 20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     K00212  AKR1C1; 20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.20  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
     K00212  AKR1C1; 20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase

Other DBs

GO:	0047006 0047115

Genes

HSA:	1645(AKR1C1)

PTR:

100607996

PPS:

100986729

GGO:	101146324 115936027

PON:	100171658(AKR1C1) 100189776

PPYG:

129006867 129006872

NLE:

100605934

SSYN:

129491830

MCC:	711198(AKR1C1) 711360(AKR1C2)

MCF:	101865536(AKR1C1) 102141103

MTHB:

126963006 126963009

MNI:	105490781 105490782

CSAB:

103237807 103237808

CATY:

105587685 105587688

PANU:

101023297

TGE:	112631308 112631309

MLEU:

105532487 105532488 105532490

RRO:

104678925

RBB:	108532991 108532992

TFN:	117083548 117083560 117087703 117087714

CANG:

105521701 105521702

CJC:	100404656(AKR1C1)

SBQ:

101042532

CIMI:

108285104

ANAN:

105710885

MMU:	77337(Akr1c21)

MCAL:

110308710

MPAH:

110315750 110333790

RNO:	291283(Akr1c2) 307092(Akr1c1)

MCOC:

116081947

ANU:

117713854

MUN:	110539888 110540933 110542801 132649305

CGE:	100770100 100770388

MAUA:

101839651 101843587

PROB:

127229804

PLEU:

114707814 114708002 114708030

MFOT:

AAMP:

NGI:

HGL:

CPOC:

100722094 100724342 100724620

CCAN:

109680485

MMMA:

107134068 107150203

OCU:	100348607(PGER1) 100352716

OPI:	101525116 101525279 101526245 118759111

ECB:

100070570

EPZ:

103540778

EAI:

106827244

DNM:	101433871 101435315

GAS:	123247018 123248678

AFZ:

127564339

TVP:	118850247 118850334

MUO:

GSH:

BBEL:

Reference

PMID:8172617

Authors

Deyashiki Y, Ogasawara A, Nakayama T, Nakanishi M, Miyabe Y, Sato K, Hara A

Title

Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder.

Journal

Biochem J 299 ( Pt 2):545-52 (1994)
DOI:10.1042/bj2990545

Sequence

[hsa:1645]

Reference

PMID:12604236

Authors

Higaki Y, Usami N, Shintani S, Ishikura S, El-Kabbani O, Hara A

Title

Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone.

Journal

Chem Biol Interact 143-144:503-13 (2003)
DOI:10.1016/S0009-2797(02)00206-5

All links

Ontology (4)   
   KEGG BRITE (2)   
   GO (2)   
Pathway (8)   
   KEGG PATHWAY (8)   
Chemical reaction (14)   
   KEGG ENZYME (3)   
   KEGG REACTION (7)   
   KEGG RCLASS (4)   
Gene (92)   
   KEGG GENES (91)   
   OC (1)   
Literature (2)   
   PubMed (2)   
All databases (120)   

Download RDF

ORTHOLOGY: K05295

Entry

K05295                      KO

Symbol

E1.1.1.149

Name

20alpha-hydroxysteroid dehydrogenase [EC:1.1.1.149]

Pathway

map00140

Steroid hormone biosynthesis

map01100

Metabolic pathways

Reaction

R02207

20alpha-hydroxy-4-pregnen-3-one:NAD+ 20-oxidoreductase

R02209

20alpha-hydroxy-4-pregnen-3-one:NADP+ 20-oxidoreductase

R03325

17alpha,20alpha-dihydroxypregn-4-en-3-one:NADP+ 20-oxidoreductase

R08958

5alpha-pregnan-20alpha-ol-3-one:NADP+ 20-oxidoreductase

R08959

5alpha-pregnane-3alpha,20alpha-diol:NADP+ 20-oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K05295  E1.1.1.149; 20alpha-hydroxysteroid dehydrogenase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.149  20alpha-hydroxysteroid dehydrogenase
     K05295  E1.1.1.149; 20alpha-hydroxysteroid dehydrogenase

Other DBs

GO:

0047006

Genes

MMU:	105349(Akr1c18)

RNO:	171516(Akr1c3)

ANU:

CGE:

MAUA:

PROB:

MORG:

AAMP:

DORD:

DSP:

HAME:

Reference

PMID:6935192

Authors

Strickler RC, Tobias B, Covey DF

Title

Human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site.

Journal

J Biol Chem 256:316-21 (1981)

All links

Ontology (3)   
   KEGG BRITE (2)   
   GO (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (8)   
   KEGG ENZYME (1)   
   KEGG REACTION (5)   
   KEGG RCLASS (2)   
Gene (12)   
   KEGG GENES (11)   
   OC (1)   
Literature (1)   
   PubMed (1)   
All databases (28)   

Download RDF

DBGET integrated database retrieval system