KEGG   ORTHOLOGY: K00319
Entry
K00319                      KO                                     

Name
mtd
Definition
methylenetetrahydromethanopterin dehydrogenase [EC:1.5.98.1]
Pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00567  Methanogenesis, CO2 => methane
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K00319  mtd; methylenetetrahydromethanopterin dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.98  With other, known, physiological acceptors
    1.5.98.1  methylenetetrahydromethanopterin dehydrogenase
     K00319  mtd; methylenetetrahydromethanopterin dehydrogenase
Other DBs
RN: R04456
COG: COG1927
GO: 0030268
Genes
MJA: MJ_1035
MFE: Mefer_1257
MVU: Metvu_0302
MFS: MFS40622_1652
MIF: Metin_0918
MJH: JH146_0907
MMP: MMP0372(mtd)
MMQ: MmarC5_1303
MMX: MmarC6_0579
MMZ: MmarC7_1368
MMD: GYY_01920
MMAK: MMKA1_03910(mtd)
MMAO: MMOS7_03850(mtd)
MMAD: MMJJ_07050
MAE: Maeo_1367
MVO: Mvol_1675
MTH: MTH_1464
MMG: MTBMA_c00500(mtd)
METC: MTCT_1331
MWO: MWSIV6_0005(mtd)
METE: tca_01413
MST: Msp_0163(mtd)
MRU: mru_2142(mtd)
MSI: Msm_1204
MEB: Abm4_0039(mtd)
MMIL: sm9_0086(mtd1) sm9_1352(mtd2)
MEYE: TL18_10280
MOL: YLM1_1676
METH: MBMB1_0003(mtd)
MFC: BRM9_0042(mtd)
MFI: DSM1535_1363(mtd)
MCUB: MCBB_0002(mtd)
MFV: Mfer_0811
MKA: MK0011(mtd)
AFU: AF_0714
FPL: Ferp_1018
GAC: GACE_0596
GAH: GAH_01690
MBAR: MSBR2_3303
MBAK: MSBR3_3304
MAC: MA_4430(mtd)
MMA: MM_1108
MMAC: MSMAC_0200
METM: MSMTP_0225
MTHR: MSTHT_1723
MTHE: MSTHC_1565
MHOR: MSHOH_0247
MBU: Mbur_0929(mtd)
MMET: MCMEM_1436
MMH: Mmah_0679
MPY: Mpsy_1459
MTP: Mthe_0809
MCJ: MCON_1052(mtd)
MHI: Mhar_1470
MHU: Mhun_2255
MLA: Mlab_0079
MBG: BN140_1676(mtd)
MEMA: MMAB1_2159(mtd)
MPI: Mpet_2185
MBN: Mboo_0530
MPL: Mpal_0329
MPD: MCP_1313(mtd)
MEZ: Mtc_1592(mtd)
RCI: RCIX2230(mtd)
 » show all
Reference
PMID:9151968
  Authors
Klein AR, Thauer RK
  Title
Overexpression of the coenzyme-F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase gene from the hyperthermophilic Methanopyrus kandleri.
  Journal
Eur J Biochem 245:386-91 (1997)
DOI:10.1111/j.1432-1033.1997.t01-1-00386.x
  Sequence
[mka:MK0011]

KEGG   ENZYME: 1.5.98.1
Entry
EC 1.5.98.1                 Enzyme                                 

Name
methylenetetrahydromethanopterin dehydrogenase;
N5,N10-methylenetetrahydromethanopterin dehydrogenase;
5,10-methylenetetrahydromethanopterin dehydrogenase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With other, known, physiological acceptors
Sysname
5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase
Reaction(IUBMB)
5,10-methylenetetrahydromethanopterin + oxidized coenzyme F420 = 5,10-methenyltetrahydromethanopterin + reduced coenzyme F420 [RN:R04456]
Reaction(KEGG)
R04456
Substrate
5,10-methylenetetrahydromethanopterin [CPD:C04377];
oxidized coenzyme F420 [CPD:C00876]
Product
5,10-methenyltetrahydromethanopterin [CPD:C04330];
reduced coenzyme F420 [CPD:C01080]
Comment
Coenzyme F420 is a 7,8-didemethyl-8-hydroxy-5-deazariboflavin derivative; methanopterin is a pterin analogue. The enzyme is involved in the formation of methane from CO2 in the methanogen Methanothermobacter thermautotrophicus.
History
EC 1.5.98.1 created 1989 as EC 1.5.99.9, modified 2004, transferred to EC 1.5.98.1 2014
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00319  methylenetetrahydromethanopterin dehydrogenase
Genes
MJA: MJ_1035
MFE: Mefer_1257
MVU: Metvu_0302
MFS: MFS40622_1652
MIF: Metin_0918
MJH: JH146_0907
MMP: MMP0372(mtd)
MMQ: MmarC5_1303
MMX: MmarC6_0579
MMZ: MmarC7_1368
MMD: GYY_01920
MMAK: MMKA1_03910(mtd)
MMAO: MMOS7_03850(mtd)
MMAD: MMJJ_07050
MAE: Maeo_1367
MVO: Mvol_1675
MTH: MTH_1464
MMG: MTBMA_c00500(mtd)
METC: MTCT_1331
MWO: MWSIV6_0005(mtd)
METE: tca_01413
MST: Msp_0163(mtd)
MRU: mru_2142(mtd)
MSI: Msm_1204
MEB: Abm4_0039(mtd)
MMIL: sm9_0086(mtd1) sm9_1352(mtd2)
MEYE: TL18_10280
MOL: YLM1_1676
METH: MBMB1_0003(mtd)
MFC: BRM9_0042(mtd)
MFI: DSM1535_1363(mtd)
MCUB: MCBB_0002(mtd)
MFV: Mfer_0811
MKA: MK0011(mtd)
AFU: AF_0714
FPL: Ferp_1018
GAC: GACE_0596
GAH: GAH_01690
MBAR: MSBR2_3303
MBAK: MSBR3_3304
MAC: MA_4430(mtd)
MMA: MM_1108
MMAC: MSMAC_0200
METM: MSMTP_0225
MTHR: MSTHT_1723
MTHE: MSTHC_1565
MHOR: MSHOH_0247
MBU: Mbur_0929(mtd)
MMET: MCMEM_1436
MMH: Mmah_0679
MPY: Mpsy_1459
MTP: Mthe_0809
MCJ: MCON_1052(mtd)
MHI: Mhar_1470
MHU: Mhun_2255
MLA: Mlab_0079
MBG: BN140_1676(mtd)
MEMA: MMAB1_2159(mtd)
MPI: Mpet_2185
MBN: Mboo_0530
MPL: Mpal_0329
MPD: MCP_1313(mtd)
MEZ: Mtc_1592(mtd)
RCI: RCIX2230(mtd)
 » show all
Reference
1  [PMID:4084309]
  Authors
Hartzell PL, Zvilius G, Escalante-Semerena JC, Donnelly MI.
  Title
Coenzyme F420 dependence of the methylenetetrahydromethanopterin dehydrogenase of Methanobacterium thermoautotrophicum.
  Journal
Biochem Biophys Res Commun 133:884-90 (1985)
DOI:10.1016/0006-291X(85)91218-5
Reference
2  [PMID:1911853]
  Authors
te Brommelstroet BW, Geerts WJ, Keltjens JT, van der Drift C, Vogels GD
  Title
Purification and properties of 5,10-methylenetetrahydromethanopterin dehydrogenase and 5,10-methylenetetrahydromethanopterin reductase, two coenzyme F420-dependent enzymes, from Methanosarcina barkeri.
  Journal
Biochim Biophys Acta 1079:293-302 (1991)
DOI:10.1016/0167-4838(91)90072-8
Other DBs
ExplorEnz - The Enzyme Database: 1.5.98.1
IUBMB Enzyme Nomenclature: 1.5.98.1
ExPASy - ENZYME nomenclature database: 1.5.98.1
BRENDA, the Enzyme Database: 1.5.98.1
CAS: 100357-01-5

KEGG   REACTION: R04456
Entry
R04456                      Reaction                               

Name
5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase
Definition
5,10-Methylenetetrahydromethanopterin + Coenzyme F420 + H+ <=> 5,10-Methenyltetrahydromethanopterin + Reduced coenzyme F420
Equation
Reaction class
RC00202  C04330_C04377
RC02628  C00876_C01080
Enzyme
Pathway
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00567  Methanogenesis, CO2 => methane
Orthology
K00319  methylenetetrahydromethanopterin dehydrogenase [EC:1.5.98.1]
Other DBs
RHEA: 16724

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