KEGG   ORTHOLOGY: K00248Help
Entry
K00248                      KO                                     

Name
ACADS, bcd
Definition
butyryl-CoA dehydrogenase [EC:1.3.8.1]
Pathway
ko00071  Fatty acid degradation
ko00280  Valine, leucine and isoleucine degradation
ko00410  beta-Alanine metabolism
ko00640  Propanoate metabolism
ko00650  Butanoate metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01130  Biosynthesis of antibiotics
ko01200  Carbon metabolism
ko01212  Fatty acid metabolism
Module
M00013  Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA
Disease
H00525  Disorders of mitochondrial fatty-acid oxidation
H01980  SCAD deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00640 Propanoate metabolism
    K00248  ACADS, bcd; butyryl-CoA dehydrogenase
   00650 Butanoate metabolism
    K00248  ACADS, bcd; butyryl-CoA dehydrogenase
  09103 Lipid metabolism
   00071 Fatty acid degradation
    K00248  ACADS, bcd; butyryl-CoA dehydrogenase
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K00248  ACADS, bcd; butyryl-CoA dehydrogenase
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K00248  ACADS, bcd; butyryl-CoA dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.8  With a flavin as acceptor
    1.3.8.1  short-chain acyl-CoA dehydrogenase
     K00248  ACADS, bcd; butyryl-CoA dehydrogenase
BRITE hierarchy
Other DBs
RN: R01175 R01178 R02661 R03172 R04432 R04751
COG: COG1960
GO: 0004085
Genes
HSA: 35(ACADS)
PTR: 742921(ACADS)
PPS: 100994372(ACADS)
GGO: 101139640(ACADS)
PON: 100172331(ACADS)
NLE: 100586242(ACADS)
MCC: 698196(ACADS)
MCF: 102116240(ACADS)
CSAB: 103239266(ACADS)
RRO: 104666263(ACADS)
RBB: 108529647(ACADS)
CJC: 100387870(ACADS)
SBQ: 101049174(ACADS)
MMU: 11409(Acads)
MCAL: 110294359(Acads)
MPAH: 110312894(Acads)
RNO: 64304(Acads)
MUN: 110545603(Acads)
CGE: 100774097(Acads)
NGI: 103740119(Acads)
HGL: 101722158(Acads)
CCAN: 109696148(Acads)
OCU: 100352290(ACADS)
TUP: 102494372(ACADS)
CFA: 477517(ACADS)
VVP: 112932920(ACADS)
AML: 100483719(ACADS)
UMR: 103678351(ACADS)
UAH: 113267053(ACADS)
ORO: 101363887(ACADS)
ELK: 111156416
FCA: 101082442(ACADS)
PTG: 102956610(ACADS)
PPAD: 109277518(ACADS)
AJU: 106971681(ACADS)
BTA: 511222(ACADS)
BOM: 102269247(ACADS)
BIU: 109571341(ACADS)
BBUB: 102390388(ACADS)
CHX: 102180069(ACADS)
OAS: 101119850(ACADS)
SSC: 396932(ACADS)
CFR: 102503720(ACADS)
CDK: 105101985(ACADS)
BACU: 103010876(ACADS)
LVE: 103083994(ACADS)
OOR: 101278842(ACADS)
DLE: 111162645(ACADS)
PCAD: 102993784(ACADS)
ECB: 100147113(ACADS)
EPZ: 103540479(ACADS)
EAI: 106844801(ACADS)
MYB: 102250514(ACADS)
MYD: 102760180(ACADS)
MNA: 107528464(ACADS)
HAI: 109386149(ACADS)
DRO: 112310812(ACADS)
PALE: 102891595(ACADS)
RAY: 107501257(ACADS)
MJV: 108397688(ACADS)
LAV: 100669421(ACADS)
TMU: 101356048
MDO: 100025804(ACADS)
SHR: 100917746(ACADS)
PCW: 110222822(ACADS)
OAA: 100090404(ACADS)
GGA: 416969(ACADS)
MGP: 100541626(ACADS)
CJO: 107321246(ACADS)
NMEL: 110406474(ACADS)
APLA: 101801937(ACADS)
ACYG: 106031343(ACADS)
TGU: 100232428(ACADS)
LSR: 110481348(ACADS)
SCAN: 103818033(ACADS)
GFR: 102031606(ACADS)
FAB: 101818866(ACADS)
PHI: 102112248(ACADS)
PMAJ: 107211533(ACADS)
CCAE: 111936603(ACADS)
CCW: 104688759(ACADS)
FPG: 101913588(ACADS)
FCH: 102052397(ACADS)
CLV: 102088733(ACADS)
EGZ: 104129891(ACADS)
NNI: 104011497(ACADS)
ACUN: 113486201(ACADS)
AAM: 106486315(ACADS)
ASN: 102368188(ACADS)
AMJ: 102559145(ACADS)
PSS: 102460079(ACADS)
CMY: 102946552(ACADS)
CPIC: 101934662(ACADS)
ACS: 100557906(acads)
PVT: 110081950(ACADS)
PBI: 103059584(ACADS)
PMUR: 107293846(ACADS)
TSR: 106547997(ACADS)
PMUA: 114586642(ACADS)
GJA: 107126092(ACADS)
XLA: 380563(acads.L)
XTR: 394882(acads)
NPR: 108787757(ACADS)
DRE: 445288(acads)
SRX: 107741687
SANH: 107689539
SGH: 107567748
IPU: 100305084(acads)
PHYP: 113544911(acads)
AMEX: 111190888(acads)
EEE: 113583217(acads)
TRU: 101071269(acads)
LCO: 104937354(acads)
NCC: 104954167(acads)
MZE: 101477731(acads)
ONL: 100699540(acads)
OLA: 101166811(acads)
XMA: 102223580(acads)
XCO: 114149491(acads)
PRET: 103473179(acads)
CVG: 107101400(acads)
NFU: 107394661(acads)
KMR: 108244766(acads)
ALIM: 106526092(acads)
AOCE: 111566122(acads)
CSEM: 103389931(acads)
POV: 109626371(acads)
LCF: 108895632(acads)
SDU: 111224280(acads)
SLAL: 111664707(acads)
HCQ: 109525105(acads)
BPEC: 110166693(acads)
MALB: 109974764(acads)
OTW: 112220230
SALP: 112070846
ELS: 105015217
SFM: 108930016(acads)
PKI: 111851473(acads)
LCM: 102355418(ACADS)
CMK: 103182182(acads)
CIN: 100175610
SPU: 579817
APLC: 110980734
SKO: 100372351
DME: Dmel_CG4703(Arc42) Dmel_CG4860(CG4860)
DSI: Dsimw501_GD19319(Dsim_GD19319) Dsimw501_GD20592(Dsim_GD20592)
DPO: Dpse_GA18369(Dpse_Arc42) Dpse_GA18485
LCQ: 111681801
AALB: 115271087
AME: 411697
BIM: 100741796
BTER: 100644786
CCAL: 108624442
SOC: 105194539
MPHA: 105830289
AEC: 105153957
ACEP: 105618056
PBAR: 105433071
VEM: 105559563
HST: 105189744
DQU: 106741964
CFO: 105248503
LHU: 105677833
PGC: 109856861
OBO: 105283842
PCF: 106793225
NVI: 100123507(Acads)
MDL: 103571272
DPA: 109544050
ATD: 109606027
NVL: 108564815
BMOR: 101743734
BMAN: 114247767
PMAC: 106711086
PRAP: 110991435
HAW: 110370948
TNL: 113503041
PXY: 105386881
DNX: 107167049
RMD: 113551422
CLEC: 106665378
ZNE: 110829314
FCD: 110852939
PVM: 113829792
CSCU: 111616279
PTEP: 107450516
PCAN: 112561493
CRG: 105344312
MYI: 110462869
OBI: 106874336
LAK: 106156920
ADF: 107340803
PDAM: 113665142
SPIS: 111326119
PTI: PHATR_25932(ACD1)
FCY: FRACYDRAFT_209569(ACD1)
TPS: THAPS_35710(ACD1)
SPAR: SPRG_09395
PAE: PA5020
PAEV: N297_5193
PAEI: N296_5193
PAEP: PA1S_27220
PAEM: U769_27475
PAEL: T223_27680
PAEG: AI22_06775
PAEC: M802_5191
PAEO: M801_5058
PMY: Pmen_0561
PMK: MDS_0639
PPSE: BN5_0454(bcd)
PPU: PP_4948
PPF: Pput_4821
PPT: PPS_4792
PPI: YSA_03995
PPX: T1E_1162(acad8)
PPUH: B479_24200
PPUT: L483_29890
PPUN: PP4_50130
PPUD: DW66_5180
PMON: X969_23660
PMOT: X970_23295
PSB: Psyr_0505
PSYR: N018_23575
PFL: PFL_0494
PPRO: PPC_0508
PFS: PFLU_0450
PFB: VO64_3531
PMAN: OU5_3012
PEN: PSEEN5004
PSA: PST_3878
PSTT: CH92_19235
PKC: PKB_5329
PSEM: TO66_02395
PSOS: POS17_0486
PALI: A3K91_1710
SFR: Sfri_2066
SLO: Shew_2868
PAT: Patl_2141
MAQ: Maqu_2845
MHC: MARHY2737
MAD: HP15_2576
MBS: MRBBS_2807(mmgC)
AMAL: I607_10830
AMAE: I876_11195
AMAO: I634_11055
AMAD: I636_11085
AMAI: I635_11485
AMAG: I533_10810
AMAC: MASE_10520
AAUS: EP12_11555
GNI: GNIT_1921(bcd)
SAGA: M5M_08525
LPF: lpl0900
LPP: lpp0931
ABO: ABO_0833 ABO_1918(acdS)
TOL: TOL_0957
RSO: RSc1762
RSN: RSPO_c01798(aidB)
RSE: F504_1627(dmdC)
RPI: Rpic_1444
REH: H16_A1530(h16_A1530) H16_B0752(h16_B0752) H16_B0850(h16_B0850)
RME: Rmet_1852
CGD: CR3_1478(bcd)
BCN: Bcen_0860
BCJ: BCAL1333
BCEO: I35_1228
BAM: Bamb_1233
BCED: DM42_376
BCON: NL30_08980
BUB: BW23_4660
BFN: OI25_4049
POL: Bpro_2570
AAV: Aave_2877
AJS: Ajs_1687
AAA: Acav_2365
VEI: Veis_1790
DAC: Daci_3315
RTA: Rta_20030
MPT: Mpe_A1777
JAG: GJA_2432
TIN: Tint_1593
GME: Gmet_1715
GUR: Gura_3040
GBM: Gbem_2832
GEO: Geob_2186
GEM: GM21_1381
GEB: GM18_1288
DAL: Dalk_1296
MXA: MXAN_0797
CCX: COCOR_00683(aidB)
HOH: Hoch_4640
SFU: Sfum_1371
BBA: Bd1973
BMX: BMS_2770(bcd)
RPE: RPE_3222
MEX: Mext_4104
RDE: RD1_3681(acdA)
HBA: Hbal_2852
SJP: SJA_C1-01450(bcd)
ACR: Acry_1573
RRU: Rru_A1308
RCE: RC1_2142
TMO: TMO_0629
BCL: ABC1506
OIH: OB1695
LBR: LVIS_1909
LBH: Lbuc_0346
CRN: CAR_c21860(acdA)
CAC: CA_C2711(bcd)
CAE: SMB_G2746(bcd)
CAY: CEA_G2719(bcd)
CPF: CPF_0092 CPF_2584(bcd)
CPR: CPR_2286(bcd)
CBO: CBO3199(bcd)
CBA: CLB_3235(bcd)
CBH: CLC_3109(bcd)
CBY: CLM_3611(bcd)
CBL: CLK_2597(bcd)
CBB: CLD_1332(bcd)
CBI: CLJ_B3471(bcd)
CBN: CbC4_1602
CBF: CLI_3338(bcd)
CBM: CBF_3330(bcd)
CKL: CKL_0455(bcd)
CKR: CKR_0400
CSR: Cspa_c04340(bcd1) Cspa_c20900(bcd3)
CPAS: Clopa_1420
CPAT: CLPA_c11000(bcd2) CLPA_c28620(bcd3)
CPAE: CPAST_c11000(bcd2) CPAST_c28620(bcd3)
CSB: CLSA_c03570(bcd1) CLSA_c40890(bcd4)
CLT: CM240_1171(bcd)
CBV: U729_1464
CLD: CLSPO_c33020(bcd3)
CTYK: CTK_C26360(bcd1) CTK_C28050(bcd4)
AMT: Amet_3091
BPB: bpr_I2485(bcd)
CSO: CLS_36820
CDF: CD630_10540(bcd2)
PDC: CDIF630_01194(bcd)
CDC: CD196_0931(bcd2)
CDL: CDR20291_0910(bcd2)
PDF: CD630DERM_10540(bcd2)
DSY: DSY1568
DHD: Dhaf_2695
PTH: PTH_0015(CaiA) PTH_0513(CaiA) PTH_1769(CaiA)
OVA: OBV_03770(acdA) OBV_16240(acdA) OBV_28830(acdA) OBV_33360(acdA) OBV_40740(acdA)
BPRM: CL3_07570
TTE: TTE0545(CaiA)
CHY: CHY_1350(bcd2) CHY_1602(bcd3)
TTM: Tthe_1660
APR: Apre_1356
MMC: Mmcs_0182
MKM: Mkms_0191
MJL: Mjls_0171
ASD: AS9A_2599
NFA: NFA_24470(fadE24)
GBR: Gbro_3567
TPR: Tpau_0702
NCA: Noca_3506
NDA: Ndas_1582
TCU: Tcur_1227
FAL: FRAAL6072
ACE: Acel_0405
GOB: Gobs_4675
PDX: Psed_4004
MIL: ML5_5681
RXY: Rxyl_1707
DRA: DR_A0250
DGE: Dgeo_2405
TTH: TT_C0238
TTJ: TTHB022
MRB: Mrub_2720
BHY: BHWA1_01911(acaD)
BRM: Bmur_1546
BPO: BP951000_1040(acaD)
BPW: WESB_2382
BIP: Bint_2792(acaD)
ACA: ACP_2397
SUS: Acid_5310
PGI: PG_1076(acdA)
PGN: PGN_1172
BACC: BRDCF_p446(bcd)
SLI: Slin_1076
TLE: Tlet_1831
TME: Tmel_0656
TAF: THA_730
FNO: Fnod_0585
CEX: CSE_15010
PIS: Pisl_1436
PCL: Pcal_0838
PAS: Pars_0456
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3968063
  Authors
Ikeda Y, Okamura-Ikeda K, Tanaka K
  Title
Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria. Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme.
  Journal
J Biol Chem 260:1311-25 (1985)
Reference
PMID:2777793
  Authors
Matsubara Y, Indo Y, Naito E, Ozasa H, Glassberg R, Vockley J, Ikeda Y, Kraus J, Tanaka K
  Title
Molecular cloning and nucleotide sequence of cDNAs encoding the precursors of rat long chain acyl-coenzyme A, short chain acyl-coenzyme A, and isovaleryl-coenzyme A dehydrogenases. Sequence homology of four enzymes of the acyl-CoA dehydrogenase family.
  Journal
J Biol Chem 264:16321-31 (1989)
  Sequence
[rno:64304]

KEGG   ORTHOLOGY: K09478Help
Entry
K09478                      KO                                     

Name
ACADSB
Definition
short/branched chain acyl-CoA dehydrogenase [EC:1.3.99.12]
Pathway
ko00071  Fatty acid degradation
ko00280  Valine, leucine and isoleucine degradation
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01130  Biosynthesis of antibiotics
ko01212  Fatty acid metabolism
Disease
H00375  SBCAD deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00071 Fatty acid degradation
    K09478  ACADSB; short/branched chain acyl-CoA dehydrogenase
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K09478  ACADSB; short/branched chain acyl-CoA dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.99  With unknown physiological acceptors
    1.3.99.12  2-methylacyl-CoA dehydrogenase
     K09478  ACADSB; short/branched chain acyl-CoA dehydrogenase
BRITE hierarchy
Other DBs
RN: R01175 R02661 R03172 R04751
GO: 0016937
Genes
HSA: 36(ACADSB)
PTR: 745464(ACADSB)
PPS: 100991276(ACADSB)
GGO: 101132470(ACADSB)
PON: 100171571(ACADSB)
NLE: 100603582(ACADSB)
MCC: 707487(ACADSB)
MCF: 102133754(ACADSB)
CSAB: 103216651(ACADSB)
RRO: 104658093(ACADSB)
RBB: 108519576(ACADSB)
CJC: 100396089(ACADSB)
SBQ: 101028121(ACADSB)
MMU: 66885(Acadsb)
MCAL: 110299023(Acadsb)
MPAH: 110326470(Acadsb)
RNO: 25618(Acadsb)
CGE: 100766828(Acadsb)
NGI: 103729261(Acadsb)
HGL: 101698912(Acadsb)
CCAN: 109691642(Acadsb)
OCU: 100351868(ACADSB)
TUP: 102474463(ACADSB)
CFA: 477856(ACADSB)
VVP: 112928830(ACADSB)
AML: 100470228(ACADSB)
UMR: 103657958(ACADSB)
UAH: 113252021(ACADSB)
ORO: 101373794(ACADSB)
ELK: 111145042
FCA: 101092794(ACADSB)
PTG: 102951023(ACADSB)
PPAD: 109252314(ACADSB)
AJU: 106969392(ACADSB)
BTA: 504301(ACADSB)
BOM: 102266366(ACADSB)
BIU: 109579124(ACADSB)
BBUB: 102397738(ACADSB)
CHX: 102177588(ACADSB)
OAS: 101102606(ACADSB)
SSC: 100154810(ACADSB)
CFR: 102517479(ACADSB)
CDK: 105085769(ACADSB)
BACU: 102999342(ACADSB)
LVE: 103077062(ACADSB)
OOR: 101289781(ACADSB)
DLE: 111172226(ACADSB)
PCAD: 102992141(ACADSB)
ECB: 100057998(ACADSB)
EAI: 106847757(ACADSB)
MYB: 102253452(ACADSB)
MYD: 102769159(ACADSB)
MNA: 107532676(ACADSB)
HAI: 109396916(ACADSB)
DRO: 112300262(ACADSB)
PALE: 102891849(ACADSB)
MJV: 108390573(ACADSB)
LAV: 100658432(ACADSB)
TMU: 101353141
MDO: 100025277(ACADSB)
SHR: 100925751(ACADSB)
PCW: 110192795(ACADSB)
OAA: 100086999(ACADSB)
GGA: 423947(ACADSB)
MGP: 100542282(ACADSB)
CJO: 107316256(ACADSB)
NMEL: 110399180(ACADSB)
APLA: 101793844(ACADSB)
ACYG: 106038988(ACADSB)
TGU: 100217590(ACADSB)
LSR: 110468433(ACADSB)
SCAN: 103813777(ACADSB)
GFR: 102040450(ACADSB)
FAB: 101819094(ACADSB)
PHI: 102100927(ACADSB)
PMAJ: 107206820(ACADSB)
CCAE: 111931386(ACADSB)
CCW: 104694570(ACADSB)
ETL: 114070836(ACADSB)
FPG: 101917969(ACADSB)
FCH: 102057808(ACADSB)
CLV: 102096980(ACADSB)
EGZ: 104128327(ACADSB)
NNI: 104022112(ACADSB)
ACUN: 113481576(ACADSB)
PADL: 103918535(ACADSB)
AAM: 106494200(ACADSB)
ASN: 102386096(ACADSB)
AMJ: 102577069(ACADSB)
PSS: 102458654(ACADSB)
CMY: 102942130(ACADSB)
CPIC: 101938408(ACADSB)
ACS: 100556766(acadsb)
PVT: 110087224(ACADSB)
PBI: 103066261(ACADSB)
PMUR: 107285940(ACADSB)
TSR: 106554066(ACADSB)
PMUA: 114597407(ACADSB)
GJA: 107116296(ACADSB)
XLA: 494679(acadsb.L)
XTR: 448259(acadsb)
NPR: 108784780(ACADSB)
DRE: 100037342(acadsb)
SRX: 107746745
SANH: 107684586
IPU: 108273611(acadsb)
PHYP: 113527247(acadsb)
AMEX: 103042655(acadsb)
EEE: 113588401(acadsb)
TRU: 101075946(acadsb)
LCO: 104926628(acadsb)
NCC: 104954036(acadsb)
MZE: 101471898(acadsb)
ONL: 100692418(acadsb)
OLA: 101163855(acadsb)
XMA: 102220838(acadsb)
XCO: 114152310(acadsb)
PRET: 103481581(acadsb)
CVG: 107090227(acadsb)
NFU: 107387801(acadsb)
KMR: 108246997(acadsb)
ALIM: 106516587(acadsb)
AOCE: 111582229(acadsb)
CSEM: 103381955(acadsb)
POV: 109626616(acadsb)
LCF: 108899015(acadsb)
SDU: 111220345(acadsb)
SLAL: 111660219(acadsb)
HCQ: 109523983(acadsb)
BPEC: 110165473(acadsb)
MALB: 109962961(acadsb)
SALP: 112075854
ELS: 105009552(acadsb)
SFM: 108939566(acadsb)
PKI: 111853681(acadsb)
LCM: 102365761(ACADSB)
CMK: 103185437(acadsb)
RTP: 109927465(acadsb)
APLC: 110988182
SKO: 100378591
DME: Dmel_CG3902(CG3902)
DER: 6545091
DSI: Dsimw501_GD12323(Dsim_GD12323)
DSR: 110185241
DPE: 6595810
DMN: 108153425
DWI: 6645938
DNV: 108650232
DHE: 111592256
MDE: 101890297
LCQ: 111690724
AAG: 5569333
AME: 409712
BIM: 100749552
BTER: 100649947
CCAL: 108628770
OBB: 114880543
AEC: 105143927
PBAR: 105428815
CFO: 105250026
LHU: 105674413
PGC: 109859061
PCF: 106790286
CSOL: 105365671
MDL: 103579394
DPA: 109540223
ATD: 109595381
BMOR: 733139(Acade)
PMAC: 106716140
PRAP: 111002788
HAW: 110372345
TNL: 113505313
PXY: 105383530
API: 100161123
DNX: 107163553
AGS: 114124068
RMD: 113551881
BTAB: 109039976
CLEC: 106664106
ZNE: 110839588
FCD: 110852222
PVM: 113821404
DPTE: 113793263
CSCU: 111633258
CEL: CELE_C55B7.4(acdh-1) CELE_K06A5.6(acdh-3) CELE_T10E9.9(acdh-4)
CBR: CBG12633 CBG12644(Cbr-acdh-1) CBG12664
TSP: Tsp_04649
PCAN: 112563554
CRG: 105329007
MYI: 110442658
OBI: 106881672
LAK: 106173907
EPA: 110246509
ADF: 107338768
AMIL: 114958115
PDAM: 113681854
SPIS: 111331973
DGT: 114515827
HMG: 100205931
AQU: 100640316
DDI: DDB_G0282967(acadsb)
DFA: DFA_08597(acadsb)
SMIN: v1.2.033419.t1(symbB.v1.2.033419.t1)
FCY: FRACYDRAFT_187779(ACD2)
TPS: THAPSDRAFT_269127(ACD3)
SPAR: SPRG_03679
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8660691 (R.norvegicus)
  Authors
Willard J, Vicanek C, Battaile KP, Van Veldhoven PP, Fauq AH, Rozen R, Vockley J
  Title
Cloning of a cDNA for short/branched chain acyl-Coenzyme A dehydrogenase from rat and characterization of its tissue expression and substrate specificity.
  Journal
Arch Biochem Biophys 331:127-33 (1996)
DOI:10.1006/abbi.1996.0290

KEGG   ORTHOLOGY: K11410Help
Entry
K11410                      KO                                     

Name
acdH
Definition
short/branched chain acyl-CoA dehydrogenase [EC:1.3.99.12]
Pathway
ko00280  Valine, leucine and isoleucine degradation
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K11410  acdH; short/branched chain acyl-CoA dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.99  With unknown physiological acceptors
    1.3.99.12  2-methylacyl-CoA dehydrogenase
     K11410  acdH; short/branched chain acyl-CoA dehydrogenase
BRITE hierarchy
Other DBs
RN: R02661 R03172
Genes
AKA: TKWG_20020
SIMP: C6571_14795
SCO: SCO2779(acdH)
SALB: XNR_4209
SMA: SAVERM_5275(fadE4)
SGR: SGR_4756
SGB: WQO_11760
SCB: SCAB_58001(acdH)
SSX: SACTE_2272
SVL: Strvi_8097
SCT: SCAT_1857(yngJ)
SFA: Sfla_4110
SBH: SBI_06919
SHY: SHJG_4280
SVE: SVEN_2568
SDV: BN159_5499(yngJ1)
SALS: SLNWT_2338
STRP: F750_2606
SFI: SFUL_2370
SALU: DC74_3256
SALL: SAZ_17345
STRE: GZL_05657
SLD: T261_5312
STRM: M444_13330
SAMB: SAM23877_2814(yngJ)
SPRI: SPRI_4763
SRW: TUE45_03394(mmgC_7)
SLE: sle_44610(sle_44610)
SRN: A4G23_01831(mmgC_3)
STRD: NI25_24960
SMAL: SMALA_2810
SLAU: SLA_2529
SALF: SMD44_03078(acdH)
SALJ: SMD11_4398(acdH)
SLX: SLAV_23940(mmgC10)
SFK: KY5_2919
SGE: DWG14_05329(mmgC_4)
SRJ: SRO_4690
KSK: KSE_26850(fadE3)
MMAR: MODMU_1452
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Zhang YX, Denoya CD, Skinner DD, Fedechko RW, McArthur HA, Morgenstern MR, Davies RA, Lobo S, Reynolds KA, Hutchinson CR
  Title
Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces coelicolor and Streptomyces avermitilis provide insights into the metabolism of small branched-chain fatty acids and macrolide antibiotic production.
  Journal
Microbiology 145 ( Pt 9):2323-34 (1999)
DOI:10.1099/00221287-145-9-2323
  Sequence
[sco:SCO2779] [sma:SAVERM_5275]

KEGG   ORTHOLOGY: K00249Help
Entry
K00249                      KO                                     

Name
ACADM, acd
Definition
acyl-CoA dehydrogenase [EC:1.3.8.7]
Pathway
ko00071  Fatty acid degradation
ko00280  Valine, leucine and isoleucine degradation
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01130  Biosynthesis of antibiotics
ko01212  Fatty acid metabolism
ko03320  PPAR signaling pathway
Module
M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA
M00087  beta-Oxidation
Disease
H00488  MCAD deficiency
H00525  Disorders of mitochondrial fatty-acid oxidation
H01400  Secondary hyperammonemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00071 Fatty acid degradation
    K00249  ACADM, acd; acyl-CoA dehydrogenase
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K00249  ACADM, acd; acyl-CoA dehydrogenase
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K00249  ACADM, acd; acyl-CoA dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.8  With a flavin as acceptor
    1.3.8.7  medium-chain acyl-CoA dehydrogenase
     K00249  ACADM, acd; acyl-CoA dehydrogenase
BRITE hierarchy
Other DBs
RN: R01175 R01279 R02661 R03172 R03777 R03857 R03990 R04095 R04751 R04754
COG: COG1960
GO: 0003995
Genes
HSA: 34(ACADM)
PTR: 469356(ACADM)
PPS: 100986310(ACADM)
GGO: 101139967(ACADM)
PON: 100440026(ACADM)
NLE: 100600902(ACADM)
MCC: 705168(ACADM)
MCF: 101867302(ACADM)
CSAB: 103224592(ACADM)
RRO: 104666522(ACADM)
RBB: 108515020(ACADM)
CJC: 100391471(ACADM)
SBQ: 101048274(ACADM)
MMU: 11364(Acadm)
MCAL: 110291322(Acadm)
MPAH: 110320920(Acadm)
RNO: 24158(Acadm)
MUN: 110552859(Acadm)
CGE: 100763159(Acadm)
NGI: 103746470(Acadm)
HGL: 101710282(Acadm)
CCAN: 109687834(Acadm)
OCU: 100347504(ACADM)
TUP: 102473504(ACADM)
CFA: 490207(ACADM)
VVP: 112924426(ACADM)
AML: 100480578(ACADM)
UMR: 103662999(ACADM)
UAH: 113254520(ACADM)
ORO: 101367783(ACADM)
ELK: 111143093
FCA: 101088421(ACADM)
PTG: 102961751(ACADM)
PPAD: 109266661(ACADM)
AJU: 106979047(ACADM)
BTA: 505968(ACADM)
BOM: 102288081(ACADM)
BIU: 109556156(ACADM)
BBUB: 102408428(ACADM)
CHX: 102179380 102190925(ACADM)
SSC: 397104(ACADM)
CFR: 102503888(ACADM)
CDK: 105096653(ACADM)
BACU: 103019579(ACADM)
LVE: 103078419(ACADM)
OOR: 101285730(ACADM)
DLE: 111178411(ACADM)
PCAD: 102977436(ACADM)
ECB: 100067343(ACADM)
EPZ: 103549430(ACADM)
EAI: 106836523(ACADM)
MYB: 102264142(ACADM)
MYD: 102759069(ACADM)
MNA: 107540115(ACADM)
HAI: 109383516(ACADM)
DRO: 112309307(ACADM)
PALE: 102892946(ACADM)
RAY: 107502426(ACADM)
MJV: 108401828(ACADM)
LAV: 100673289(ACADM)
TMU: 101357421
MDO: 100616899(ACADM)
SHR: 100927873(ACADM)
PCW: 110195692(ACADM)
OAA: 100074936(ACADM)
MGP: 104917156(ACADM)
CJO: 107307389(ACADM)
NMEL: 110391998(ACADM)
ACYG: 106049147(ACADM)
TGU: 100218051(ACADM) 100229817
LSR: 110477130(ACADM) 110481226
SCAN: 103815091(ACADM)
GFR: 102036158(ACADM)
FAB: 101819568(ACADM) 101820718
PHI: 102108551 102111183(ACADM)
CCW: 104695114(ACADM)
ETL: 114065491(ACADM)
FPG: 101912214 101919277(ACADM)
CLV: 102093964(ACADM)
EGZ: 104123852(ACADM)
NNI: 104009229(ACADM)
ACUN: 113483021(ACADM)
PADL: 103913986(ACADM) 103915499
AAM: 106486529(ACADM)
ASN: 102386917(ACADM)
AMJ: 102576335(ACADM)
PSS: 102462849(ACADM)
CMY: 102940018(ACADM)
CPIC: 101946138(ACADM)
ACS: 100566884(acadm)
PVT: 110079530(ACADM)
PBI: 103059274(ACADM)
PMUR: 107285068(ACADM)
PMUA: 114598843(ACADM)
GJA: 107113019(ACADM)
XLA: 446467(acadm.L) 447486(acadm.S)
XTR: 100494748(acadm)
NPR: 108804935(ACADM)
DRE: 406283(acadm)
SRX: 107729303(acadm) 107734933
CCAR: 109101178
IPU: 108278040(acadm)
PHYP: 113524400(acadm)
AMEX: 103046142(acadm)
EEE: 113576501(acadm)
TRU: 101068726(acadm)
LCO: 104926191(acadm)
NCC: 104961847(acadm)
MZE: 101473542(acadm)
ONL: 100693621(acadm)
OLA: 101171694(acadm)
XMA: 102232409(acadm)
XCO: 114146211(acadm)
PRET: 103479933(acadm)
NFU: 107383505(acadm)
KMR: 108232778(acadm)
ALIM: 106520768(acadm)
AOCE: 111587374
CSEM: 103396705(acadm)
POV: 109646119(acadm)
LCF: 108884276(acadm)
SDU: 111231077(acadm)
SLAL: 111668434(acadm)
HCQ: 109516871(acadm)
BPEC: 110155710(acadm)
MALB: 109955259(acadm)
SASA: 100194550(acadm)
SALP: 112076234(acadm)
ELS: 105006063(acadm)
PKI: 111846042(acadm)
LCM: 102354968(ACADM)
CMK: 103174736(acadm)
RTP: 109912184 109924720(acadm)
SPU: 591118
APLC: 110975775
DME: Dmel_CG12262(Mcad)
DER: 6543839
DSI: Dsimw501_GD14030(Dsim_GD14030)
DSR: 110189116
DPE: 6595907
DMN: 108151814
DWI: 6646461
DAZ: 108612852
DNV: 108651121
DHE: 111595087
MDE: 101888184
LCQ: 111676596
AAG: 5564469
AME: 408567
BIM: 100740892
BTER: 100649997
CCAL: 108625165
OBB: 114882791
SOC: 105201828
AEC: 105145806
ACEP: 105624188
PBAR: 105428726
VEM: 105567315
HST: 105187540
DQU: 106746765
CFO: 105256672
LHU: 105675870
PGC: 109859835
OBO: 105286556
PCF: 106790593
NVI: 100114108
CSOL: 105366845
MDL: 103572763
BMOR: 101746258
BMAN: 114246897
PMAC: 106720042
PRAP: 111000704
HAW: 110373858
TNL: 113507884
PXY: 105381602
API: 100159764
DNX: 107173947
RMD: 113548656
CLEC: 106668284
PVM: 113802667
CSCU: 111624924
PTEP: 107441230
CEL: CELE_K05F1.3(acdh-8) CELE_T08G2.3(acdh-10) CELE_T25G12.5(acdh-7)
BMY: Bm1_33775
TSP: Tsp_04159
PCAN: 112576334
CRG: 105321895
MYI: 110467447
OBI: 106875072
EPA: 110248247
AMIL: 114961177
PDAM: 113676993
SPIS: 111339449
DGT: 114530916
HMG: 100201412
AQU: 100634812
ATH: AT3G06810(IBR3)
CRB: 17890642
BRP: 103870719
BOE: 106295467
THJ: 104802695
CPAP: 110815047
TCC: 18603544
GRA: 105796851
GAB: 108483320
DZI: 111279648
EGR: 104428294
VRA: 106760127
VAR: 108321128
VUN: 114163870
CCAJ: 109807681
CAM: 101506672
LJA: Lj6g3v1468260.1(Lj6g3v1468260.1)
ADU: 107483566
AIP: 107639030
FVE: 101298511
RCN: 112197393
PPER: 18791656
PAVI: 110750204
PXB: 103943694
ZJU: 107433159
CSV: 101207559
CMO: 103483866
MCHA: 111009226
CMAX: 111479342
CMOS: 111457691
CPEP: 111790714
JCU: 105643467
MESC: 110611131
JRE: 108987299
VVI: 100258517(ACAD10)
CANN: 107870225
NSY: 104213400
NTO: 104108785
NAU: 109217351
INI: 109155797
SIND: 105156871
OEU: 111377432
LSV: 111917264
CCAV: 112527445
BVG: 104884208
SOE: 110798270
NNU: 104598895
OSA: 4344267
DOSA: Os07t0675000-01(Os07g0675000)
OBR: 102709857
BDI: 100836704
ATS: 109781256(LOC109781256)
SBI: 8074440
ZMA: 100502333
SITA: 101775070
PDA: 103711411
EGU: 105045148
MUS: 103995889
DCT: 110103978
PEQ: 110023661
AOF: 109842748
ATR: 18431303
MNG: MNEG_3217
APRO: F751_5052
ERC: Ecym_5214
KMX: KLMA_60029(ACAD11)
PIC: PICST_33103(ACD99)
CAL: CAALFM_CR08920WA(CaO19.7288)
NCR: NCU01181(acd-3) NCU09885
NTE: NEUTE1DRAFT127677(NEUTE1DRAFT_127677) NEUTE1DRAFT90322(NEUTE1DRAFT_90322)
MGR: MGG_08661
ANG: ANI_1_1322124(An14g03240) ANI_1_160154(An17g01150)
ABP: AGABI1DRAFT113662(AGABI1DRAFT_113662)
ABV: AGABI2DRAFT191688(AGABI2DRAFT_191688)
MGL: MGL_3154
MRT: MRET_2124
STM: STM0857
SENI: CY43_04595
SEI: SPC_0856
SEC: SCH_0851(acdC)
SHB: SU5_01526
SED: SeD_A0960
SEG: SG0838
SEL: SPUL_2111
SET: SEN0803
SENA: AU38_04170
SENO: AU37_04155
SENV: AU39_04160
SENQ: AU40_04630
SENL: IY59_04230
SEEP: I137_09610
SENB: BN855_8370
SENE: IA1_04365
PAY: PAU_00629
PCQ: PcP3B5_11960(mmgC_5) PcP3B5_15090(mmgC_6) PcP3B5_21800(aidB_2) PcP3B5_24260(mmgC_8) PcP3B5_24320(bbsG) PcP3B5_31070 PcP3B5_42220(mmgC_12) PcP3B5_42240(acrC_4) PcP3B5_57470(acrC_5)
PPF: Pput_3258
PPT: PPS_3280
PPX: T1E_5242
PPUD: DW66_3708
PMON: X969_15810
PMOT: X970_15455
PSYR: N018_14900
PEN: PSEEN3343
PKC: PKB_1537(acadl1) PKB_2127 PKB_3130(Acad10) PKB_4383(acd) PKB_4543(acadl3) PKB_5300
PSES: PSCI_4460
PALI: A3K91_1699
PSYA: AOT82_723
ACC: BDGL_000388(hcaD) BDGL_001010(acadM) BDGL_001771(acadL) BDGL_002476(acad8) BDGL_002513(fadE)
SFR: Sfri_2069
SSE: Ssed_3347
CPS: CPS_0666
PHA: PSHAb0374(fadE)
MHC: MARHY0848(fadE) MARHY1169(fadE) MARHY3319(acdA)
MARJ: MARI_11810(carC) MARI_18340(mmgC_1) MARI_18370(mmgC_2) MARI_20920(mmgC_4) MARI_32110(mmgC_5)
AMAL: I607_11085
AMAE: I876_11455
AMAO: I634_11310
AMAD: I636_11335
AMAI: I635_11740
AMAG: I533_11095
AMAC: MASE_10735
AAUS: EP12_11810
SDE: Sde_0166
MICC: AUP74_00507(mmgC_1) AUP74_02052(bbsG) AUP74_02726(mmgC_4)
FTU: FTT_1529(fadE)
FTF: FTF1529(fadE)
FTW: FTW_0402
FTH: FTH_0585(fadE)
FTN: FTN_1437(fadE)
GAI: IMCC3135_12750(acdA_2) IMCC3135_14040(bbsG) IMCC3135_14625(acdA_4)
HCO: LOKO_03637(mmgC_4)
SALN: SALB1_2691
CVI: CV_1785
AMAH: DLM_3567
RSY: RSUY_23300(acrC_1) RSUY_32580(acdA_2) RSUY_41470(bbsG)
REH: H16_A0101(h16_A0101) H16_A1091(h16_A1091) H16_A1291(h16_A1291) H16_A2458(abmD) H16_A2596(h16_A2596) H16_B0014(h16_B0014) H16_B0580(h16_B0580) H16_B0683(h16_B0683) H16_B0699(h16_B0699) H16_B0703(h16_B0703) H16_B0721(h16_B0721) H16_B0722(h16_B0722) H16_B0913(h16_B0913) H16_B1367(h16_B1367) H16_B1826(h16_B1826) H16_B2157(h16_B2157)
CNC: CNE_1c10340(mmgC2) CNE_1c12820(mmgC3) CNE_1c15030(mmgC4) CNE_1c23670(abmD) CNE_1c24790(mmgC5) CNE_1c26980(acdA3) CNE_2c05230(mmgC1) CNE_2c06350(mmgC4) CNE_2c06520(mmgC5) CNE_2c13260(mmgC8) CNE_2c17670(mmgC10) CNE_2c17810(bbsG2) CNE_BB1p04100 CNE_BB1p04240(acdA1) CNE_BB1p08620(bbsG) CNE_BB1p09750(mmgC3) CNE_BB1p11290(mmgC5)
CGD: CR3_0891(acd) CR3_1009(acd) CR3_1771(acd) CR3_2946(acd) CR3_3108(acd) CR3_4505(acd)
BMJ: BMULJ_01671(acd)
BDL: AK34_4160
PNE: Pnec_0573
BPER: BN118_0337
BPT: Bpet0045(acd1) Bpet0552(acd4) Bpet1936(acd10) Bpet2157(acd11) Bpet2270(acd12)
BAV: BAV3021
TEA: KUI_1575(acd12)
TEG: KUK_0906(acd12)
TAS: TASI_1546
TAT: KUM_1151(acd12)
ODI: ODI_R1508
LIM: L103DPR2_00024(mmgC_1) L103DPR2_00577(acdA_2) L103DPR2_01878(acrC_2) L103DPR2_02663(bbsG)
LIH: L63ED372_00053(acdA_1) L63ED372_00595(acdA_2) L63ED372_00603(mmgC_2) L63ED372_01672(bbsG_1) L63ED372_02307(bbsG_2) L63ED372_02960(mmgC_7) L63ED372_02972(mmgC_9)
HPSE: HPF_03095(acdA1) HPF_03630(mmgC2) HPF_10760(mmgC5) HPF_12660(mmgC6) HPF_12710(mmgC8) HPF_12735(mmgC9) HPF_12740(acdA3) HPF_12890(mmgC10) HPF_12940 HPF_12980 HPF_13565(acrC4) HPF_22460(bbsG2)
CBAA: SRAA_0665
CBAB: SMCB_1379
MPT: Mpe_A1953
JAG: GJA_2070 GJA_4012 GJA_5503(fadE31)
HSE: Hsero_2798(caiA)
HRB: Hrubri_2849(caiA)
CFU: CFU_1206(fadE2)
CARE: LT85_3601
TIN: Tint_1589
THI: THI_0877
NEU: NE2348(fadE1)
OTR: OTERR_22130(acd) OTERR_27830(acd)
DAR: Daro_2353
AZO: azo1931(abmD)
AOA: dqs_2086
BPRC: D521_1603
DML: Dmul_11600(acdA3)
DAT: HRM2_27100(acd9)
CCX: COCOR_02170(mmgC) COCOR_02177(bbsG1) COCOR_04669(mmgC1) COCOR_04995(yngJ3) COCOR_06468
CCRO: CMC5_035010(fadE) CMC5_040120(fadE) CMC5_062100(fadE) CMC5_071760(fadE)
SAT: SYN_02128
DBR: Deba_1502
BMX: BMS_3396
AMIH: CO731_01957(bbsG) CO731_02016(acdA_1) CO731_04586 CO731_05063(mmgC_3) CO731_05564(acdA_3)
SME: SMc01639
SMI: BN406_02075(yngJ)
SMER: DU99_12610
SMD: Smed_2175
SFD: USDA257_c45500(yngJ)
ATU: Atu2572(acd)
ARA: Arad_4635(acd2) Arad_9261
ATF: Ach5_24570(acd)
AVI: Avi_6022(acd)
AGR: AGROH133_08714(acd)
REC: RHECIAT_CH0004333(acd2)
RHL: LPU83_4049(acd2)
RHT: NT26_3990
BMEL: DK63_1970
BMEE: DK62_985
BABO: DK55_449
BABR: DO74_1438
BABT: DK49_212
BABB: DK48_1677
BABU: DK53_439
BABS: DK51_1023
BABC: DO78_356
BMS: BR0412
BSZ: DK67_1344
BOV: BOV_0420
BCAR: DK60_497
BCAS: DA85_01970
BMR: BMI_I416
BPV: DK65_944
MEX: Mext_4597
MEA: Mex_1p5048(acd)
MDI: METDI5649(acd)
MCH: Mchl_5058
META: Y590_23530
RVA: Rvan_2902
PLEO: OHA_1_02541(ydbM) OHA_1_04296(acdA)
HDI: HDIA_3923(acdA)
PDE: Pden_5091
DSH: Dshi_1004
OTM: OSB_31120(mmgC_5)
RID: RIdsm_00059(mmgC_2) RIdsm_00634(mmgC_4) RIdsm_01116(acd_1) RIdsm_01165(mmgC_7) RIdsm_01186(mmgC_8) RIdsm_01196(mmgC_9) RIdsm_01199(mmgC_10) RIdsm_01334 RIdsm_02007(acdA_6) RIdsm_03757(acdA_9) RIdsm_03930(mmgC_15) RIdsm_04074(mmgC_16) RIdsm_05447(mmgC_17) RIdsm_05477 RIdsm_05484(mmgC_19) RIdsm_05507 RIdsm_05521(acd_3) RIdsm_05556(mmgC_26) RIdsm_05569 RIdsm_05601
MARU: FIU81_04285(bbsG) FIU81_04990(acdA3) FIU81_05550(mmgC2)
ROT: FIV09_01525(bbsG) FIV09_19135(acdA3)
HBA: Hbal_2840
ADO: A6F68_00915(acrC_2) A6F68_02492(bbsG)
MAG: amb2588
MAGN: WV31_06320
TXI: TH3_14040
PUB: SAR11_0249(mmgC)
BTK: BT9727_2128(mmgC) BT9727_2327(acdA)
BTL: BALH_2096(mmgC) BALH_2288(bcd) BALH_2769(acdA)
BMYC: DJ92_1789
BMQ: BMQ_2353
BMD: BMD_2315
BMEG: BG04_4726
BAG: Bcoa_1013
BCOA: BF29_2706
BACO: OXB_1250
BBEV: BBEV_2891
GGH: GHH_c09690(bbsG) GHH_c12400(mmgC2) GHH_c28570
GEA: GARCT_01049(bbsG) GARCT_01323(mmgC_2)
ANL: GFC29_510
LSP: Bsph_3232
VPN: A21D_02479(mmgC_3)
PSYO: PB01_02545
ASOC: CB4_01995(mmgC_2)
AAD: TC41_0184(acd) TC41_0201(acd)
JEO: JMA_08890
SLP: Slip_2083
CHY: CHY_1732
LPIL: LIP_0226
MTU: Rv0131c(fadE1) Rv0154c(fadE2) Rv0231(fadE4) Rv0975c(fadE13) Rv3140(fadE23)
MRA: MRA_0138(fadE1) MRA_0162(fadE2) MRA_0239(fadE4) MRA_0982(fadE13) MRA_3173(fadE23)
MTUR: CFBS_0141(fadE1) CFBS_0167(fadE2) CFBS_0247(fadE4) CFBS_1027(fadE13) CFBS_3317(fadE23)
MTO: MTCTRI2_0134(fadE1) MTCTRI2_0158(fadE2) MTCTRI2_0235(fadE4) MTCTRI2_0998(fadE13) MTCTRI2_3203(fadE23)
MTD: UDA_0131c(fadE1) UDA_0154c(fadE2) UDA_0231(fadE4) UDA_0975c(fadE13) UDA_3140(fadE23)
MTN: ERDMAN_0153(fadE1) ERDMAN_0178(fadE2) ERDMAN_0259(fadE4) ERDMAN_1082(fadE13) ERDMAN_3440(fadE23)
MTUT: HKBT1_0141(fadE1) HKBT1_0167(fadE2) HKBT1_0247(fadE4) HKBT1_1025(fadE13) HKBT1_3304(fadE23)
MTUU: HKBT2_0141(fadE1) HKBT2_0167(fadE2) HKBT2_0247(fadE4) HKBT2_1030(fadE13) HKBT2_3309(fadE23)
MTQ: HKBS1_0141(fadE1) HKBS1_0167(fadE2) HKBS1_0247(fadE4) HKBS1_1027(fadE13) HKBS1_3315(fadE23)
MBO: BQ2027_MB0136C(fadE1) BQ2027_MB0159C(fadE2) BQ2027_MB0236(fadE4) BQ2027_MB1000C(fadE13) BQ2027_MB3164(fadE23)
MBB: BCG_0165c(fadE1) BCG_0190c(fadE2) BCG_0268(fadE4) BCG_1029c(fadE13) BCG_3163(fadE23)
MBT: JTY_0135(fadE1) JTY_0160(fadE2) JTY_0237(fadE4) JTY_1000(fadE13) JTY_3158(fadE23)
MBM: BCGMEX_0135c(fadE1) BCGMEX_0160c(fadE2) BCGMEX_0237(fadE4) BCGMEX_1001c(fadE13) BCGMEX_3160(fadE23)
MAF: MAF_01310(fadE1) MAF_01540(fadE2) MAF_02310(fadE4) MAF_09840(fadE13) MAF_31480(fadE23)
MCE: MCAN_01341(fadE1) MCAN_01591(fadE2) MCAN_02371(fadE4) MCAN_09791(fadE13) MCAN_31541(fadE23)
MCQ: BN44_10158(fadE) BN44_10183(fadE) BN44_10266(fadE) BN44_11077(fadE) BN44_60647(fadE)
MCV: BN43_10152(fadE) BN43_10176(fadE) BN43_10260(fadE) BN43_20455(fadE) BN43_60126(fadE)
MCX: BN42_10170(fadE) BN42_10193(fadE) BN42_10276(fadE) BN42_20793(fadE) BN42_41183(fadE)
MCZ: BN45_10148(fadE) BN45_10172(fadE) BN45_10254(fadE) BN45_20284(fadE) BN45_60146(fadE)
MLE: ML0660(fadE23)
MLB: MLBr00660(fadE23)
MPA: MAP_0723(fadE12) MAP_0913c(fadE13) MAP_1713(fadE20) MAP_3189(fadE23) MAP_3539c(fadE1) MAP_3570c(fadE2) MAP_3669(fadE4) MAP_3877c(fadE20)
MUL: MUL_1151(fadE4) MUL_2432(fadE23) MUL_2756 MUL_2757 MUL_4704(fadE13) MUL_4790(fadE1)
MMI: MMAR_0156(fadE2_1) MMAR_0331(fadE1) MMAR_0374(fadE2) MMAR_0488(fadE4) MMAR_1509(fadE23) MMAR_3132 MMAR_3512 MMAR_4532(fadE13) MMAR_4741(fadE12_1)
MMAE: MMARE11_01430(fadE2_1) MMARE11_03010(fadE1) MMARE11_03370(fadE2) MMARE11_04450(fadE4) MMARE11_14220(fadE23) MMARE11_34290 MMARE11_43460(fadE13) MMARE11_45690(fadE12_1) MMARE11_51300(fadE1_1)
MLI: MULP_00141(fadE2_1) MULP_00308(fadE1) MULP_00360(fadE2) MULP_00488(fadE4) MULP_01627(fadE23) MULP_03764 MULP_04749(fadE13) MULP_04964(fadE12_1) MULP_05541(fadE1_1)
MJD: JDM601_0253(fadE2_1) JDM601_0703(fadE1_1) JDM601_0735(fadE12_1) JDM601_0739 JDM601_0929(fadE13) JDM601_2515(fadE2_1) JDM601_2850(fadE23) JDM601_3840(fadE30) JDM601_4264
CJK: jk0229(fadE2) jk0296(fadE4) jk1462(fadE6) jk1479(fadE7)
CUR: cu0606(fadE2) cu1687(fadE4) cu1753(fadE6)
CUA: CU7111_0202 CU7111_0598(fadE2) CU7111_1626(fadE4) CU7111_1690(fadE1)
CKP: ckrop_0571(fadE1) ckrop_1641(fadE3)
CRD: CRES_0201(fadE4) CRES_1598(fadE6) CRES_2009(fadE2)
CVA: CVAR_0420(fadE3) CVAR_0504(fadE2) CVAR_1933(fadE6) CVAR_2801(fadE8)
CGY: CGLY_06175(fadE2) CGLY_13530(fadE5) CGLY_14055
NFA: NFA_21770(fadE19) NFA_22680(fadE21) NFA_24990(fadE26) NFA_25560(fadE27) NFA_25620 NFA_33820(fadE30) NFA_34080(fadE31) NFA_35440(fadE33) NFA_38250(fadE35) NFA_40720 NFA_4420(fadE1) NFA_44930(fadE38) NFA_53310(fadE45)
RHS: A3Q41_00343(mmgC_3) A3Q41_00902(bbsG_1) A3Q41_01196(mmgC_4) A3Q41_02284 A3Q41_02357(bbsG_2) A3Q41_02996(bbsG_3) A3Q41_03449(bcd_2) A3Q41_03648
RHU: A3Q40_00386(mmgC_1) A3Q40_00775(bbsG_1) A3Q40_01950(bcd_1) A3Q40_02889(bbsG_2) A3Q40_03067
GRU: GCWB2_01970(acdA1) GCWB2_02150(acdA2) GCWB2_06025(acrC4) GCWB2_06285 GCWB2_06930 GCWB2_07520(mmgC8) GCWB2_08340(bbsG2) GCWB2_11690(acrC9) GCWB2_11995(bbsG3) GCWB2_18000(acrC12) GCWB2_19350(mmgC21) GCWB2_22420(bbsG4) GCWB2_23700(acdA13)
GOM: D7316_00515(mmgC_2) D7316_02044(acrC_4) D7316_02137(bbsG_1) D7316_02183(acrC_6) D7316_02291(mmgC_9) D7316_02363(bbsG_2) D7316_02372(mmgC_10) D7316_02377 D7316_02490(mmgC_11) D7316_02495(bbsG_3) D7316_03003(carC_6) D7316_03225 D7316_03594(bcd_2) D7316_03675(bbsG_4) D7316_03727(acrC_7) D7316_04884(mmgC_16) D7316_05225(carC_9)
SCO: SCO1690(SCI30A.11) SCO2774(acdH2) SCO6787(acdH3)
SMA: SAVERM_1381(fadE15) SAVERM_5280(fadE7) SAVERM_6614(fadE17)
SCB: SCAB_58051(fadE7) SCAB_72831
SBH: SBI_00178(fadE1) SBI_03203(fadE14) SBI_06924(fadE26) SBI_08383(fadE32) SBI_08652(fadE33) SBI_08656(fadE34) SBI_09842(fadE39) SBI_09854(fadE42)
SRW: TUE45_02151(bbsG) TUE45_03388(acrC) TUE45_06579(acdA_10) TUE45_pSRc_0461(mmgC) TUE45_pSRc_0573(TUE45_pSRTUE45c_0573)
SLE: sle_17280(sle_17280) sle_44660(sle_44660) sle_54280(sle_54280)
SRN: A4G23_00929(bbsG) A4G23_01821(acrC_2) A4G23_05008(mmgC_8) A4G23_05252
SLX: SLAV_03290 SLAV_07580(mmgC3) SLAV_10170(acrC2) SLAV_23980(acrC5) SLAV_29015(bbsG1) SLAV_34450(bbsG2) SLAV_39985(acrC9)
KRH: KRH_20400
IDO: I598_0824(bbsG)
CFI: Celf_2634
NDK: I601_0429(bbsG_1) I601_1096(mmgC_10) I601_1161(bbsG_2) I601_2575(bbsG_3) I601_3358(acrC_1)
NDA: Ndas_2921
STRR: EKD16_04790(acrC3) EKD16_20695(bbsG)
NML: Namu_2477
SEN: SACE_2743(fadE22) SACE_2745(fadE21) SACE_2758 SACE_2850(acdA-3) SACE_3126(fadE13) SACE_3565 SACE_4125(fadE1) SACE_5017(acdA) SACE_5025 SACE_5380(fadE31) SACE_5699
SACC: EYD13_09370(mmgC3) EYD13_09425(bbsG) EYD13_13765(mmgC5) EYD13_16815(acdA3)
AMD: AMED_1547(acd) AMED_2478(acd) AMED_2886(acd) AMED_3140(acd) AMED_7171(acd) AMED_7193(acd) AMED_7904(acd) AMED_8367(acd)
AMM: AMES_1537(acd) AMES_2451(acd) AMES_2857(acd) AMES_3106(acd) AMES_7062(acd) AMES_7084(acd) AMES_7785(acd) AMES_8239(acd)
AMZ: B737_1538(acd) B737_2452(acd) B737_2858(acd) B737_3107(acd) B737_7062(acd) B737_7084(acd) B737_7785(acd) B737_8240(acd)
AOI: AORI_1635(acd) AORI_2441(acd) AORI_2862(acd) AORI_2887(acd) AORI_6731(acd) AORI_7154(acd)
ACTI: UA75_13565
ACAD: UA74_13480
AHG: AHOG_12700(bbsG)
ACTN: L083_7394
SNA: Snas_2907
RCA: Rcas_1888
HAU: Haur_0958
TRO: trd_1340
DFC: DFI_07265
TRA: Trad_2322
TTH: TT_C0779
MRB: Mrub_0762
LIL: LA_1130 LA_1930(caiA) LA_3363(caiA) LA_3627(caiA)
LIE: LIF_A0916 LIF_A1550(caiA) LIF_A2697(caiA) LIF_A2916(caiA)
LIS: LIL_10591(caiA3) LIL_10875(caiA4) LIL_11064(caiA5) LIL_12096(caiA7)
LBJ: LBJ_1583(caiA-2) LBJ_2860
LBL: LBL_0211 LBL_1801(caiA-2)
LBF: LBF_0057 LBF_2232(caiA-2) LBF_3219(caiA-4)
GAU: GAU_3272
GBA: J421_5579
KOS: KORDIASMS9_00359(mmgC)
TTK: TST_1750(aCADM)
TAC: Ta0398
TVO: TVG1231223(TVG1231223) TVG1371752(TVG1371752)
FAI: FAD_1664
CDIV: CPM_0442
HMA: rrnAC1983(acdI) rrnB0264(acdH)
HHI: HAH_2488(acdI) HAH_4374(acdH)
NPH: NP_1596A(acd5) NP_1754A(acd11) NP_1870A(acd9) NP_2628A(acd2) NP_2934A(acd7) NP_3004A(acd6) NP_3460A(acd3) NP_4214A(acd12) NP_4254A(acd4)
HME: HFX_4014(acd_11)
HLA: Hlac_0221
NMG: Nmag_2124(acd3) Nmag_3408(acd8)
SALI: L593_01045
SIR: SiRe_2103
MSE: Msed_0274
MCN: Mcup_1795
AHO: Ahos_0309
PAI: PAE2070
PIS: Pisl_1853
PAS: Pars_2103
PYR: P186_0336
POG: Pogu_2784
TNE: Tneu_1268
CMA: Cmaq_0556
TUZ: TUZN_0939
TTN: TTX_1113(acd)
VDI: Vdis_1483
VMO: VMUT_0127
ASC: ASAC_1042
ACIA: SE86_06335
KCR: Kcr_1036
BARC: AOA65_0028
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8356049
  Authors
Kim JJ, Wang M, Paschke R
  Title
Crystal structures of medium-chain acyl-CoA dehydrogenase from pig liver mitochondria with and without substrate.
  Journal
Proc Natl Acad Sci U S A 90:7523-7 (1993)
DOI:10.1073/pnas.90.16.7523
  Sequence
[ssc:397104]
Reference
  Authors
Toogood HS, van Thiel A, Basran J, Sutcliffe MJ, Scrutton NS, Leys D
  Title
Extensive domain motion and electron transfer in the human electron transferring flavoprotein.medium chain Acyl-CoA dehydrogenase complex.
  Journal
J Biol Chem 279:32904-12 (2004)
DOI:10.1074/jbc.M404884200
  Sequence
[hsa:34]

KEGG   ENZYME: 1.3.8.1Help
Entry
EC 1.3.8.1                  Enzyme                                 

Name
short-chain acyl-CoA dehydrogenase;
butyryl-CoA dehydrogenase;
butanoyl-CoA dehydrogenase;
butyryl dehydrogenase;
unsaturated acyl-CoA reductase;
ethylene reductase;
enoyl-coenzyme A reductase;
unsaturated acyl coenzyme A reductase;
butyryl coenzyme A dehydrogenase;
short-chain acyl CoA dehydrogenase;
short-chain acyl-coenzyme A dehydrogenase;
3-hydroxyacyl CoA reductase;
butanoyl-CoA:(acceptor) 2,3-oxidoreductase;
ACADS (gene name).
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
BRITE hierarchy
Sysname
short-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase
Reaction(IUBMB)
a short-chain acyl-CoA + electron-transfer flavoprotein = a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein [RN:R01178]
Reaction(KEGG)
Substrate
short-chain acyl-CoA [CPD:C20675];
electron-transfer flavoprotein [CPD:C04253]
Product
short-chain trans-2,3-dehydroacyl-CoA [CPD:C20676];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids beta-oxidation. The enzyme catalyses the oxidation of saturated short-chain acyl-CoA thioesters to give a trans 2,3-unsaturated product by removal of the two pro-R-hydrogen atoms. The enzyme from beef liver accepts substrates with acyl chain lengths of 3 to 8 carbon atoms. The highest activity was reported with either butanoyl-CoA [2] or pentanoyl-CoA [4]. The enzyme from rat has only 10% activity with hexanoyl-CoA (compared to butanoyl-CoA) and no activity with octanoyl-CoA [6]. cf. EC 1.3.8.7, medium-chain acyl-CoA dehydrogenase, EC 1.3.8.8, long-chain acyl-CoA dehydrogenase, and EC 1.3.8.9, very-long-chain acyl-CoA dehydrogenase.
History
EC 1.3.8.1 created 1961 as EC 1.3.2.1, transferred 1964 to EC 1.3.99.2, transferred 2011 to EC 1.3.8.1, modified 2012
Pathway
ec00071  Fatty acid degradation
ec00280  Valine, leucine and isoleucine degradation
ec00410  beta-Alanine metabolism
ec00640  Propanoate metabolism
ec00650  Butanoate metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
ec01130  Biosynthesis of antibiotics
Orthology
K00248  butyryl-CoA dehydrogenase
Genes
HSA: 35(ACADS)
PTR: 742921(ACADS)
PPS: 100994372(ACADS)
GGO: 101139640(ACADS)
PON: 100172331(ACADS)
NLE: 100586242(ACADS)
MCC: 698196(ACADS)
MCF: 102116240(ACADS)
CSAB: 103239266(ACADS)
RRO: 104666263(ACADS)
RBB: 108529647(ACADS)
CJC: 100387870(ACADS)
SBQ: 101049174(ACADS)
MMU: 11409(Acads)
MCAL: 110294359(Acads)
MPAH: 110312894(Acads)
RNO: 64304(Acads)
MUN: 110545603(Acads)
CGE: 100774097(Acads)
NGI: 103740119(Acads)
HGL: 101722158(Acads)
CCAN: 109696148(Acads)
OCU: 100352290(ACADS)
TUP: 102494372(ACADS)
CFA: 477517(ACADS)
VVP: 112932920(ACADS)
AML: 100483719(ACADS)
UMR: 103678351(ACADS)
UAH: 113267053(ACADS)
ORO: 101363887(ACADS)
ELK: 111156416
FCA: 101082442(ACADS)
PTG: 102956610(ACADS)
PPAD: 109277518(ACADS)
AJU: 106971681(ACADS)
BTA: 511222(ACADS)
BOM: 102269247(ACADS)
BIU: 109571341(ACADS)
BBUB: 102390388(ACADS)
CHX: 102180069(ACADS)
OAS: 101119850(ACADS)
SSC: 396932(ACADS)
CFR: 102503720(ACADS)
CDK: 105101985(ACADS)
BACU: 103010876(ACADS)
LVE: 103083994(ACADS)
OOR: 101278842(ACADS)
DLE: 111162645(ACADS)
PCAD: 102993784(ACADS)
ECB: 100147113(ACADS)
EPZ: 103540479(ACADS)
EAI: 106844801(ACADS)
MYB: 102250514(ACADS)
MYD: 102760180(ACADS)
MNA: 107528464(ACADS)
HAI: 109386149(ACADS)
DRO: 112310812(ACADS)
PALE: 102891595(ACADS)
RAY: 107501257(ACADS)
MJV: 108397688(ACADS)
LAV: 100669421(ACADS)
TMU: 101356048
MDO: 100025804(ACADS)
SHR: 100917746(ACADS)
PCW: 110222822(ACADS)
OAA: 100090404(ACADS)
GGA: 416969(ACADS)
MGP: 100541626(ACADS)
CJO: 107321246(ACADS)
NMEL: 110406474(ACADS)
APLA: 101801937(ACADS)
ACYG: 106031343(ACADS)
TGU: 100232428(ACADS)
LSR: 110481348(ACADS)
SCAN: