KEGG   ORTHOLOGY: K00316
Entry
K00316                      KO                                     

Name
spdH
Definition
spermidine dehydrogenase [EC:1.5.99.6]
Pathway
ko00330  Arginine and proline metabolism
ko00410  beta-Alanine metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K00316  spdH; spermidine dehydrogenase
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K00316  spdH; spermidine dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.99  With unknown physiological acceptors
    1.5.99.6  spermidine dehydrogenase
     K00316  spdH; spermidine dehydrogenase
Other DBs
RN: R01914 R01915
GO: 0050289
Genes
ESA: ESA_01921
CSK: ES15_2077
CSZ: CSSP291_09175
CSJ: CSK29544_03197
CCON: AFK62_09295
CDM: AFK67_09545
CSI: P262_03032
CMJ: AFK66_010080
CUI: AFK65_09710
CMW: AFK63_09185
CTU: CTU_20670
YRU: BD65_631
SMAR: SM39_3239
SPE: Spro_3641
SPLY: Q5A_019235
SERF: L085_09905
EBI: EbC_23290
PAE: PA3713(spdH)
PAEV: N297_3837
PAEI: N296_3837
PAG: PLES_12691(spdH)
PAF: PAM18_1233(spdH)
PAEP: PA1S_06530
PAEM: U769_06320
PAEL: T223_06255
PAEU: BN889_04106(spdH)
PAEG: AI22_27060
PAEC: M802_3834
PAEO: M801_3702
PFS: PFLU_1208
PPUU: PputUW4_01030(spdH)
POJ: PtoMrB4_28930(spdH)
SAGA: M5M_17030
APAC: S7S_17560
AHA: AHA_2947
ASA: ASA_2962
AVR: B565_1361
CVI: CV_3055
REH: H16_A1592(h16_A1592)
RME: Rmet_1600
RGE: RGE_05530
CJI: CJSA_1098
CJEJ: N564_01122
CJEU: N565_01166
CJEN: N755_01160
CJEI: N135_01194
CLA: CLA_1077
CIS: CINS_1041
CVO: CVOL_1051
CPEL: CPEL_1181
COJ: CORN_1144
CARM: CARM_1095
SPHD: HY78_02055
SECH: B18_01550
SSY: SLG_33610
SMIC: SmB9_04860(spdH)
ASZ: ASN_2151(spdH)
SRO: Sros_0365
NJA: NSJP_0330
 » show all
Reference
  Authors
Dasu VV, Nakada Y, Ohnishi-Kameyama M, Kimura K, Itoh Y
  Title
Characterization and a role of Pseudomonas aeruginosa spermidine dehydrogenase in polyamine catabolism.
  Journal
Microbiology 152:2265-72 (2006)
DOI:10.1099/mic.0.28920-0
  Sequence
[pae:PA3713]

KEGG   ENZYME: 1.5.99.6
Entry
EC 1.5.99.6                 Enzyme                                 

Name
spermidine dehydrogenase;
spermidine:(acceptor) oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With unknown physiological acceptors
Sysname
spermidine:acceptor oxidoreductase
Reaction(IUBMB)
spermidine + acceptor + H2O = propane-1,3-diamine + 4-aminobutanal + reduced acceptor [RN:R01915]
Reaction(KEGG)
R01915 > R01914
Substrate
spermidine [CPD:C00315];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Product
propane-1,3-diamine [CPD:C00986];
4-aminobutanal [CPD:C00555];
reduced acceptor [CPD:C00030]
Comment
A flavohemoprotein (FAD). Ferricyanide, 2,6-dichloroindophenol and cytochrome c can act as acceptor. 4-Aminobutanal condenses non-enzymically to 1-pyrroline.
History
EC 1.5.99.6 created 1976
Pathway
ec00330  Arginine and proline metabolism
ec00410  beta-Alanine metabolism
ec01100  Metabolic pathways
Orthology
K00316  spermidine dehydrogenase
Genes
ESA: ESA_01921
CSK: ES15_2077
CSZ: CSSP291_09175
CSJ: CSK29544_03197
CCON: AFK62_09295
CDM: AFK67_09545
CSI: P262_03032
CMJ: AFK66_010080
CUI: AFK65_09710
CMW: AFK63_09185
CTU: CTU_20670
YRU: BD65_631
SMAR: SM39_3239
SPE: Spro_3641
SPLY: Q5A_019235
SERF: L085_09905
EBI: EbC_23290
PAE: PA3713(spdH)
PAEV: N297_3837
PAEI: N296_3837
PAG: PLES_12691(spdH)
PAF: PAM18_1233(spdH)
PAEP: PA1S_06530
PAEM: U769_06320
PAEL: T223_06255
PAEU: BN889_04106(spdH)
PAEG: AI22_27060
PAEC: M802_3834
PAEO: M801_3702
PFS: PFLU_1208
PPUU: PputUW4_01030(spdH)
POJ: PtoMrB4_28930(spdH)
SAGA: M5M_17030
APAC: S7S_17560
AHA: AHA_2947
ASA: ASA_2962
AVR: B565_1361
CVI: CV_3055
REH: H16_A1592(h16_A1592)
RME: Rmet_1600
RGE: RGE_05530
CJI: CJSA_1098
CJEJ: N564_01122
CJEU: N565_01166
CJEN: N755_01160
CJEI: N135_01194
CLA: CLA_1077
CIS: CINS_1041
CVO: CVOL_1051
CPEL: CPEL_1181
COJ: CORN_1144
CARM: CARM_1095
SPHD: HY78_02055
SECH: B18_01550
SSY: SLG_33610
SMIC: SmB9_04860(spdH)
ASZ: ASN_2151(spdH)
SRO: Sros_0365
NJA: NSJP_0330
 » show all
Reference
1  [PMID:4918845]
  Authors
Tabor CW, Kellogg PD.
  Title
Identification of flavin adenine dinucleotide and heme in a homogeneous spermidine dehydrogenase from Serratia marcescens.
  Journal
J Biol Chem 245:5424-33 (1970)
Reference
2
  Authors
Tabor, H. and Tabor, C.W.
  Title
Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine, and related amines. IIE2a Speridine dehydrogenase.
  Journal
Adv Enzymol Relat Areas Mol Biol 36:225-226 (1972)
Other DBs
ExplorEnz - The Enzyme Database: 1.5.99.6
IUBMB Enzyme Nomenclature: 1.5.99.6
ExPASy - ENZYME nomenclature database: 1.5.99.6
BRENDA, the Enzyme Database: 1.5.99.6
CAS: 9076-64-6

KEGG   REACTION: R01915
Entry
R01915                      Reaction                               

Name
Spermidine:(acceptor) oxidoreductase
Definition
Spermidine + Acceptor + H2O <=> 1,3-Diaminopropane + 4-Aminobutyraldehyde + Reduced acceptor
Equation
Reaction class
RC00053  C00315_C00986
RC00225  C00315_C00555
Enzyme
Pathway
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
Orthology
K00316  spermidine dehydrogenase [EC:1.5.99.6]
Other DBs
RHEA: 14276

DBGET integrated database retrieval system