KEGG   ORTHOLOGY: K00232
Entry
K00232                      KO                                     

Name
E1.3.3.6, ACOX1, ACOX3
Definition
acyl-CoA oxidase [EC:1.3.3.6]
Pathway
ko00071  Fatty acid degradation
ko00410  beta-Alanine metabolism
ko00592  alpha-Linolenic acid metabolism
ko00640  Propanoate metabolism
ko01040  Biosynthesis of unsaturated fatty acids
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01200  Carbon metabolism
ko01212  Fatty acid metabolism
ko03320  PPAR signaling pathway
ko04024  cAMP signaling pathway
ko04146  Peroxisome
Module
M00013  Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA
M00087  beta-Oxidation
M00113  Jasmonic acid biosynthesis
M00861  beta-Oxidation, peroxisome, VLCFA
Disease
H00407  Peroxisomal beta-oxidation enzyme deficiency
H02096  Peroxisomal acyl-CoA oxidase deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00640 Propanoate metabolism
    K00232  E1.3.3.6, ACOX1, ACOX3; acyl-CoA oxidase
  09103 Lipid metabolism
   00071 Fatty acid degradation
    K00232  E1.3.3.6, ACOX1, ACOX3; acyl-CoA oxidase
   00592 alpha-Linolenic acid metabolism
    K00232  E1.3.3.6, ACOX1, ACOX3; acyl-CoA oxidase
   01040 Biosynthesis of unsaturated fatty acids
    K00232  E1.3.3.6, ACOX1, ACOX3; acyl-CoA oxidase
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K00232  E1.3.3.6, ACOX1, ACOX3; acyl-CoA oxidase
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    K00232  E1.3.3.6, ACOX1, ACOX3; acyl-CoA oxidase
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    K00232  E1.3.3.6, ACOX1, ACOX3; acyl-CoA oxidase
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K00232  E1.3.3.6, ACOX1, ACOX3; acyl-CoA oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.3  With oxygen as acceptor
    1.3.3.6  acyl-CoA oxidase
     K00232  E1.3.3.6, ACOX1, ACOX3; acyl-CoA oxidase
Other DBs
RN: R01175 R01279 R03777 R03857 R03990 R04751 R04754 R07888 R07892 R07896 R07934 R07950 R12356
GO: 0003997
Genes
HSA: 51(ACOX1) 8310(ACOX3)
PTR: 454895(ACOX1) 461115(ACOX3)
PPS: 100973171(ACOX3) 100984758(ACOX1)
GGO: 101145668(ACOX1) 101152360(ACOX3)
PON: 100172283(ACOX1) 100172575(ACOX3)
NLE: 100590927(ACOX3) 100595934(ACOX1)
MCC: 705197(ACOX1) 722634(ACOX3)
MCF: 102131652(ACOX3) 102145989(ACOX1)
CSAB: 103243017(ACOX1) 103246430(ACOX3)
RRO: 104678969(ACOX3) 104681285(ACOX1)
RBB: 108537328(ACOX1) 108543226(ACOX3)
CJC: 100394823(ACOX3) 100401745(ACOX1)
SBQ: 101029701(ACOX3) 101036109(ACOX1)
MMU: 11430(Acox1) 80911(Acox3)
MCAL: 110294025(Acox3) 110304682(Acox1)
MPAH: 110330653(Acox3) 110331272(Acox1)
RNO: 50681(Acox1) 83522(Acox3)
MUN: 110548021(Acox1) 110559473(Acox3)
CGE: 100689199(Acox1) 100767060(Acox3)
NGI: 103732704(Acox1) 103733928(Acox3)
HGL: 101705097(Acox1) 101719939(Acox3)
CCAN: 109683482(Acox1) 109687438(Acox3)
OCU: 100338450(ACOX1) 103347455(ACOX3)
TUP: 102482193(ACOX1) 102486878(ACOX3)
CFA: 483322(ACOX1) 488790(ACOX3)
VVP: 112920542(ACOX3) 112920813(ACOX1)
AML: 100463549(ACOX3) 100471606(ACOX1)
UMR: 103665753(ACOX1) 103676728(ACOX3)
UAH: 113244611(ACOX1) 113245696(ACOX3)
ORO: 101372647(ACOX3) 101380271(ACOX1)
FCA: 101082279(ACOX1) 101088745(ACOX3)
PTG: 102949456(ACOX3) 102964654(ACOX1)
PPAD: 109269729(ACOX3) 109276909(ACOX1)
AJU: 106982705(ACOX3) 106987755(ACOX1)
BTA: 510065(ACOX3) 513996(ACOX1)
BOM: 102266983(ACOX1) 102283461(ACOX3)
BIU: 109560748(ACOX3) 109573351(ACOX1)
BBUB: 102403281(ACOX1) 102416647(ACOX3)
CHX: 102170734(ACOX1) 102177788(ACOX3)
OAS: 101118626(ACOX1) 101119642(ACOX3)
SSC: 100113422(ACOX1) 100523005(ACOX3)
CFR: 102512004(ACOX1) 102515875(ACOX3)
CDK: 105103342(ACOX3) 105105527(ACOX1)
BACU: 102998639(ACOX1) 103015927(ACOX3)
LVE: 103074495(ACOX1) 103089784(ACOX3)
OOR: 101275698(ACOX1) 101287447(ACOX3)
PCAD: 102982781(ACOX3) 102988733(ACOX1) 112062893
ECB: 100051466(ACOX1) 100056690(ACOX3)
EPZ: 103546599(ACOX1) 103559319(ACOX3)
EAI: 106830317(ACOX1) 106840065(ACOX3)
MYB: 102247645(ACOX3) 102259193(ACOX1)
MYD: 102752805(ACOX1) 102766056(ACOX3)
MNA: 107524067(ACOX3) 107536619(ACOX1)
HAI: 109372914(ACOX3) 109383700(ACOX1)
DRO: 112298663(ACOX1) 112316811(ACOX3)
PALE: 102892373(ACOX3) 102896015(ACOX1)
RAY: 107501215(ACOX3) 107501445(ACOX1)
MJV: 108403833 108406048(ACOX1)
LAV: 100668073(ACOX3) 100676729(ACOX1)
MDO: 100019995(ACOX3) 100022432(ACOX1)
PCW: 110212210(ACOX3) 110219261(ACOX1)
OAA: 100083493(ACOX1) 103169536(ACOX3)
GGA: 417366(ACOX1) 422869(ACOX3)
MGP: 100538886(ACOX3) 100540963(ACOX1)
CJO: 107313952(ACOX3) 107322018(ACOX1)
NMEL: 110398066(ACOX3) 110407463(ACOX1)
APLA: 101800606(ACOX1) 101800622(ACOX3)
ACYG: 106034764(ACOX1) 106034787(ACOX3)
TGU: 100224774(ACOX3) 100230333(ACOX1)
LSR: 110476585(ACOX1) 110481907(ACOX3)
SCAN: 103819860(ACOX1) 103823998(ACOX3)
GFR: 102037832(ACOX3) 102045190(ACOX1)
FAB: 101805996(ACOX1) 101822181(ACOX3)
PHI: 102104224(ACOX1) 102108066(ACOX3)
PMAJ: 107203234(ACOX3) 107212501(ACOX1)
CCAE: 111928222(ACOX3) 111937542(ACOX1)
CCW: 104690761(ACOX3) 104694389(ACOX1)
ETL: 114061614(ACOX3) 114070254(ACOX1)
FPG: 101911195(ACOX3) 101922049(ACOX1)
FCH: 102048868(ACOX3) 102050660(ACOX1)
CLV: 102090446(ACOX3) 102091425(ACOX1)
EGZ: 104125311(ACOX1) 104130192(ACOX3)
NNI: 104018048(ACOX3) 104022875(ACOX1)
ACUN: 113479302(ACOX3) 113486929(ACOX1)
PADL: 103917481(ACOX1) 103920941(ACOX3)
AAM: 106483845(ACOX1) 106498739(ACOX3)
ASN: 102374619(ACOX3) 102378195(ACOX1) 102379811
AMJ: 102561327(ACOX1) 102568948(ACOX3) 102569403
PSS: 102446224(ACOX3) 102463291(ACOX1)
CMY: 102942495(ACOX1) 102945590(ACOX3)
CPIC: 101934853(ACOX3) 101943673(ACOX1)
ACS: 100560789(acox3) 100562736(acox1)
PVT: 110085171(ACOX1) 110085518(ACOX3)
PBI: 103048183 103053067(ACOX3)
PMUR: 107290782(ACOX1) 107300237(ACOX3)
TSR: 106541917(ACOX3) 106552226(ACOX1)
PMUA: 114590631(ACOX1) 114603795(ACOX3)
GJA: 107113191(ACOX1) 107119031(ACOX3)
XLA: 108697971(acox3.L) 403357(acox1.S) 735228(acox1.L)
XTR: 100380064(acox3) 548479(acox1)
NPR: 108785824(ACOX3) 108800482(ACOX1)
DRE: 406421(acox3) 449662(acox1)
SRX: 107708257(acox3) 107715490(acox1)
SANH: 107660714(acox3) 107661972 107702990(acox1)
SGH: 107561335(acox1) 107597901(acox3)
CCAR: 109073412
IPU: 108267732(acox3) 108273108(acox1)
PHYP: 113538347(acox1) 113540558(acox3)
AMEX: 103030473(acox1) 103033929(acox3)
EEE: 113573498(acox3) 113583258(acox1)
TRU: 101072207(acox1) 101077705(acox3)
LCO: 104932977(acox1) 104939398(acox3)
NCC: 104944575(acox1)
MZE: 101471122(acox1) 101477744(acox3)
ONL: 100699523(acox3) 100707091(acox1)
XMA: 102224659(acox3) 102236229(acox1)
XCO: 114144967(acox1) 114157406(acox3)
PRET: 103469727(acox1) 103480145(acox3)
CVG: 107100572(acox1) 107104334(acox3)
NFU: 107382251(acox1) 107384495(acox3)
KMR: 108242282(acox3) 108248782(acox1)
ALIM: 106518764(acox1) 106535206(acox3)
AOCE: 111564180(acox3) 111564207(acox1)
CSEM: 103383777(acox1) 103391807(acox3)
POV: 109627396(acox1) 109642523(acox3)
LCF: 108875870(acox1) 108895242(acox3)
SDU: 111223643(acox3) 111236302(acox1)
SLAL: 111659758(acox1) 111667919(acox3)
HCQ: 109516527(acox3) 109519788(acox1)
BPEC: 110156769 110166142(acox1) 110166186 110170775(acox3)
MALB: 109957253(acox3) 109966252(acox1)
SASA: 100306814(acox3) 100380782(ACOX)
OTW: 112214543(acox3) 112230324
ELS: 105021629(acox1) 105027197(acox3)
SFM: 108938686(acox3) 108940037(acox1)
PKI: 111842627(acox3) 111848198(acox1)
LCM: 102347012(ACOX3) 102353101(ACOX1)
CMK: 103175663(acox1) 103177355(acox3)
RTP: 109929565 109934355(acox1)
DME: Dmel_CG17544(CG17544) Dmel_CG4586(CG4586) Dmel_CG5009(CG5009) Dmel_CG9527(CG9527) Dmel_CG9707(Acox57D-p) Dmel_CG9709(Acox57D-d)
DSI: Dsimw501_GD11316(Dsim_GD11316) Dsimw501_GD11593(Dsim_GD11593) Dsimw501_GD11595(Dsim_GD11595) Dsimw501_GD16824(Dsim_GD16824) Dsimw501_GD21764(Dsim_GD21764) Dsimw501_GD22578(Dsim_GD22578)
DPTE: 113794175
CEL: CELE_C48B4.1(acox-1.5) CELE_F08A8.1(acox-1.1) CELE_F08A8.2(acox-1.2) CELE_F08A8.3(acox-1.3) CELE_F08A8.4(acox-1.4) CELE_F58F9.7(acox-3) CELE_F59F4.1(acox-1.6)
ATH: AT1G06290(ACX3) AT1G06310(ACX6) AT2G35690(ACX5) AT3G06690 AT3G51840(ACX4) AT4G16760(ACX1) AT5G65110(ACX2)
LJA: Lj0g3v0333489.3(Lj0g3v0333489.3) Lj1g3v0385510.1(Lj1g3v0385510.1) Lj1g3v2358960.1(Lj1g3v2358960.1) Lj1g3v2358960.2(Lj1g3v2358960.2) Lj1g3v2370090.1(Lj1g3v2370090.1) Lj2g3v2000290.3(Lj2g3v2000290.3) Lj2g3v2000290.4(Lj2g3v2000290.4) Lj4g3v1221460.1(Lj4g3v1221460.1) Lj4g3v1223640.1(Lj4g3v1223640.1) Lj4g3v2820140.1(Lj4g3v2820140.1)
DOSA: Os01t0159400-01(Os01g0159400) Os05t0163700-01(Os05g0163700) Os06t0103500-01(Os06g0103500) Os06t0346300-00(Os06g0346300) Os06t0347100-01(Os06g0347100) Os06t0354500-01(Os06g0354500) Os11t0605500-01(Os11g0605500)
ATS: 109732666(LOC109732666) 109747304(LOC109747304) 109748134(LOC109748134) 109748989(LOC109748989) 109750750(LOC109750750)
MNG: MNEG_5833
SCE: YGL205W(POX1)
ERC: Ecym_1214
KMX: KLMA_20263(POX1)
NCS: NCAS_0E00630(NCAS0E00630)
NDI: NDAI_0I02880(NDAI0I02880)
TPF: TPHA_0A05790(TPHA0A05790)
TBL: TBLA_0I03240(TBLA0I03240)
TDL: TDEL_0D05820(TDEL0D05820)
KAF: KAFR_0F04110(KAFR0F04110)
PIC: PICST_39759(ACOX2) PICST_75424(POX1)
CDU: CD36_64100 CD36_81790(POX2) CD36_81950(POX1)
SLB: AWJ20_2391(POX1) AWJ20_249(POX1) AWJ20_3356(POX1)
MAW: MAC_05128
CMT: CCM_00678
MBE: MBM_00470
ANI: AN6752.2
ANG: ANI_1_176044(An05g01410) ANI_1_1992094(An11g04940)
CIM: CIMG_10832(CIMG01874) CIMG_12750(CIMG01877) CIMG_13106(CIMG07097)
ABE: ARB_08051
TVE: TRV_04366
CNE: CNG00320
CNB: CNBG4450
ABP: AGABI1DRAFT108106(AGABI1DRAFT_108106) AGABI1DRAFT43395(AGABI1DRAFT_43395) AGABI1DRAFT79987(AGABI1DRAFT_79987)
ABV: AGABI2DRAFT225220(AGABI2DRAFT_225220) AGABI2DRAFT227257(AGABI2DRAFT_227257) AGABI2DRAFT227725(AGABI2DRAFT_227725)
MGL: MGL_4209
MRT: MRET_1422
SMIN: v1.2.019398.t1(symbB.v1.2.019398.t1) v1.2.034764.t1(symbB.v1.2.034764.t1) v1.2.034764.t2(symbB.v1.2.034764.t2)
PTI: PHATRDRAFT_19979(AOX1)
FCY: FRACYDRAFT_210789(ACOX1)
TPS: THAPSDRAFT_263878(AOX1_1)
NGD: NGA_0437010(ACOX) NGA_0437020(ACOX)
PLU: plu2336
PAY: PAU_02326(aco)
XBV: XBW1_2150
XNE: XNC1_0653
XNM: XNC2_0640
PFS: PFLU_3198
ACAV: VI35_08295
BAM: Bamb_6234
MXA: MXAN_6432
CCX: COCOR_07019(mmgC3)
MPA: MAP_2101
MAO: MAP4_1722
MAVI: RC58_08610
MAVU: RE97_08610
MAV: MAV_2078
MIT: OCO_20410
MIA: OCU_20510
MID: MIP_02874
MYO: OEM_18240
MIR: OCQ_19190
MUL: MUL_1233
MMC: Mmcs_3435
MKM: Mkms_3498
MJL: Mjls_3446
MMI: MMAR_3631
MMM: W7S_09570
MSHG: MSG_03314
MVA: Mvan_3808
MGI: Mflv_2726
MPHL: MPHLCCUG_03447(acrC_10)
MVQ: MYVA_3631
MHAS: MHAS_01392(acrC_2)
MAB: MAB_3588
MABB: MASS_3592
MCHE: BB28_18350
MSTE: MSTE_03719
MSAL: DSM43276_03385(acrC_6)
MMIN: MMIN_31800
ASD: AS9A_0357
CJK: jk1941(acx)
CUR: cu1845
CAR: cauri_2169(acx)
CRD: CRES_1991(acx)
CVA: CVAR_2774(acx)
COA: DR71_1321
CSX: CSING_11215(acx)
CCJ: UL81_09715(acx)
CSP: WM42_1846
CMIN: NCTC10288_00399(acx)
CEE: CENDO_03170(acrC)
NFA: NFA_24790
RER: RER_16630
REY: O5Y_07945
ROP: ROP_17180
REQ: REQ_37470
RHB: NY08_4763
RFA: A3L23_02825(acrC_1)
RHS: A3Q41_00537(acrC_1)
RHU: A3Q40_00273(acrC_1)
GBR: Gbro_1022
GOR: KTR9_0919
GRU: GCWB2_04890(acrC3)
GOM: D7316_04605(acrC_8)
TPR: Tpau_0678
SCO: SCO3247(SCE29.16c)
SMA: SAVERM_3706(aco)
SHY: SHJG_1655
SALU: DC74_617
STRE: GZL_08643
SLD: T261_3448
STRM: M444_03475
SLE: sle_03510(sle_03510)
SALJ: SMD11_2049
SLX: SLAV_01670(mmgC1)
SFK: KY5_6075c
LXX: Lxx21820(acx2)
CMI: CMM_0813
CMS: CMS0070
CMC: CMN_00769
MTS: MTES_1132
MOO: BWL13_00192(mmgC_2)
MLV: CVS47_00170(fadE)
MOY: CVS54_00613(fadE)
AUW: AURUGA1_00085(fadE)
MALK: MalAC0309_0010(acx2)
ART: Arth_2142
ARM: ART_0691
AAU: AAur_2138
ACH: Achl_1889
AAI: AARI_16120(aco)
KRH: KRH_16780
BCV: Bcav_3568
JDE: Jden_2376
LMOI: VV02_21660
XCE: Xcel_3111
IDO: I598_2042(fadE)
CFL: Cfla_2935
CFI: Celf_3192
SERJ: SGUI_2849
BLIN: BLSMQ_2105
NCA: Noca_0437
NDK: I601_1658
KFL: Kfla_6493
PSIM: KR76_03245
TFU: Tfu_2239
NDA: Ndas_3221
NAL: B005_0176
STRR: EKD16_07215(mmgC3)
GOB: Gobs_0304
MMAR: MODMU_0321
KRA: Krad_4030
SACC: EYD13_17575(acrC3)
AMD: AMED_8080
AMN: RAM_41510
AMM: AMES_7958
AMZ: B737_7959
AOI: AORI_6907
AMYY: YIM_05110(mmgC2)
PDX: Psed_6176
PSEA: WY02_14800
PSEH: XF36_25955
PAUT: Pdca_64430
SESP: BN6_30630
ALO: CRK58445
MIL: ML5_4604
ASE: ACPL_5569
ACTN: L083_3683
AFS: AFR_23290
ACTS: ACWT_5439
CAI: Caci_3363
SRU: SRU_1701
SRM: SRM_01907(caiA)
FJO: Fjoh_3394
FJG: BB050_04220(mmgC_2)
MARM: YQ22_11090
CBAL: M667_07620
CBAT: M666_07655
ZGA: ZOBELLIA_2370(acxA)
NDO: DDD_0071
 » show all
Reference
  Authors
Oaxaca-Castillo D, Andreoletti P, Vluggens A, Yu S, van Veldhoven PP, Reddy JK, Cherkaoui-Malki M
  Title
Biochemical characterization of two functional human liver acyl-CoA oxidase isoforms 1a and 1b encoded by a single gene.
  Journal
Biochem Biophys Res Commun 360:314-9 (2007)
DOI:10.1016/j.bbrc.2007.06.059
  Sequence
[hsa:51]

KEGG   ORTHOLOGY: K12405
Entry
K12405                      KO                                     

Name
HSD17B4
Definition
(3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2 [EC:1.1.1.- 4.2.1.107 4.2.1.119]
Pathway
ko00120  Primary bile acid biosynthesis
ko01040  Biosynthesis of unsaturated fatty acids
ko01100  Metabolic pathways
ko01212  Fatty acid metabolism
ko04146  Peroxisome
Module
M00104  Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
M00861  beta-Oxidation, peroxisome, VLCFA
M00862  beta-Oxidation, peroxisome, tri/dihydroxycholestanoyl-CoA => choloyl/chenodeoxycholoyl-CoA
Disease
H00407  Peroxisomal beta-oxidation enzyme deficiency
H02095  Perrault syndrome
H02098  D-bifunctional protein deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    K12405  HSD17B4; (3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2
   01040 Biosynthesis of unsaturated fatty acids
    K12405  HSD17B4; (3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    K12405  HSD17B4; (3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-  
     K12405  HSD17B4; (3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.107  3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase
     K12405  HSD17B4; (3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2
    4.2.1.119  enoyl-CoA hydratase 2
     K12405  HSD17B4; (3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2
Other DBs
RN: R04809 R04810 R04812 R04813 R07935 R07936 R07951 R07952 R09698
GO: 0033989
Genes
HSA: 3295(HSD17B4)
PTR: 462019(HSD17B4)
PPS: 100981028(HSD17B4)
GGO: 101129538(HSD17B4)
PON: 100448539(HSD17B4)
NLE: 100590035(HSD17B4)
MCC: 698369(HSD17B4)
MCF: 102123675(HSD17B4)
CSAB: 103244395(HSD17B4)
RRO: 104654581(HSD17B4)
RBB: 108529825(HSD17B4)
CJC: 100390100(HSD17B4)
SBQ: 101036776(HSD17B4)
MMU: 15488(Hsd17b4)
MCAL: 110284447(Hsd17b4)
MPAH: 110332881(Hsd17b4)
RNO: 79244(Hsd17b4)
CGE: 103161104(Hsd17b4)
NGI: 103745113(Hsd17b4)
HGL: 101713520(Hsd17b4)
CCAN: 109674145
OCU: 100346781(HSD17B4)
TUP: 102468828(HSD17B4)
CFA: 474630(HSD17B4)
VVP: 112932403(HSD17B4)
AML: 100471749(HSD17B4)
UMR: 103670554(HSD17B4)
UAH: 113261629(HSD17B4)
ORO: 101385731(HSD17B4)
ELK: 111158891
FCA: 101091840(HSD17B4)
PTG: 102968873(HSD17B4)
PPAD: 109278892(HSD17B4)
AJU: 106975089(HSD17B4)
BTA: 493643(HSD17B4)
BOM: 102268517(HSD17B4)
BBUB: 102412917(HSD17B4)
CHX: 102172142(HSD17B4)
OAS: 101114519(HSD17B4)
SSC: 397574(HSD17B4)
CFR: 102508317(HSD17B4)
CDK: 105104293(HSD17B4)
LVE: 103084787(HSD17B4)
OOR: 101282963(HSD17B4)
DLE: 111183342(HSD17B4)
PCAD: 102996127(HSD17B4)
ECB: 100034046(HSD17B4)
EPZ: 103548315(HSD17B4)
EAI: 106833039(HSD17B4)
MYB: 102240475(HSD17B4)
MYD: 102767159(HSD17B4)
MNA: 107530713(HSD17B4)
HAI: 109374101(HSD17B4)
DRO: 112315031(HSD17B4)
LAV: 100659299(HSD17B4)
TMU: 101356123
MDO: 100028098(HSD17B4)
SHR: 100932771(HSD17B4)
PCW: 110202743(HSD17B4)
OAA: 100081754(HSD17B4)
GGA: 395785(HSD17B4)
CJO: 107306670(HSD17B4)
NMEL: 110389447(HSD17B4)
APLA: 101791118(HSD17B4)
ACYG: 106048362(HSD17B4)
TGU: 100218226(HSD17B4)
LSR: 110479177(HSD17B4)
SCAN: 103821465(HSD17B4)
GFR: 102036502(HSD17B4)
FAB: 101807233(HSD17B4)
PHI: 102109547(HSD17B4)
PMAJ: 107216347(HSD17B4)
CCAE: 111941198(HSD17B4)
CCW: 104690497(HSD17B4)
ETL: 114056305(HSD17B4)
FPG: 101917400(HSD17B4)
FCH: 102058406(HSD17B4)
CLV: 102095771(HSD17B4)
EGZ: 104122491(HSD17B4)
NNI: 104014571(HSD17B4)
ACUN: 113489653(HSD17B4)
PADL: 103912347(HSD17B4)
ASN: 102371766(HSD17B4)
AMJ: 102571005(HSD17B4)
PSS: 102451304(HSD17B4)
CPIC: 101945395(HSD17B4)
ACS: 100558484(hsd17b4)
PVT: 110084344(HSD17B4)
PBI: 103063870(HSD17B4)
PMUR: 107294349(HSD17B4)
TSR: 106543382(HSD17B4)
PMUA: 114606393(HSD17B4)
GJA: 107116225(HSD17B4)
XLA: 444492(hsd17b4.L)
XTR: 613082(hsd17b4)
NPR: 108787696(HSD17B4)
DRE: 393105(hsd17b4)
SANH: 107703629(hsd17b4)
SGH: 107571774(hsd17b4)
IPU: 108265438(hsd17b4)
PHYP: 113529268(hsd17b4)
AMEX: 103046836(hsd17b4)
EEE: 113571049(hsd17b4)
TRU: 101062498(hsd17b4)
LCO: 104920820(hsd17b4)
NCC: 104966339(hsd17b4)
MZE: 101482787(hsd17b4)
ONL: 100706762(hsd17b4)
OLA: 101159921(hsd17b4)
XMA: 102223774(hsd17b4)
XCO: 114154573(hsd17b4)
PRET: 103470095(hsd17b4)
CVG: 107086311(hsd17b4)
NFU: 107394149(hsd17b4)
KMR: 108233704(hsd17b4)
ALIM: 106513677(hsd17b4)
AOCE: 111564685(hsd17b4)
POV: 109637138(hsd17b4)
LCF: 108882142(hsd17b4)
SDU: 111230866(hsd17b4)
SLAL: 111645149(hsd17b4)
HCQ: 109526033(hsd17b4)
BPEC: 110167024(hsd17b4)
MALB: 109956607(hsd17b4)
SASA: 106585849(hsd17b4)
OTW: 112247069(hsd17b4)
SALP: 111974039(hsd17b4)
ELS: 105014609(hsd17b4)
SFM: 108938133(hsd17b4)
PKI: 111856620(hsd17b4)
LCM: 102356548(HSD17B4)
CMK: 103181119(hsd17b4)
BFO: 118409354
CIN: 100187421
SPU: 581580
DME: Dmel_CG3415(Mfe2)
DMN: 108161558
AAG: 5568633
AALB: 109428196
AME: 409986
NVI: 100123018
TCA: 663655(17-beta-HD4)
API: 100167575
DNX: 107163428
AGS: 114120233
RMD: 113555196
CEL: CELE_E04F6.3(maoc-1) CELE_M03A8.1(dhs-28)
NVE: 5504006
DDI: DDB_G0291247(mfeA)
 » show all
Reference
PMID:9089413
  Authors
Jiang LL, Miyazawa S, Souri M, Hashimoto T
  Title
Structure of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein.
  Journal
J Biochem 121:364-9 (1997)
DOI:10.1093/oxfordjournals.jbchem.a021596
  Sequence
[hsa:3295]
Reference
  Authors
Koski KM, Haapalainen AM, Hiltunen JK, Glumoff T
  Title
Crystal structure of 2-enoyl-CoA hydratase 2 from human peroxisomal multifunctional enzyme type 2.
  Journal
J Mol Biol 345:1157-69 (2005)
DOI:10.1016/j.jmb.2004.11.009
  Sequence
[hsa:3295]

KEGG   ORTHOLOGY: K07513
Entry
K07513                      KO                                     

Name
ACAA1
Definition
acetyl-CoA acyltransferase 1 [EC:2.3.1.16]
Pathway
ko00071  Fatty acid degradation
ko00280  Valine, leucine and isoleucine degradation
ko00592  alpha-Linolenic acid metabolism
ko01040  Biosynthesis of unsaturated fatty acids
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01212  Fatty acid metabolism
ko03320  PPAR signaling pathway
ko04146  Peroxisome
Module
M00087  beta-Oxidation
M00113  Jasmonic acid biosynthesis
M00861  beta-Oxidation, peroxisome, VLCFA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00071 Fatty acid degradation
    K07513  ACAA1; acetyl-CoA acyltransferase 1
   00592 alpha-Linolenic acid metabolism
    K07513  ACAA1; acetyl-CoA acyltransferase 1
   01040 Biosynthesis of unsaturated fatty acids
    K07513  ACAA1; acetyl-CoA acyltransferase 1
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K07513  ACAA1; acetyl-CoA acyltransferase 1
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    K07513  ACAA1; acetyl-CoA acyltransferase 1
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K07513  ACAA1; acetyl-CoA acyltransferase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.16  acetyl-CoA C-acyltransferase
     K07513  ACAA1; acetyl-CoA acyltransferase 1
Other DBs
RN: R00238 R00927 R01177 R03778 R03858 R03991 R04546 R04742 R04747 R07891 R07895 R07899 R07937 R07953
GO: 0003988
Genes
HSA: 30(ACAA1)
PTR: 460268(ACAA1)
PPS: 100994212(ACAA1)
GGO: 101141231(ACAA1)
PON: 100461213(ACAA1)
NLE: 100597596(ACAA1)
MCC: 696743(ACAA1)
MCF: 102143849(ACAA1)
CSAB: 103221068(ACAA1)
RRO: 104657451(ACAA1)
RBB: 108512243(ACAA1)
CJC: 100412554(ACAA1)
SBQ: 101052252(ACAA1)
MMU: 113868(Acaa1a) 235674(Acaa1b)
MPAH: 110327492(Acaa1) 110328451
RNO: 24157(Acaa1a) 501072(Acaa1b)
HGL: 101713505(Acaa1) 101714191
OCU: 100340554(ACAA1)
TUP: 102470441(ACAA1)
CFA: 477023(ACAA1)
VVP: 112921659(ACAA1)
AML: 100475784(ACAA1)
UMR: 103682196(ACAA1)
UAH: 113253780(ACAA1)
ORO: 101363464(ACAA1)
ELK: 111159048
FCA: 101087343(ACAA1)
PTG: 102967023(ACAA1)
PPAD: 109248748(ACAA1)
AJU: 106966644(ACAA1)
BTA: 508324(ACAA1)
BOM: 102280228(ACAA1)
BIU: 109576258(ACAA1)
BBUB: 102396359(ACAA1)
CHX: 102184764(ACAA1)
OAS: 101110625(ACAA1)
SSC: 100515577(ACAA1)
CFR: 102506838(ACAA1)
CDK: 105090693(ACAA1)
BACU: 103013122(ACAA1)
LVE: 103088661(ACAA1)
OOR: 101278829(ACAA1)
DLE: 111164349(ACAA1)
PCAD: 102974484(ACAA1)
ECB: 100050082(ACAA1)
EPZ: 103553900(ACAA1)
EAI: 106834267(ACAA1)
MYB: 102247718(ACAA1)
MYD: 102759768(ACAA1)
MNA: 107524306
HAI: 109393490(ACAA1)
DRO: 112309850(ACAA1)
PALE: 102890231(ACAA1)
RAY: 107499599(ACAA1)
MJV: 108401028(ACAA1)
LAV: 100667518(ACAA1)
TMU: 101341576
MDO: 100021694(ACAA1)
SHR: 100932858(ACAA1)
PCW: 110192929(ACAA1)
OAA: 100090526(ACAA1)
GGA: 770094(ACAA1)
MGP: 100542533(ACAA1)
CJO: 107308790(ACAA1)
NMEL: 110394676(ACAA1)
APLA: 101797981(ACAA1)
ACYG: 106036840(ACAA1)
TGU: 100232310(ACAA1)
LSR: 110484539(ACAA1)
SCAN: 103812699(ACAA1)
GFR: 102044074(ACAA1)
FAB: 101816553(ACAA1)
PHI: 102108642(ACAA1)
PMAJ: 107200236(ACAA1)
CCAE: 111925455(ACAA1)
CCW: 104686412(ACAA1)
ETL: 114065135(ACAA1)
FPG: 101923424(ACAA1)
FCH: 102050522(ACAA1)
CLV: 102088336(ACAA1)
EGZ: 104130983(ACAA1)
NNI: 104021752(ACAA1)
ACUN: 113476335(ACAA1)
AAM: 106494846(ACAA1)
ASN: 102368605(ACAA1)
AMJ: 102562558(ACAA1)
PSS: 102455625(ACAA1)
CMY: 102932084
CPIC: 101943221(ACAA1)
ACS: 100567075(acaa1)
PVT: 110085831(ACAA1)
PBI: 103056268
PMUR: 107284371(ACAA1)
TSR: 106554068(ACAA1)
PMUA: 114606975(ACAA1)
GJA: 107107954(ACAA1)
XLA: 380296(acaa1.L)
XTR: 780143(acaa1)
NPR: 108797614(ACAA1)
DRE: 431754(acaa1)
IPU: 100528276(acaa1)
PHYP: 113541245(acaa1)
AMEX: 103044652(acaa1)
EEE: 113581209(acaa1)
TRU: 101063902(acaa1)
LCO: 104927325(acaa1)
NCC: 104959411(acaa1)
MZE: 101465882(acaa1)
ONL: 100709821(acaa1)
OLA: 101173322(acaa1)
XMA: 102223074(acaa1)
XCO: 114144298(acaa1)
PRET: 103473178(acaa1)
CVG: 107094433(acaa1)
NFU: 107394222(acaa1)
KMR: 108251775(acaa1)
ALIM: 106535425(acaa1)
AOCE: 111563089(acaa1)
CSEM: 103383387(acaa1)
LCF: 108888719(acaa1)
SDU: 111232969(acaa1)
SLAL: 111651959(acaa1)
BPEC: 110175545(acaa1)
MALB: 109971785(acaa1)
SASA: 106579756
OTW: 112235894(acaa1)
SALP: 112076835(acaa1)
ELS: 105007694(acaa1)
SFM: 108934024(acaa1)
PKI: 111837860(acaa1)
LCM: 102348225(ACAA1)
CMK: 103191285(acaa1)
RTP: 109921355(acaa1)
BFO: 118424439
APLC: 110989318
SKO: 100372855
PCAN: 112564571
CRG: 105319875
MYI: 110452917
LAK: 106157535
ATH: AT1G04710(PKT4) AT2G33150(PKT3) AT5G48880(KAT5)
VRA: 106772635
VAR: 108326422
LJA: Lj0g3v0197249.1(Lj0g3v0197249.1) Lj0g3v0197249.2(Lj0g3v0197249.2) Lj0g3v0259119.1(Lj0g3v0259119.1)
NNU: 104587903
DOSA: Os02t0817700-02(Os02g0817700) Os10t0457600-01(Os10g0457600)
ATS: 109779883(LOC109779883) 109787002(LOC109787002)
ZMA: 100192501 100193233 100274263(pco082145)
ATR: 18444168
CRE: CHLREDRAFT_138637(ATO1)
APRO: F751_5597
SCE: YIL160C(POT1)
ERC: Ecym_4003
KMX: KLMA_20220(POT1)
NDI: NDAI_0C02520(NDAI0C02520)
TPF: TPHA_0E00110(TPHA0E00110)
TBL: TBLA_0E01830(TBLA0E01830)
TDL: TDEL_0F05590(TDEL0F05590)
KAF: KAFR_0H00110(KAFR0H00110)
PIC: PICST_55180(POT13) PICST_79854(POT11)
SLB: AWJ20_1140(POT1) AWJ20_2360(POT1)
NTE: NEUTE1DRAFT68512(NEUTE1DRAFT_68512) NEUTE1DRAFT77879(NEUTE1DRAFT_77879) NEUTE1DRAFT87502(NEUTE1DRAFT_87502)
CMT: CCM_01627
ANG: ANI_1_452024(An02g03320) ANI_1_76114(An13g00590) ANI_1_770074(An08g05400) ANI_1_942184(An04g05720)
CNE: CNA04700
CNB: CNBA4520
ABP: AGABI1DRAFT112317(AGABI1DRAFT_112317) AGABI1DRAFT32206(AGABI1DRAFT_32206) AGABI1DRAFT51517(AGABI1DRAFT_51517)
ABV: AGABI2DRAFT175902(AGABI2DRAFT_175902) AGABI2DRAFT193507(AGABI2DRAFT_193507) AGABI2DRAFT239518(AGABI2DRAFT_239518)
MGL: MGL_3510
MRT: MRET_0926
SMIN: v1.2.036595.t1(symbB.v1.2.036595.t1) v1.2.036596.t1(symbB.v1.2.036596.t1) v1.2.036597.t1(symbB.v1.2.036597.t1)
PTI: PHATRDRAFT_41969(KCT1)
TPS: THAPSDRAFT_36742(KCT2)
SPAR: SPRG_04484
 » show all
Reference
  Authors
GOLDMAN DS
  Title
Studies on the fatty acid oxidizing system of animal tissues. VII. The beta-ketoacyl coenzyme A cleavage enzyme.
  Journal
J Biol Chem 208:345-57 (1954)
Reference
  Authors
Sordillo JE, Sharma S, Poon A, Lasky-Su J, Belanger K, Milton DK, Bracken MB, Triche EW, Leaderer BP, Gold DR, Litonjua AA
  Title
Effects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1.
  Journal
BMC Med Genet 12:158 (2011)
DOI:10.1186/1471-2350-12-158

KEGG   ORTHOLOGY: K08764
Entry
K08764                      KO                                     

Name
SCP2, SCPX
Definition
sterol carrier protein 2 [EC:2.3.1.176]
Pathway
ko00120  Primary bile acid biosynthesis
ko01040  Biosynthesis of unsaturated fatty acids
ko01100  Metabolic pathways
ko01212  Fatty acid metabolism
ko03320  PPAR signaling pathway
ko04146  Peroxisome
Module
M00104  Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
M00861  beta-Oxidation, peroxisome, VLCFA
M00862  beta-Oxidation, peroxisome, tri/dihydroxycholestanoyl-CoA => choloyl/chenodeoxycholoyl-CoA
Disease
H00407  Peroxisomal beta-oxidation enzyme deficiency
H00874  Leukoencephalopathy with dystonia and motor neuropathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    K08764  SCP2, SCPX; sterol carrier protein 2
   01040 Biosynthesis of unsaturated fatty acids
    K08764  SCP2, SCPX; sterol carrier protein 2
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    K08764  SCP2, SCPX; sterol carrier protein 2
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K08764  SCP2, SCPX; sterol carrier protein 2
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.176  propanoyl-CoA C-acyltransferase
     K08764  SCP2, SCPX; sterol carrier protein 2
Other DBs
RN: R03719 R04811 R07937 R07953
GO: 0033814
Genes
HSA: 6342(SCP2)
PTR: 456862(SCP2)
PPS: 100986541(SCP2)
GGO: 101143883(SCP2)
PON: 100173072(SCP2)
NLE: 100597097(SCP2)
MCC: 715765(SCP2)
MCF: 102140312(SCP2)
CSAB: 103224800(SCP2)
RRO: 104669256(SCP2)
RBB: 108531191(SCP2)
CJC: 100388218(SCP2)
SBQ: 101036680(SCP2)
MMU: 20280(Scp2)
MCAL: 110292209(Scp2)
MPAH: 110323135(Scp2)
RNO: 25541(Scp2)
MUN: 110563883(Scp2)
CGE: 100757558(Scp2)
NGI: 103730241(Scp2)
HGL: 101705283(Scp2)
CCAN: 109693360(Scp2)
OCU: 100008683(SCP2)
TUP: 102487249(SCP2)
CFA: 479564(SCP2)
VVP: 112926124(SCP2)
AML: 100469567(SCP2)
UMR: 103670702(SCP2)
UAH: 113254655(SCP2)
ORO: 101367151(SCP2)
ELK: 111143445
FCA: 101093036(SCP2)
PTG: 102951550(SCP2)
PPAD: 109266864(SCP2)
AJU: 106987886(SCP2)
BTA: 508918(SCP2)
BOM: 102281973
BIU: 109556283(SCP2)
BBUB: 102409865(SCP2)
CHX: 102182369(SCP2)
OAS: 101117285(SCP2)
SSC: 397439(SCP2)
CFR: 102516689(SCP2)
CDK: 105090773(SCP2)
BACU: 103008562(SCP2)
LVE: 103081853
OOR: 101279314(SCP2)
DLE: 111175824(SCP2)
PCAD: 102988699(SCP2)
ECB: 100061338(SCP2)
EPZ: 103558615(SCP2)
EAI: 106833182(SCP2)
MYB: 102242920(SCP2)
MYD: 102765227(SCP2)
MNA: 107535398(SCP2)
DRO: 112314454(SCP2)
PALE: 102884769(SCP2)
RAY: 107497927(SCP2)
MJV: 108403979(SCP2)
LAV: 100666078
TMU: 101347488
MDO: 100017946(SCP2)
SHR: 100922562(SCP2)
PCW: 110209359(SCP2)
OAA: 100084202(SCP2)
GGA: 396550(SCP2)
MGP: 100541979(SCP2)
CJO: 107317654(SCP2)
NMEL: 110402526(SCP2)
APLA: 101803933(SCP2)
ACYG: 106032940(SCP2)
TGU: 100218387(SCP2)
LSR: 110470146(SCP2)
SCAN: 103815029(SCP2)
GFR: 102042799(SCP2)
FAB: 101820874(SCP2)
PHI: 102105546(SCP2)
PMAJ: 107208151(SCP2)
CCAE: 111933041(SCP2)
CCW: 104695523(SCP2)
ETL: 114062766(SCP2)
FPG: 101913645(SCP2)
FCH: 102053527(SCP2)
CLV: 102087499(SCP2)
EGZ: 104131500(SCP2)
ACUN: 113483071(SCP2)
PADL: 103913664(SCP2)
AAM: 106491062(SCP2)
AMJ: 102570791(SCP2)
PSS: 102461487(SCP2)
CMY: 102931842
CPIC: 101937963(SCP2)
ACS: 100559527(scp2)
PVT: 110082239(SCP2)
PBI: 103053379(SCP2)
PMUR: 107283044(SCP2)
TSR: 106546053(SCP2)
PMUA: 114598987(SCP2)
GJA: 107120559(SCP2)
XLA: 108715604 494715(scp2.L)
XTR: 548512(scp2)
NPR: 108783818(SCP2)
DRE: 393839(scp2a)
SRX: 107719264(scp2) 107722381
SANH: 107681719(scp2)
SGH: 107593851(scp2)
CCAR: 109091477
IPU: 108267621(scp2)
PHYP: 113540595
AMEX: 103022159(scp2)
EEE: 113570128(scp2)
TRU: 101069006(scp2)
LCO: 104936979(scp2)
NCC: 104949681(scp2)
MZE: 101481799(scp2)
ONL: 100711328
OLA: 101175107(scp2)
XMA: 102226285
XCO: 114145905(scp2)
PRET: 103479011(scp2)
CVG: 107083609(scp2)
NFU: 107384403
KMR: 108238206(scp2)
ALIM: 106527182(scp2)
AOCE: 111587618(scp2)
CSEM: 103395834(scp2)
POV: 109646608(scp2)
LCF: 108883814(scp2)
SDU: 111228861(scp2)
SLAL: 111670554(scp2)
HCQ: 109521343(scp2)
BPEC: 110173449(scp2) 110173461
MALB: 109970643(scp2)
SASA: 106569705(scp2)
OTW: 112260891(scp2)
SALP: 112069550
ELS: 105022798(scp2)
SFM: 108935159(scp2)
PKI: 111847545(scp2)
LCM: 102354489
CMK: 103185291(scp2)
RTP: 109913670(scp2)
BFO: 118431877
APLC: 110986063
SKO: 100368127(SCP2) 100368276
DME: Dmel_CG17320(ScpX) Dmel_CG17597(CG17597)
DSI: Dsimw501_GD21807(Dsim_GD21807)
MDE: 101899830
LCQ: 111680181
AAG: 5575668
AME: 408904
BIM: 100748275
BTER: 100647066
CCAL: 108628439
OBB: 114870987
SOC: 105201416
MPHA: 105840706
AEC: 105153563
ACEP: 105618569
PBAR: 105432859
VEM: 105559618
HST: 105189995
DQU: 106742407
CFO: 105251216
LHU: 105675589
PGC: 109861339
OBO: 105274767
PCF: 106788866
NVI: 100123951
CSOL: 105363609
MDL: 103571215
TCA: 657233(Scpx)
DPA: 109539789
ATD: 109602926
NVL: 108556749
BMOR: 692782(Scpx)
BMAN: 114242327
PRAP: 110993930
HAW: 110373174
TNL: 113497353
PXY: 105382506
API: 100161454
DNX: 107161308
AGS: 114122268
RMD: 113555937
BTAB: 109035142
CLEC: 106670708
ZNE: 110831910
FCD: 110850871
PVM: 113823286
TUT: 107367461
CSCU: 111639045
CEL: CELE_Y57A10C.6(daf-22)
CBR: CBG20965
BMY: Bm1_53275
MYI: 110461537
OBI: 106877352
AMIL: 114970597
DGT: 114526215
AQU: 100638133
NCR: NCU03372
NTE: NEUTE1DRAFT84532(NEUTE1DRAFT_84532)
MGR: MGG_02409
SSCK: SPSK_02507
MAW: MAC_03561
MAJ: MAA_02626
MBE: MBM_04974
ANG: ANI_1_216184(An04g00740)
PBL: PAAG_11860(PAAG_04374)
ABE: ARB_01676
TVE: TRV_00032
PTE: PTT_11137
TASA: A1Q1_03740
ABP: AGABI1DRAFT110046(AGABI1DRAFT_110046)
ABV: AGABI2DRAFT190063(AGABI2DRAFT_190063)
SFR: Sfri_0743
CPS: CPS_0669
PSEO: OM33_12585
PSPO: PSPO_a2037
ADI: B5T_02065
APAC: S7S_16300
AXE: P40_09880
GPB: HDN1F_17110(tioL)
AAA: Acav_2987
HPSE: HPF_13290(paaJ2)
EBA: ebA306(tioL) ebA5797
TCL: Tchl_1577
PLA: Plav_0155
BRS: S23_06920
RPB: RPB_4078
RPD: RPD_3814
XAU: Xaut_4071
CAK: Caul_0450
SPSE: SULPSESMR1_04594(fadA)
SWI: Swit_4119
SMIC: SmB9_09260
AZL: AZL_a11110(fadA)
TMO: TMO_0975
MJL: Mjls_1512
MVQ: MYVA_4960
MCHT: MCHIJ_01810(ltp1_1)
ASD: AS9A_0934
NSR: NS506_04193(scp2)
GOR: KTR9_3195
 » show all
Reference
  Authors
Russell DW
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712
Reference
  Authors
Stanley WA, Filipp FV, Kursula P, Schuller N, Erdmann R, Schliebs W, Sattler M, Wilmanns M
  Title
Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p.
  Journal
Mol Cell 24:653-63 (2006)
DOI:10.1016/j.molcel.2006.10.024
  Sequence
[hsa:6342]
Reference
  Authors
Ferdinandusse S, Denis S, Mooijer PA, Zhang Z, Reddy JK, Spector AA, Wanders RJ
  Title
Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid.
  Journal
J Lipid Res 42:1987-95 (2001)

KEGG   ENZYME: 1.3.3.6
Entry
EC 1.3.3.6                  Enzyme                                 

Name
acyl-CoA oxidase;
fatty acyl-CoA oxidase;
acyl coenzyme A oxidase;
fatty acyl-coenzyme A oxidase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With oxygen as acceptor
Sysname
acyl-CoA:oxygen 2-oxidoreductase
Reaction(IUBMB)
acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2 [RN:R00388]
Reaction(KEGG)
Substrate
acyl-CoA [CPD:C00040];
O2 [CPD:C00007]
Product
trans-2,3-dehydroacyl-CoA [CPD:C00658];
H2O2 [CPD:C00027]
Comment
A flavoprotein (FAD). Acts on CoA derivatives of fatty acids with chain lengths from 8 to 18.
History
EC 1.3.3.6 created 1986
Pathway
ec00071  Fatty acid degradation
ec00410  beta-Alanine metabolism
ec00592  alpha-Linolenic acid metabolism
ec00640  Propanoate metabolism
ec01040  Biosynthesis of unsaturated fatty acids
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00232  acyl-CoA oxidase
Genes
HSA: 51(ACOX1) 8310(ACOX3)
PTR: 454895(ACOX1) 461115(ACOX3)
PPS: 100973171(ACOX3) 100984758(ACOX1)
GGO: 101145668(ACOX1) 101152360(ACOX3)
PON: 100172283(ACOX1) 100172575(ACOX3)
NLE: 100590927(ACOX3) 100595934(ACOX1)
MCC: 705197(ACOX1) 722634(ACOX3)
MCF: 102131652(ACOX3) 102145989(ACOX1)
CSAB: 103243017(ACOX1) 103246430(ACOX3)
RRO: 104678969(ACOX3) 104681285(ACOX1)
RBB: 108537328(ACOX1) 108543226(ACOX3)
CJC: 100394823(ACOX3) 100401745(ACOX1)
SBQ: 101029701(ACOX3) 101036109(ACOX1)
MMU: 11430(Acox1) 80911(Acox3)
MCAL: 110294025(Acox3) 110304682(Acox1)
MPAH: 110330653(Acox3) 110331272(Acox1)
RNO: 50681(Acox1) 83522(Acox3)
MUN: 110548021(Acox1) 110559473(Acox3)
CGE: 100689199(Acox1) 100767060(Acox3)
NGI: 103732704(Acox1) 103733928(Acox3)
HGL: 101705097(Acox1) 101719939(Acox3)
CCAN: 109683482(Acox1) 109687438(Acox3)
OCU: 100338450(ACOX1) 103347455(ACOX3)
TUP: 102482193(ACOX1) 102486878(ACOX3)
CFA: 483322(ACOX1) 488790(ACOX3)
VVP: 112920542(ACOX3) 112920813(ACOX1)
AML: 100463549(ACOX3) 100471606(ACOX1)
UMR: 103665753(ACOX1) 103676728(ACOX3)
UAH: 113244611(ACOX1) 113245696(ACOX3)
ORO: 101372647(ACOX3) 101380271(ACOX1)
FCA: 101082279(ACOX1) 101088745(ACOX3)
PTG: 102949456(ACOX3) 102964654(ACOX1)
PPAD: 109269729(ACOX3) 109276909(ACOX1)
AJU: 106982705(ACOX3) 106987755(ACOX1)
BTA: 510065(ACOX3) 513996(ACOX1)
BOM: 102266983(ACOX1) 102283461(ACOX3)
BIU: 109560748(ACOX3) 109573351(ACOX1)
BBUB: 102403281(ACOX1) 102416647(ACOX3)
CHX: 102170734(ACOX1) 102177788(ACOX3)
OAS: 101118626(ACOX1) 101119642(ACOX3)
SSC: 100113422(ACOX1) 100523005(ACOX3)
CFR: 102512004(ACOX1) 102515875(ACOX3)
CDK: 105103342(ACOX3) 105105527(ACOX1)
BACU: 102998639(ACOX1) 103015927(ACOX3)
LVE: 103074495(ACOX1) 103089784(ACOX3)
OOR: 101275698(ACOX1) 101287447(ACOX3)
PCAD: 102982781(ACOX3) 102988733(ACOX1) 112062893
ECB: 100051466(ACOX1) 100056690(ACOX3)
EPZ: 103546599(ACOX1) 103559319(ACOX3)
EAI: 106830317(ACOX1) 106840065(ACOX3)
MYB: 102247645(ACOX3) 102259193(ACOX1)
MYD: 102752805(ACOX1) 102766056(ACOX3)
MNA: 107524067(ACOX3) 107536619(ACOX1)
HAI: 109372914(ACOX3) 109383700(ACOX1)
DRO: 112298663(ACOX1) 112316811(ACOX3)
PALE: 102892373(ACOX3) 102896015(ACOX1)
RAY: 107501215(ACOX3) 107501445(ACOX1)
MJV: 108403833 108406048(ACOX1)
LAV: 100668073(ACOX3) 100676729(ACOX1)
MDO: 100019995(ACOX3) 100022432(ACOX1)
PCW: 110212210(ACOX3) 110219261(ACOX1)
OAA: 100083493(ACOX1) 103169536(ACOX3)
GGA: 417366(ACOX1) 422869(ACOX3)
MGP: 100538886(ACOX3) 100540963(ACOX1)
CJO: 107313952(ACOX3) 107322018(ACOX1)
NMEL: 110398066(ACOX3) 110407463(ACOX1)
APLA: 101800606(ACOX1) 101800622(ACOX3)
ACYG: 106034764(ACOX1) 106034787(ACOX3)
TGU: 100224774(ACOX3) 100230333(ACOX1)
LSR: 110476585(ACOX1) 110481907(ACOX3)
SCAN: 103819860(ACOX1) 103823998(ACOX3)
GFR: 102037832(ACOX3) 102045190(ACOX1)
FAB: 101805996(ACOX1) 101822181(ACOX3)
PHI: 102104224(ACOX1) 102108066(ACOX3)
PMAJ: 107203234(ACOX3) 107212501(ACOX1)
CCAE: 111928222(ACOX3) 111937542(ACOX1)
CCW: 104690761(ACOX3) 104694389(ACOX1)
ETL: 114061614(ACOX3) 114070254(ACOX1)
FPG: 101911195(ACOX3) 101922049(ACOX1)
FCH: 102048868(ACOX3) 102050660(ACOX1)
CLV: 102090446(ACOX3) 102091425(ACOX1)
EGZ: 104125311(ACOX1) 104130192(ACOX3)
NNI: 104018048(ACOX3) 104022875(ACOX1)
ACUN: 113479302(ACOX3) 113486929(ACOX1)
PADL: 103917481(ACOX1) 103920941(ACOX3)
AAM: 106483845(ACOX1) 106498739(ACOX3)
ASN: 102374619(ACOX3) 102378195(ACOX1) 102379811
AMJ: 102561327(ACOX1) 102568948(ACOX3) 102569403
PSS: 102446224(ACOX3) 102463291(ACOX1)
CMY: 102942495(ACOX1) 102945590(ACOX3)
CPIC: 101934853(ACOX3) 101943673(ACOX1)
ACS: 100560789(acox3) 100562736(acox1)
PVT: 110085171(ACOX1) 110085518(ACOX3)
PBI: 103048183 103053067(ACOX3)
PMUR: 107290782(ACOX1) 107300237(ACOX3)
TSR: 106541917(ACOX3) 106552226(ACOX1)
PMUA: 114590631(ACOX1) 114603795(ACOX3)
GJA: 107113191(ACOX1) 107119031(ACOX3)
XLA: 108697971(acox3.L) 403357(acox1.S) 735228(acox1.L)
XTR: 100380064(acox3) 548479(acox1)
NPR: 108785824(ACOX3) 108800482(ACOX1)
DRE: 406421(acox3) 449662(acox1)
SRX: 107708257(acox3) 107715490(acox1)
SANH: 107660714(acox3) 107661972 107702990(acox1)
SGH: 107561335(acox1) 107597901(acox3)
CCAR: 109073412
IPU: 108267732(acox3) 108273108(acox1)
PHYP: 113538347(acox1) 113540558(acox3)
AMEX: 103030473(acox1) 103033929(acox3)
EEE: 113573498(acox3) 113583258(acox1)
TRU: 101072207(acox1) 101077705(acox3)
LCO: 104932977(acox1) 104939398(acox3)
NCC: 104944575(acox1)
MZE: 101471122(acox1) 101477744(acox3)
ONL: 100699523(acox3) 100707091(acox1)
XMA: 102224659(acox3) 102236229(acox1)
XCO: 114144967(acox1) 114157406(acox3)
PRET: 103469727(acox1) 103480145(acox3)
CVG: 107100572(acox1) 107104334(acox3)
NFU: 107382251(acox1) 107384495(acox3)
KMR: 108242282(acox3) 108248782(acox1)
ALIM: 106518764(acox1) 106535206(acox3)
AOCE: 111564180(acox3) 111564207(acox1)
CSEM: 103383777(acox1) 103391807(acox3)
POV: 109627396(acox1) 109642523(acox3)
LCF: 108875870(acox1) 108895242(acox3)
SDU: 111223643(acox3) 111236302(acox1)
SLAL: 111659758(acox1) 111667919(acox3)
HCQ: 109516527(acox3) 109519788(acox1)
BPEC: 110156769 110166142(acox1) 110166186 110170775(acox3)
MALB: 109957253(acox3) 109966252(acox1)
SASA: 100306814(acox3) 100380782(ACOX)
OTW: 112214543(acox3) 112230324
ELS: 105021629(acox1) 105027197(acox3)
SFM: 108938686(acox3) 108940037(acox1)
PKI: 111842627(acox3) 111848198(acox1)
LCM: 102347012(ACOX3) 102353101(ACOX1)
CMK: 103175663(acox1) 103177355(acox3)
RTP: 109929565 109934355(acox1)
DME: Dmel_CG17544(CG17544) Dmel_CG4586(CG4586) Dmel_CG5009(CG5009) Dmel_CG9527(CG9527) Dmel_CG9707(Acox57D-p) Dmel_CG9709(Acox57D-d)
DSI: Dsimw501_GD11316(Dsim_GD11316) Dsimw501_GD11593(Dsim_GD11593) Dsimw501_GD11595(Dsim_GD11595) Dsimw501_GD16824(Dsim_GD16824) Dsimw501_GD21764(Dsim_GD21764) Dsimw501_GD22578(Dsim_GD22578)
DPTE: 113794175
CEL: CELE_C48B4.1(acox-1.5) CELE_F08A8.1(acox-1.1) CELE_F08A8.2(acox-1.2) CELE_F08A8.3(acox-1.3) CELE_F08A8.4(acox-1.4) CELE_F58F9.7(acox-3) CELE_F59F4.1(acox-1.6)
ATH: AT1G06290(ACX3) AT1G06310(ACX6) AT2G35690(ACX5) AT3G06690 AT3G51840(ACX4) AT4G16760(ACX1) AT5G65110(ACX2)
LJA: Lj0g3v0333489.3(Lj0g3v0333489.3) Lj1g3v0385510.1(Lj1g3v0385510.1) Lj1g3v2358960.1(Lj1g3v2358960.1) Lj1g3v2358960.2(Lj1g3v2358960.2) Lj1g3v2370090.1(Lj1g3v2370090.1) Lj2g3v2000290.3(Lj2g3v2000290.3) Lj2g3v2000290.4(Lj2g3v2000290.4) Lj4g3v1221460.1(Lj4g3v1221460.1) Lj4g3v1223640.1(Lj4g3v1223640.1) Lj4g3v2820140.1(Lj4g3v2820140.1)
DOSA: Os01t0159400-01(Os01g0159400) Os05t0163700-01(Os05g0163700) Os06t0103500-01(Os06g0103500) Os06t0346300-00(Os06g0346300) Os06t0347100-01(Os06g0347100) Os06t0354500-01(Os06g0354500) Os11t0605500-01(Os11g0605500)
ATS: 109732666(LOC109732666) 109747304(LOC109747304) 109748134(LOC109748134) 109748989(LOC109748989) 109750750(LOC109750750)
MNG: MNEG_5833
SCE: YGL205W(POX1)
ERC: Ecym_1214
KMX: KLMA_20263(POX1)
NCS: NCAS_0E00630(NCAS0E00630)
NDI: NDAI_0I02880(NDAI0I02880)
TPF: TPHA_0A05790(TPHA0A05790)
TBL: TBLA_0I03240(TBLA0I03240)
TDL: TDEL_0D05820(TDEL0D05820)
KAF: KAFR_0F04110(KAFR0F04110)
PIC: PICST_39759(ACOX2) PICST_75424(POX1)
CDU: CD36_64100 CD36_81790(POX2) CD36_81950(POX1)
SLB: AWJ20_2391(POX1) AWJ20_249(POX1) AWJ20_3356(POX1)
MAW: MAC_05128
CMT: CCM_00678
MBE: MBM_00470
ANI: AN6752.2
ANG: ANI_1_176044(An05g01410) ANI_1_1992094(An11g04940)
CIM: CIMG_10832(CIMG01874) CIMG_12750(CIMG01877) CIMG_13106(CIMG07097)
ABE: ARB_08051
TVE: TRV_04366
CNE: CNG00320
CNB: CNBG4450
ABP: AGABI1DRAFT108106(AGABI1DRAFT_108106) AGABI1DRAFT43395(AGABI1DRAFT_43395) AGABI1DRAFT79987(AGABI1DRAFT_79987)
ABV: AGABI2DRAFT225220(AGABI2DRAFT_225220) AGABI2DRAFT227257(AGABI2DRAFT_227257) AGABI2DRAFT227725(AGABI2DRAFT_227725)
MGL: MGL_4209
MRT: MRET_1422
SMIN: v1.2.019398.t1(symbB.v1.2.019398.t1) v1.2.034764.t1(symbB.v1.2.034764.t1) v1.2.034764.t2(symbB.v1.2.034764.t2)
PTI: PHATRDRAFT_19979(AOX1)
FCY: FRACYDRAFT_210789(ACOX1)
TPS: THAPSDRAFT_263878(AOX1_1)
NGD: NGA_0437010(ACOX) NGA_0437020(ACOX)
PLU: plu2336
PAY: PAU_02326(aco)
XBV: XBW1_2150
XNE: XNC1_0653
XNM: XNC2_0640
PFS: PFLU_3198
ACAV: VI35_08295
BAM: Bamb_6234
MXA: MXAN_6432
CCX: COCOR_07019(mmgC3)
MPA: MAP_2101
MAO: MAP4_1722
MAVI: RC58_08610
MAVU: RE97_08610
MAV: MAV_2078
MIT: OCO_20410
MIA: OCU_20510
MID: MIP_02874
MYO: OEM_18240
MIR: OCQ_19190
MUL: MUL_1233
MMC: Mmcs_3435
MKM: Mkms_3498
MJL: Mjls_3446
MMI: MMAR_3631
MMM: W7S_09570
MSHG: MSG_03314
MVA: Mvan_3808
MGI: Mflv_2726
MPHL: MPHLCCUG_03447(acrC_10)
MVQ: MYVA_3631
MHAS: MHAS_01392(acrC_2)
MAB: MAB_3588
MABB: MASS_3592
MCHE: BB28_18350
MSTE: MSTE_03719
MSAL: DSM43276_03385(acrC_6)
MMIN: MMIN_31800
ASD: AS9A_0357
CJK: jk1941(acx)
CUR: cu1845
CAR: cauri_2169(acx)
CRD: CRES_1991(acx)
CVA: CVAR_2774(acx)
COA: DR71_1321
CSX: CSING_11215(acx)
CCJ: UL81_09715(acx)
CSP: WM42_1846
CMIN: NCTC10288_00399(acx)
CEE: CENDO_03170(acrC)
NFA: NFA_24790
RER: RER_16630
REY: O5Y_07945
ROP: ROP_17180
REQ: REQ_37470
RHB: NY08_4763
RFA: A3L23_02825(acrC_1)
RHS: A3Q41_00537(acrC_1)
RHU: A3Q40_00273(acrC_1)
GBR: Gbro_1022
GOR: KTR9_0919
GRU: GCWB2_04890(acrC3)
GOM: D7316_04605(acrC_8)
TPR: Tpau_0678
SCO: SCO3247(SCE29.16c)
SMA: SAVERM_3706(aco)
SHY: SHJG_1655
SALU: DC74_617
STRE: GZL_08643
SLD: T261_3448
STRM: M444_03475
SLE: sle_03510(sle_03510)
SALJ: SMD11_2049
SLX: SLAV_01670(mmgC1)
SFK: KY5_6075c
LXX: Lxx21820(acx2)
CMI: CMM_0813
CMS: CMS0070
CMC: CMN_00769
MTS: MTES_1132
MOO: BWL13_00192(mmgC_2)
MLV: CVS47_00170(fadE)
MOY: CVS54_00613(fadE)
AUW: AURUGA1_00085(fadE)
MALK: MalAC0309_0010(acx2)
ART: Arth_2142
ARM: ART_0691
AAU: AAur_2138
ACH: Achl_1889
AAI: AARI_16120(aco)
KRH: KRH_16780
BCV: Bcav_3568
JDE: Jden_2376
LMOI: VV02_21660
XCE: Xcel_3111
IDO: I598_2042(fadE)
CFL: Cfla_2935
CFI: Celf_3192
SERJ: SGUI_2849
BLIN: BLSMQ_2105
NCA: Noca_0437
NDK: I601_1658
KFL: Kfla_6493
PSIM: KR76_03245
TFU: Tfu_2239
NDA: Ndas_3221
NAL: B005_0176
STRR: EKD16_07215(mmgC3)
GOB: Gobs_0304
MMAR: MODMU_0321
KRA: Krad_4030
SACC: EYD13_17575(acrC3)
AMD: AMED_8080
AMN: RAM_41510
AMM: AMES_7958
AMZ: B737_7959
AOI: AORI_6907
AMYY: YIM_05110(mmgC2)
PDX: Psed_6176
PSEA: WY02_14800
PSEH: XF36_25955
PAUT: Pdca_64430
SESP: BN6_30630
ALO: CRK58445
MIL: ML5_4604
ASE: ACPL_5569
ACTN: L083_3683
AFS: AFR_23290
ACTS: ACWT_5439
CAI: Caci_3363
SRU: SRU_1701
SRM: SRM_01907(caiA)
FJO: Fjoh_3394
FJG: BB050_04220(mmgC_2)
MARM: YQ22_11090
CBAL: M667_07620
CBAT: M666_07655
ZGA: ZOBELLIA_2370(acxA)
NDO: DDD_0071
 » show all
Reference
1  [PMID:7462191]
  Authors
Kawaguchi A, Tsubotani S, Seyama Y, Yamakawa T, Osumi T, Hashimoto T, Kikuchi T, Ando M, Okuda S.
  Title
Stereochemistry of dehydrogenation catalyzed by Acyl-CoA oxidase.
  Journal
J Biochem (Tokyo) 88:1481-6 (1980)
DOI:10.1093/oxfordjournals.jbchem.a133118
Reference
2  [PMID:7400120]
  Authors
Osumi T, Hashimoto T, Ui N.
  Title
Purification and properties of acyl-CoA oxidase from rat liver.
  Journal
J Biochem (Tokyo) 87:1735-46 (1980)
DOI:10.1093/oxfordjournals.jbchem.a132918
Other DBs
ExplorEnz - The Enzyme Database: 1.3.3.6
IUBMB Enzyme Nomenclature: 1.3.3.6
ExPASy - ENZYME nomenclature database: 1.3.3.6
BRENDA, the Enzyme Database: 1.3.3.6
CAS: 61116-22-1

KEGG   ENZYME: 4.2.1.119
Entry
EC 4.2.1.119                Enzyme                                 

Name
enoyl-CoA hydratase 2;
2-enoyl-CoA hydratase 2;
AtECH2;
ECH2;
MaoC;
MFE-2;
PhaJAc;
D-3-hydroxyacyl-CoA hydro-lyase;
D-specific 2-trans-enoyl-CoA hydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
(3R)-3-hydroxyacyl-CoA hydro-lyase
Reaction(IUBMB)
(3R)-3-hydroxyacyl-CoA = (2E)-2-enoyl-CoA + H2O [RN:R09698]
Reaction(KEGG)
R09698 > R07935 R07951
Substrate
(3R)-3-hydroxyacyl-CoA [CPD:C01086]
Product
(2E)-2-enoyl-CoA [CPD:C00658];
H2O [CPD:C00001]
Comment
This enzyme catalyses a hydration step in peroxisomal beta-oxidation. The human multifunctional enzyme type 2 (MFE-2) is a 79000 Da enzyme composed of three functional units: (3R)-hydroxyacyl-CoA dehydrogenase, 2-enoyl-CoA hydratase 2 and sterol carrier protein 2-like units [1]. The enzymes from Aeromonas caviae [4] and Arabidopsis thaliana [5] are monofunctional enzymes. 2-Enoyl-CoA hydratase 3 from Candida tropicalis is a part from multifunctional enzyme type 2 [3].
History
EC 4.2.1.119 created 2009
Pathway
ec01040  Biosynthesis of unsaturated fatty acids
ec01100  Metabolic pathways
Orthology
K12405  (3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2
K19658  peroxisomal enoyl-CoA hydratase 2
K19659  enoyl-CoA hydratase
Genes
HSA: 3295(HSD17B4)
PTR: 462019(HSD17B4)
PPS: 100981028(HSD17B4)
GGO: 101129538(HSD17B4)
PON: 100448539(HSD17B4)
NLE: 100590035(HSD17B4)
MCC: 698369(HSD17B4)
MCF: 102123675(HSD17B4)
CSAB: 103244395(HSD17B4)
RRO: 104654581(HSD17B4)
RBB: 108529825(HSD17B4)
CJC: 100390100(HSD17B4)
SBQ: 101036776(HSD17B4)
MMU: 15488(Hsd17b4)
MCAL: 110284447(Hsd17b4)
MPAH: 110332881(Hsd17b4)
RNO: 79244(Hsd17b4)
CGE: 103161104(Hsd17b4)
NGI: 103745113(Hsd17b4)
HGL: 101713520(Hsd17b4)
CCAN: 109674145
OCU: 100346781(HSD17B4)
TUP: 102468828(HSD17B4)
CFA: 474630(HSD17B4)
VVP: 112932403(HSD17B4)
AML: 100471749(HSD17B4)
UMR: 103670554(HSD17B4)
UAH: 113261629(HSD17B4)
ORO: 101385731(HSD17B4)
ELK: 111158891
FCA: 101091840(HSD17B4)
PTG: 102968873(HSD17B4)
PPAD: 109278892(HSD17B4)
AJU: 106975089(HSD17B4)
BTA: 493643(HSD17B4)
BOM: 102268517(HSD17B4)
BBUB: 102412917(HSD17B4)
CHX: 102172142(HSD17B4)
OAS: 101114519(HSD17B4)
SSC: 397574(HSD17B4)
CFR: 102508317(HSD17B4)
CDK: 105104293(HSD17B4)
LVE: 103084787(HSD17B4)
OOR: 101282963(HSD17B4)
DLE: 111183342(HSD17B4)
PCAD: 102996127(HSD17B4)
ECB: 100034046(HSD17B4)
EPZ: 103548315(HSD17B4)
EAI: 106833039(HSD17B4)
MYB: 102240475(HSD17B4)
MYD: 102767159(HSD17B4)
MNA: 107530713(HSD17B4)
HAI: 109374101(HSD17B4)
DRO: 112315031(HSD17B4)
LAV: 100659299(HSD17B4)
TMU: 101356123
MDO: 100028098(HSD17B4)
SHR: 100932771(HSD17B4)
PCW: 110202743(HSD17B4)
OAA: 100081754(HSD17B4)
GGA: 395785(HSD17B4)
CJO: 107306670(HSD17B4)
NMEL: 110389447(HSD17B4)
APLA: 101791118(HSD17B4)
ACYG: 106048362(HSD17B4)
TGU: 100218226(HSD17B4)
LSR: 110479177(HSD17B4)
SCAN: 103821465(HSD17B4)
GFR: 102036502(HSD17B4)
FAB: 101807233(HSD17B4)
PHI: 102109547(HSD17B4)
PMAJ: 107216347(HSD17B4)
CCAE: 111941198(HSD17B4)
CCW: 104690497(HSD17B4)
ETL: 114056305(HSD17B4)
FPG: 101917400(HSD17B4)
FCH: 102058406(HSD17B4)
CLV: 102095771(HSD17B4)
EGZ: 104122491(HSD17B4)
NNI: 104014571(HSD17B4)
ACUN: 113489653(HSD17B4)
PADL: 103912347(HSD17B4)
ASN: 102371766(HSD17B4)
AMJ: 102571005(HSD17B4)
PSS: 102451304(HSD17B4)
CPIC: 101945395(HSD17B4)
ACS: 100558484(hsd17b4)
PVT: 110084344(HSD17B4)
PBI: 103063870(HSD17B4)
PMUR: 107294349(HSD17B4)
TSR: 106543382(HSD17B4)
PMUA: 114606393(HSD17B4)
GJA: 107116225(HSD17B4)
XLA: 444492(hsd17b4.L)
XTR: 613082(hsd17b4)
NPR: 108787696(HSD17B4)
DRE: 393105(hsd17b4)
SANH: 107703629(hsd17b4)
SGH: 107571774(hsd17b4)
IPU: 108265438(hsd17b4)
PHYP: 113529268(hsd17b4)
AMEX: 103046836(hsd17b4)
EEE: 113571049(hsd17b4)
TRU: 101062498(hsd17b4)
LCO: 104920820(hsd17b4)
NCC: 104966339(hsd17b4)
MZE: 101482787(hsd17b4)
ONL: 100706762(hsd17b4)
OLA: 101159921(hsd17b4)
XMA: 102223774(hsd17b4)
XCO: 114154573(hsd17b4)
PRET: 103470095(hsd17b4)
CVG: 107086311(hsd17b4)
NFU: 107394149(hsd17b4)
KMR: 108233704(hsd17b4)
ALIM: 106513677(hsd17b4)
AOCE: 111564685(hsd17b4)
POV: 109637138(hsd17b4)
LCF: 108882142(hsd17b4)
SDU: 111230866(hsd17b4)
SLAL: 111645149(hsd17b4)
HCQ: 109526033(hsd17b4)
BPEC: 110167024(hsd17b4)
MALB: 109956607(hsd17b4)
SASA: 106585849(hsd17b4)
OTW: 112247069(hsd17b4)
SALP: 111974039(hsd17b4)
ELS: 105014609(hsd17b4)
SFM: 108938133(hsd17b4)
PKI: 111856620(hsd17b4)
LCM: 102356548(HSD17B4)
CMK: 103181119(hsd17b4)
BFO: 118409354
CIN: 100187421
SPU: 581580
DME: Dmel_CG3415(Mfe2)
DMN: 108161558
AAG: 5568633
AALB: 109428196
AME: 409986
NVI: 100123018
TCA: 663655(17-beta-HD4)
API: 100167575
DNX: 107163428
AGS: 114120233
RMD: 113555196
CEL: CELE_E04F6.3(maoc-1) CELE_M03A8.1(dhs-28)
CBR: CBG13089(Cbr-maoc-1)
BMY: Bm1_24050
NVE: 5504006
ATH: AT1G76150(ECH2)
ALY: 9325125
CRB: 17896162
BRP: 103832064
BOE: 106300265
RSZ: 108817730
THJ: 104813765
CPAP: 110818108
CIT: 102628415
TCC: 18591652
GRA: 105770003
GHI: 107904979
GAB: 108453194
EGR: 104448895
VRA: 106762546
VAR: 108343556
VUN: 114164056
CCAJ: 109802448
CAM: 101492992
LJA: Lj1g3v2268360.1(Lj1g3v2268360.1) Lj1g3v2268360.2(Lj1g3v2268360.2)
ADU: 107460260
AIP: 107609751
LANG: 109343989
FVE: 101293547
RCN: 112174118
PPER: 18792035
PMUM: 103321173
PAVI: 110746650
MDM: 103440214
ZJU: 107422728
CSV: 101212798
CMO: 103488374
MCHA: 111014062
CMAX: 111492280
CMOS: 111462566
CPEP: 111806066
RCU: 8267862
JCU: 105635268
HBR: 110636119
POP: 7494669
PEU: 105137277
JRE: 109018894
VVI: 100262653
SLY: 101253171
SPEN: 107005416
SOT: 102584477
CANN: 107850442
INI: 109184502
SIND: 105178076
OEU: 111379149
HAN: 110908076
LSV: 111889535
CCAV: 112513425
BVG: 104884406
SOE: 110790608
NNU: 104603702
OSA: 4347752
DOSA: Os09t0544900-01(Os09g0544900)
BDI: 100844320
ATS: 109758253(LOC109758253)
PDA: 103701068
EGU: 105055161
MUS: 103970614
DCT: 110113475
PEQ: 110023970
AOF: 109848560
ATR: 18424521
PPP: 112281828
SSCK: SPSK_04458
MBE: MBM_09500
LBC: LACBIDRAFT_189724(MFP-2)
ABP: AGABI1DRAFT114661(AGABI1DRAFT_114661)
ABV: AGABI2DRAFT194845(AGABI2DRAFT_194845)
DDI: DDB_G0291247(mfeA)
DFA: DFA_00521(mfeB)
VTA: B0498(phaJ)
SPL: Spea_1753
SHL: Shal_1988
FBL: Fbal_0386
AHA: AHA_2422
ASA: ASA_2281(phaJ)
AMED: B224_2076
ACAV: VI35_11530
AEL: NCTC12917_02268(phaJ)
HTU: Htur_2338
NMG: Nmag_3411
 » show all
Reference
1  [PMID:15644212]
  Authors
Koski KM, Haapalainen AM, Hiltunen JK, Glumoff T
  Title
Crystal structure of 2-enoyl-CoA hydratase 2 from human peroxisomal multifunctional enzyme type 2.
  Journal
J Mol Biol 345:1157-69 (2005)
DOI:10.1016/j.jmb.2004.11.009
  Sequence
[hsa:3295]
Reference
2  [PMID:9457873]
  Authors
Fukui T, Shiomi N, Doi Y
  Title
Expression and characterization of (R)-specific enoyl coenzyme A hydratase involved in polyhydroxyalkanoate biosynthesis by Aeromonas caviae.
  Journal
J Bacteriol 180:667-73 (1998)
DOI:10.1128/JB.180.3.667-673.1998
  Sequence
Reference
3  [PMID:12832794]
  Authors
Koski MK, Haapalainen AM, Hiltunen JK, Glumoff T
  Title
Crystallization and preliminary crystallographic data of 2-enoyl-CoA hydratase 2  domain of Candida tropicalis peroxisomal multifunctional enzyme type 2.
  Journal
Acta Crystallogr D Biol Crystallogr 59:1302-5 (2003)
DOI:10.1107/S090744490300982X
Reference
4  [PMID:11134939]
  Authors
Hisano T, Fukui T, Iwata T, Doi Y
  Title
Crystallization and preliminary X-ray analysis of (R)-specific enoyl-CoA hydratase from Aeromonas caviae involved in polyhydroxyalkanoate biosynthesis.
  Journal
Acta Crystallogr D Biol Crystallogr 57:145-7 (2001)
DOI:10.1107/S0907444900014062
Reference
5  [PMID:16982622]
  Authors
Goepfert S, Hiltunen JK, Poirier Y
  Title
Identification and functional characterization of a monofunctional peroxisomal enoyl-CoA hydratase 2 that participates in the degradation of even cis-unsaturated fatty acids in Arabidopsis thaliana.
  Journal
J Biol Chem 281:35894-903 (2006)
DOI:10.1074/jbc.M606383200
  Sequence
[ath:AT1G76150]
Reference
6  [PMID:1879422]
  Authors
Engeland K, Kindl H
  Title
Evidence for a peroxisomal fatty acid beta-oxidation involving D-3-hydroxyacyl-CoAs. Characterization of two forms of hydro-lyase that convert D-(-)-3-hydroxyacyl-CoA into 2-trans-enoyl-CoA.
  Journal
Eur J Biochem 200:171-8 (1991)
DOI:10.1111/j.1432-1033.1991.tb21064.x
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.119
IUBMB Enzyme Nomenclature: 4.2.1.119
ExPASy - ENZYME nomenclature database: 4.2.1.119
BRENDA, the Enzyme Database: 4.2.1.119

KEGG   ENZYME: 2.3.1.16
Entry
EC 2.3.1.16                 Enzyme                                 

Name
acetyl-CoA C-acyltransferase;
beta-ketothiolase;
3-ketoacyl-CoA thiolase;
KAT;
beta-ketoacyl coenzyme A thiolase;
beta-ketoacyl-CoA thiolase;
beta-ketoadipyl coenzyme A thiolase;
beta-ketoadipyl-CoA thiolase;
3-ketoacyl CoA thiolase;
3-ketoacyl coenzyme A thiolase;
3-ketoacyl thiolase;
3-ketothiolase;
3-oxoacyl-CoA thiolase;
3-oxoacyl-coenzyme A thiolase;
6-oxoacyl-CoA thiolase;
acetoacetyl-CoA beta-ketothiolase;
acetyl-CoA acyltransferase;
ketoacyl-CoA acyltransferase;
ketoacyl-coenzyme A thiolase;
long-chain 3-oxoacyl-CoA thiolase;
oxoacyl-coenzyme A thiolase;
pro-3-ketoacyl-CoA thiolase;
thiolase I;
type I thiolase;
2-methylacetoacetyl-CoA thiolase [misleading]
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acyl-CoA:acetyl-CoA C-acyltransferase
Reaction(IUBMB)
acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA (overall reaction) [RN:R00391];
(1a) [acetyl-CoA C-acyltransferase]-S-acyl-L-cysteine + acetyl-CoA = 3-oxoacyl-CoA + [acetyl-CoA C-acyltransferase]-L-cysteine;
(1b) acyl-CoA + [acetyl-CoA C-acyltransferase]-L-cysteine = [acetyl-CoA C-acyltransferase]-S-acyl-L-cysteine + CoA
Reaction(KEGG)
Substrate
acyl-CoA [CPD:C00040];
acetyl-CoA [CPD:C00024];
[acetyl-CoA C-acyltransferase]-S-acyl-L-cysteine;
[acetyl-CoA C-acyltransferase]-L-cysteine
Product
CoA [CPD:C00010];
3-oxoacyl-CoA [CPD:C00264];
[acetyl-CoA C-acyltransferase]-L-cysteine;
[acetyl-CoA C-acyltransferase]-S-acyl-L-cysteine
Comment
The enzyme, found in both eukaryotes and in prokaryotes, is involved in degradation pathways such as fatty acid beta-oxidation. The enzyme acts on 3-oxoacyl-CoAs to produce acetyl-CoA and an acyl-CoA shortened by two carbon atoms. The reaction starts with the acylation of a nucleophilic cysteine at the active site by a 3-oxoacyl-CoA, with the concomitant release of acetyl-CoA. In the second step the acyl group is transferred to CoA. Most enzymes have a broad substrate range for the 3-oxoacyl-CoA. cf. EC 2.3.1.9, acetyl-CoA C-acetyltransferase.
History
EC 2.3.1.16 created 1961, modified 2019
Pathway
ec00062  Fatty acid elongation
ec00071  Fatty acid degradation
ec00280  Valine, leucine and isoleucine degradation
ec00281  Geraniol degradation
ec00362  Benzoate degradation
ec00592  alpha-Linolenic acid metabolism
ec00642  Ethylbenzene degradation
ec01040  Biosynthesis of unsaturated fatty acids
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K00632  acetyl-CoA acyltransferase
K07508  acetyl-CoA acyltransferase 2
K07509  acetyl-CoA acyltransferase
K07513  acetyl-CoA acyltransferase 1
Genes
HSA: 10449(ACAA2) 30(ACAA1) 3032(HADHB)
PTR: 455414(ACAA2) 459080(HADHB) 460268(ACAA1)
PPS: 100978867(HADHB) 100986504(ACAA2) 100994212(ACAA1)
GGO: 101126225(HADHB) 101141231(ACAA1) 101146857(ACAA2)
PON: 100171644(ACAA2) 100451914(HADHB) 100461213(ACAA1)
NLE: 100594135(HADHB) 100595632(ACAA2) 100597596(ACAA1)
MCC: 696743(ACAA1) 698025(HADHB) 709350(ACAA2)
MCF: 101865671(ACAA2) 102143422(HADHB) 102143849(ACAA1)
CSAB: 103220641(HADHB) 103221068(ACAA1) 103222430(ACAA2)
RRO: 104656838(ACAA2) 104657451(ACAA1) 104677890(HADHB)
RBB: 108512243(ACAA1) 108532680(HADHB) 108539750(ACAA2)
CJC: 100393472(HADHB) 100402284(ACAA2) 100412554(ACAA1)
SBQ: 101036389(ACAA2) 101047392(HADHB) 101052252(ACAA1)
MMU: 113868(Acaa1a) 231086(Hadhb) 235674(Acaa1b) 52538(Acaa2)
MCAL: 110284792(Acaa2) 110294692(Hadhb) 110301085 110301257
MPAH: 110324296(Hadhb) 110327492(Acaa1) 110328451 110333199(Acaa2)
RNO: 170465(Acaa2) 171155(Hadhb) 24157(Acaa1a) 501072(Acaa1b)
HGL: 101713505(Acaa1) 101714191 101721744(Acaa2) 101725212(Hadhb)
CCAN: 109684530 109685833(Hadhb) 109695737 109698177(Acaa2)
OCU: 100339733(ACAA2) 100340554(ACAA1) 100347496 100355110(HADHB)
TUP: 102470441(ACAA1) 102473069(ACAA2) 102490283(HADHB) 102493259
CFA: 477023(ACAA1) 490568(ACAA2) 607926(HADHB)
VVP: 112908533(HADHB) 112921659(ACAA1) 112925318(ACAA2)
AML: 100469907(HADHB) 100475784(ACAA1) 100476344(ACAA2)
UMR: 103664100(ACAA2) 103671671(HADHB) 103682196(ACAA1)
UAH: 113253408(ACAA2) 113253780(ACAA1) 113270781(HADHB)
ORO: 101363464(ACAA1) 101364557(HADHB) 101378384(ACAA2)
FCA: 101084279(HADHB) 101087343(ACAA1) 101089302(ACAA2) 111559111
PTG: 102966174(HADHB) 102967023(ACAA1) 102967396(ACAA2)
PPAD: 109248748(ACAA1) 109267291(HADHB) 109275723(ACAA2)
AJU: 106966644(ACAA1) 106967831(HADHB) 106974956(ACAA2)
BTA: 281811(HADHB) 508324(ACAA1) 522006(ACAA2)
BOM: 102270140(ACAA2) 102280228(ACAA1) 102286383(HADHB)
BIU: 109566316(HADHB) 109576258(ACAA1)
BBUB: 102391006(ACAA2) 102396359(ACAA1) 102397671(HADHB)
CHX: 102183474(ACAA2) 102184764(ACAA1) 102188776(HADHB)
OAS: 101109685(HADHB) 101110625(ACAA1) 101111925(ACAA2)
SSC: 100312959(ACAA2) 100515577(ACAA1) 397017(HADHB)
CFR: 102506838(ACAA1) 102507636(HADHB) 102510739(ACAA2)
CDK: 105090693(ACAA1) 105098512(HADHB) 105103279(ACAA2)
BACU: 103002167(HADHB) 103010085(ACAA2) 103013122(ACAA1)
LVE: 103080580 103086899(HADHB) 103088661(ACAA1) 103089821(ACAA2)
OOR: 101278829(ACAA1) 101280546(ACAA2) 101287376(HADHB)
DLE: 111164349(ACAA1) 111174989(HADHB) 111180263(ACAA2)
PCAD: 102974484(ACAA1) 102977338(HADHB) 102982675(ACAA2)
ECB: 100050082(ACAA1) 100069345(ACAA2) 100071371(HADHB)
EPZ: 103546461(HADHB) 103547459(ACAA2) 103553900(ACAA1)
EAI: 106832480 106832685(HADHB) 106834267(ACAA1) 106834604(ACAA2)
MYB: 102247718(ACAA1) 102258815(ACAA2) 102263535(HADHB)
MYD: 102752001(HADHB) 102756865(ACAA2) 102759768(ACAA1)
MNA: 107524306 107534209(HADHB) 107546630(ACAA2)
HAI: 109376904(ACAA2) 109383145(HADHB) 109393490(ACAA1)
DRO: 112297765(HADHB) 112309850(ACAA1) 112322907(ACAA2)
PALE: 102889560(HADHB) 102890231(ACAA1) 102895865(ACAA2)
RAY: 107499599(ACAA1) 107505206(HADHB)
MJV: 108400223(ACAA2) 108401028(ACAA1) 108401860(HADHB)
LAV: 100667518(ACAA1) 100669834(ACAA2) 100671092(HADHB)
MDO: 100020101(ACAA2) 100021694(ACAA1) 100618372(HADHB)
SHR: 100919041(ACAA2) 100926185(HADHB) 100932858(ACAA1)
PCW: 110192929(ACAA1) 110198152(ACAA2) 110206511(HADHB)
OAA: 100077748(ACAA2) 100078294(HADHB) 100090526(ACAA1)
GGA: 426847(ACAA2) 770094(ACAA1)
MGP: 100542533(ACAA1) 100543276(ACAA2) 100548234(HADHB)
CJO: 107305710(ACAA2) 107308790(ACAA1) 107312380(HADHB)
NMEL: 110390054(ACAA2) 110394676(ACAA1) 110397115(HADHB)
APLA: 101791052(ACAA2) 101797981(ACAA1) 101799509(HADHB)
ACYG: 106036840(ACAA1) 106037343(ACAA2) 106048393(HADHB)
TGU: 100231849(ACAA2) 100232310(ACAA1)
LSR: 110478449(HADHB) 110478717(ACAA2) 110484539(ACAA1)
SCAN: 103812699(ACAA1) 103820669(ACAA2) 103824692(HADHB)
GFR: 102031582(HADHB) 102031671(ACAA2) 102044074(ACAA1)
FAB: 101813933(HADHB) 101816553(ACAA1) 101820899(ACAA2)
PHI: 102099098(ACAA2) 102103886(HADHB) 102108642(ACAA1)
PMAJ: 107198381(ACAA2) 107198788(HADHB) 107200236(ACAA1)
CCAE: 111922398(HADHB) 111925455(ACAA1) 111940954(ACAA2)
CCW: 104683134(HADHB) 104686412(ACAA1) 104686724(ACAA2)
ETL: 114064115(ACAA2) 114065135(ACAA1) 114072281(HADHB)
FPG: 101914495(HADHB) 101917832(ACAA2) 101923424(ACAA1)
FCH: 102050522(ACAA1) 102058082(ACAA2) 102059513(HADHB)
CLV: 102088336(ACAA1) 102090854(ACAA2) 102092691(HADHB)
EGZ: 104130919(HADHB) 104130983(ACAA1) 104134191(ACAA2)
NNI: 104010858(ACAA2) 104014721(HADHB) 104021752(ACAA1)
ACUN: 113476335(ACAA1) 113478820(HADHB) 113489837(ACAA2)
PADL: 103919461(ACAA2) 103923906(HADHB)
AAM: 106487890(ACAA2) 106494846(ACAA1) 106499628(HADHB)
ASN: 102368605(ACAA1) 102376718(ACAA2) 102387623(HADHB)
AMJ: 102559598(HADHB) 102562558(ACAA1) 102568981(ACAA2)
PSS: 102446655(ACAA2) 102455625(ACAA1) 102461261(HADHB)
CMY: 102932084 102938453(ACAA2) 102938987(HADHB)
CPIC: 101942506(HADHB) 101943221(ACAA1) 101948785(ACAA2)
ACS: 100554020(acaa2) 100558242(hadhb) 100567075(acaa1)
PVT: 110085831(ACAA1) 110090044(ACAA2) 110090548(HADHB)
PBI: 103049409(ACAA2) 103052587(HADHB) 103056268
PMUR: 107284131(ACAA2) 107284371(ACAA1) 107291032(HADHB)
TSR: 106541762(HADHB) 106545855(ACAA2) 106554068(ACAA1)
PMUA: 114594985(HADHB) 114606439(ACAA2) 114606975(ACAA1)
GJA: 107107954(ACAA1) 107109968(ACAA2) 107113773(HADHB)
XLA: 108705465(acaa2.S) 108717269 379769(hadhb.S) 380296(acaa1.L) 380424(acaa2.L)
XTR: 394747(hadhb) 779631(acaa2) 780143(acaa1)
NPR: 108790694(ACAA2) 108797614(ACAA1) 108802535(HADHB)
DRE: 336606(hadhb) 406325(acaa2) 431754(acaa1)
CCAR: 109113064
IPU: 100304819(acaa2) 100528276(acaa1) 108257741(hadhb)
PHYP: 113529092(hadhb) 113533324(acaa2) 113541245(acaa1)
AMEX: 103039096(acaa2) 103044652(acaa1) 103046325(hadhb)
EEE: 113581209(acaa1) 113590681(acaa2) 113591047(hadhb)
TRU: 101062577(acaa2) 101063902(acaa1) 101076593(hadhb)
LCO: 104921655(acaa2) 104925674(hadhb) 104927325(acaa1)
NCC: 104956691(acaa2) 104959411(acaa1) 104960957(hadhb)
MZE: 101465882(acaa1) 101471466(hadhb) 101475921(acaa2)
ONL: 100699406(acaa2) 100709781(hadhb) 100709821(acaa1)
OLA: 101156136(hadhb) 101171672(acaa2) 101173322(acaa1)
XMA: 102223074(acaa1) 102225065(acaa2) 102232549(hadhb)
XCO: 114144298(acaa1) 114154595(acaa2) 114158666(hadhb)
PRET: 103457287(hadhb) 103470032(acaa2) 103473178(acaa1)
CVG: 107082845 107089652(acaa2) 107094433(acaa1)
NFU: 107377791(hadhb) 107394222(acaa1) 107394253(acaa2)
KMR: 108233358(hadhb) 108233695(acaa2) 108251775(acaa1)
ALIM: 106532026(hadhb) 106535425(acaa1)
AOCE: 111563089(acaa1) 111577286(acaa2) 111589018(hadhb)
CSEM: 103381162(hadhb) 103383387(acaa1) 103397146 103397771(acaa2)
POV: 109637054(acaa2) 109646259(hadhb)
LCF: 108881684(acaa2) 108888719(acaa1) 108888909(hadhb)
SDU: 111232969(acaa1) 111236472(acaa2) 111240320(hadhb)
SLAL: 111651959(acaa1) 111661536(hadhb) 111665974(acaa2)
HCQ: 109527328(acaa2) 109528731(hadhb)
BPEC: 110155754(acaa2) 110175545(acaa1) 110175575(hadhb)
MALB: 109956563(acaa2) 109962386(hadhb) 109971785(acaa1)
SASA: 106579756 106580430(THIM) 106585052(THIM) 106608385(hadhb)
SALP: 111957767 111974321 112072179(hadhb) 112076835(acaa1)
ELS: 105007694(acaa1) 105014304(acaa2) 105018050(hadhb)
SFM: 108920128(acaa2) 108929413(hadhb) 108934024(acaa1)
PKI: 111837860(acaa1) 111851523(hadhb) 111854352(acaa2)
LCM: 102348225(ACAA1) 102358248(ACAA2) 102362426(HADHB)
CMK: 103183148(hadhb) 103187341(acaa2) 103191285(acaa1)
RTP: 109910715(hadhb) 109912458 109921355(acaa1)
DME: Dmel_CG4581(Mtpbeta) Dmel_CG4600(yip2)
DSI: Dsimw501_GD23636(Dsim_GD23636) Dsimw501_GD25003(Dsim_GD25003)
DYA: Dyak_GE11519 Dyak_GE18877(Dyak_yip2)