KEGG   ORTHOLOGY: K00300
Entry
K00300                      KO                                     

Name
mtdA
Definition
methylenetetrahydrofolate/methylenetetrahydromethanopterin dehydrogenase (NADP+) [EC:1.5.1.5 1.5.1.-]
Pathway
ko00670  One carbon pool by folate
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01240  Biosynthesis of cofactors
Module
M00140  C1-unit interconversion, prokaryotes
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K00300  mtdA; methylenetetrahydrofolate/methylenetetrahydromethanopterin dehydrogenase (NADP+)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    K00300  mtdA; methylenetetrahydrofolate/methylenetetrahydromethanopterin dehydrogenase (NADP+)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     K00300  mtdA; methylenetetrahydrofolate/methylenetetrahydromethanopterin dehydrogenase (NADP+)
    1.5.1.-  
     K00300  mtdA; methylenetetrahydrofolate/methylenetetrahydromethanopterin dehydrogenase (NADP+)
Other DBs
RN: R01220 R08059
GO: 0004488
Genes
MCA: MCA0508
METU: GNH96_13770
MMT: Metme_2715
MDN: JT25_018050
MDH: AYM39_08875
MKO: MKLM6_1850
METL: U737_08940
MAH: MEALZ_3221(mtdA)
MBUR: EQU24_04570
MPSY: CEK71_10730
MMAI: sS8_1023
MEJ: Q7A_616
MEC: Q7C_2202
NHL: Nhal_3872
MPT: Mpe_A3259
METR: BSY238_260(mtdA)
MEA: Mex_1p1728(mtdA)
MDI: METDI2480(mtdA)
MEX: Mext_1797
MCH: Mchl_2133
MPO: Mpop_1749
MET: M446_6554
MNO: Mnod_7114
MOR: MOC_4192
META: Y590_08590
MAQU: Maq22A_c19275(mtdA)
MSC: BN69_1176
MCG: GL4_3376
RBA: RB10295(mtdA)
PSL: Psta_2659
PIR: VN12_15785(mtdA)
RUL: UC8_11070(mtdA)
MFF: MFFC18_24480(mtdA)
ROL: CA51_24720(mtdA)
AHEL: Q31a_40210(mtdA)
LCRE: Pla8534_42860(mtdA)
BVO: Pan97_44440(mtdA)
AMUC: Pan181_45490(mtdA)
PND: Pla175_50930(mtdA)
PLM: Plim_3754
PEH: Spb1_04100(mtdA)
PLS: VT03_31910(mtdA)
PLH: VT85_19965(mtdA)
FMR: Fuma_03860(mtdA)
GMR: GmarT_10990(mtdA)
MRI: Mal4_08500(mtdA)
SDYN: Mal52_22850(mtdA)
PLON: Pla110_21490(mtdA)
GES: VT84_01765(mtdA)
FTJ: FTUN_3065
IPA: Isop_1012
SACI: Sinac_4955
PBOR: BSF38_04914(mtdA)
AGV: OJF2_60600(mtdA)
 » show all
Reference
PMID:8144463
  Authors
Chistoserdova LV, Lidstrom ME
  Title
Genetics of the serine cycle in Methylobacterium extorquens AM1: identification of sgaA and mtdA and sequences of sgaA, hprA, and mtdA.
  Journal
J Bacteriol 176:1957-68 (1994)
DOI:10.1128/JB.176.7.1957-1968.1994
  Sequence
Reference
PMID:9765566
  Authors
Vorholt JA, Chistoserdova L, Lidstrom ME, Thauer RK
  Title
The NADP-dependent methylene tetrahydromethanopterin dehydrogenase in Methylobacterium extorquens AM1.
  Journal
J Bacteriol 180:5351-6 (1998)
DOI:10.1128/JB.180.20.5351-5356.1998
  Sequence

KEGG   ORTHOLOGY: K10714
Entry
K10714                      KO                                     

Name
mtdB
Definition
methylene-tetrahydromethanopterin dehydrogenase [EC:1.5.1.-]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K10714  mtdB; methylene-tetrahydromethanopterin dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.-  
     K10714  mtdB; methylene-tetrahydromethanopterin dehydrogenase
Other DBs
RN: R08059
Genes
MCA: MCA3018 MCA3019
METU: GNH96_03100 GNH96_03105
MMT: Metme_1303 Metme_3921 Metme_3922
MDN: JT25_003485 JT25_003490 JT25_022620
MDH: AYM39_15705 AYM39_15710
MKO: MKLM6_3243 MKLM6_3244
METL: U737_17075 U737_17080
MAH: MEALZ_1371(mtdB) MEALZ_1372(mtdB)
MBUR: EQU24_06155 EQU24_06160
MPSY: CEK71_02175 CEK71_02180
MEJ: Q7A_614
MEC: Q7C_2200
NHL: Nhal_3874
BXE: Bxe_B2431(mtdB)
BXB: DR64_4759(mtdB)
VPD: VAPA_1c31480(mtdB2)
MPT: Mpe_A2607
LCH: Lcho_3152
RGE: RGE_40230(mtdB)
MFA: Mfla_1660
MMB: Mmol_1346
MEH: M301_1556
MEP: MPQ_1567
MBAC: BN1209_0745(mtdB)
RGA: RGR602_PC01566(mtdB)
XAU: Xaut_1787
SNO: Snov_0752
MEA: Mex_1p1761(mtdB)
MDI: METDI2513(mtdB)
MEX: Mext_1829
MCH: Mchl_2164
MPO: Mpop_1780
MET: M446_5778
MNO: Mnod_6002
MOR: MOC_0683
META: Y590_08760
MAQU: Maq22A_c16460(mtdB)
MSL: Msil_2385
MTUN: MTUNDRAET4_2721(mtdB)
HDN: Hden_1479
HMC: HYPMC_1629(mtdB)
FIL: BN1229_v1_0588(mtdB)
FIY: BN1229_v1_0590(mtdB)
MSC: BN69_1052
PLEO: OHA_1_01037(mtdA)
MCG: GL4_1788
HDI: HDIA_2310(mtdB)
ALI: AZOLI_p10688(mtdB1) AZOLI_p10891(mtdB2)
ABS: AZOBR_p270085(mtdB)
MOX: DAMO_0455
BARC: AOA65_2063
 » show all
Reference
  Authors
Goenrich M, Bursy J, Hubner E, Linder D, Schwartz AC, Vorholt JA
  Title
Purification and characterization of the methylene tetrahydromethanopterin dehydrogenase MtdB and the methylene tetrahydrofolate dehydrogenase FolD from Hyphomicrobium zavarzinii ZV580.
  Journal
Arch Microbiol 177:299-303 (2002)
DOI:10.1007/s00203-001-0394-y

KEGG   REACTION: R08059
Entry
R08059                      Reaction                               

Definition
5,10-Methylenetetrahydromethanopterin + NADP+ <=> 5,10-Methenyltetrahydromethanopterin + NADPH
Equation
Reaction class
RC00001  C00005_C00006
RC00202  C04330_C04377
Enzyme
1.5.1.-
Pathway
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Orthology
K00300  methylenetetrahydrofolate/methylenetetrahydromethanopterin dehydrogenase (NADP+) [EC:1.5.1.5 1.5.1.-]
K10714  methylene-tetrahydromethanopterin dehydrogenase [EC:1.5.1.-]
Other DBs
RHEA: 53387

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