| Entry |
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| Name |
methylenetetrahydromethanopterin dehydrogenase;
N5,N10-methylenetetrahydromethanopterin dehydrogenase;
5,10-methylenetetrahydromethanopterin dehydrogenase
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| Class |
Oxidoreductases;
Acting on the CH-NH group of donors;
With other, known, physiological acceptors
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| Sysname |
5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase
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| Reaction(IUBMB) |
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420 = 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420 [RN: R04456]
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| Reaction(KEGG) |
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| Substrate |
5,10-methylenetetrahydromethanopterin [CPD: C04377];
oxidized coenzyme F420 [CPD: C00876]
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| Product |
5,10-methenyltetrahydromethanopterin [CPD: C04330];
reduced coenzyme F420 [CPD: C01080]
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| Comment |
Coenzyme F420 is a 7,8-didemethyl-8-hydroxy-5-deazariboflavin derivative; methanopterin is a pterin analogue. The enzyme is involved in the formation of methane from CO2 in the methanogen Methanothermobacter thermautotrophicus.
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| History |
EC 1.5.98.1 created 1989 as EC 1.5.99.9, modified 2004, transferred to EC 1.5.98.1 2014
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| Pathway |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K00319 | methylenetetrahydromethanopterin dehydrogenase |
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| Genes |
» show all
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| Reference |
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| Authors |
Hartzell PL, Zvilius G, Escalante-Semerena JC, Donnelly MI. |
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| Title |
Coenzyme F420 dependence of the methylenetetrahydromethanopterin dehydrogenase of Methanobacterium thermoautotrophicum. |
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| Journal |
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| Reference |
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| Authors |
te Brommelstroet BW, Geerts WJ, Keltjens JT, van der Drift C, Vogels GD |
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| Title |
Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F420-dependent enzymes, from Methanosarcina barkeri. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.5.98.1 |
| ExPASy - ENZYME nomenclature database: | 1.5.98.1 |
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