KEGG   ORTHOLOGY: K00270
Entry
K00270                      KO                                     

Name
pdh
Definition
phenylalanine dehydrogenase [EC:1.4.1.20]
Pathway
ko00350  Tyrosine metabolism
ko00360  Phenylalanine metabolism
ko00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K00270  pdh; phenylalanine dehydrogenase
   00360 Phenylalanine metabolism
    K00270  pdh; phenylalanine dehydrogenase
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K00270  pdh; phenylalanine dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.4  Acting on the CH-NH2 group of donors
   1.4.1  With NAD+ or NADP+ as acceptor
    1.4.1.20  phenylalanine dehydrogenase
     K00270  pdh; phenylalanine dehydrogenase
Other DBs
RN: R00688 R09830
GO: 0050175
Genes
BTD: BTI_5242
BUU: WS70_19890
BUL: BW21_4864
BUD: AQ610_28820
BHA: BH0218(pdh)
BIF: N288_11510
BACO: OXB_2922
BEO: BEH_00940
BON: A361_12115
BHK: B4U37_11725
OIH: OB2878
GKA: GK2031(pdh)
GTN: GTNG_1916
GGH: GHH_c20750(pdh)
ANM: GFC28_427(pdh)
AAMY: GFC30_1772(pdh)
ANL: GFC29_1197(pdh)
VPN: A21D_01988(pdh)
PSYO: PB01_19085
ESI: Exig_0386
EAN: Eab7_0362(pdh)
JEO: JMA_35970
TMR: Tmar_1152
AG: BAA08816(pdh)
 » show all
Reference
PMID:8535000
  Authors
Yamada A, Dairi T, Ohno Y, Huang XL, Asano Y
  Title
Nucleotide sequencing of phenylalanine dehydrogenase gene from Bacillus badius IAM 11059.
  Journal
Biosci Biotechnol Biochem 59:1994-5 (1995)
DOI:10.1271/bbb.59.1994
  Sequence
Reference
PMID:3311741
  Authors
Asano Y, Nakazawa A, Endo K, Hibino Y, Ohmori M, Numao N, Kondo K
  Title
Phenylalanine dehydrogenase of Bacillus badius. Purification, characterization and gene cloning.
  Journal
Eur J Biochem 168:153-9 (1987)
DOI:10.1111/j.1432-1033.1987.tb13399.x

KEGG   ENZYME: 1.4.1.20
Entry
EC 1.4.1.20                 Enzyme                                 

Name
phenylalanine dehydrogenase;
L-phenylalanine dehydrogenase;
PHD
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-phenylalanine:NAD+ oxidoreductase (deaminating)
Reaction(IUBMB)
L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH + H+ [RN:R00688]
Reaction(KEGG)
R00688;
(other) R00145 R00146 R09830
Substrate
L-phenylalanine [CPD:C00079];
H2O [CPD:C00001];
NAD+ [CPD:C00003]
Product
phenylpyruvate [CPD:C00166];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzymes from Bacillus badius and Sporosarcina ureae are highly specific for L-phenylalanine; that from Bacillus sphaericus also acts on L-tyrosine.
History
EC 1.4.1.20 created 1989
Pathway
ec00350  Tyrosine metabolism
ec00360  Phenylalanine metabolism
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00270  phenylalanine dehydrogenase
Genes
BTD: BTI_5242
BUU: WS70_19890
BUL: BW21_4864
BUD: AQ610_28820
BHA: BH0218(pdh)
BIF: N288_11510
BACO: OXB_2922
BEO: BEH_00940
BON: A361_12115
BHK: B4U37_11725
OIH: OB2878
GKA: GK2031(pdh)
GTN: GTNG_1916
GGH: GHH_c20750(pdh)
ANM: GFC28_427(pdh)
AAMY: GFC30_1772(pdh)
ANL: GFC29_1197(pdh)
VPN: A21D_01988(pdh)
PSYO: PB01_19085
ESI: Exig_0386
EAN: Eab7_0362(pdh)
JEO: JMA_35970
TMR: Tmar_1152
 » show all
Reference
1  [PMID:3112142]
  Authors
Asano Y, Nakazawa A, Endo K.
  Title
Novel phenylalanine dehydrogenases from Sporosarcina ureae and Bacillus sphaericus. Purification and characterization.
  Journal
J Biol Chem 262:10346-54 (1987)
Reference
2  [PMID:3311741]
  Authors
Asano Y, Nakazawa A, Endo K, Hibino Y, Ohmori M, Numao N, Kondo K.
  Title
Phenylalanine dehydrogenase of Bacillus badius. Purification, characterization and gene cloning.
  Journal
Eur J Biochem 168:153-9 (1987)
DOI:10.1111/j.1432-1033.1987.tb13399.x
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.20
IUBMB Enzyme Nomenclature: 1.4.1.20
ExPASy - ENZYME nomenclature database: 1.4.1.20
BRENDA, the Enzyme Database: 1.4.1.20
CAS: 69403-12-9

KEGG   REACTION: R00688
Entry
R00688                      Reaction                               

Name
L-phenylalanine:NAD+ oxidoreductase (deaminating)
Definition
L-Phenylalanine + H2O + NAD+ <=> Phenylpyruvate + Ammonia + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00006  C00079_C00166
Enzyme
Pathway
rn00360  Phenylalanine metabolism
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K00270  phenylalanine dehydrogenase [EC:1.4.1.20]
Other DBs
RHEA: 21411

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