KEGG   ORTHOLOGY: K00213
Entry
K00213                      KO                                     

Name
DHCR7
Definition
7-dehydrocholesterol reductase [EC:1.3.1.21]
Pathway
ko00100  Steroid biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00101  Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol
M00917  Phytosterol biosynthesis, squalene 2,3-epoxide => campesterol/sitosterol
Disease
H00161  Smith-Lemli-Opitz syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    K00213  DHCR7; 7-dehydrocholesterol reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.21  7-dehydrocholesterol reductase
     K00213  DHCR7; 7-dehydrocholesterol reductase
Other DBs
RN: R01451 R01456 R07487 R07492
GO: 0047598
Genes
HSA: 1717(DHCR7)
PTR: 451393(DHCR7)
PPS: 100977099(DHCR7)
GGO: 101137517(DHCR7)
PON: 100172090(DHCR7)
NLE: 100580795(DHCR7)
MCC: 106993167(DHCR7)
MCF: 102120769(DHCR7)
CSAB: 103243806(DHCR7)
RRO: 104677122(DHCR7)
RBB: 108538891(DHCR7)
CJC: 100414321(DHCR7)
SBQ: 101045756(DHCR7)
MMU: 13360(Dhcr7)
MCAL: 110298721(Dhcr7)
MPAH: 110322282(Dhcr7)
RNO: 64191(Dhcr7)
MUN: 110546825(Dhcr7)
CGE: 100771700(Dhcr7)
HGL: 101703035(Dhcr7)
CCAN: 109689788(Dhcr7)
TUP: 102493586(DHCR7)
CFA: 483675(DHCR7)
VVP: 112924153(DHCR7)
AML: 100467495(DHCR7)
UMR: 103671131(DHCR7)
UAH: 113243974(DHCR7)
ORO: 101368291(DHCR7)
ELK: 111150224
FCA: 101089143(DHCR7)
PTG: 102956988(DHCR7)
PPAD: 109246918(DHCR7)
AJU: 106982857(DHCR7)
BTA: 514745(DHCR7)
BOM: 102276304(DHCR7)
BIU: 109554435(DHCR7)
BBUB: 102394070(DHCR7)
CHX: 102171848(DHCR7)
OAS: 101118320(DHCR7)
SSC: 100627707(DHCR7)
CFR: 102517817(DHCR7)
CDK: 105104565(DHCR7)
BACU: 103016099(DHCR7)
LVE: 103089128(DHCR7)
OOR: 101275459(DHCR7)
DLE: 111183623(DHCR7)
PCAD: 102989395(DHCR7)
ECB: 100061433(DHCR7)
EPZ: 103564418(DHCR7)
EAI: 106822732(DHCR7)
MYD: 102760533(DHCR7)
MNA: 107540362(DHCR7)
HAI: 109389313(DHCR7)
DRO: 112317115(DHCR7)
PALE: 102892007(DHCR7)
RAY: 107503327(DHCR7)
MJV: 108394434(DHCR7)
LAV: 100670197(DHCR7)
TMU: 101359219
MDO: 100017714(DHCR7)
SHR: 111721517(DHCR7)
PCW: 110197175(DHCR7)
OAA: 100074666(DHCR7)
GGA: 422982(DHCR7)
MGP: 100550588
CJO: 107314280(DHCR7)
NMEL: 110401504(DHCR7)
APLA: 101800178(DHCR7)
ACYG: 106044822(DHCR7)
TGU: 100230558(DHCR7)
LSR: 110469627(DHCR7)
SCAN: 103822109(DHCR7)
GFR: 102043315(DHCR7)
FAB: 101808729(DHCR7)
PHI: 102100206(DHCR7)
PMAJ: 107206252(DHCR7)
CCAE: 111930662(DHCR7)
CCW: 104697600(DHCR7)
ETL: 114070759(DHCR7)
FPG: 101914766(DHCR7)
FCH: 102053203(DHCR7)
CLV: 102086618(DHCR7)
EGZ: 104124694(DHCR7)
NNI: 104009409(DHCR7)
ACUN: 113481362(DHCR7)
PADL: 103925768(DHCR7)
AAM: 106498340(DHCR7)
ASN: 102380697(DHCR7)
AMJ: 106737545(DHCR7)
PSS: 102459270(DHCR7)
CMY: 102947477(DHCR7)
CPIC: 101947621(DHCR7)
ACS: 100565806(dhcr7)
PVT: 110073543(DHCR7)
PBI: 103061207(DHCR7)
GJA: 107121513(DHCR7)
XLA: 379273(dhcr7) 380248(dhcr7.L)
XTR: 394844(dhcr7)
NPR: 108785887(DHCR7)
DRE: 378446(dhcr7)
SRX: 107727115(dhcr7) 107730061
IPU: 108271323(dhcr7)
PHYP: 113536460(dhcr7)
AMEX: 103033332(dhcr7)
EEE: 113578447(dhcr7)
LCO: 104935369(dhcr7)
MZE: 101465690(dhcr7)
ONL: 100690153(dhcr7)
OLA: 101175471(dhcr7)
XMA: 102220981(dhcr7)
XCO: 114143530(dhcr7)
PRET: 103462241(dhcr7)
CVG: 107084879(dhcr7)
NFU: 107395662(dhcr7)
KMR: 108237854(dhcr7)
ALIM: 106522244(dhcr7)
AOCE: 111567200(dhcr7)
CSEM: 103378635(dhcr7)
POV: 109624743(dhcr7)
LCF: 108897736(dhcr7)
SDU: 111222421(dhcr7)
SLAL: 111672324(dhcr7)
HCQ: 109524562(dhcr7)
BPEC: 110162584(dhcr7)
MALB: 109963393(dhcr7)
SASA: 106562054(dhcr7) 106587139
OTW: 112249041 112263572(dhcr7)
ELS: 105017269(dhcr7)
SFM: 108941239(dhcr7)
PKI: 111848083(dhcr7)
LCM: 102362669(DHCR7)
CMK: 103175009(dhcr7)
RTP: 109935399(dhcr7)
BFO: 118417666
CIN: 100176643
APLC: 110978603
SKO: 100376362
CLEC: 106662750
ZNE: 110832336
PVM: 113824348
TUT: 107368480
DPTE: 113792916
CRG: 105325856
OBI: 106876505
LAK: 106169024
NVE: 5509996
EPA: 110242772
AMIL: 114960291
PDAM: 113683113
SPIS: 111321947
DGT: 114531730
AQU: 100636367
ATH: AT1G50430(DWF5)
ALY: 9330313
CRB: 17900471
BOE: 106328352
THJ: 104809047
CPAP: 110808001
CIT: 102631279
TCC: 18595600
GRA: 105777576
GAB: 108489075
EGR: 104450695
GMX: 102659420
GSJ: 114422541
VRA: 106772893
VUN: 114167643
CCAJ: 109807985
CAM: 101512763
LJA: Lj3g3v2039890.1(Lj3g3v2039890.1)
ADU: 107482511
AIP: 107638378
LANG: 109357091
FVE: 101313328
RCN: 112187284
PPER: 18783828
PMUM: 103327428
PAVI: 110749995
CSV: 101215997
CMO: 103500620
MCHA: 111016744
CMAX: 111494288
CMOS: 111464317
CPEP: 111778421
RCU: 8259961
JCU: 105646146
MESC: 110631355
JRE: 109004249
QSU: 112034052
VVI: 100256426
SOT: 102589505 102604909(StDWF5)
NSY: 104249643
NTO: 104116435
NAU: 109241331
INI: 109190803
SIND: 105157928
LSV: 111910394
CCAV: 112516735
DCR: 108205433
BVG: 104907279
SOE: 110785582
NNU: 104611738
OSA: 4329318
DOSA: Os02t0465400-01(Os02g0465400)
OBR: 102721516
BDI: 100831660
ATS: 109780148(LOC109780148)
SBI: 8084478
ZMA: 100282098(pco110886)
SITA: 101767487
PDA: 103715514
MUS: 103989528
DCT: 110113328
AOF: 109840367
ATR: 18440694
SMO: SELMODRAFT_135440(DWF5-2) SELMODRAFT_185064(DWF5-1)
APRO: F751_0259
MGR: MGG_03765
CMT: CCM_08633
SPAR: SPRG_01085
CBU: CBU_1158
CBD: CBUD_1256
CBC: CbuK_1025
LLO: LLO_1320(DWF)
LFA: LFA_1070(DWF)
LHA: LHA_0011(DWF)
LLG: 44548918_01594(DWF)
LJR: NCTC11533_02823(DWF)
LCJ: NCTC11976_02540(DWF)
TMC: LMI_2237(DWF)
PNL: PNK_0661(dhcr7)
PUV: PUV_11120(DWF5)
WCH: wcw_1842(dhcr7)
VG: 14445997(H012_gp836) 9925469(R807)
 » show all
Reference
PMID:9465114
  Authors
Moebius FF, Fitzky BU, Lee JN, Paik YK, Glossmann H
  Title
Molecular cloning and expression of the human delta7-sterol reductase.
  Journal
Proc Natl Acad Sci U S A 95:1899-902 (1998)
DOI:10.1073/pnas.95.4.1899
  Sequence
[hsa:1717]

KEGG   ENZYME: 1.3.1.21
Entry
EC 1.3.1.21                 Enzyme                                 

Name
7-dehydrocholesterol reductase;
DHCR7 (gene name);
7-DHC reductase;
7-dehydrocholesterol dehydrogenase/cholesterol oxidase;
Delta7-sterol reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
cholesterol:NADP+ Delta7-oxidoreductase
Reaction(IUBMB)
cholesterol + NADP+ = cholesta-5,7-dien-3beta-ol + NADPH + H+ [RN:R01456]
Reaction(KEGG)
R01456;
(other) R01451 R07487 R07492
Substrate
cholesterol [CPD:C00187];
NADP+ [CPD:C00006]
Product
cholesta-5,7-dien-3beta-ol [CPD:C01164];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme is part of the cholesterol biosynthesis pathway.
History
EC 1.3.1.21 created 1972, modified 2013
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00213  7-dehydrocholesterol reductase
Genes
HSA: 1717(DHCR7)
PTR: 451393(DHCR7)
PPS: 100977099(DHCR7)
GGO: 101137517(DHCR7)
PON: 100172090(DHCR7)
NLE: 100580795(DHCR7)
MCC: 106993167(DHCR7)
MCF: 102120769(DHCR7)
CSAB: 103243806(DHCR7)
RRO: 104677122(DHCR7)
RBB: 108538891(DHCR7)
CJC: 100414321(DHCR7)
SBQ: 101045756(DHCR7)
MMU: 13360(Dhcr7)
MCAL: 110298721(Dhcr7)
MPAH: 110322282(Dhcr7)
RNO: 64191(Dhcr7)
MUN: 110546825(Dhcr7)
CGE: 100771700(Dhcr7)
HGL: 101703035(Dhcr7)
CCAN: 109689788(Dhcr7)
TUP: 102493586(DHCR7)
CFA: 483675(DHCR7)
VVP: 112924153(DHCR7)
AML: 100467495(DHCR7)
UMR: 103671131(DHCR7)
UAH: 113243974(DHCR7)
ORO: 101368291(DHCR7)
ELK: 111150224
FCA: 101089143(DHCR7)
PTG: 102956988(DHCR7)
PPAD: 109246918(DHCR7)
AJU: 106982857(DHCR7)
BTA: 514745(DHCR7)
BOM: 102276304(DHCR7)
BIU: 109554435(DHCR7)
BBUB: 102394070(DHCR7)
CHX: 102171848(DHCR7)
OAS: 101118320(DHCR7)
SSC: 100627707(DHCR7)
CFR: 102517817(DHCR7)
CDK: 105104565(DHCR7)
BACU: 103016099(DHCR7)
LVE: 103089128(DHCR7)
OOR: 101275459(DHCR7)
DLE: 111183623(DHCR7)
PCAD: 102989395(DHCR7)
ECB: 100061433(DHCR7)
EPZ: 103564418(DHCR7)
EAI: 106822732(DHCR7)
MYD: 102760533(DHCR7)
MNA: 107540362(DHCR7)
HAI: 109389313(DHCR7)
DRO: 112317115(DHCR7)
PALE: 102892007(DHCR7)
RAY: 107503327(DHCR7)
MJV: 108394434(DHCR7)
LAV: 100670197(DHCR7)
TMU: 101359219
MDO: 100017714(DHCR7)
SHR: 111721517(DHCR7)
PCW: 110197175(DHCR7)
OAA: 100074666(DHCR7)
GGA: 422982(DHCR7)
MGP: 100550588
CJO: 107314280(DHCR7)
NMEL: 110401504(DHCR7)
APLA: 101800178(DHCR7)
ACYG: 106044822(DHCR7)
TGU: 100230558(DHCR7)
LSR: 110469627(DHCR7)
SCAN: 103822109(DHCR7)
GFR: 102043315(DHCR7)
FAB: 101808729(DHCR7)
PHI: 102100206(DHCR7)
PMAJ: 107206252(DHCR7)
CCAE: 111930662(DHCR7)
CCW: 104697600(DHCR7)
ETL: 114070759(DHCR7)
FPG: 101914766(DHCR7)
FCH: 102053203(DHCR7)
CLV: 102086618(DHCR7)
EGZ: 104124694(DHCR7)
NNI: 104009409(DHCR7)
ACUN: 113481362(DHCR7)
PADL: 103925768(DHCR7)
AAM: 106498340(DHCR7)
ASN: 102380697(DHCR7)
AMJ: 106737545(DHCR7)
PSS: 102459270(DHCR7)
CMY: 102947477(DHCR7)
CPIC: 101947621(DHCR7)
ACS: 100565806(dhcr7)
PVT: 110073543(DHCR7)
PBI: 103061207(DHCR7)
GJA: 107121513(DHCR7)
XLA: 379273(dhcr7) 380248(dhcr7.L)
XTR: 394844(dhcr7)
NPR: 108785887(DHCR7)
DRE: 378446(dhcr7)
SRX: 107727115(dhcr7) 107730061
IPU: 108271323(dhcr7)
PHYP: 113536460(dhcr7)
AMEX: 103033332(dhcr7)
EEE: 113578447(dhcr7)
LCO: 104935369(dhcr7)
MZE: 101465690(dhcr7)
ONL: 100690153(dhcr7)
OLA: 101175471(dhcr7)
XMA: 102220981(dhcr7)
XCO: 114143530(dhcr7)
PRET: 103462241(dhcr7)
CVG: 107084879(dhcr7)
NFU: 107395662(dhcr7)
KMR: 108237854(dhcr7)
ALIM: 106522244(dhcr7)
AOCE: 111567200(dhcr7)
CSEM: 103378635(dhcr7)
POV: 109624743(dhcr7)
LCF: 108897736(dhcr7)
SDU: 111222421(dhcr7)
SLAL: 111672324(dhcr7)
HCQ: 109524562(dhcr7)
BPEC: 110162584(dhcr7)
MALB: 109963393(dhcr7)
SASA: 106562054(dhcr7) 106587139
OTW: 112249041 112263572(dhcr7)
ELS: 105017269(dhcr7)
SFM: 108941239(dhcr7)
PKI: 111848083(dhcr7)
LCM: 102362669(DHCR7)
CMK: 103175009(dhcr7)
RTP: 109935399(dhcr7)
BFO: 118417666
CIN: 100176643
APLC: 110978603
SKO: 100376362
CLEC: 106662750
ZNE: 110832336
PVM: 113824348
TUT: 107368480
DPTE: 113792916
CRG: 105325856
OBI: 106876505
LAK: 106169024
NVE: 5509996
EPA: 110242772
AMIL: 114960291
PDAM: 113683113
SPIS: 111321947
DGT: 114531730
AQU: 100636367
ATH: AT1G50430(DWF5)
ALY: 9330313
CRB: 17900471
BOE: 106328352
THJ: 104809047
CPAP: 110808001
CIT: 102631279
TCC: 18595600
GRA: 105777576
GAB: 108489075
EGR: 104450695
GMX: 102659420
GSJ: 114422541
VRA: 106772893
VUN: 114167643
CCAJ: 109807985
CAM: 101512763
LJA: Lj3g3v2039890.1(Lj3g3v2039890.1)
ADU: 107482511
AIP: 107638378
LANG: 109357091
FVE: 101313328
RCN: 112187284
PPER: 18783828
PMUM: 103327428
PAVI: 110749995
CSV: 101215997
CMO: 103500620
MCHA: 111016744
CMAX: 111494288
CMOS: 111464317
CPEP: 111778421
RCU: 8259961
JCU: 105646146
MESC: 110631355
JRE: 109004249
QSU: 112034052
VVI: 100256426
SOT: 102589505 102604909(StDWF5)
NSY: 104249643
NTO: 104116435
NAU: 109241331
INI: 109190803
SIND: 105157928
LSV: 111910394
CCAV: 112516735
DCR: 108205433
BVG: 104907279
SOE: 110785582
NNU: 104611738
OSA: 4329318
DOSA: Os02t0465400-01(Os02g0465400)
OBR: 102721516
BDI: 100831660
ATS: 109780148(LOC109780148)
SBI: 8084478
ZMA: 100282098(pco110886)
SITA: 101767487
PDA: 103715514
MUS: 103989528
DCT: 110113328
AOF: 109840367
ATR: 18440694
SMO: SELMODRAFT_135440(DWF5-2) SELMODRAFT_185064(DWF5-1)
APRO: F751_0259
MGR: MGG_03765
CMT: CCM_08633
SPAR: SPRG_01085
CBU: CBU_1158
CBD: CBUD_1256
CBC: CbuK_1025
LLO: LLO_1320(DWF)
LFA: LFA_1070(DWF)
LHA: LHA_0011(DWF)
LLG: 44548918_01594(DWF)
LJR: NCTC11533_02823(DWF)
LCJ: NCTC11976_02540(DWF)
TMC: LMI_2237(DWF)
PNL: PNK_0661(dhcr7)
PUV: PUV_11120(DWF5)
WCH: wcw_1842(dhcr7)
 » show all
Reference
1  [PMID:14189869]
  Authors
DEMPSEY ME, SEATON JD, SCHROEPFER GJ Jr, TROCKMAN RW.
  Title
THE INTERMEDIARY ROLE OF DELTA-5,7-CHOLESTADIEN-3-BETA-OL IN CHOLESTEROL BIOSYNTHESIS.
  Journal
J Biol Chem 239:1381-7 (1964)
Reference
2  [PMID:9465114]
  Authors
Moebius FF, Fitzky BU, Lee JN, Paik YK, Glossmann H
  Title
Molecular cloning and expression of the human delta7-sterol reductase.
  Journal
Proc Natl Acad Sci U S A 95:1899-902 (1998)
DOI:10.1073/pnas.95.4.1899
  Sequence
[hsa:1717]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.21
IUBMB Enzyme Nomenclature: 1.3.1.21
ExPASy - ENZYME nomenclature database: 1.3.1.21
BRENDA, the Enzyme Database: 1.3.1.21
CAS: 9080-21-1

KEGG   REACTION: R07487
Entry
R07487                      Reaction                               

Definition
5-Dehydroavenasterol <=> Isofucosterol
Equation
Reaction class
RC00138  C08821_C15783
Enzyme
Pathway
rn00100  Steroid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00917  Phytosterol biosynthesis, squalene 2,3-epoxide => campesterol/sitosterol
Orthology
K00213  7-dehydrocholesterol reductase [EC:1.3.1.21]

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